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Total 333 results found since Jan 2013.

Cardiovascular Parameters in a Swine Model of Normobaric Hypoxia Treated With 5-Hydroxymethyl-2-Furfural (5-HMF)
Conclusion: 5-HMF treatment decreased P50, improved SaO2, and mitigated increases in PAP in this swine model of NH. Introduction The reduction of barometric pressure at altitude is associated with reduced partial pressure of ambient Oxygen (PO2). With lower ambient PO2, it can be anticipated that alveolar (PAO2), arterial O2 (PaO2) and blood O2 content (CaO2) will decrease accordingly, resulting in a widely recognized decrease in maximal O2 consumption (VO2) (Dill and Adams, 1972; Lucas et al., 2011). In humans, with acute exposure to altitude, maximal VO2 decrements are measurable at elevations even as low as 580 ...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research

Chronic high-rate pacing induces heart failure with preserved ejection fraction-like phenotype in Ossabaw swine
We examined whether chronic cardiometabolic stress in Ossabaw swine, which possess a genetic propensity for obesity and cardiovascular complications, produces an HFpEF-like phenotype. Swine were fed standard chow (lean;n = 13) or an excess calorie, high-fat, high-fructose diet (obese;n = 16) for ~ 18 weeks with lean (n = 5) and obese (n = 8) swine subjected to right ventricular pacing (180 beats/min for ~ 4 weeks) to induce heart failure (HF). Baseline blood pressure, heart rate, LV end-diastolic volume, and ejection fraction were similar between groups. High-rate pacing increased LV end-diastolic...
Source: Basic Research in Cardiology - October 12, 2022 Category: Cardiology Source Type: research

Perturbations in myocardial perfusion and oxygen balance in swine with multiple risk factors: a novel model of ischemia and no obstructive coronary artery disease
In conclusion, common comorbidities in swine result in CMD, in the absence of appreciable atherosclerosis, which is severe en ough to produce perturbations in myocardial oxygen balance, particularly during exercise, resembling key features of INOCA.
Source: Basic Research in Cardiology - February 24, 2020 Category: Cardiology Source Type: research

Reduced nitric oxide bioavailability impairs myocardial oxygen balance during exercise in swine with multiple risk factors
In conclusion, five months of combined exposure to DM + HFD + CKD produces coronary endothelial dysfunction due to impaired NO bioavailability, resulting in impaired myocardial perfusion at rest and during exercise.
Source: Basic Research in Cardiology - August 26, 2021 Category: Cardiology Source Type: research

Exercise Facilitates Early Recognition of Cardiac and Vascular Remodeling in Chronic Thrombo-Embolic Pulmonary Hypertension in a Novel CTEPH Swine Model.
In conclusion, embolization in combination with endothelial dysfunction results in CTEPH in swine. Exercise increased RV afterload, exacerbated the V/Q mismatch and unmasked RV dysfunction. PMID: 29167118 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - November 22, 2017 Category: Physiology Authors: Stam K, van Duin RWB, Uitterdijk A, Cai Z, Duncker DJ, Merkus D Tags: Am J Physiol Heart Circ Physiol Source Type: research

Cerebral blood flow augmentation using a cardiac-gated intracranial pulsating balloon pump in a swine model of elevated ICP.
CONCLUSIONSThe preliminary results indicate that optimized protocols of ICBP activation may have beneficial effects on cerebral physiological parameters, with minimal effect on systemic parameters. Further studies are warranted to explore whether ICBP protocols may be of clinical benefit in patients with brain injuries with increased ICP. PMID: 30978692 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - April 11, 2019 Category: Neurosurgery Authors: Doron O, Or T, Battino L, Rosenthal G, Barnea O Tags: J Neurosurg Source Type: research

Cerebral blood flow quantification in swine using pseudo‐continuous arterial spin labeling
Conclusion:This study demonstrates the feasibility of PCASL for CBF quantification in swine. Quantification of CBF using PCASL in swine can be further developed as an accessible and cost‐effective model of human cerebral perfusion for investigating injuries that affect blood flow. J. Magn. Reson. Imaging 2012;. © 2012 Wiley Periodicals, Inc.
Source: Journal of Magnetic Resonance Imaging - September 16, 2013 Category: Radiology Authors: Megan E. Johnston, Zhenlin Zheng, Joseph A. Maldjian, Christopher T. Whitlow, Michael J. Morykwas, Youngkyoo Jung Tags: Original Research Source Type: research

Preclinical Evaluation of Biopolymer-Delivered Circulating Angiogenic Cells in a Swine Model of Hibernating Myocardium Myocardial Infarction
Conclusions— In this preclinical swine model of ischemic and hibernating myocardium, the combined delivery of circulating angiogenic cells and a collagen-based matrix restored perfusion, reduced hibernation, and improved myocardial wall motion.
Source: Circulation: Cardiovascular Imaging - November 19, 2013 Category: Radiology Authors: Giordano, C., Thorn, S. L., Renaud, J. M., Al-Atassi, T., Boodhwani, M., Klein, R., Kuraitis, D., Dwivedi, G., Zhang, P., DaSilva, J. N., Ascah, K. J., deKemp, R. A., Suuronen, E. J., Beanlands, R. S. B., Ruel, M. Tags: Animal models of human disease, Other Treatment, Nuclear cardiology and PET, Chronic ischemic heart disease Myocardial Infarction Source Type: research

Characterization of the liver-macrophages isolated from a mixed primary culture of neonatal swine hepatocytes
In this study, we aim to apply this method to the neonatal swine liver. Swine parenchymal hepatocytes were isolated by a two-step collagenase perfusion method and cultured in T75 culture flasks. Similar to the rat and bovine cells, the swine hepatocytes retained an epithelial cell morphology for only a few days and progressively changed into fibroblastic cells. After 5–13 days of culture, macrophage-like cells actively proliferated on the mixed fibroblastic cell sheet. Gentle shaking of the culture flask followed by the transfer and brief incubation of the culture supernatant resulted in a quick and selective adhesion o...
Source: Results in Immunology - November 6, 2014 Category: Allergy & Immunology Source Type: research

Nerve detection using optical spectroscopy, an evaluation in four different models: In human and swine, in ‐vivo, and post mortem
ConclusionThis study shows and discusses similarities and differences in nerve and surrounding tissues between human in vivo and post mortem, and swine in vivo and post mortem; this could support the discussion to use an alternative model to optimize and validate optical techniques for clinical nerve identification. Lasers Surg. Med. © 2017 Wiley Periodicals, Inc.
Source: Lasers in Surgery and Medicine - November 1, 2017 Category: Laser Surgery Authors: Gerrit C. Langhout, Torre M. Bydlon, Marjolein van der Voort, Manfred M üller, Jeroen Kortsmit, Gerald Lucassen, Andrea J.R. Balthasar, Geert‐Jan van Geffen, Thorsten Steinfeldt, Henricus J.C.M. Sterenborg, Benno H.W. Hendriks, Theo J.M. Ruers Tags: Preclinical Reports Source Type: research

Effect of Rapamycin on mesenchymal stem cells treatment for swine myocardial infarction
Conclusions: Four weeks after MSCs transplantation for curing AMI, the myocardial perfusion and glucose metabolism improved significantly in the Rapamycin group; however, the cardiac function was decreased. It is speculated that Rapamycin might have impacted the effect of MSCs transplantation in infarcted hearts. The mechanism needs further research. Index on SPECT, PET and MRI in Three GroupsControl group MSCs groupRapamycin groupP valueSRS24.43±5.4728.63±3.3420.50±7.70<0.05Defect area (cm2)41.57±12.4844.25±12.8022.50±10.74<0.05SCR12.80±4.9715.33±8.636.20&...
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Cai, M., Feng, G., Li, L., Zhang, G., Yang, X. Tags: Cardiovascular Basic Science: Metabolism and Molecular Imaging Source Type: research

3D-Printed Coronary Implants Are Effective for Percutaneous Creation of Swine Models with Focal Coronary Stenosis
AbstractReliable, closed-chest methods for creating large animal models of acute myocardial hypoperfusion are limited. We demonstrated the feasibility and efficacy of using magnetic resonance (MR) –compatible 3D-printed coronary implants for establishing swine models of myocardial hypoperfusion. We designed, manufactured, and percutaneously deployed implants in 13 swine to selectively create focal coronary stenosis. To test the efficacy of the implants to cause hypoperfusion or ischemia in the perfused territory, we evaluated regional wall motion, myocardial perfusion, and infarction using MR imaging. The overall swine s...
Source: Journal of Cardiovascular Translational Research - May 10, 2020 Category: Cardiology Source Type: research

Effects of circulatory arrest and cardiopulmonary bypass on cerebral autoregulation in neonatal swine
CONCLUSIONS: In a validated swine model of cardiac surgery, DH-CPB had a significant effect on cerebral autoregulation, whereas DHCA and SCP did not.IMPACT: Approximately half of the patients who survive neonatal heart surgery with cardiopulmonary bypass (CPB) experience neurodevelopmental delays. This preclinical investigation takes steps to elucidate and isolate potential perioperative risk factors of neurologic injury, such as impairment of cerebral autoregulation, associated with cardiac surgical procedures involving CPB. We demonstrate a method to characterize cerebral autoregulation during CPB pump flow changes in a ...
Source: Pediatric Research - May 5, 2021 Category: Pediatrics Authors: Jonah A Padawer-Curry Lindsay E Volk Constantine D Mavroudis Tiffany S Ko Vincent C Morano David R Busch Tami M Rosenthal Richard W Melchior Brandon C Shade Kellie L Schiavo Timothy W Boorady Alexander L Schmidt Kristen N Andersen Jake S Breimann Jharna J Source Type: research