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Drug: Insulin

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Total 141 results found since Jan 2013.

Glucose and Fat Metabolism in Narcolepsy and the Effect of Sodium Oxybate: A Hyperinsulinemic-Euglycemic Clamp Study
Conclusion:We show that narcolepsy patients are more insulin sensitive and may have a lower rate of lipolysis than matched controls. SXB stimulated lipolysis in narcolepsy patients, possibly accounting for the weight loss after treatment. While sodium oxybate tended to decrease systemic insulin sensitivity, it increased hepatic insulin sensitivity, suggesting tissue-specific effects.Citation:Donjacour CE; Aziz NA; Overeem S; Kalsbeek A; Pijl H; Lammers GJ. Glucose and fat metabolism in narcolepsy and the effect of sodium oxybate: a hyperinsulinemic-euglycemic clamp study. SLEEP 2014;37(4):795-801.
Source: Sleep - April 1, 2014 Category: Sleep Medicine Source Type: research

Endocrine and metabolic aspects of narcolepsy type 1 in children
CONCLUSIONS: We found a high prevalence of large BMI gain in the period immediately after the onset of narcolepsy, which had almost normalized at the long-term follow-up. The onset of narcolepsy led to early puberty in both sexes. Linear growth was not affected. We did not find any strong indicators of metabolic disturbances.PMID:34098245 | DOI:10.1016/j.ejpn.2021.05.009
Source: European Journal of Paediatric Neurology - June 7, 2021 Category: Neurology Authors: Attila Szak ács Jovanna Dahlgren Jannie Eklund A Stefan Aronson Tove Hallb öök Niklas Darin Source Type: research

Effect of Age on Diabetogenicity of Alloxan in Ossabaw Miniature Swine.
This study supports previous research that the effects of alloxan are dependent on the developmental maturity of the animal. PMID: 30894246 [PubMed - as supplied by publisher]
Source: Comparative Medicine - March 19, 2019 Category: Zoology Authors: Badin JK, Progar V, Pareddy A, Cagle J, Alloosh M, Sturek M Tags: Comp Med Source Type: research

Untangling Narcolepsy and Diabetes: Pathomechanisms with Eyes on Therapeutic Options.
Abstract Narcolepsy (NA) is a primary sleep disorder characterized by loss of hypocretinergic/orexinergic neurons. NA is associated with an increased risk for metabolic disorders such as diabetes mellitus (DM). Proposed mechanisms for this association are alterations in food intake, disruption of energy balance, glucose tolerance, and insulin sensitivity, as well as inflammation and genetic factors. Orexin deficiency, is associated with increased food intake and reduced basal metabolic rate (BMR) both leading to obesity. The anti-apoptotic effect of orexin on pancreatic beta-cells, increase in peripheral insulin s...
Source: Brain Research - April 14, 2019 Category: Neurology Authors: Mohammadi S, Dolatshahi M, Zare-Shahabadi A, Rahmani F Tags: Brain Res Source Type: research

The risk of type 1 diabetes not increased by swine flu vaccine Pandemrix
A study in children published inDiabetologiareports that Pandemrix increased neither the risk of developing autoantibodies against insulin-producing beta cells nor the occurrence of type 1 diabetes.Science Daily
Source: Society for Endocrinology - October 10, 2017 Category: Endocrinology Source Type: news

Effect of Caloric Restriction on Metabolic Dysfunction of Young Rapacz Familial Hypercholesterolemic Swine (Sus scrofa).
We examined whether parameters of metabolic syndrome including weight and adiposity, serum cholesterol, and glucoregulatory function could be modulated by restriction of caloric intake in the FH swine. Three groups of FH swine (n = 6 per group) were fed without restriction (AL), 80% of AL caloric intake, or 60% of AL caloric intake for 8.8 ± 0.5 mo beginning 2 wk after weaning. Caloric intake influenced the rate and magnitude of body weight gain and change in adiposity, as determined by dual-emission X-ray absorptiometry. At the conclusion of the study, pigs in the AL group reached a total least-square mean body weight of...
Source: Comparative Medicine - December 1, 2017 Category: Zoology Authors: Bekiares NA, Chen AS, Shanmuganayagam D, Meyers AD, Crenshaw TD, Krueger CG, Reed JD Tags: Comp Med Source Type: research

Effects of Insulin-degrading enzyme on the proliferation of swine Sertoli cells
Cell Mol Biol (Noisy-le-grand). 2023 Jan 31;69(1):13-18. doi: 10.14715/cmb/2022.69.1.3.ABSTRACTSertoli cells, the only somatic cells in testis seminiferous tubules, provide a supporting microenvironment for male germ cells and play essential roles in spermatogenesis. The insulin-degrading enzyme (IDE), a ubiquitous zinc peptidase of the inverzincin family, plays crucial role in sperm production, as IDE-knockout mice presented decreased testis weight and impaired sperm viability and morphology. However, whether and how IDE affects swine Sertoli cell proliferation remains unclear. Thus, in the present study, we aimed to eval...
Source: Mol Biol Cell - May 22, 2023 Category: Molecular Biology Authors: Mingrui Zhang Hongmei Gao Yile Sun Zhiguo Liu Fei Guo Bingyuan Wang Yulian Mu Source Type: research

Proteomic profiling of the hypothalamus in two mouse models of narcolepsy
This article is protected by copyright. All rights reserved
Source: Proteomics - May 1, 2017 Category: Biochemistry Authors: Sausan Azzam, Daniela Schlatzer, David Nethery, Dania Saleh, Xiaolin Li, Afaf Akladious, Mark R. Chance, Kingman P. Strohl Tags: Research Article Source Type: research

High Fat, High Fructose, High Cholesterol Feeding Causes Severe NASH and Cecal Microbiota Dysbiosis in Juvenile Ossabaw Swine.
Abstract Pediatric obesity and nonalcoholic steatohepatitis (NASH) are on the rise in industrialized countries, yet our ability to mechanistically examine this relationship is limited by the lack of a suitable higher animal model. Here, we examined the effects of high fat, high fructose corn syrup, high cholesterol Western style diet (WD)-induced obesity on NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine. Juvenile female Ossabaw swine (5 weeks old) were fed WD (43.0% fat; 17.8% high fructose corn syrup; 2% cholesterol) or low-fat diet (CON/lean; 10.5% fat) for 16 wks (n=6 each) or 36 wks (n=4 each). WD...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 12, 2017 Category: Physiology Authors: Panasevich MR, Meers GM, Linden MA, Booth FW, Perfield JW, Fritsche KL, Wankhade UD, Chintapalli SV, Shankar K, Ibdah JA, Rector RS Tags: Am J Physiol Endocrinol Metab Source Type: research

Lazaroid U-74389G Administration in Pancreatic Ischemia-Reperfusion Injury: A Swine Model Encompassing Ischemic Preconditioning.
CONCLUSION: This swine model of pancreatic ischemia and reperfusion, encompassing preconditioning, indicates that U-74389G lazaroid does not seem to exert protective effects from pancreatic damage. PMID: 25791552 [PubMed - in process]
Source: JOP - March 23, 2015 Category: Gastroenterology Authors: Chrysikos DT, Sergentanis TN, Zagouri F, Psaltopoulou T, Theodoropoulos G, Flessas I, Agrogiannis G, Alexakis N, Lymperi M, Katsarou AI, Patsouris ES, Zografos CG, Papalois AE Tags: JOP Source Type: research

Extracorporeal Membrane Oxygenation Improving Survival and Alleviating Kidney Injury in a Swine Model of Cardiac Arrest Compared to Conventional Cardiopulmonary Resuscitation.
Conclusions: Compared with CCPR, ECMO improves survival rate and alleviates AKI in a swine model of CA. The mechanism of which might be via downregulating AKI biomarkers and apoptosis in kidney. PMID: 30058582 [PubMed - in process]
Source: Chinese Medical Journal - August 5, 2018 Category: General Medicine Authors: Yuan XL, Li CS, Zhang Y, Ling JY, Zhang Q, Liang Y, Liu B, Zhao LX Tags: Chin Med J (Engl) Source Type: research