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Total 307 results found since Jan 2013.

Narcolepsy in Adolescence — A Missed Diagnosis: A Case Report
In this report, we present a case of an adolescent male with all four cardinal symptoms of narcolepsy who was misdiagnosed with epilepsy, psychosis, and depression. We also discuss various issues regarding narcolepsy in children and adolescents. Case Report Mr. A, an 18-year-old man, presented to psychiatry outpatient services with excessive daytime sleepiness of approximately 1.5 years’ duration. When the chronology of symptoms was evaluated, it was evident that about 1.5 years before presentation, the patient had an episode of high-grade fever (101–103?F) and was empirically treated for typhoid and malaria. Within a ...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue adolescence misdiagnosis narcolepsy Source Type: research

Treatment with sodium oxybate decreases body mass index in narcolepsy type 1
Introduction: Individuals with narcolepsy type 1 often gain body weight after disease onset, frequently leading to obesity. Previous work suggested this weight gain may be counteracted by treatment with sodium oxybate (SXB). This has not yet been confirmed, and long-term follow-up data are not available. We assessed body mass index (BMI) change after initiating treatment with SXB and compared this with BMI change after initiating treatment with modafinil in narcolepsy type 1.
Source: Sleep Medicine - December 1, 2017 Category: Sleep Medicine Authors: M. Schinkelshoek, I. Smolders, C. Donjacour, W. van der Meijden, E. van Zwet, R. Fronczek, G.J. Lammers Tags: Narcolepsy Source Type: research

Narcolepsy treatments: comparison of pitolisant, modafinil and sodium oxybate via a network meta-analysis
Introduction: Narcolepsy, a chronic disabling disease, is characterized by two main symptoms: the excessive daytime sleepiness (EDS) measured by the Epworth Sleepiness Scale (ESS) and/or the Maintenance Wakefulness Test (MWT) and the cataplexy attacks rate (CAR). We performed a Multiple-Treatment comparison of three main treatments on EDS, CAR and  Safety in randomized clinical trials (RCTs) through a Network meta-analysis (NMA).
Source: Sleep Medicine - December 1, 2017 Category: Sleep Medicine Authors: G. Plazzi, P. Lehert Tags: Narcolepsy Source Type: research

Pitolisant (Wakix) for Narcolepsy
Date: February 8, 2021 Issue #:  1617Summary:  The FDA has approved pitolisant (Wakix– Harmony), a histamine-3 (H3)-receptor antagonist/inverse agonist, for treatment of excessive daytime sleepiness (EDS) or cataplexy in adults with narcolepsy. It is the first H3-receptor antagonist/inverse agonist to become available in the US and the first non-controlled substance to receive FDA approval for these indications. Pitolisant has been available in Europe since 2016.
Source: The Medical Letter - January 12, 2021 Category: Drugs & Pharmacology Authors: admin Tags: Adderall Alertec Amphetamine Anafranil armodafinil Clomipramine Effexor fluoxetine Methylphenidate Narcolepsy Nuvigil pitolisant Provigil Prozac Ritalin SNRIs Sodium oxybate solriamfetol SSRIS Sunosi Tricyclic antid Source Type: research

The Risk of Hospitalization for Motor Vehicle Accident Injury in Narcolepsy and the Benefits of Stimulant Use: A Nationwide Cohort Study in Taiwan
Conclusions:Patients with narcolepsy may have a higher risk of hospitalization for MVAI and stimulant use could mitigate such risk.Citation:Tzeng NS, Hsing SC, Chung CH, Chang HA, Kao YC, Mao WC, Yang CC, Kuo TB, Chen TY, Chien WC. The risk of hospitalization for motor vehicle accident injury in narcolepsy and the benefits of stimulant use: a nationwide cohort study in Taiwan.J Clin Sleep Med. 2019;15(6):881–889.
Source: Journal of Clinical Sleep Medicine : JCSM - June 15, 2019 Category: Sleep Medicine Source Type: research

Narcolepsy with cataplexy and pregnancy: a case-control study.
Abstract This was a retrospective case-control study in 25 patients with narcolepsy with cataplexy and 75 women in the control group. Patients completed the questionnaire by Maurovich-Horvat et al. (J. Sleep Res., 2013, 22: 496-512). We personally interviewed 25 patients with narcolepsy with cataplexy using the administered questionnaire regarding conception, pregnancy, delivery, perinatal and breastfeeding periods. Patients with narcolepsy with cataplexy reported 59 pregnancies versus 164 in the control group. In 16 cases (27.1%), a disease before pregnancy was present compared with eight cases (4.9%) in the con...
Source: Journal of Sleep Research - June 1, 2017 Category: Sleep Medicine Authors: Calvo-Ferrandiz E, Peraita-Adrados R Tags: J Sleep Res Source Type: research

Narcolepsy and Other Central Hypersomnias
This article focuses on the clinical presentation, pathophysiology, diagnosis, differential diagnosis, and management of narcolepsy type 1 and narcolepsy type 2, idiopathic hypersomnia, Kleine-Levin syndrome, and other central disorders of hypersomnolence, as defined in the International Classification of Sleep Disorders, Third Edition (ICSD-3). Recent Findings: In ICSD-3, the names of some central disorders of hypersomnolence have been changed: narcolepsy with cataplexy and narcolepsy without cataplexy have been renamed narcolepsy type 1 and narcolepsy type 2, respectively. A low level of hypocretin-1/orexin-A in the CSF...
Source: CONTINUUM: Lifelong Learning in Neurology - August 1, 2017 Category: Neurology Tags: Review Articles Source Type: research

Comorbidity of Narcolepsy and Psychotic Disorders: A Nationwide Population-Based Study in Taiwan
ConclusionsThis nationwide study revealed that narcolepsy and psychotic disorders commonly co-occur. Pharmacotherapy for narcolepsy was not associated with the risk of psychotic disorders. Our findings serve as a reminder that clinicians must consider the comorbidity of narcolepsy and psychosis.
Source: Frontiers in Psychiatry - March 24, 2020 Category: Psychiatry Source Type: research

Attention-Deficit/Hyperactivity Disorder (ADHD) Symptoms in Pediatric Narcolepsy: A Cross-Sectional Study
Conclusions:Pediatric patients with narcolepsy have high levels of treatment-resistant attention-deficit/hyperactivity disorder (ADHD) symptoms. The optimal treatment for ADHD symptoms in these patients warrants further evaluation in longitudinal intervention studies.Citation:Lecendreux M, Lavault S, Lopez R, Inocente CO, Konofal E, Cortese S, Franco P, Arnulf I, Dauvilliers Y. Attention-deficit/hyperactivity disorder (adhd) symptoms in pediatric narcolepsy: a cross-sectional study. SLEEP 2015;38(8):1285–1295.
Source: Sleep - August 1, 2015 Category: Sleep Medicine Source Type: research

Pharmacological management of narcolepsy with and without cataplexy.
Authors: Kallweit U, Bassetti CL Abstract Introduction Narcolepsy is an orphan neurological disease and presents with sleep- wake, motoric, neuropsychiatric and metabolic symptoms. Narcolepsy with cataplexy is most commonly caused by an immune-mediated process including genetic and environmental factors, resulting in the selective loss of hypocretin-producing neurons. Narcolepsy has a major impact on workableness and quality of life. Areas covered This review provides an overview of the temporal available treatment options for narcolepsy (type 1 and 2) in adults, including authorization status by regulatory agencie...
Source: Expert Opinion on Pharmacotherapy - April 28, 2017 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Narcolepsy with cataplexy and pregnancy: a case –control study
Summary This was a retrospective case–control study in 25 patients with narcolepsy with cataplexy and 75 women in the control group. Patients completed the questionnaire by Maurovich‐Horvat et al. (J. Sleep Res., 2013, 22: 496–512). We personally interviewed 25 patients with narcolepsy with cataplexy using the administered questionnaire regarding conception, pregnancy, delivery, perinatal and breastfeeding periods. Patients with narcolepsy with cataplexy reported 59 pregnancies versus 164 in the control group. In 16 cases (27.1%), a disease before pregnancy was present compared with eight cases (4.9%) in the control...
Source: Journal of Sleep Research - June 1, 2017 Category: Neurology Authors: Elena Calvo ‐Ferrandiz, Rosa Peraita‐Adrados Tags: Regular Research Paper Source Type: research

Evaluating pitolisant as a narcolepsy treatment option.
Authors: de Biase S, Pellitteri G, Gigli GL, Valente M Abstract INTRODUCTION: Narcolepsy is a chronic sleep disorder characterized by a pentad of excessive daytime sleepiness (EDS), cataplexy, sleep paralysis, hypnagogic/hypnopompic hallucinations, and disturbed nocturnal sleep. Treatment of narcolepsy remains challenging and current therapy is strictly symptomatically based. AREAS COVERED: The present manuscript is based on an extensive Internet and PubMed search from 1990 to 2020. It is focused on the clinical and pharmacological properties of pitolisant in the treatment of narcolepsy. EXPERT OPINION: Cur...
Source: Expert Opinion on Pharmacotherapy - September 19, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Experience with the use of modafinil in the treatment of narcolepsy in a outpatient facility specialized in diurnal excessive sleepiness in São Paulo
In this study, modafinil was effective for the control of the symptoms related do narcolepsy in 66% of the studied patients. The side effects such as headache, parestesias and diarrhea were the main reasons for the discontinuation of treatment with modafinil. It is important to clinically follow up the patients for a long period to evaluate symptomatology, control of use, tolerability and re-evaluation of the more effective therapeutic dosage able to control narcolepsy. Due to its high cost and clinical benefits, this drug should be on the government׳s list of free drugs for the treatment of these patients.
Source: Sleep Science - November 6, 2014 Category: Sleep Medicine Source Type: research

Treatment Options for Narcolepsy
Abstract Narcolepsy type 1 and narcolepsy type 2 are central disorders of hypersomnolence. Narcolepsy type 1 is characterized by excessive daytime sleepiness and cataplexy and is associated with hypocretin-1 deficiency. On the other hand, in narcolepsy type 2, cerebrospinal fluid hypocretin-1 levels are normal and cataplexy absent. Despite major advances in our understanding of narcolepsy mechanisms, its current management is only symptomatic. Treatment options may vary from a single drug that targets several symptoms, or multiple medications that each treats a specific symptom. In recent years, narcolepsy treatme...
Source: CNS Drugs - May 6, 2016 Category: Neurology Source Type: research

The Comorbidity of Focal Epilepsy and Narcolepsy Type 1 - Two Case Reports.
Authors: Klobucnikova K, Siarnik P, Muchova I, Štofko J, Kollar B Abstract The aim of this study is to remind the possibility of co-occurrence of epilepsy and narcolepsy. In the first case report, narcolepsy type 1 was diagnosed in 29-year-old female. After one year of the treatment with modafinil a new episodes of automatic behavior appeared. Patient was reevaluated and the diagnosis of focal epilepsy with partial complex seizures was established. Patient was treated with modafinil and lamotrigine and became seizure-free. In the second case report a 21-year-old female was referred with a typical history of narco...
Source: Neuroendocrinology Letters - September 7, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research