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Cancer: Melanoma

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Total 81 results found since Jan 2013.

Genes, Vol. 10, Pages 915: Melanoma-Bearing Libechov Minipig (MeLiM): The Unique Swine Model of Hereditary Metastatic Melanoma
Skalnikova National cancer databases document that melanoma is the most aggressive and deadly cutaneous malignancy with worldwide increasing incidence in the Caucasian population. Around 10% of melanomas occur in families. Several germline mutations were identified that might help to indicate individuals at risk for preventive interventions and early disease detection. More than 50% of sporadic melanomas carry mutations in Ras/Raf/mitogen-activated protein kinase (MAPK/MEK) pathway, which may represent aims of novel targeted therapies. Despite advances in targeted therapies and immunotherapies, the outcomes in metasta...
Source: Genes - November 8, 2019 Category: Genetics & Stem Cells Authors: Vratislav Horak Anna Palanova Jana Cizkova Veronika Miltrova Petr Vodicka Helena Kupcova Skalnikova Tags: Review Source Type: research

Vitamin D receptor and CD86 expression in the skin of vitamin D-deficient swine.
In this study, we examined the effect of vitamin D deficiency and sufficiency on VDR, NF-κB, and CD86 in the epidermis of Yucatan microswine tragi. All of these proteins have known roles in the pathogenesis of cutaneous malignancies such as melanoma and non-melanoma skin cancer. There was weaker and less discrete nuclear staining for VDR and weaker CD86 immunoreactivity with patchy membranous expression in the epidermis of vitamin D-deficient compared to vitamin D-sufficient swine. There was no difference in the immunostaining for NF-κB. Since VDR and CD86 expression are decreased in the setting of melanoma and non-melan...
Source: Experimental and Molecular Pathology - November 13, 2013 Category: Pathology Authors: Trowbridge RM, Mitkov MV, Hunter WJ, Agrawal DK Tags: Exp Mol Pathol Source Type: research

Sensors, Vol. 19, Pages 2815: Photoacoustic/Ultrasound/Optical Coherence Tomography Evaluation of Melanoma Lesion and Healthy Skin in a Swine Model
In this study, we imaged a swine model with spontaneous melanoma using these modalities and compared the images with images of nearby healthy skin. Histology images were used for validation.
Source: Sensors - June 23, 2019 Category: Biotechnology Authors: Karl Kratkiewicz Rayyan Manwar Ali Rajabi-Estarabadi Joseph Fakhoury Jurgita Meiliute Steven Daveluy Darius Mehregan Kamran (Mohammad) Avanaki Tags: Article Source Type: research

Researchers find hint of a link between flu vaccine and miscarriage
Researchers studying the impact of the flu vaccine in pregnancy have found a possible link between miscarriage early in pregnancy in women who received the flu vaccine two years in a row. It’s the first study to identify a potential link between miscarriage and the flu vaccine and the first to assess the effect of repeat influenza […]Related:Melinda Gates decries ‘loss of U.S. leadership’ in global aidFormer CDC chief launches $225 million global health initiativeNew clinical trial might change the standard treatment for melanoma
Source: Washington Post: To Your Health - September 13, 2017 Category: Consumer Health News Source Type: news

What to know about a study of flu vaccine and miscarriage
Researchers studying the flu vaccine in pregnancy have found a hint of a possible link between miscarriage early in pregnancy and the flu vaccine in women who received a certain version of the vaccine two years in a row. It’s the first study to identify a potential link between miscarriage and the flu vaccine and the first […]Related:Melinda Gates decries ‘loss of U.S. leadership’ in global aidFormer CDC chief launches $225 million global health initiativeNew clinical trial might change the standard treatment for melanoma
Source: Washington Post: To Your Health - September 13, 2017 Category: Consumer Health News Source Type: news

Classical swine fever virus triggers RIG-I and MDA5-dependent signaling pathway to IRF-3 and NF-kappaB activation to promote secretion of interferon and inflammatory cytokines in porcine alveolar macrophages
Conclusions: It indicates that CSFV can be recognized by both RIG-I and MDA5 to initiate the RIG-I signaling pathway to trigger innate defenses against infection.
Source: Virology Journal - September 13, 2013 Category: Virology Authors: Xiao-Ying DongWen-Jun LiuMing-Qiu ZhaoJia-Ying WangJing-Jing PeiYong-Wen LuoChun-Mei JuJin-Ding Chen Source Type: research

Classical swine fever virus triggers RIG-I and MDA5-dependent signaling pathway to IRF-3 and NF-¿B activation to promote secretion of interferon and inflammatory cytokines in porcine alveolar macrophages
Conclusions: It indicates that CSFV can be recognized by both RIG-I and MDA5 to initiate the RIG-I signaling pathway to trigger innate defenses against infection.
Source: Virology Journal - September 13, 2013 Category: Virology Authors: Xiao-Ying DongWen-Jun LiuMing-Qiu ZhaoJia-Ying WangJing-Jing PeiYong-Wen LuoChun-Mei JuJin-Ding Chen Source Type: research

The role of αβ T-cells in spontaneous regression of melanoma tumors in swine.
Abstract Using a porcine model, we describe Melanoma-Associated CD4+CD8hi T-lymphocytes (MATL) in peripheral blood that increase during melanoma regression. These MATL possess the CD4+CD8hi phenotype and they have their direct counterparts in Tumor Infiltrating Lymphocytes (TIL) isolated from melanoma loci. Both MATL and CD4+CD8hi TIL have a similar expression of selected markers indicating that they represent effector/memory αβ T-cell subset. Moreover, although TIL also contain CD4-CD8+ T-cells, only CD4+CD8hi TIL expand during melanoma regression. Importantly, TIL isolated from different pigs and different mel...
Source: Developmental and Comparative Immunology - October 8, 2018 Category: Allergy & Immunology Authors: Cizkova J, Sinkorova Z, Strnadova K, Cervinkova M, Horak V, Sinkora J, Stepanova K, Sinkora M Tags: Dev Comp Immunol Source Type: research

Antiviral Role of Serine Incorporator 5 (SERINC5) Proteins in Classical Swine Fever Virus Infection
In this study, overexpression of SERINC5 in PK-15 and 3D4/2 cells significantly inhibited the growth of CSFV, whereas SERINC5 silencing enhanced CSFV growth. Additionally, CSFV infection reduced SERINC5 production in cells and tissues. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to identify and analyze protein and peptide molecules that potentially interact with SERINC5. A total of 33 cellular protein candidates were identified. Next, SERINC5 was shown to interact with melanoma differentiation-associated protein 5 (MDA5) by yeast two-hybrid, protein co-localization and co-immunoprecipitation assays. ...
Source: Frontiers in Microbiology - September 3, 2020 Category: Microbiology Source Type: research

Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research