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This flu season has now reached pandemic levels (but it ’ s not technically a pandemic)
This flu season is turning out to be so intense that the number of people seeking care at doctors' offices and emergency rooms has surged to levels not reported since the peak of the 2009 swine flu pandemic, federal officials said Friday. For yet another week, flu continues to get worse. “We were hoping to have […]Related:Robin Williams’s suicide was followed by a sharp rise in ‘copycat’ deathsBillionaire Patrick Soon-Shiong, who just purchased the Los Angeles Times, is a controversial figure in medicineFDA ramps up warnings about kratom, calling unregulated herb an ‘opioid’
Source: Washington Post: To Your Health - February 9, 2018 Category: Consumer Health News Source Type: news

Narcolepsy in Adolescence — A Missed Diagnosis: A Case Report
In this report, we present a case of an adolescent male with all four cardinal symptoms of narcolepsy who was misdiagnosed with epilepsy, psychosis, and depression. We also discuss various issues regarding narcolepsy in children and adolescents. Case Report Mr. A, an 18-year-old man, presented to psychiatry outpatient services with excessive daytime sleepiness of approximately 1.5 years’ duration. When the chronology of symptoms was evaluated, it was evident that about 1.5 years before presentation, the patient had an episode of high-grade fever (101–103?F) and was empirically treated for typhoid and malaria. Within a ...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue adolescence misdiagnosis narcolepsy Source Type: research

Measurement of narcolepsy symptoms: The Narcolepsy Severity Scale
Conclusions: The NSS can be considered a reliable and valid clinical tool for the quantification of narcolepsy symptoms to monitor and optimize narcolepsy management.
Source: Neurology - April 3, 2017 Category: Neurology Authors: Dauvilliers, Y., Beziat, S., Pesenti, C., Lopez, R., Barateau, L., Carlander, B., Luca, G., Tafti, M., Morin, C. M., Billiard, M., Jaussent, I. Tags: Narcolepsy ARTICLE Source Type: research

Childhood narcolepsy and autism spectrum disorders – an underdiagnosed neuropsychiatric association?
Introduction: Childhood narcolepsy is associated with various emotional, behavioural and cognitive dysfunctions as well as with psychiatric and neurodevelopmental disorders: anxiety, depression, attention deficit hyperactivity disorder and psychosis. A relationship between these conditions is not clear –comorbidity as well as similar pathophysiological mechanisms can be suggested. The aim of our study is to describe four children with narcolepsy type 1 (NT1) and new comorbidity of autism spectrum disorder (ASD)–Asperger syndrome.
Source: Sleep Medicine - December 1, 2017 Category: Sleep Medicine Authors: I. P říhodová, I. Dudová, M. Mohaplová, M. Hrdlička, S. Nevšímalová Tags: Narcolepsy Source Type: research

We forget that flu once plagued the economy as coronavirus does today
The epidemic of 1918-21 is overshadowed by war and the Great Depression. But it holds lessons for us stillIt is a sobering thought that, according to the many well-researched accounts to have appeared in recent weeks, this Johnson/Cummings government seems to have been prepared to risk 250,000 deaths from the policy of “herd immunity”. This approach was, mercifully, laid to rest after theintervention of Professor Neil Ferguson, of Imperial College London, on 16 March. There followed the introduction of lockdown and what some of us prefer to call “physical distancing.”Commentators have been putting the 27,000 or mor...
Source: Guardian Unlimited Science - May 3, 2020 Category: Science Authors: William Keegan Tags: Economics Business Coronavirus outbreak Science Infectious diseases World news Flu Society Brexit UK news Boris Johnson European Union Foreign policy Source Type: news

High Rates of Psychiatric Comorbidity in Narcolepsy: Findings From the Burden of Narcolepsy Disease (BOND) Study of 9,312 Patients in the United States.
CONCLUSIONS: Narcolepsy is associated with significant comorbid psychiatric illness burden and higher psychiatric medication usage compared with the non-narcolepsy population. PMID: 27835717 [PubMed - as supplied by publisher]
Source: Journal of Clinical Psychiatry - November 13, 2016 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Chronic pain in narcolepsy type 1 and type 2 - an underestimated reality.
The objective of the study was to determine the frequency and the characteristic of chronic pain according to the type of narcolepsy. We also investigated the effect of the interaction between the nutritional status and the type of narcolepsy. It was a cross-sectional study using self-administered questionnaires. Patients with narcolepsy (33 type 1 and 33 type 2), from Universidade Federal de São Paulo, Brazil, matched by age and gender to 33 control subjects were included. Both types of narcolepsy presented a high frequency of chronic pain (84.84% type 1 versus 75.75% type 2), with indistinct pain characteristics between...
Source: Journal of Sleep Research - June 19, 2018 Category: Sleep Medicine Authors: Cremaschi RC, Hirotsu C, Tufik S, Coelho FM Tags: J Sleep Res Source Type: research

Facial expression recognition and emotional regulation in narcolepsy with cataplexy.
Abstract Cataplexy is pathognomonic of narcolepsy with cataplexy, and defined by a transient loss of muscle tone triggered by strong emotions. Recent researches suggest abnormal amygdala function in narcolepsy with cataplexy. Emotion treatment and emotional regulation strategies are complex functions involving cortical and limbic structures, like the amygdala. As the amygdala has been shown to play a role in facial emotion recognition, we tested the hypothesis that patients with narcolepsy with cataplexy would have impaired recognition of facial emotional expressions compared with patients affected with central hy...
Source: Journal of Sleep Research - December 10, 2012 Category: Sleep Medicine Authors: Bayard S, Croisier Langenier M, Dauvilliers Y Tags: J Sleep Res Source Type: research

Listening to the Patient Voice in Narcolepsy: Diagnostic Delay, Disease Burden, and Treatment Efficacy
Conclusions:This study provides unique insight into the narcolepsy disease experience. The study quantifies the problem of diagnostic delay for narcolepsy patients in the United States and highlights that symptoms are more likely to be missed if they develop before 18 y of age. These results suggest that narcolepsy awareness efforts should be aimed at parents, pediatric health care providers, school professionals, and children/adolescents themselves. Disease burden is high because of problems with fatigue, cognition, and persistence of residual symptoms despite treatment.Citation:Maski K, Steinhart E, Williams D, Scammell ...
Source: Journal of Clinical Sleep Medicine : JCSM - March 15, 2017 Category: Sleep Medicine Source Type: research

Comorbid psychiatric disorders among patients with narcolepsy.
CONCLUSION: Comorbid psychiatric disorders are common among Arab (Saudi) patients with narcolepsy compared with the general population. Therefore, clinicians should be aware of the comorbidity of narcolepsy and psychiatric disorders, particularly depression. PMID: 31280401 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - July 5, 2019 Category: Sleep Medicine Authors: Alasim H, AlQazlan S, Albanyan S, Alsalhi A, Buraik A, Olaish AH, Almeneessier AS, Alosaimi FD, AlHadi A, BaHammam AS Tags: Sleep Breath Source Type: research

Mortality and comorbidities in narcolepsy - an Olmsted County, Minnesota community-based study (S14.005)
Conclusions:There was a non-significant increase in age-adjusted mortality with narcolepsy. Close attention should be given to the significantly increased comorbidities of obstructive sleep apnea, low back pain, depression, anxiety, and thyroid disease.Disclosure: Dr. Cohen has nothing to disclose. Dr. Mandrekar has nothing to disclose. Dr. St. Louis has received personal compensation for activities with Axovant, Inc. and Inspire, Inc. Dr. Silber has received royalty payments from UpToDate. Dr. Kotagal has received personal compensation for activities with INC Research. Dr. Kotagal has received royalty payments from UpToDate.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Cohen, A., Mandrekar, J., St. Louis, E., Silber, M., Kotagal, S. Tags: Highlights in Sleep Science Source Type: research

Narcolepsy with cataplexy and pregnancy: a case-control study.
Abstract This was a retrospective case-control study in 25 patients with narcolepsy with cataplexy and 75 women in the control group. Patients completed the questionnaire by Maurovich-Horvat et al. (J. Sleep Res., 2013, 22: 496-512). We personally interviewed 25 patients with narcolepsy with cataplexy using the administered questionnaire regarding conception, pregnancy, delivery, perinatal and breastfeeding periods. Patients with narcolepsy with cataplexy reported 59 pregnancies versus 164 in the control group. In 16 cases (27.1%), a disease before pregnancy was present compared with eight cases (4.9%) in the con...
Source: Journal of Sleep Research - June 1, 2017 Category: Sleep Medicine Authors: Calvo-Ferrandiz E, Peraita-Adrados R Tags: J Sleep Res Source Type: research

Comorbid psychiatric disorders among patients with narcolepsy
ConclusionComorbid psychiatric disorders are common among Arab (Saudi) patients with narcolepsy compared with the general population. Therefore, clinicians should be aware of the comorbidity of narcolepsy and psychiatric disorders, particularly depression.
Source: Sleep and Breathing - July 5, 2019 Category: Respiratory Medicine Source Type: research

Neuropsychiatric Correlates of Narcolepsy
This study reviews recent evidence for the association between narcolepsy and neuropsychiatric disorders. We also critically analyze studies that have addressed the neuropsychiatric correlates of patients with narcolepsy, with a discussion of the possible pathophysiological mechanisms linking narcolepsy and neuropsychiatric disorders.Recent FindingsNeuropsychiatric manifestations are common among patients with narcolepsy as narcolepsy and some neuropsychiatric disorders share common clinical features. This may create challenges in making the correct diagnosis, and hence result in a delay in starting appropriate treatment. ...
Source: Current Psychiatry Reports - June 4, 2020 Category: Psychiatry Source Type: research

Frequencies and Associations of Narcolepsy-Related Symptoms: A Cross-Sectional Study
Conclusions:Narcolepsy-related symptoms are associated with poor quality of life and worse psychological parameters.Citation:Kim LJ, Coelho FM, Hirotsu C, Araujo P, Bittencourt L, Tufik S, Andersen ML. Frequencies and associations of narcolepsy-related symptoms: a cross-sectional study. J Clin Sleep Med 2015;11(12):1377–1384.
Source: Journal of Clinical Sleep Medicine : JCSM - December 15, 2015 Category: Sleep Medicine Source Type: research