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Nutrition: Calcium

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Total 177 results found since Jan 2013.

Calcium, magnesium, potassium, and sodium oxybates oral solution for cataplexy or excessive daytime sleepiness associated with narcolepsy
Expert Opin Pharmacother. 2023 Apr 15. doi: 10.1080/14656566.2023.2204187. Online ahead of print.ABSTRACTINTRODUCTION: Lower-sodium oxybate (LXB) is a novel formulation that is approved by the US Food and Drug Administration (FDA) to treat cataplexy and excessive daytime sleepiness (EDS) in adult patients and children ≥ 7 years with narcolepsy. LXB contains 92 percent less sodium than sodium oxybate (SXB), which adds 550-1640 mg of sodium/day at usual doses of 3-9 grams per day. The FDA has declared LXB to be clinically superior to SXB due to greater safety by reducing the chronic sodium load. Narcolepsy patients have hi...
Source: Expert Opinion on Pharmacotherapy - April 15, 2023 Category: Drugs & Pharmacology Authors: Vivien C Abad Source Type: research

Validation of a novel partial resuscitative endovascular balloon occlusion of the aorta device in a swine hemorrhagic shock model: Fine tuning flow to optimize bleeding control and reperfusion injury
CONCLUSION Prolonged pREBOA at a moderate distal flow rate provided adequate hemorrhage control, improved survival, and had evidence of decreased ischemic injury versus fREBOA. Prophylactic aggressive calcium supplementation may have utility before and during the reperfusion phase.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - June 23, 2020 Category: Orthopaedics Tags: 2020 EAST PODIUM PAPER Source Type: research

Autoantibodies in Pandemrix ®-induced narcolepsy: Nine candidate autoantigens fail the conformational autoantibody test.
Conclusions: None of the nine labelled proteins proposed to be autoantigens were detected in the radiobinding assays for conformation-dependent autoantibodies. The results emphasise the need of further studies to identify autoantigen(s) and clarify the mechanisms in Pandemrix®-induced NT1. PMID: 31328572 [PubMed - as supplied by publisher]
Source: Autoimmunity - July 23, 2019 Category: Allergy & Immunology Tags: Autoimmunity Source Type: research

Jazz Pharmaceuticals Announces U.S. FDA Approval of Xywav(TM) (calcium, magnesium, potassium, and sodium oxybates) Oral Solution for Cataplexy or Excessive Daytime Sleepiness Associated with Narcolepsy
Xywav is the first FDA approved new treatment option indicated for both cataplexy and excessive daytime sleepiness in people living with narcolepsy in more than 15 years Xywav contains 92 percent less sodium per nightly dose than sodium oxybate, a curre... Biopharmaceuticals, Neurology, FDA Jazz Pharmaceuticals, Xywav, Cataplexy, Narcolepsy
Source: HSMN NewsFeed - July 22, 2020 Category: Pharmaceuticals Source Type: news

Xywav - A Mixed-Salt Oxybate Oral Solution for Idiopathic Hypersomnia
Date: December 27, 2021 Issue #:  1640Summary: Xywav (Jazz), an oral solution that contains calcium, magnesium, potassium, and sodium oxybates, has been approved by the FDA for treatment of idiopathic hypersomnia in adults. It is the first drug to be approved in the US for this indication.Xywav was approved in 2020 for treatment of excessive daytime sleepiness or cataplexy in patients ≥7 years old with narcolepsy. It contains about 92% less sodium than sodium oxybate oral solution(Xyrem), which has been available in the US for years for use in patients ≥7 years old with narcolepsy.
Source: The Medical Letter - December 10, 2021 Category: Drugs & Pharmacology Authors: admin Tags: Alertec armodafinil Methylphenidate Narcolepsy Nuvigil pitolisant Provigil Ritalin Sodium oxybate solriamfetol Sunosi Wakix Xyrem Xywav Source Type: research

Lazaroid U-74389G Administration in Pancreatic Ischemia-Reperfusion Injury: A Swine Model Encompassing Ischemic Preconditioning.
CONCLUSION: This swine model of pancreatic ischemia and reperfusion, encompassing preconditioning, indicates that U-74389G lazaroid does not seem to exert protective effects from pancreatic damage. PMID: 25791552 [PubMed - in process]
Source: JOP - March 23, 2015 Category: Gastroenterology Authors: Chrysikos DT, Sergentanis TN, Zagouri F, Psaltopoulou T, Theodoropoulos G, Flessas I, Agrogiannis G, Alexakis N, Lymperi M, Katsarou AI, Patsouris ES, Zografos CG, Papalois AE Tags: JOP Source Type: research

Viruses, Vol. 10, Pages 460: Classical Swine Fever Virus p7 Protein Interacts with Host Protein CAMLG and Regulates Calcium Permeability at the Endoplasmic Reticulum
Manuel V. Borca We have previously shown that Classical Swine Fever Virus (CSFV) p7 is an essential nonstructural protein with a viroporin activity, a critical function in the progression of virus infection. We also identified p7 domains and amino acid residues critical for pore formation. Here, we describe how p7 specifically interacts with host protein CAMLG, an integral ER transmembrane protein involved in intracellular calcium release regulation and signal response generation. Detection of interaction as well as the identification of p7 areas mediating interaction with CAMLG was performed by yeast two-hybrid. p7-...
Source: Viruses - August 28, 2018 Category: Virology Authors: Douglas P. Gladue Eneko Largo Lauren G. Holinka Elizabeth Ramirez-Medina Elizabeth A. Vuono Keith A. Berggren Guillermo R. Risatti Jose L. Nieva Manuel V. Borca Tags: Communication Source Type: research

Intracellular changes of a swine tracheal cell line infected with a Mycoplasma hyopneumoniae pathogenic strain
Publication date: Available online 5 September 2019Source: Microbial PathogenesisAuthor(s): Fernanda M.A. Leal Zimmer, Hercules Moura, John R. Barr, Henrique Bunselmeyer FerreiraAbstractMycoplasma hyopneumoniae is the etiological agent of enzootic pneumonia (EP), a widespread disease that causes major economic losses to the pig industry. The swine host response plays an important role in the outcome of M. hyopneumoniae infections. The whole proteome of newborn pig trachea (NPTr) epithelial cells infected with the M. hyopneumoniae pathogenic strain 7448 was analyzed using an LC-MS/MS approach to shed light on intracellular ...
Source: Microbial Pathogenesis - September 5, 2019 Category: Infectious Diseases Source Type: research

Toxicity and antimicrobial effect of silver nanoparticles in swine sperms.
Abstract Bacterial contamination in swine semen affects the quality and longevity of sperm and consequently fertility is reduced. Antibiotics have been used to prevent bacterial growth, but the frequency of bacterial resistance to various antibiotics are increasing. Silver nanoparticles (AgNPs) of 10-20 nm in size have shown a biocide effect in bacteria and fungi microorganisms without toxicity to certain mammalian cells. The goal of this study was to analyze both, antimicrobial activity against Staphylococcus aureus and toxicity in swine sperms after 10-20 nm AgNPs treatment. S. aureus proliferation decreased w...
Source: Systems Biology in Reproductive Medicine - May 25, 2020 Category: Reproduction Medicine Authors: Pérez-Duran F, Acosta-Torres LS, Serrano-Díaz PN, Toscano-Torres IA, Olivo-Zepeda IB, García-Caxin E, Nuñez-Anita RE Tags: Syst Biol Reprod Med Source Type: research

Simple Tips for Staying Healthy This Cold and Flu Season
As we head into fall, many Americans are getting the flu shot to prepare for the winter ahead. According to the Centers for Disease Control and Prevention (CDC), up to 20 percent of the U.S. population will get the flu. Moreover, the National Institutes of Health (NIH) estimates there are nearly one billion cases of the common cold each year in the U.S. Aside from washing our hands, what else can we do to boost our immune system? Let's explore some important and simple tips that can help you stay healthy during the winter season. Don't Overdo Vitamin C When you come down with the flu, most people think large doses of vita...
Source: Healthy Living - The Huffington Post - October 30, 2015 Category: Consumer Health News Source Type: news

Mp34-01 renal histopathology after calcium oxalate stone induction: crystalluric and tubular effects of high urinary oxalate excretion in a swine model
Swine are good models for stone disease as they closely resemble humans for gastrointestinal and renal morphology and function. We have developed a swine model that manifests hyperoxaluria and calcium oxalate (CaOx) stone formation via two methods: (1) enhanced oxalate (Ox) biosynthesis, from hydroxyproline (HYP) feeding; or (2) enhanced dietary Ox absorption (by feeding sodium oxalate). Histopathology characterized changes in crystalluric and renal tubular parameters in gilts (adult virgin sows) fed either HYP or Ox.
Source: The Journal of Urology - April 1, 2015 Category: Urology & Nephrology Authors: Kristina L. Penniston, Denise J. Schwahn, Thomas D. Crenshaw, Stephen Y. Nakada Tags: Stone Disease: Basic Research II Source Type: research

Effect of High-Calcium Diet on Coronary Artery Disease in Ossabaw Miniature Swine With Metabolic Syndrome Coronary Heart Disease
Conclusion There was no detectable effect of high calcium diets (from dairy or calcium carbonate) on coronary artery calcium deposition in metabolic syndrome swine.
Source: JAHA:Journal of the American Heart Association - August 13, 2015 Category: Cardiology Authors: Phillips-Eakley, A. K., McKenney-Drake, M. L., Bahls, M., Newcomer, S. C., Radcliffe, J. S., Wastney, M. E., Van Alstine, W. G., Jackson, G., Alloosh, M., Martin, B. R., Sturek, M., Weaver, C. M. Tags: Coronary Heart Disease Source Type: research

Effect of three different bariatric obesity surgery procedures on nutrient and energy digestibility using a swine experimental model
Morbid obesity is a worldwide health concern that compromises life quality and health status of obese human subjects. Bariatric surgery for treating morbid obesity remains as one of the best alternatives to promote excess weight loss and to reduce co-morbidities. We have not found studies reporting nutrients and energy balance considering digestibility trials in humans following surgery. The purpose of this study was to determine protein, lipid, fiber, energy, calcium, and phosphorous digestibility in a swine model that underwent ileal transposition (IT), sleeve gastrectomy with ileal transposition (SGIT), Roux-en-Y gastri...
Source: Experimental Biology and Medicine - September 10, 2015 Category: Research Authors: Gandarillas, M., Hodgkinson, S. M., Riveros, J. L., Bas, F. Tags: Endocrinology and Nutrition Source Type: research

Amygdala GABAergic neuron activity dynamic during cataplexy of narcolepsy
Recent studies showed activation of the GABAergic neurons in the central nucleus of the amygdala (CeA) triggered cataplexy of sleep disorder narcolepsy. However, there is still no direct evidence on CeA GABAergic neurons' real-time dynamic during cataplexy. We used a deep brain calcium imaging tool to image the intrinsic calcium transient as a marker of neuronal activity changes in the narcoleptic VGAT-Cre mice by expressing the calcium sensor GCaMP6 into genetically defined CeA GABAergic neurons. Two distinct GABAergic neuronal groups involved in cataplexy were identified: spontaneous cataplexy-ON and predator odor-induce...
Source: eLife - August 14, 2019 Category: Biomedical Science Tags: Neuroscience Source Type: research