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Total 181 results found since Jan 2013.

Narcolepsy in Adolescence — A Missed Diagnosis: A Case Report
In this report, we present a case of an adolescent male with all four cardinal symptoms of narcolepsy who was misdiagnosed with epilepsy, psychosis, and depression. We also discuss various issues regarding narcolepsy in children and adolescents. Case Report Mr. A, an 18-year-old man, presented to psychiatry outpatient services with excessive daytime sleepiness of approximately 1.5 years’ duration. When the chronology of symptoms was evaluated, it was evident that about 1.5 years before presentation, the patient had an episode of high-grade fever (101–103?F) and was empirically treated for typhoid and malaria. Within a ...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue adolescence misdiagnosis narcolepsy Source Type: research

Alterations in the structural covariance network of the hypothalamus in patients with narcolepsy
ConclusionWe found that the structural covariance network of the hypothalamus, as assessed from the subunit volumes of hypothalamic regions using a graph theoretical analysis, is different in patients with narcolepsy compared to healthy controls. These findings may contribute to the understanding of the pathogenesis of narcolepsy.
Source: Neuroradiology - January 11, 2022 Category: Radiology Source Type: research

Narcolepsy Type 1 and Idiopathic Generalized Epilepsy: Diagnostic and Therapeutic Challenges in Dual Cases
Conclusions:Narcolepsy type 1 may occur in association with idiopathic generalized epilepsy, leading to remarkable diagnostic and therapeutic challenges. Electrophysiological studies as well as a comprehensive somnologic interview can help confirm the diagnosis in patients with ambiguous neurological history. Sodium oxybate in combination with antiepileptic drugs is safe and effective in treating cataplexy and excessive daytime sleepiness.Citation:Baiardi S, Vandi S, Pizza F, Alvisi L, Toscani L, Zambrelli E, Tinuper P, Mayer G, Plazzi G. Narcolepsy type 1 and idiopathic generalized epilepsy: diagnostic and therapeutic cha...
Source: Journal of Clinical Sleep Medicine : JCSM - November 14, 2015 Category: Sleep Medicine Source Type: research

Anterior hippocampus volume loss in narcolepsy with cataplexy.
Abstract Narcolepsy with cataplexy is a lifelong disease resulting from the loss of hypocretin neurons in the hypothalamus; structural changes are not, however, limited only to the hypothalamus. We previously revealed an overall hippocampal volume loss in narcolepsy with cataplexy. The aim of this study is to describe the volume reduction of the anterior and posterior parts of the hippocampus in patients with narcolepsy with cataplexy in comparison with a control group. The anterior hippocampus is more involved in episodic memory and imagination, and the posterior hippocampus in spatial memory. Manual magnetic res...
Source: Journal of Sleep Research - November 13, 2018 Category: Sleep Medicine Authors: Křečková M, Kemlink D, Šonka K, Krásenský J, Bušková J, Vaněčková M, Němcová V Tags: J Sleep Res Source Type: research

Grey matter atrophy in narcolepsy: An Activation Likelihood Estimation meta-analysis
Publication date: Available online 28 March 2015 Source:Neuroscience & Biobehavioral Reviews Author(s): Hsu-Huei Weng , Chih-Feng Chen , Yuan-Hsiung Tsai , Chih-Ying Wu , Meng Lee , Yu-Ching Lin , Cheng-Ta Yang , Ying-Huang Tsai , Chun-Yuh Yang The authors reviewed the literature on the use of voxel-based morphometry (VBM) in narcolepsy magnetic resonance imaging (MRI) studies via the use of a meta-analysis of neuroimaging to identify concordant and specific structural deficits in patients with narcolepsy as compared with healthy subjects. We used PubMed to retrieve articles published between January 2000 and Mar...
Source: Neuroscience and Biobehavioral Reviews - March 28, 2015 Category: Neuroscience Source Type: research

Gray matter atrophy in narcolepsy: An activation likelihood estimation meta-analysis
Publication date: Available online 28 March 2015 Source:Neuroscience & Biobehavioral Reviews Author(s): Hsu-Huei Weng , Chih-Feng Chen , Yuan-Hsiung Tsai , Chih-Ying Wu , Meng Lee , Yu-Ching Lin , Cheng-Ta Yang , Ying-Huang Tsai , Chun-Yuh Yang The authors reviewed the literature on the use of voxel-based morphometry (VBM) in narcolepsy magnetic resonance imaging (MRI) studies via the use of a meta-analysis of neuroimaging to identify concordant and specific structural deficits in patients with narcolepsy as compared with healthy subjects. We used PubMed to retrieve articles published between January 2000 and Mar...
Source: Neuroscience and Biobehavioral Reviews - April 6, 2015 Category: Neuroscience Source Type: research

White matter alterations in narcolepsy patients with cataplexy: tract‐based spatial statistics
Summary Functional imaging studies and voxel‐based morphometry analysis of brain magnetic resonance imaging showed abnormalities in the hypothalamus–thalamus–orbitofrontal pathway, demonstrating altered hypocretin pathway in narcolepsy. Those distinct morphometric changes account for problems in wake–sleep control, attention and memory. It also raised the necessity to evaluate white matter changes. To investigate brain white matter alterations in drug‐naïve narcolepsy patients with cataplexy and to explore relationships between white matter changes and patient clinical characteristics, drug‐naïve narcolepsy p...
Source: Journal of Sleep Research - November 28, 2015 Category: Neurology Authors: Yun K. Park, Oh‐Hun Kwon, Eun Yeon Joo, Jae‐Hun Kim, Jong M. Lee, Sung T. Kim, Seung B. Hong Tags: Regular Research Paper Source Type: research

Structural anomaly in the reticular formation in narcolepsy type 1, suggesting lower levels of neuromelanin
Publication date: Available online 29 May 2019Source: NeuroImage: ClinicalAuthor(s): Natasha Morales Drissi, Marcel Warntjes, Alexander Wessén, Attila Szakacs, Niklas Darin, Tove Hallböök, Anne-Marie Landtblom, Helena Gauffin, Maria EngströmAbstractThe aim of this study was to investigate structural changes in the brain stem of adolescents with narcolepsy, a disorder characterized by excessive daytime sleepiness, fragmented night-time sleep, and cataplexy. For this purpose, we used quantitative magnetic resonance imaging to obtain R1 and R2 relaxation rates, proton density, and myelin maps in adolescents with narcoleps...
Source: NeuroImage: Clinical - May 31, 2019 Category: Radiology Source Type: research

A case of REM sleep behavior disorder, narcolepsy-cataplexy, parkinsonism and rheumatoid arthritis.
Abstract A patient is reported in whom signs and symptoms of REM sleep behavior disorder (RBD) and narcolepsy have been associated for almost two decades with a late development of parkinsonism and rheumatoid arthritis. A 78-year-old male patient in whom RBD was first diagnosed was followed-up by clinical examination, videopolysomnography, multiple sleep latency test, cerebral magnetic resonance imaging, and dopamine transporter imaging by single-photon emission computerized tomography. The patient was found to present for almost two decades, in addition to RBD, also narcolepsy. Moreover, a late development of par...
Source: Behavioural Neurology - April 25, 2013 Category: Neurology Authors: Cosentino FI, Distefano A, Plazzi G, Schenck CH, Ferri R Tags: Behav Neurol Source Type: research

A Case of REM Sleep Behavior Disorder, Narcolepsy-Cataplexy, Parkinsonism, and Rheumatoid Arthritis.
Abstract A patient is reported in whom signs and symptoms of REM sleep behavior disorder (RBD) and narcolepsy have been associated for almost two decades with a late development of parkinsonism and rheumatoid arthritis. A 78-year-old male patient in whom RBD was first diagnosed was followed-up by clinical examination, video-polysomnography, multiple sleep latency test, cerebral magnetic resonance imaging, and dopamine transporter imaging by single-photon emission computerized tomography. The patient was found to present for almost two decades, in addition to RBD, also narcolepsy. Moreover, a late development of pa...
Source: Behavioural Neurology - May 19, 2014 Category: Neurology Authors: Cosentino FI, Distefano A, Plazzi G, Schenck CH, Ferri R Tags: Behav Neurol Source Type: research

Pituitary Macrotumor Causing Narcolepsy ‐Cataplexy in a Dachshund
In this report, a pituitary mass is described as a unique cause of narcolepsy‐cataplexy in a dog. A 6‐year‐old male neutered Dachshund had presented for acute onset of feeding‐induced cataplexy and was found to have a pituitary macrotumor on magnetic resonance imaging (MRI). Cerebral spinal fluid hypocretin‐1 levels were normal, indicating that tumor effect on the ventral lateral nucleus of the hypothalamus was not the cause of the dog's narcolepsy‐cataplexy. The dog was also negative for the hypocretin receptor 2 gene mutation associated with narcolepsy in Dachshunds, ruling out familial narcolepsy. The Dachsh...
Source: Journal of Veterinary Internal Medicine - October 31, 2016 Category: Veterinary Research Authors: S. Schmid, A. Hodshon, S. Olin, I. Pfeiffer, S. Hecht Tags: Case Report Source Type: research

Anterior hippocampus volume loss in narcolepsy with cataplexy
AbstractNarcolepsy with cataplexy is a lifelong disease resulting from the loss of hypocretin neurons in the hypothalamus; structural changes are not, however, limited only to the hypothalamus. We previously revealed an overall hippocampal volume loss in narcolepsy with cataplexy. The aim of this study is to describe the volume reduction of the anterior and posterior parts of the hippocampus in patients with narcolepsy with cataplexy in comparison with a control group. The anterior hippocampus is more involved in episodic memory and imagination, and the posterior hippocampus in spatial memory. Manual magnetic resonance ima...
Source: Journal of Sleep Research - November 13, 2018 Category: Neurology Authors: Martina K řečková, David Kemlink, Karel Šonka, Jan Krásenský, Jitka Bušková, Manuela Vaněčková, Veronika Němcová Tags: REGULAR RESEARCH PAPER Source Type: research

IJERPH, Vol. 19, Pages 15482: Abnormal Regional Spontaneous Neural Activity and Functional Connectivity in Unmedicated Patients with Narcolepsy Type 1: A Resting-State fMRI Study
Conclusions: We found that multiple functional activities related to the processing of emotional regulation and sensory information processing were abnormal, and some were related to clinical characteristics. fALFF in the left postcentral or right precentral gyrus may be used as a biomarker of narcolepsy, whereas fALFF in the right fusiform and the FC strength of the left temporal pole middle temporal gyrus with the putamen may be clinical indicators to assess the drowsiness severity of narcolepsy.
Source: International Journal of Environmental Research and Public Health - November 22, 2022 Category: Environmental Health Authors: Lanxiang Wu Qingqing Zhan Qian Liu Suheng Xie Sheng Tian Liang Xie Wei Wu Tags: Article Source Type: research

Moebius syndrome and narcolepsy.
We report on a patient with Moebius syndrome and the clinical presentation of a narcolepsy cataplexy syndrome. With the hypoplasia of the brainstem in the cranial magnetic resonance imaging, we were able to show the morphological correlate of Moebius syndrome. Comorbidity was detected by cognitive tests, polysomnography and detection of hypocretin in the cerebrospinal fluid. Despite normal sleep onset latency and only one episode of sleep onset rapid eye movement (REM) in the multiple sleep latency test, where expressiveness is significantly reduced in cases of paralysis of horizontal eye movement, the diagnosis of parasom...
Source: Der Nervenarzt - November 13, 2014 Category: Neurology Authors: Krämer S, Goldammer U, Sindern E Tags: Nervenarzt Source Type: research

Symptomatic narcolepsy as a presenting feature of neuromyelitis optica
Pradeep Kallollimath, Amruth Gujjar, Megharanjini PatilAnnals of Indian Academy of Neurology 2018 21(2):156-158 Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness. It can be either primary or symptomatic due to other neurologic disorders. Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder in which symptomatic narcolepsy is being described as one of the core clinical features. Here, we report a patient with NMO who presented with narcolepsy. Signal changes on magnetic resonance imaging in hypothalamus and other periventricular regions of high aquaporin-4 expression should prompt ...
Source: Annals of Indian Academy of Neurology - July 20, 2018 Category: Neurology Authors: Pradeep Kallollimath Amruth Gujjar Megharanjini Patil Source Type: research