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Source: Frontiers of Neurology and Neuroscience
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Sleep Problems in Narcolepsy and the Role of Hypocretin/Orexin Deficiency
Front Neurol Neurosci. 2021;45:103-116. doi: 10.1159/000514959. Epub 2021 May 28.ABSTRACTSince its description in the 19th century, narcolepsy type 1 (NT1) has been considered as a model sleep disorder, and after the discovery of rapid eye movement (REM) sleep onset in the disorder, a gateway to understanding REM sleep. The discovery that NT1 is caused by hypocretin/orexin deficiency, together with neurochemical studies of this system, has helped to establish how this neuropeptide regulates the organization of sleep and wake in humans. Current analyses suggest that the main functions of the hypocretin/orexin system are (1)...
Source: Frontiers of Neurology and Neuroscience - May 30, 2021 Category: Neuroscience Authors: Emmanuel Mignot Jamie Zeitzer Fabio Pizza Giuseppe Plazzi Source Type: research
