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Total 793 results found since Jan 2013.

For Taunton Children Battling Rare Disease, Flu Season Is Life Or Death
TAUNTON (CBS) – Flu season is here, and for a Taunton family with two babies battling a rare disease, the months are particularly stressful. From the outside, they appear picture-perfect: Amanda and Billy Bettuchi and their three beautiful kids. But you can’t tell a whole health story just by looking. “It’s Severe Combined Immunodeficiency (SCID), so Shane was born with no immune system at all. They have to go through chemo first for 10 days and then they get the bone marrow transplant after that at three months old,” mom Amanda (Acorn) Bettuchi explained. Sweet Shane, not even a year old, is still recove...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 9, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Syndicated CBSN Boston Syndicated Local flu season Juli McDonald Taunton News Source Type: news

Artificial Lung Technology Treatment Normally Used For Lung Transplant Patients Saves Lives Of Critically Ill Flu Patients
In recent weeks the intensive critical care units at University Health Network's Toronto General Hospital have used Extra Corporeal Lung Support (ECLS) to support five influenza (flu) patients in their recovery from severe respiratory problems. ECLS systems are normally used at the hospital as a bridge to lung transplantation but increasingly, the hospital is using ECLS on patients where the usual breathing machines (ventilators) cannot support the patient whose lungs need time to rest and heal...
Source: Health News from Medical News Today - January 21, 2013 Category: Consumer Health News Tags: Flu / Cold / SARS Source Type: news

An Overview of Hypocretin based Therapy in Narcolepsy.
Authors: Takenoshita S, Sakai N, Chiba Y, Matsumura M, Yamaguchi M, Nishino S Abstract INTRODUCTION: Narcolepsy with cataplexy is most commonly caused by a loss of hypocretin/orexin peptide-producing neurons in the hypothalamus (i.e., Narcolepsy Type 1). Since hypocretin deficiency is assumed to be the main cause of narcoleptic symptoms, hypocretin replacement will be the most essential treatment for narcolepsy. Unfortunately, this option is still not available clinically. There are many potential approaches to replace hypocretin in the brain for narcolepsy such as intranasal administration of hypocretin peptides, ...
Source: Expert Opinion on Investigational Drugs - April 7, 2018 Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research

The Omicron Wave Is Receding But the Pandemic Is Far From Over
The U.S. has experienced a brutal winter wave of COVID-19, driven by the highly transmissible Omicron variant. Daily deaths are higher today than they were during the peak of last fall’s Delta wave, and have plateaued at about 2,500 per day. Many hospitals are still under huge strain and are postponing elective surgeries to free up beds for patients with COVID-19. Daily cases have been higher than during the Delta surge, despite multiple eager predictions in the past that we had reached herd immunity and that the pandemic was over. Nevertheless, there are promising signs that we are turning a corner. New daily cases ...
Source: TIME: Health - February 15, 2022 Category: Consumer Health News Authors: Gavin Yamey, Abraar Karan and Ranu Dhillon Tags: Uncategorized COVID-19 Source Type: news

Swine hepatitis E virus: cross-species infection, pork safety and chronic infection.
Abstract Swine hepatitis E virus (swine HEV) belongs to the species Orthohepevirus A within the genus Orthohepevirus in the family Hepeviridae. Four different genotypes of swine HEV within the species Orthohepevirus A have been identified so far from domesticated and wild swine population: genotypes 3 (HEV-3) and 4 (HEV-4) swine HEVs are zoonotic and infect humans, whereas HEV-5 and HEV-6 are only identified from swine. As a zoonotic agent, swine HEV is an emerging public health concern in many industrialized countries. Pigs are natural reservoir for HEV, consumption of raw or undercooked pork is an important rout...
Source: Virus Research - April 21, 2020 Category: Virology Authors: Sooryanarain H, Meng XJ Tags: Virus Res Source Type: research

Cellular Therapies for the Treatment of Hematological Malignancies; Swine Are an Ideal Preclinical Model
The absence of clinically relevant large animal tumor models has historically forced experimental cellular therapies for hematological malignancies to translate directly from murine models to clinical trials. However, recent advances highlight swine as an ideal large animal model to demonstrate the safety of murine proof of concept studies prior to their implementation clinically. The availability of the MHC defined MGH miniature swine herd has been key for the development of novel approaches for hematopoietic cell and solid organ transplantation. New spontaneously arising hematological malignancies in these swine, specifi...
Source: Frontiers in Oncology - June 20, 2019 Category: Cancer & Oncology Source Type: research

The Impact Of 2009 Pandemic H1n1 Influenza A Virus On Veterinary Students ’ Perception Of Xenotransplantation
The objective was to analyze the impact of this pandemic on the acceptance of xenotransplantation among veterinary science degree students.
Source: Transplantation Proceedings - March 20, 2018 Category: Transplant Surgery Authors: Mart ínez-Alarcón Laura, Ríos Antonio, Ramis Guillermo, Quereda Juan José, Herrero Juan Manuel, Mendonça Livia, Muñoz Antonio, Ramírez Pablo, Parrilla Pascual Source Type: research

Earlier transplants for liver disease kids may cut brain damage risk
Liver disease affects brain development, impact of which increases the longer the wait for a transplant, irrespective of drug treatment, say researchers Related items fromOnMedica Should we have compulsory measles vaccination at school entry? Swine flu jab in pregnancy safe for children as well as mothers Hunt announces Medicines and Medical Devices Safety Review Doctors campaign against ‘too much medicine’ Parental confidence in immunisation programme ‘very high’
Source: OnMedica Latest News - July 28, 2019 Category: UK Health Source Type: news

Characteristics of Cardiac Allograft Vasculopathy Induced by Immunomodulation in the Miniature Swine.
Conclusion: CAV mimicking human heart transplantation can be developed by appropriate immunomodulation in the swine. In swine CAV, proliferated SMCs seen in the intimal thickening were demonstrated to be from the donor origin. PMID: 24747545 [PubMed - as supplied by publisher]
Source: Annals of Thoracic and Cardiovascular Surgery - April 18, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Amano J, Akashima T, Terasaki T, Wada Y, Ito-Amano M, Suzuki JI, Isobe M Tags: Ann Thorac Cardiovasc Surg Source Type: research

Eliminating Xenoantigen Expression on Swine RBC
Conclusions: Xenoantigenicity of swine RBC can be eliminated via gene disruption. These results suggest that the gene knockout approach may be able reduce antigenicity in other pig tissues to levels that enable the xenotransplantation humoral barrier to be overcome.
Source: Transplantation - February 23, 2017 Category: Transplant Surgery Tags: Original Basic Science-General Source Type: research

Video-assisted thoracoscopic surgery in swine: an animal model for thoracoscopic lobectomy training
The objective of this study is to demonstrate the technique of lobectomy using videothoracoscopy in swine, highlighting the steps to be taken during its use in surgical experimentation. METHODS During the advanced course on video-assisted and thoracoscopic procedures carried out at IRCAD Latin America, Barretos, Brazil, 40 swine were used for the hands-on course on video-assisted upper left lobectomy. Monopulmonary ventilation was performed by blocking the left main bronchus. Surgical procedures were performed using three ports and the anterior dissection technique (fissureless approach). The pulmonary hilar structures we...
Source: Interactive CardioVascular and Thoracic Surgery - July 22, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Tedde, M. L., Brito Filho, F., Belmonte, E. d. A., Pinto Filho, D. R., Pereira, S. T. F. L., Okumura, E. M., Melani, A. G. F., Gossot, D. Tags: Cardiac - pharmacology, Education, Transplantation - heart Thoracic Source Type: research

Subtotal hepatectomy in swine for studying small‐for‐size syndrome and portal inflow modulation: is it reliable?
ConclusionsSubtotal hepatectomy of 90% in swine is a reliable model for SFSS inducing a significant increase in HVPG. However, in view of the relevant differences between swine and human splanchnic anatomy, this model is inadequate for studying the effects of PIM by SAL and splenectomy.
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 30, 2015 Category: Gastroenterology Authors: Benjamin Darnis, Kayvan Mohkam, Zoé Schmitt, Stanislas Ledochowski, Jean‐Paul Vial, Serge Duperret, Catherine Vogt, Hassan Demian, Nicolas Golse, Salim Mezoughi, Christian Ducerf, Jean‐Yves Mabrut Tags: Original Article Source Type: research

Miniature Swine as a Clinically Relevant Model of Graft-Versus-Host Disease.
Abstract Miniature swine provide a preclinical model of hematopoietic cell transplantation (HCT) for studies of graft-versus-host disease. HCT between MHC-matched or -mismatched pigs can be performed to mimic clinical scenarios with outcomes that closely resemble those observed in human HCT recipients. With myeloablative conditioning, HCT across MHC barriers is typically fatal, with pigs developing severe (grade III or IV) GVHD involving the gastrointestinal tract, liver, and skin. Unlike rodent models, miniature swine provide an opportunity to perform extended longitudinal studies on individual animals, because m...
Source: Comparative Medicine - October 17, 2015 Category: Zoology Authors: Duran-Struuck R, Huang CA, Orf K, Bronson RT, Sachs DH, Spitzer TR Tags: Comp Med Source Type: research

Adenovirus-mediated transfer of hepatocyte growth factor gene to human dental pulp stem cells under good manufacturing practice improves their potential for periodontal regeneration in swine
Conclusion: This study indicated that HGF-hDPSCs produced under GMP conditions significantly improved periodontal bone regeneration in swine; thus, this method represents a potential clinical application for periodontal regeneration.
Source: Stem Cell Research and Therapy - December 15, 2015 Category: Stem Cells Authors: Yu CaoZhenhai LiuYilin XieJingchao HuHua WangZhipeng FanChunmei ZhangJingsong WangChu-Tse WuSonglin Wang Source Type: research