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Total 281 results found since Jan 2013.

Effect of metabolic syndrome and aging on Ca2+ dysfunction in coronary smooth muscle and coronary artery disease severity in Ossabaw miniature swine.
CONCLUSIONS: Ca2+ dysregulation, mainly the SR Ca2+ store, in CSM is more pronounced in lean old compared to both MetS groups, which is indicative of mild, proliferative CAD. MetS old and MetS young swine exhibit Ca2+ dysfunction that is typical of late, severe disease. The more advanced, complex plaques in MetS old swine suggest that the "aging milieu" potentiates effects of Ca2+ handling dysfunction in CAD. PMID: 29730333 [PubMed - as supplied by publisher]
Source: Experimental Gerontology - May 3, 2018 Category: Geriatrics Authors: Badin JK, Bruning RS, Sturek M Tags: Exp Gerontol Source Type: research

Experimental study in vivo ablation of swine pancreas using high-intensity focused ultrasound
Conclusions: It was feasible and safe to use HIFU for ablation of the pancreas in swine.
Source: Journal of Cancer Research and Therapeutics - March 31, 2019 Category: Cancer & Oncology Authors: Guanghui Huang Xin Ye Xia Yang Aimin Zheng Wenhong Li Jiao Wang Xiaoying Han Zhigang Wei Min Meng Yang Ni Chengkun Qin Xingbo Fei Liulin Xiong Source Type: research

Anesthesia in swine : Optimizing a laboratory model to optimize translational research.
In conclusion, swine are an excellent laboratory animal for bench to bedside research and can be managed properly when basic knowledge and adequate skills on careful handling, anesthesia and surgical considerations are present. PMID: 25384955 [PubMed - as supplied by publisher]
Source: Der Anaesthesist - November 12, 2014 Category: Anesthesiology Authors: Pehböck D, Dietrich H, Klima G, Paal P, Lindner KH, Wenzel V Tags: Anaesthesist Source Type: research

Elucidation of Percutaneously Accessible Lymph Nodes in Swine: A Large Animal Model for Interventional Lymphatic Research
Conclusions The swine exhibits reproducible lymphatic anatomy with at least 4 percutaneously accessible lymph nodes/lymph node groups. Based on these results, the swine may be a suitable large animal model for research into lymphatic interventions.
Source: Journal of Vascular and Interventional Radiology - November 17, 2016 Category: Radiology Source Type: research

Pilot study on the effects of low intensity focused ultrasound in a swine model of neuropathic pain
CONCLUSIONS: The results demonstrate that a 5-cm depth can be reached with external liFUS and alters pain behavior and allodynia in a large-animal model of neuropathic pain.PMID:33862597 | DOI:10.3171/2020.9.JNS202962
Source: Journal of Neurosurgery - April 16, 2021 Category: Neurosurgery Authors: Abigail Hellman Teresa Maietta Alicia Clum Kanakaharini Byraju Nataly Raviv Michael D Staudt Erin Jeannotte Goutam Ghoshal Damian Shin Paul Neubauer Emery Williams Tamas Heffter Clif Burdette Jiang Qian Julia Nalwalk Julie G Pilitsis Source Type: research

Facing emotions in narcolepsy with cataplexy: haemodynamic and behavioural responses during emotional stimulation
Summary Narcolepsy with cataplexy is a complex sleep disorder that affects the modulation of emotions: cataplexy, the key symptom of narcolepsy, is indeed strongly linked with emotions that usually trigger the episodes. Our study aimed to investigate haemodynamic and behavioural responses during emotional stimulation in narco‐cataplexy. Twelve adult drug‐naive narcoleptic patients (five males; age: 33.3 ± 9.4 years) and 12 healthy controls (five males; age: 30.9 ± 9.5 years) were exposed to emotional stimuli (pleasant, unpleasant and neutral pictures). Heart rate, arterial blood pressure and mean cerebral blood...
Source: Journal of Sleep Research - February 1, 2014 Category: Neurology Authors: Massimiliano Zambotti, Fabio Pizza, Naima Covassin, Stefano Vandi, Nicola Cellini, Luciano Stegagno, Giuseppe Plazzi Tags: Regular Research Paper Source Type: research

Epicardial Catheter Ablation Using High-Intensity Ultrasound: Validation in a Swine Model Original Articles
Conclusions— Compared with radiofrequency, HIU ablation in vivo demonstrates significantly deeper and larger lesions with greater epicardial sparing in a dose-dependent manner. Further development of this catheter may lead to a promising alternative to epicardial radiofrequency ablation.
Source: Circulation: Arrhythmia and Electrophysiology - December 15, 2015 Category: Cardiology Authors: Nazer, B., Salgaonkar, V., Diederich, C. J., Jones, P. D., Duggirala, S., Tanaka, Y., Ng, B., Sievers, R., Gerstenfeld, E. P. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Animal Models of Human Disease, Translational Studies Original Articles Source Type: research

Endurance exercise training does not limit coronary atherosclerosis in familial hypercholesterolemic swine
We sought to determine the role of endurance exercise in coronary heart disease development in a swine model of familial hypercholesterolemia (FH) that exhibits robust, complex atherosclerosis. Quantitative in  vivo imaging of CHD was determined using coronary intravascular ultrasound. Prior and concommitent treadmill training failed to attenuate CHD in FH swine. AbstractHuman studies demonstrate that physical activity reduces both morbidity and mortality of coronary heart disease (CHD) including decreased progression and/or regression of CHD with life ‐style modification which includes exercise. However, evidence suppo...
Source: Physiological Reports - February 26, 2019 Category: Physiology Authors: Darla L. Tharp, Isabelle Masseau, Jan Ivey, Maurice Harold Laughlin, Douglas K. Bowles Tags: Original Research Source Type: research

Ultrasound‐Targeted Microbubble Destruction Enhances Gene Expression of microRNA‐21 in Swine Heart via Intracoronary Delivery
ConclusionUnder suitable conditions, UTMD can efficiently enhance gene expression in swine heart regardless of the delivery routes. The intravenous injection might be superior to intracoronary injection with less invasiveness and lower requirement of the technique. And for those undergoing percutanesous coronary intervention, intracoronary injection seems to be another alternative.
Source: Echocardiography - January 1, 2015 Category: Cardiology Authors: Yangchun Liu, Lang Li, Qiang Su, Tao Liu, Zhiying Ma, Huafeng Yang Tags: Original Investigation Source Type: research