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Total 82 results found since Jan 2013.

The Genetics of Life and Death: Virus-Host Interactions Underpinning Resistance to African Swine Fever, a Viral Hemorrhagic Disease
Conclusion and Future Perspectives The mechanisms which result in reduced viral replication and lack of disease in African wild suids after ASFV infection are largely unknown. The data so far indicate that this is not due to an intrinsic difference in the ability of the virus to replicate in macrophages from these hosts. A more likely explanation is that the innate immune system of these hosts is better able to control virus replication resulting in a reduced systemic infection and reduced pathogenesis. This may involve a balance between virus and host factors which has evolved over long term infections of these hosts. Se...
Source: Frontiers in Genetics - May 2, 2019 Category: Genetics & Stem Cells Source Type: research

Cellular Therapies for the Treatment of Hematological Malignancies; Swine Are an Ideal Preclinical Model
The absence of clinically relevant large animal tumor models has historically forced experimental cellular therapies for hematological malignancies to translate directly from murine models to clinical trials. However, recent advances highlight swine as an ideal large animal model to demonstrate the safety of murine proof of concept studies prior to their implementation clinically. The availability of the MHC defined MGH miniature swine herd has been key for the development of novel approaches for hematopoietic cell and solid organ transplantation. New spontaneously arising hematological malignancies in these swine, specifi...
Source: Frontiers in Oncology - June 20, 2019 Category: Cancer & Oncology Source Type: research

Cadmium induces apoptosis and autophagy in swine small intestine by downregulating the PI3K/Akt pathway
In conclusion, our findings suggest that Cd induces intestinal apoptosis and autophagy in swine by inactivating the PI3K/Akt signaling pathway.PMID:35091949 | DOI:10.1007/s11356-022-18863-2
Source: Cell Research - January 29, 2022 Category: Cytology Authors: Haoran Zhang Jiaqiang Huang Jie Yang Jingzeng Cai Qi Liu Xintong Zhang Jun Bao Ziwei Zhang Source Type: research

Antigen detection and apoptosis in Mongolian gerbil's kidney experimentally intraperitoneally infected by swine Hepatitis E virus.
We examined the effect of Hepatitis E virus (HEV) on the renal tissue pathogenesis, morphological damages and related molecular mechanisms following swine HEV suspension intraperitoneally inoculation in Mongolian gerbils. The microscopic and ultramicroscopic analyses of kidney tissue structure were carried out at different points after inoculation of HEV. The immunohistochemistry, real-time PCR and Western blot were performed to explore the molecular mechanisms associated with HEV presence in the renal tissues. Real-time PCR revealed that the copies of HEV RNA in the kidney were detected at 7 dpi, and peaked at 14 dpi at a...
Source: Virus Research - December 24, 2015 Category: Virology Authors: Soomro MH, Shi R, She R, Yang Y, Hu F, Li H, Ayan A Tags: Virus Res Source Type: research

Viruses, Vol. 11, Pages 789: Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin
c Kvansakul Subversion of programmed cell death-based host defence systems is a prominent feature of infections by large DNA viruses. African swine fever virus (ASFV) is a large DNA virus and sole member of the Asfarviridae family that harbours the B-cell lymphoma 2 or Bcl-2 homolog A179L. A179L has been shown to bind to a range of cell death-inducing host proteins, including pro-apoptotic Bcl-2 proteins as well as the autophagy regulator Beclin. Here we report the crystal structure of A179L bound to the Beclin BH3 motif. A179L engages Beclin using the same canonical ligand-binding groove that is utilized to bind to pr...
Source: Viruses - August 26, 2019 Category: Virology Authors: Suresh Banjara Gareth L. Shimmon Linda K. Dixon Christopher L. Netherton Mark G. Hinds Marc Kvansakul Tags: Article Source Type: research

A Teen Was Diagnosed With the Flu. He Actually Had Cancer
(TAMPA, Fla.) — A Florida teen who was initially diagnosed with the flu is now being treated for cancer. WFTS news reported this week that 16-year-old Hunter Brady is undergoing rounds of chemotherapy at a Tampa children’s hospital as he fights stage 4 Hodgkin’s lymphoma. The teen started to feel weak in November, and Brady’s pediatrician told him it was most likely the flu. But his family rushed him to the emergency room several weeks later when he was having trouble breathing. Brady’s mother, Cheryl Brady, says his right lung was collapsed and his left lung was 30 percent collapsed. Hunter B...
Source: TIME: Health - March 2, 2018 Category: Consumer Health News Authors: Associated Press Tags: Uncategorized APH Cancer healthytime onetime Source Type: news

Higher Total Body Irradiation (TBI) Dose-Intensity in Fludarabine (Flu)/TBI-Based Reduced-Intensity Conditioning (RIC) Regimen Is Associated with Inferior Survival in Non-Hodgkin Lymphoma (NHL) Patients Undergoing Allogeneic Hematopoietic Cell Transplantation (alloHCT).
Disease relapse is the most common cause of therapy failure in NHL patients undergoing RIC alloHCT. Whether increasing TBI dose from 2Gy to 4Gy in RIC-platform can provide improved disease control without increasing non-relapse mortality (NRM) is not known. Using the CIBMTR database we evaluated the outcomes of NHL patients receiving RIC alloHCT with either Flu/2Gy TBI vs. Flu/4Gy TBI.
Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Mehdi Hamadani, Carlos Litovich, Manoj Khanal, Mohamed A. Kharfan-Dabaja, Kwang Woo Ahn Tags: 24 Source Type: research

Romidepsin (Rom) Enhances the Cytotoxicity of Fludarabine (Flu), Clofarabine (Clo) and Busulfan (Bu) in Malignant T-Cells
T-cell malignancies are a rare group of lymphoid hematologic disorders. Patients with relapsed disease or aggressive subtypes have poor outcomes, even with stem cell transplantation. In an effort to identify a more efficacious conditioning regimen, we investigated the synergistic cytotoxicity of the nucleoside analogs Flu and Clo, the DNA alkylating agent Bu, and the histone deacetylase inhibitor Rom in malignant established T-cell lines and patient samples.
Source: Biology of Blood and Marrow Transplantation - February 19, 2016 Category: Hematology Authors: Ben C. Valdez, Jonathan E. Brammer, Yang Li, David Murray, Esmeralda C. Teo, Yan Liu, Chitra Hosing, Yago Nieto, Richard E. Champlin, Borje S. Andersson Tags: Lymphoma/Multiple Myeloma Source Type: research

Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses
María Maximina B. Moreno-Altamirano1*, Simon E. Kolstoe2 and Francisco Javier Sánchez-García1* 1Laboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico 2School of Health Sciences, University of Portsmouth, Portsmouth, United Kingdom Over the last decade, there has been significant advances in the understanding of the cross-talk between metabolism and immune responses. It is now evident that immune cell effector function strongly depends on the metabolic pathw...
Source: Frontiers in cellular and infection microbiology - April 17, 2019 Category: Microbiology Source Type: research

Clinical Responses to CAR.CD30-T Cells in Patients with CD30+ Lymphomas Relapsed after Multiple Treatments Including Brentuximab Vedotin
Conclusions:We show that CD30.CAR-Ts combined with lymphodepletion with benda/ flu are safe and at 2 x 108 CAR T cells/m2 demonstrate excellent antitumor activity for pts with r/r CD30+ lymphomas. We also find that the addition of flu is critical for enhancing cytokines important for T cell growth and persistence. Finally, we demonstrate a significant PFS advantage in pts with r/r CD30+ lymphoma who received the highest dose level combined with benda and flu.DisclosuresGrover: Seattle Genetics: Consultancy. Park: G1 Therapeutics: Consultancy; Gilead: Speakers Bureau; Seattle Genetics: Research Funding; Teva: Research Fundi...
Source: Blood - November 21, 2018 Category: Hematology Authors: Grover, N. S., Park, S. I., Ivanova, A., Eldridge, P., McKay, K., Cheng, C. J. A., Laing, S., Covington, D., West, J., Sharf, S. E., Morrison, J. K., Scott, S., Crecelius, E., Shelley, D., Alexander, M., Buchanan, F. B., Kassam, E. H., McElfresh, M., Pint Tags: 624. Hodgkin Lymphoma and T/NK Cell Lymphoma-Clinical Studies: Immunotherapy and Targeted Strategies Source Type: research

Allogeneic Hematopoietic Stem Cell Transplantation Using Fludarabine/Melphalan and Low-Dose Total Body Irradiation: A Single Center Analysis
Conclusion: The current study proved that disease status at allo-HCT were mainly in non-remission. In such a situation, RIC using Flu/Mel/TBI was well tolerated with relatively low NRM, and was sufficient to allow engraftment for elderly or frail patients with hematopoietic malignancies.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Mino, T., Katayama, Y., Terasaki, T., Kochi, Y., Jinnouchi, F., Okatani, T., Imanaka, R., Kyo, K., Itagaki, M., Katsutani, S., Muta, T., Iwato, K., Asaoku, H. Tags: 721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities: Poster I Source Type: research

Fludarabine plus reduced-intensity busulfan versus fludarabine plus myeloablative busulfan in patients with non-Hodgkin lymphoma undergoing allogeneic hematopoietic cell transplantation
In this study, Flu/Bu4 was associated with worse OS compared with Flu/Bu2 because of high NRM in patients with NHL.PMID:36631705 | DOI:10.1007/s00277-023-05084-x
Source: Cancer Control - January 11, 2023 Category: Cancer & Oncology Authors: Kimimori Kamijo Yoshimitsu Shimomura Akihito Shinohara Shohei Mizuno Minoru Kanaya Yoshiaki Usui Sung-Won Kim Takahide Ara Ishikazu Mizuno Takuro Kuriyama Hideyuki Nakazawa Ken-Ichi Matsuoka Shigeru Kusumoto Nobuo Maseki Masaki Yamaguchi Takashi Ashida Ma Source Type: research