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Nutrition: Calcium

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Total 118 results found since Jan 2013.

Calcium, magnesium, potassium, and sodium oxybates oral solution for cataplexy or excessive daytime sleepiness associated with narcolepsy
Expert Opin Pharmacother. 2023 Apr 15. doi: 10.1080/14656566.2023.2204187. Online ahead of print.ABSTRACTINTRODUCTION: Lower-sodium oxybate (LXB) is a novel formulation that is approved by the US Food and Drug Administration (FDA) to treat cataplexy and excessive daytime sleepiness (EDS) in adult patients and children ≥ 7 years with narcolepsy. LXB contains 92 percent less sodium than sodium oxybate (SXB), which adds 550-1640 mg of sodium/day at usual doses of 3-9 grams per day. The FDA has declared LXB to be clinically superior to SXB due to greater safety by reducing the chronic sodium load. Narcolepsy patients have hi...
Source: Expert Opinion on Pharmacotherapy - April 15, 2023 Category: Drugs & Pharmacology Authors: Vivien C Abad Source Type: research

Validation of a novel partial resuscitative endovascular balloon occlusion of the aorta device in a swine hemorrhagic shock model: Fine tuning flow to optimize bleeding control and reperfusion injury
CONCLUSION Prolonged pREBOA at a moderate distal flow rate provided adequate hemorrhage control, improved survival, and had evidence of decreased ischemic injury versus fREBOA. Prophylactic aggressive calcium supplementation may have utility before and during the reperfusion phase.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - June 23, 2020 Category: Orthopaedics Tags: 2020 EAST PODIUM PAPER Source Type: research

Autoantibodies in Pandemrix ®-induced narcolepsy: Nine candidate autoantigens fail the conformational autoantibody test.
Conclusions: None of the nine labelled proteins proposed to be autoantigens were detected in the radiobinding assays for conformation-dependent autoantibodies. The results emphasise the need of further studies to identify autoantigen(s) and clarify the mechanisms in Pandemrix®-induced NT1. PMID: 31328572 [PubMed - as supplied by publisher]
Source: Autoimmunity - July 23, 2019 Category: Allergy & Immunology Tags: Autoimmunity Source Type: research

Jazz Pharmaceuticals Announces U.S. FDA Approval of Xywav(TM) (calcium, magnesium, potassium, and sodium oxybates) Oral Solution for Cataplexy or Excessive Daytime Sleepiness Associated with Narcolepsy
Xywav is the first FDA approved new treatment option indicated for both cataplexy and excessive daytime sleepiness in people living with narcolepsy in more than 15 years Xywav contains 92 percent less sodium per nightly dose than sodium oxybate, a curre... Biopharmaceuticals, Neurology, FDA Jazz Pharmaceuticals, Xywav, Cataplexy, Narcolepsy
Source: HSMN NewsFeed - July 22, 2020 Category: Pharmaceuticals Source Type: news

Xywav - A Mixed-Salt Oxybate Oral Solution for Idiopathic Hypersomnia
Date: December 27, 2021 Issue #:  1640Summary: Xywav (Jazz), an oral solution that contains calcium, magnesium, potassium, and sodium oxybates, has been approved by the FDA for treatment of idiopathic hypersomnia in adults. It is the first drug to be approved in the US for this indication.Xywav was approved in 2020 for treatment of excessive daytime sleepiness or cataplexy in patients ≥7 years old with narcolepsy. It contains about 92% less sodium than sodium oxybate oral solution(Xyrem), which has been available in the US for years for use in patients ≥7 years old with narcolepsy.
Source: The Medical Letter - December 10, 2021 Category: Drugs & Pharmacology Authors: admin Tags: Alertec armodafinil Methylphenidate Narcolepsy Nuvigil pitolisant Provigil Ritalin Sodium oxybate solriamfetol Sunosi Wakix Xyrem Xywav Source Type: research

Viruses, Vol. 10, Pages 460: Classical Swine Fever Virus p7 Protein Interacts with Host Protein CAMLG and Regulates Calcium Permeability at the Endoplasmic Reticulum
Manuel V. Borca We have previously shown that Classical Swine Fever Virus (CSFV) p7 is an essential nonstructural protein with a viroporin activity, a critical function in the progression of virus infection. We also identified p7 domains and amino acid residues critical for pore formation. Here, we describe how p7 specifically interacts with host protein CAMLG, an integral ER transmembrane protein involved in intracellular calcium release regulation and signal response generation. Detection of interaction as well as the identification of p7 areas mediating interaction with CAMLG was performed by yeast two-hybrid. p7-...
Source: Viruses - August 28, 2018 Category: Virology Authors: Douglas P. Gladue Eneko Largo Lauren G. Holinka Elizabeth Ramirez-Medina Elizabeth A. Vuono Keith A. Berggren Guillermo R. Risatti Jose L. Nieva Manuel V. Borca Tags: Communication Source Type: research

Intracellular changes of a swine tracheal cell line infected with a Mycoplasma hyopneumoniae pathogenic strain
Publication date: Available online 5 September 2019Source: Microbial PathogenesisAuthor(s): Fernanda M.A. Leal Zimmer, Hercules Moura, John R. Barr, Henrique Bunselmeyer FerreiraAbstractMycoplasma hyopneumoniae is the etiological agent of enzootic pneumonia (EP), a widespread disease that causes major economic losses to the pig industry. The swine host response plays an important role in the outcome of M. hyopneumoniae infections. The whole proteome of newborn pig trachea (NPTr) epithelial cells infected with the M. hyopneumoniae pathogenic strain 7448 was analyzed using an LC-MS/MS approach to shed light on intracellular ...
Source: Microbial Pathogenesis - September 5, 2019 Category: Infectious Diseases Source Type: research

Toxicity and antimicrobial effect of silver nanoparticles in swine sperms.
Abstract Bacterial contamination in swine semen affects the quality and longevity of sperm and consequently fertility is reduced. Antibiotics have been used to prevent bacterial growth, but the frequency of bacterial resistance to various antibiotics are increasing. Silver nanoparticles (AgNPs) of 10-20 nm in size have shown a biocide effect in bacteria and fungi microorganisms without toxicity to certain mammalian cells. The goal of this study was to analyze both, antimicrobial activity against Staphylococcus aureus and toxicity in swine sperms after 10-20 nm AgNPs treatment. S. aureus proliferation decreased w...
Source: Systems Biology in Reproductive Medicine - May 25, 2020 Category: Reproduction Medicine Authors: Pérez-Duran F, Acosta-Torres LS, Serrano-Díaz PN, Toscano-Torres IA, Olivo-Zepeda IB, García-Caxin E, Nuñez-Anita RE Tags: Syst Biol Reprod Med Source Type: research

Effect of High-Calcium Diet on Coronary Artery Disease in Ossabaw Miniature Swine With Metabolic Syndrome Coronary Heart Disease
Conclusion There was no detectable effect of high calcium diets (from dairy or calcium carbonate) on coronary artery calcium deposition in metabolic syndrome swine.
Source: JAHA:Journal of the American Heart Association - August 13, 2015 Category: Cardiology Authors: Phillips-Eakley, A. K., McKenney-Drake, M. L., Bahls, M., Newcomer, S. C., Radcliffe, J. S., Wastney, M. E., Van Alstine, W. G., Jackson, G., Alloosh, M., Martin, B. R., Sturek, M., Weaver, C. M. Tags: Coronary Heart Disease Source Type: research

Amygdala GABAergic neuron activity dynamic during cataplexy of narcolepsy
Recent studies showed activation of the GABAergic neurons in the central nucleus of the amygdala (CeA) triggered cataplexy of sleep disorder narcolepsy. However, there is still no direct evidence on CeA GABAergic neurons' real-time dynamic during cataplexy. We used a deep brain calcium imaging tool to image the intrinsic calcium transient as a marker of neuronal activity changes in the narcoleptic VGAT-Cre mice by expressing the calcium sensor GCaMP6 into genetically defined CeA GABAergic neurons. Two distinct GABAergic neuronal groups involved in cataplexy were identified: spontaneous cataplexy-ON and predator odor-induce...
Source: eLife - August 14, 2019 Category: Biomedical Science Tags: Neuroscience Source Type: research

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy
Recent studies showed activation of the GABAergic neurons in the central nucleus of the amygdala (CeA) triggered cataplexy of sleep disorder narcolepsy. However, there is still no direct evidence on CeA GABAergic neurons ’ real-time dynamic during cataplexy. We used a deep brain calcium imaging tool to image the intrinsic calcium transient as a marker of neuronal activity changes in the narcoleptic VGAT-Cre mice by expressing the calcium sensor GCaMP6 into genetically defined CeA GABAergic neurons. Two distinct GA BAergic neuronal groups involved in cataplexy were identified: spontaneous cataplexy-ON and predator odor-in...
Source: eLife - August 14, 2019 Category: Biomedical Science Tags: Neuroscience Source Type: research

The Network of Interactions Between Classical Swine Fever Virus Nonstructural Protein p7 and Host Proteins
Classical swine fever (CSF) is a highly contagious viral disease causing severe economic losses to the swine industry. As viroporins of viruses modulate the cellular ion balance and then take over the cellular machinery, blocking the activity of viroporin or developing viroporin-defective attenuated vaccines offers new approaches to treat or prevent viral infection. Non-structural protein p7 of CSF virus (CSFV) is a viroporin, which was highly involved in CSFV virulence. Deciphering the interaction between p7 and host proteins will aid our understanding of the mechanism of p7-cellular protein interaction affecting CSFV rep...
Source: Frontiers in Microbiology - November 30, 2020 Category: Microbiology Source Type: research

Enhanced denitrification of dispersed swine wastewater using Ca(OH) < sub > 2 < /sub > -pretreated rice straw as a solid carbon source
Chemosphere. 2022 Jun 13:135316. doi: 10.1016/j.chemosphere.2022.135316. Online ahead of print.ABSTRACTIn a pilot-scale packed bed reactor, the denitrification performance and microbial community structure of the dispersed swine wastewater treatment using calcium hydroxide (Ca(OH)2) pretreated rice straw as a carbon source were investigated. In a Ca(OH)2-pretreated rice straw supported denitrification system (Ca(OH)2-RS), the removal efficiency of NO3--N was 96.39% at an influent NO3--N load of 0.04 kg/(m3•d). Meanwhile, there was no obvious accumulation of NO2--N or chemical oxygen demand (COD) in the effluent of Ca(OH)...
Source: Chemosphere - June 16, 2022 Category: Chemistry Authors: Lianhua Yuan Leilei Tan Zhiqiang Shen Yuexi Zhou Xuwen He Xuemin Chen Source Type: research