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Total 124 results found since Jan 2013.

Narcolepsy in Adolescence — A Missed Diagnosis: A Case Report
In this report, we present a case of an adolescent male with all four cardinal symptoms of narcolepsy who was misdiagnosed with epilepsy, psychosis, and depression. We also discuss various issues regarding narcolepsy in children and adolescents. Case Report Mr. A, an 18-year-old man, presented to psychiatry outpatient services with excessive daytime sleepiness of approximately 1.5 years’ duration. When the chronology of symptoms was evaluated, it was evident that about 1.5 years before presentation, the patient had an episode of high-grade fever (101–103?F) and was empirically treated for typhoid and malaria. Within a ...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue adolescence misdiagnosis narcolepsy Source Type: research

Pitolisant (Wakix) for Narcolepsy
Date: February 8, 2021 Issue #:  1617Summary:  The FDA has approved pitolisant (Wakix– Harmony), a histamine-3 (H3)-receptor antagonist/inverse agonist, for treatment of excessive daytime sleepiness (EDS) or cataplexy in adults with narcolepsy. It is the first H3-receptor antagonist/inverse agonist to become available in the US and the first non-controlled substance to receive FDA approval for these indications. Pitolisant has been available in Europe since 2016.
Source: The Medical Letter - January 12, 2021 Category: Drugs & Pharmacology Authors: admin Tags: Adderall Alertec Amphetamine Anafranil armodafinil Clomipramine Effexor fluoxetine Methylphenidate Narcolepsy Nuvigil pitolisant Provigil Prozac Ritalin SNRIs Sodium oxybate solriamfetol SSRIS Sunosi Tricyclic antid Source Type: research

Spontaneous Adverse Drug Reaction Reports for Neonates and Infants in the UK 2001 ‐2010: Content and Utility analysis
ConclusionsThe frequency of YC reports for those <2 years is low, neonates are poorly represented, and recording of gestational age is poor. With the exception of vaccinations, spontaneous reports alone are not currently generating the data required, and important safety messages from the regulator do not match reporting patterns. Additional reporting strategies are required to improve the quantity and quality of suspected ADR data in young children.
Source: British Journal of Clinical Pharmacology - August 31, 2016 Category: Drugs & Pharmacology Authors: Daniel B. Hawcutt, Nicki ‐Jayne Russell, Hannah Maqsood, Koushan Kouranloo, Simon Gomberg, Catriona Waitt, Andrew Sharp, Andrew Riordan, Mark A. Turner Tags: PAEDIATRIC CLINICAL PHARMACOLOGY Source Type: research

Spontaneous adverse drug reaction reports for neonates and infants in the UK 2001 –2010: content and utility analysis
ConclusionsThe frequency of YC reports for those <2 years is low, neonates are poorly represented, and recording of gestational age is poor. With the exception of vaccinations, spontaneous reports alone are not currently generating the data required, and important safety messages from the regulator do not match reporting patterns. Additional reporting strategies are required to improve the quantity and quality of suspected ADR data in young children.
Source: British Journal of Clinical Pharmacology - September 11, 2016 Category: Drugs & Pharmacology Authors: Daniel B. Hawcutt, Nicki ‐Jayne Russell, Hannah Maqsood, Koushan Kouranloo, Simon Gomberg, Catriona Waitt, Andrew Sharp, Andrew Riordan, Mark A. Turner Tags: PAEDIATRIC CLINICAL PHARMACOLOGY Source Type: research

Antidepressant-Like Effects and Cognitive Enhancement of Coadministration of Chaihu Shugan San and Fluoxetine: Dependent on the BDNF-ERK-CREB Signaling Pathway in the Hippocampus and Frontal Cortex.
Conclusion. Finally, we found that both CSS and coadministration of CSS and FLU play an antidepressant role, which may be due to the regulation of the BDNF/ERK/CREB signaling pathway in the hippocampus and frontal cortex. Among them, the coadministration of CSS and FLU can enhance the antidepressant effect of CSS or FLU alone, and the underlying mechanism needs further investigation. PMID: 32185198 [PubMed - in process]
Source: Biomed Res - March 20, 2020 Category: Research Authors: Yan L, Xu X, He Z, Wang S, Zhao L, Qiu J, Wang D, Gong Z, Qiu X, Huang H Tags: Biomed Res Int Source Type: research

Tissue bioconcentration and effects of fluoxetine in zebrafish (Danio rerio) and red crucian cap (Carassius auratus) after short-term and long-term exposure.
Abstract Fluoxetion (FLU) is an antidepressant pharmaceutical most commonly detected in the aquatic environment. The present study aims to elucidate the tissue accumulation and effects of FLU using two different fish models. First, the multiple effects and the FLU levels in fish, were examined in zebrafish (Danio rerio) embryos exposed to FLU concentrations (0, 0.1, 1, 10, 100, 1000 μg/L) from 4 h post-fertilization (hpf) until 120 hpf. Exposure to FLU accelerated heart rates, postponed hatching time, and increased swimming speed of fish. A dynamic response of acetylcholinesterase (AChE) activity was also dis...
Source: Chemosphere - April 16, 2018 Category: Chemistry Authors: Pan C, Yang M, Xu H, Xu B, Jiang L, Wu M Tags: Chemosphere Source Type: research

Molecules, Vol. 27, Pages 22: Antidepressant-like Effects of Combined Fluoxetine and Zinc Treatment in Mice Exposed to Chronic Restraint Stress Are Related to Modulation of Histone Deacetylase
l Nowak Chronic stress is the key factor contributing to the development of depressive symptoms. Chronic restraint stress (CRS) is well validated and is one of the most commonly used models to induce depressive-like behavior in rodents. The present study aimed to evaluate whether fluoxetine (FLU 5 mg/kg) and zinc (Zn 10mg/kg) given simultaneously induce a more pronounced antidepressant-like effect in the CRS model than both those compounds given alone. Behavioral assessment was performed using the tail suspension and splash tests (TST and ST, respectively). Furthermore, the effects of CRS, FLU and Zn given alone and co...
Source: Molecules - December 21, 2021 Category: Chemistry Authors: Paulina Misztak Magdalena Sowa-Ku ćma Patrycja Pa ńczyszyn-Trzewik Bernadeta Szewczyk Gabriel Nowak Tags: Article Source Type: research

Danio rerio embryos on Prozac − Effects on the detoxification mechanism and embryo development
In conclusion, this study shows that FLU can impact zebrafish embryo development, at concentrations found in effluents of WWTPs, concomitantly with changes in antioxidant enzymes, and the transcription of key genes involved in detoxification and development. These finding raises additional concerns supporting the need to monitor the presence of this compound in aquatic reservoirs.
Source: Aquatic Toxicology - August 6, 2016 Category: Toxicology Source Type: research

Danio rerio embryos on Prozac – Effects on the detoxification mechanism and embryo development
In conclusion, this study shows that FLU can impact zebrafish embryo development, at concentrations found in effluents of WWTPs, concomitantly with changes in antioxidant enzymes, and the transcription of key genes involved in detoxification and development. These finding raises additional concerns supporting the need to monitor the presence of this compound in aquatic reservoirs.
Source: Aquatic Toxicology - August 8, 2016 Category: Toxicology Source Type: research

Danio rerio embryos on Prozac - Effects on the detoxification mechanism and embryo development.
In conclusion, this study shows that FLU can impact zebrafish embryo development, at concentrations found in effluents of WWTPs, concomitantly with changes in antioxidant enzymes, and the transcription of key genes involved in detoxification and development. These finding raises additional concerns supporting the need to monitor the presence of this compound in aquatic reservoirs. PMID: 27513977 [PubMed - as supplied by publisher]
Source: Aquatic Toxicology - August 5, 2016 Category: Toxicology Authors: Cunha V, Rodrigues P, Santos MM, Moradas-Ferreira P, Ferreira M Tags: Aquat Toxicol Source Type: research

Simultaneous determination of fluoxetine and norfluoxetine in dried blood spots using high-performance liquid chromatography-tandem mass spectrometry.
CONCLUSIONS: The presented data support the clinical use of DBS for therapeutic drug monitoring of FLU. PMID: 28987790 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - October 4, 2017 Category: Biochemistry Authors: da Silva ACC, Raasch JR, Vargas TG, Peteffi GP, Hahn RZ, Antunes MV, Perassolo MS, Linden R Tags: Clin Biochem Source Type: research

The Herb-Drug Pharmacokinetic Interaction of Fluoxetine and Its Metabolite Norfluoxetine with a Traditional Chinese Medicine in Rats by LC-MS/MS.
Conclusion: There were some differences in pharmacokinetic parameters between the FLU group and multiple dose groups, and CSGS can affect the pharmacokinetics of fluoxetine. PMID: 31871472 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - December 25, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Fluoxetine exposure for more than 2 days decreases the neuronal plasticity mediated by CRMP2 in differentiated PC12 cells.
CONCLUSIONS: The results demonstrated that neuronal plasticity was increased by FLU exposure at day 1, but exposure with FLU for more than 2 days had opposite effect on it. The reduction in neuronal plasticity with FLU exposure for more than 2 days might be involved in some aspects of the therapeutic effect of antidepressant on depression. PMID: 32070769 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - February 14, 2020 Category: Neurology Authors: Wu Z, Wang G, Wang H, Xiao L, Wei Y, Yang C Tags: Brain Res Bull Source Type: research

Gender-specific effects of fluoxetine on hippocampal glucocorticoid receptor phosphorylation and behavior in chronically stressed rats.
Abstract Chronic psychosocial isolation stress (CPSI) modulates glucocorticoid receptor (GR) functioning in Wistar male rat hippocampus (HIPPO) through alteration of nuclear GR phosphorylation and its upstream kinases signaling, which parallels animal depressive-like behavior. The current study investigated potential gender specificities regarding the effect of chronic therapy by an antidepressant fluoxetine (FLU) on GR signaling in HIPPO and depressive-like behavior in CPSI animals. FLU was administrated to female and male naïve or CPSI rats for 21 days and GR protein, its phosphorylation status and upstream kin...
Source: Neuropharmacology - January 23, 2013 Category: Drugs & Pharmacology Authors: Mitic M, Simic I, Djordjevic J, Radojcic MB, Adzic M Tags: Neuropharmacology Source Type: research

Interactive effects of selected pharmaceutical mixtures on bioaccumulation and biochemical status in crucian carp (Carassius auratus).
Abstract The aim of this study was to evaluate the interactive effects of fluoxetine (FLU), roxithromycin (ROX) and propranolol (PRP) on the bioaccumulation and biochemical responses in the crucian carp Carassius auratus. After 7 days of binary exposure (ROX + FLU and PRP + FLU), the addition of waterborne FLU at nominal concentrations of 4, 20 and 100 μg L(-1) significantly increased the accumulation of ROX and PRP in fish livers in most cases, although elevated ROX and PRP bioaccumulation levels were not observed in muscles or gills. The inductive response of 7-ethoxyresorufin O-deethylase (EROD) to PRP a...
Source: Chemosphere - January 19, 2016 Category: Chemistry Authors: Ding J, Lu G, Li Y Tags: Chemosphere Source Type: research