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Total 163 results found since Jan 2013.

Probiotic pickled turnip touted as ‘flu wonder cure’
Conclusion This simple experiment showed that giving a bacterial extract found in Japanese pickled turnip to mice, as a preventative treatment for flu, reduced some of the symptomatic effects of flu upon subsequent infection. Specifically, it lessened body weight loss and reduced declines in general health during a seven-day flu period. While the results are encouraging, it is too soon to roll out the red carpet and welcome a “new wonder cure” as both the headlines in the Daily Express and Mail Online suggest. For instance, mice given the Japanese pickle extract still experienced declines in body weight of approximate...
Source: NHS News Feed - November 6, 2013 Category: Consumer Health News Tags: Food/diet Medical practice Medication Swine flu Source Type: news

Glucose and Fat Metabolism in Narcolepsy and the Effect of Sodium Oxybate: A Hyperinsulinemic-Euglycemic Clamp Study
Conclusion:We show that narcolepsy patients are more insulin sensitive and may have a lower rate of lipolysis than matched controls. SXB stimulated lipolysis in narcolepsy patients, possibly accounting for the weight loss after treatment. While sodium oxybate tended to decrease systemic insulin sensitivity, it increased hepatic insulin sensitivity, suggesting tissue-specific effects.Citation:Donjacour CE; Aziz NA; Overeem S; Kalsbeek A; Pijl H; Lammers GJ. Glucose and fat metabolism in narcolepsy and the effect of sodium oxybate: a hyperinsulinemic-euglycemic clamp study. SLEEP 2014;37(4):795-801.
Source: Sleep - April 1, 2014 Category: Sleep Medicine Source Type: research

Differential secretome profiling of swine tracheal cell line infected with mycoplasmas of swine respiratory tract.
Abstract Mycoplasma hyopneumoniae and Mycoplasma flocculare are genetically similar. However, M. hyopneumoniae causes porcine enzootic pneumonia, while M. flocculare is a commensal bacterium. M. hyopneumoniae and M. flocculare do not penetrate their host cells, and secreted proteins are important for bacterium-host interplay. Thus, the secretomes of a swine trachea cell line (NPTr) infected with M. hyopneumoniae 7448 (a pathogenic strain), M. hyopneumoniae J (a non-pathogenic strain) and M. flocculare were compared to shed light in bacterium-host interactions. Medium from the cultures was collected, and secreted p...
Source: Journal of Proteomics - August 31, 2018 Category: Biochemistry Authors: Dos Anjos Leal Zimmer FM, Paludo GP, Moura H, Barr JR, Ferreira HB Tags: J Proteomics Source Type: research

Research could lead to 'universal' flu vaccine
Conclusion This is promising research that takes us a step closer to developing a universal flu vaccine. Despite headlines suggesting otherwise, no universal jab has yet been developed. The researchers say that this new particle is capable of enhancing the body’s immune response compared with the currently used flu vaccine, and that the new complex offers protection against a wider variety of flu strains. It is important to remember that this research is still in its early stages. This technology development may well lead to the generation of a new type of vaccine. However, significant research is still required to move ...
Source: NHS News Feed - May 23, 2013 Category: Consumer Health News Tags: Medical practice Medication Heart/lungs Source Type: news

Is The Shocking News of the Sugar Industry's Influence Over Harvard Researchers Really Shocking?
Hey, Sugar, pay no attention to the man behind the curtain. Today, the Journal of the American Medical Association dropped an alleged bombshell when it disclosed that the sugar industry lobby influenced research on coronary heart disease by effectively bribing Harvard researchers to promote the theory that dietary fat, and not sugar, causes heart disease. The story is trending on Facebook at this very moment, and the JAMA Facebook post states that "Policymaking committees should consider giving less weight to food industry-funded studies, and include mechanistic and animal studies as well as studies appraising the effec...
Source: Healthy Living - The Huffington Post - September 14, 2016 Category: Consumer Health News Source Type: news

Benefits of exercise referral schemes not as large as hoped
Roll-out of schemes should be rethought to maximise effectiveness, say researchers Related items fromOnMedica Short intense exercise regimes may aid weight loss What promotes uptake and retention in group-based weight management services? New GP guidelines help patients and staff get fit GPs to spearhead swine flu mass vaccination NHS sets out H1N1 vaccination targets
Source: OnMedica Latest News - November 19, 2019 Category: UK Health Source Type: news

Two different genotypes of H1N2 swine influenza virus isolated in northern China and their pathogenicity in animals
Publication date: Available online 9 December 2014 Source:Veterinary Microbiology Author(s): Huanliang Yang , Yan Chen , Chuanling Qiao , Chuantian Xu , Minghua Yan , Xiaoguang Xin , Zhigao Bu , Hualan Chen During 2006 and 2007, two swine-origin triple-reassortant influenza A (H1N2) viruses were isolated from pigs in northern China, and the antigenic characteristics of the hemagglutinin protein of the viruses were examined. Genotyping and phylogenetic analyses demonstrated different emergence patterns for the two H1N2 viruses, Sw/Hebei/10/06 and Sw/Tianjin/1/07. Sequences for the other genes encoding the internal protein...
Source: Veterinary Microbiology - December 11, 2014 Category: Veterinary Research Source Type: research

Immune efficacy of an adenoviral vector-based swine influenza vaccine against antigenically distinct H1N1 strains in mice.
Abstract Avian-like H1N1 swine influenza viruses are prevalent in pigs and have occasionally crossed the species barrier and infected humans, which highlights the importance of preventing swine influenza. Human adenovirus serotype 5 (Ad5) has been tested in human influenza vaccine clinical trials and has exhibited a reliable safety profile. Here, we generated a replication-defective, recombinant adenovirus (designated as rAd5-avH1HA) expressing the hemagglutinin gene of an avian-like H1N1 virus (A/swine/Zhejiang/199/2013, ZJ/199/13). Using a BALB/c mouse model, we showed that a two-dose intramuscular administratio...
Source: Antiviral Research - September 20, 2017 Category: Virology Authors: Wu Y, Yang D, Xu B, Liang W, Sui J, Chen Y, Yang H, Chen H, Wei P, Qiao C Tags: Antiviral Res Source Type: research

Vaccine development for protecting swine against influenza virus.
Abstract Influenza virus infects a wide variety of species including humans, pigs, horses, sea mammals and birds. Weight loss caused by influenza infection and/or co-infection with other infectious agents results in significant financial loss in swine herds. The emergence of pandemic H1N1 (A/CA/04/2009/H1N1) and H3N2 variant (H3N2v) viruses, which cause disease in both humans and livestock constitutes a concerning public health threat. Influenza virus contains eight single-stranded, negative-sense RNA genome segments. This genetic structure allows the virus to evolve rapidly by antigenic drift and shift. Antigen-s...
Source: Animal Health Research Reviews - December 1, 2012 Category: Veterinary Research Authors: Chen Q, Madson D, Miller CL, Harris DL Tags: Anim Health Res Rev Source Type: research

Immune efficacy of an adenoviral vector-based swine influenza vaccine against antigenically distinct H1N1 strains in mice
Publication date: Available online 20 September 2017 Source:Antiviral Research Author(s): Yunpu Wu, Dawei Yang, Bangfeng Xu, Wenhua Liang, Jinyu Sui, Yan Chen, Huanliang Yang, Hualan Chen, Ping Wei, Chuanling Qiao Avian-like H1N1 swine influenza viruses are prevalent in pigs and have occasionally crossed the species barrier and infected humans, which highlights the importance of preventing swine influenza. Human adenovirus serotype 5 (Ad5) has been tested in human influenza vaccine clinical trials and has exhibited a reliable safety profile. Here, we generated a replication-defective, recombinant adenovirus (designated as...
Source: Antiviral Therapy - September 21, 2017 Category: Virology Source Type: research

A swine model of acute thrombocytopenia with prolonged bleeding time produced by busulfan.
In this study, we generated a swine model of acute thrombocytopenia with prolonged bleeding times by administering the chemotherapeutic drug busulfan. First, we tested multiple doses of busulfan (4, 6, and 8 mg/kg) in pigs, and found that 6 mg/kg of busulfan is an optimal dose for producing a safe and moderate thrombocytopenia, with a platelet count of less than 30,000/µl. The pigs administered 6 mg/kg of busulfan (n=8) reached half their initial counts at day 7, counts below 30,000/µl at day 12, and their nadirs at day 15 (on average). The minimal platelet count was 14,000/µl. With this dose of busulfan (6 mg/kg), blee...
Source: Experimental Animals - June 24, 2016 Category: Research Tags: Exp Anim Source Type: research

Kim Kardashian Faces Backlash Over Tweet About Flu Weight Loss
Kim Kardashian tweeting about losing weight isn’t particularly surprising, but saying her recent flu was “an amazing diet”? That raised more than a few eyebrows. The reality star tweeted on Wednesday morning that the flu is a great way to lose weight, adding that she dropped six pounds just in time for the Met Gala on May 1. The flu can be an amazing diet. So happy it came in time for the Met lol #6lbsdown— Kim Kardashian West (@KimKardashian) April 19, 2017 The reactions to the tweet have been heavily mixed, as a lot of people are noting that the flu can lead to death. @KimKardashia...
Source: Healthy Living - The Huffington Post - April 19, 2017 Category: Consumer Health News Source Type: news

Immunogenicity and efficacy of a recombinant adenovirus expressing hemagglutinin from the H5N1 subtype of swine influenza virus in mice.
In this study we generated a replication-defective recombinant adenovirus (rAd-H5HA-EGFP) expressing the hemagglutinin (HA) gene of H5N1 A/Swine/Fujian/1/2001 (SW/FJ/1/01) and evaluated its immunogenicity and protective efficacy in BALB/c mice. The recombinant virus induced high levels of hemagglutination inhibition (HI) antibody at a median tissue culture infective dose of 10(8) or 10(7). Compared with mice in the control groups, the mice vaccinated with rAd-H5HA-EGFP did not show apparent weight loss after challenge with either the homologous SW/FJ/1/01 or the heterologous H5N1 A/Chicken/Hunan/77/2005 (CK/HuN/77/05). Rep...
Source: Canadian Journal of Veterinary Research - April 1, 2014 Category: Veterinary Research Authors: Wu Y, Qiao C, Yang H, Chen Y, Xin X, Chen H Tags: Can J Vet Res Source Type: research

Effect of three different bariatric obesity surgery procedures on nutrient and energy digestibility using a swine experimental model
Morbid obesity is a worldwide health concern that compromises life quality and health status of obese human subjects. Bariatric surgery for treating morbid obesity remains as one of the best alternatives to promote excess weight loss and to reduce co-morbidities. We have not found studies reporting nutrients and energy balance considering digestibility trials in humans following surgery. The purpose of this study was to determine protein, lipid, fiber, energy, calcium, and phosphorous digestibility in a swine model that underwent ileal transposition (IT), sleeve gastrectomy with ileal transposition (SGIT), Roux-en-Y gastri...
Source: Experimental Biology and Medicine - September 10, 2015 Category: Research Authors: Gandarillas, M., Hodgkinson, S. M., Riveros, J. L., Bas, F. Tags: Endocrinology and Nutrition Source Type: research