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Cancer: Acute Leukemia
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Total 111 results found since Jan 2013.
Addition of Melphalan to Fludarabine/Busulfan (FLU/BU4/MEL) Provides Survival Benefit for Patients with Myeloid Malignancy Following Allogeneic Bone Marrow Transplantation/Peripheral Blood Stem Cell Transplantation
In conclusion, FLU/BU4/MEL had curative potential even for patients with advanced myeloid malignancies, accompanied by the rapid complete chimerism achievement after allo-BMT/PBSCT. The NRM should be minimized to further improve the outcomes.DisclosuresYokota: Bristol-Myers Squibb: Research Funding; Pfizer Inc.: Research Funding; MSD K.K.: Research Funding; CHUGAI PHARMACEUTICAL CO., LTD.: Research Funding; Celgene: Research Funding. Shibayama: Bristol-Meyer Squibb K.K: Honoraria, Research Funding; Novartis Pharma K.K.: Honoraria, Research Funding; Fujimoto Pharmaceutical: Honoraria, Research Funding; Ono Pharmaceutical Co...
Source: Blood - November 21, 2018 Category: Hematology Authors: Ueda, T., Maeda, T., Fukushima, K., Fujita, J., Kusakabe, S., Yokota, T., Shibayama, H., Tomiyama, Y., Kanakura, Y. Tags: 721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities: Poster I Source Type: research
Favorable Outcome with Conditioning Regimen of Flu/Bu4/Mel in Acute Myeloid Leukemia Patients in Remission Undergoing Cord Blood Transplantation
: Cord blood transplantation (CBT) is a curative therapeutic option for patients with acute myeloid leukemia (AML) who do not have human leukocyte antigen-matched donors. The decline in early non-relapse mortality (NRM) after CBT has significantly improved overall survival (OS) during the past 20 years because of advances in CBT practices, such as more careful patient selection, use of safer conditioning regimens, better unit selection of cord blood, and improvement in supportive care. A previous study reported a conditioning regimen comprising fludarabine, busulfan, and melphalan (Flu/Bu4/Mel) developed for patients under...
Source: Biology of Blood and Marrow Transplantation - July 31, 2022 Category: Hematology Authors: Shohei Mizuno, Akiyoshi Takami, Koji Kawamura, Yoshimitsu Shimomura, Yasuyuki Arai, Takaaki Konuma, Yukiyasu Ozawa, Masashi Sawa, Shuichi Ota, Satoshi Takahashi, Naoyuki Anzai, Nobuhiro Hiramoto, Makoto Onizuka, Hirohisa Nakamae, Masatsugu Tanaka, Makoto Source Type: research
Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses
María Maximina B. Moreno-Altamirano1*, Simon E. Kolstoe2 and Francisco Javier Sánchez-García1*
1Laboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico
2School of Health Sciences, University of Portsmouth, Portsmouth, United Kingdom
Over the last decade, there has been significant advances in the understanding of the cross-talk between metabolism and immune responses. It is now evident that immune cell effector function strongly depends on the metabolic pathw...
Source: Frontiers in cellular and infection microbiology - April 17, 2019 Category: Microbiology Source Type: research
Comparative Effectiveness of Busulfan/Cyclophosphamide Versus Busulfan/Fludarabine Myeloablative Conditioning for Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia
ConclusionBu/Cy and Bu/Flu in alloHCT for AML results in comparable incidences of infection, GvHD, RM, NRM, RFS, and OS. This was despite Bu/Flu patients being older and more likely to have adverse cytogenetics and an unrelated donor. Bu/Flu is better tolerated with less toxicity. Faster hematopoietic recovery and shorter LOS with Bu/Flu reflects PBSC graft use and has implications for health care resource utilization. Future prospective studies with larger cohorts and cost-effectiveness analyses comparing these conditioning strategies are warranted. In this analysis, no mutations appeared to be sensitive to use of the mor...
Source: Blood - November 21, 2018 Category: Hematology Authors: Patel, S. S., Rybicki, L., Emrick, A., Winslow, V., Starn, J., Elberson, J., Hodgeman, B., Pohlman, B., Bolwell, B. J., Gerds, A. T., Hamilton, B. K., Hanna, R., Kalaycio, M., Majhail, N. S., Sobecks, R. Tags: 721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities: Poster II Source Type: research
Is Treosulfan-Based Conditioning Attractive as a Reduced-Intensity Conditioning Regimen in Korea?
CONCLUSION: This study suggests that Treo/Flu conditioning may be an alternative to Bu/Flu regimen in elderly patients with high-risk who are not suitable for standard conditioning.PMID:37698206 | DOI:10.3346/jkms.2023.38.e281
Source: Journal of Korean Medical Science - September 12, 2023 Category: Biomedical Science Authors: Se Hyung Kim Young Sok Ji Jina Yun Seong Hyeok Choi Sung Hee Lim Chan Kyu Kim Seong Kyu Park Source Type: research
