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Procedure: Liver Transplant

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Total 101 results found since Jan 2013.

Earlier transplants for liver disease kids may cut brain damage risk
Liver disease affects brain development, impact of which increases the longer the wait for a transplant, irrespective of drug treatment, say researchers Related items fromOnMedica Should we have compulsory measles vaccination at school entry? Swine flu jab in pregnancy safe for children as well as mothers Hunt announces Medicines and Medical Devices Safety Review Doctors campaign against ‘too much medicine’ Parental confidence in immunisation programme ‘very high’
Source: OnMedica Latest News - July 28, 2019 Category: UK Health Source Type: news

Subtotal hepatectomy in swine for studying small‐for‐size syndrome and portal inflow modulation: is it reliable?
ConclusionsSubtotal hepatectomy of 90% in swine is a reliable model for SFSS inducing a significant increase in HVPG. However, in view of the relevant differences between swine and human splanchnic anatomy, this model is inadequate for studying the effects of PIM by SAL and splenectomy.
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 30, 2015 Category: Gastroenterology Authors: Benjamin Darnis, Kayvan Mohkam, Zoé Schmitt, Stanislas Ledochowski, Jean‐Paul Vial, Serge Duperret, Catherine Vogt, Hassan Demian, Nicolas Golse, Salim Mezoughi, Christian Ducerf, Jean‐Yves Mabrut Tags: Original Article Source Type: research

Miniature Swine as a Clinically Relevant Model of Graft-Versus-Host Disease.
Abstract Miniature swine provide a preclinical model of hematopoietic cell transplantation (HCT) for studies of graft-versus-host disease. HCT between MHC-matched or -mismatched pigs can be performed to mimic clinical scenarios with outcomes that closely resemble those observed in human HCT recipients. With myeloablative conditioning, HCT across MHC barriers is typically fatal, with pigs developing severe (grade III or IV) GVHD involving the gastrointestinal tract, liver, and skin. Unlike rodent models, miniature swine provide an opportunity to perform extended longitudinal studies on individual animals, because m...
Source: Comparative Medicine - October 17, 2015 Category: Zoology Authors: Duran-Struuck R, Huang CA, Orf K, Bronson RT, Sachs DH, Spitzer TR Tags: Comp Med Source Type: research

Portal blood arterialization with an extracorporeal device to treat toxic acute hepatic failure in a swine model.
CONCLUSIONS: Arterial blood supply in the portal system through the L.E.O2 NARDO device is easily applicable, efficacious, and safe in a swine model of AHF induced by CCl4 intoxication. PMID: 25501739 [PubMed - in process]
Source: The International Journal of Artificial Organs - December 9, 2014 Category: Transplant Surgery Authors: Puviani L, Cavallari G, Bonaiuto E, Cannistrà M, Zullo A, Pariali M, Pisano A, Atzeni F, Nardo B Tags: Int J Artif Organs Source Type: research

Cross-Circulation for Extracorporeal Liver Support in a Swine Model
Although machine perfusion has gained momentum as an organ preservation technique in liver transplantation, persistent organ shortages and high waitlist mortality highlight unmet needs for improved organ salvage strategies. Beyond preservation, extracorporeal organ support platforms can also aid the development and evaluation of novel therapeutics. Here, we report the use of veno-arterial-venous (V-AV) cross-circulation (XC) with a swine host to provide normothermic support to extracorporeal livers. Functional, biochemical, and morphological analyses of the extracorporeal livers and swine hosts were performed over 12 hours...
Source: ASAIO Journal - April 1, 2022 Category: Medical Devices Tags: Biomedical Engineering Source Type: research

Cannulation Selection of Portal Venous and Splenic Venous Catheterization in Venovenous Bypass of Swine Orthotopic Liver Transplantation.
CONCLUSIONS Our results show that VVB via splenic venous catheterization in swine OLT: 1) shortens the AP time; 2) keeps the hemodynamics stable; and 3) reduces the occurrence of postoperative complications. Thus, SVC appears to be superior to PVC. PMID: 27251849 [PubMed - in process]
Source: Annals of Transplantation - June 3, 2016 Category: Transplant Surgery Authors: Wang MY, Wang MH, Peng Y, You HB, Chen XF, Zhao L, Gan L, Li M, Li JZ, Gong JP, Li XH Tags: Ann Transplant Source Type: research

TAK-242 treatment ameliorates liver ischemia/reperfusion injury by inhibiting TLR4 signaling pathway in a swine model of Maastricht-category-III cardiac death.
CONCLUSIONS: These results indicates that TLR4 signaling pathway may contribute to ischemia/reperfusion injury in the liver grafts, and blocking TLR4 pathway with TAk-242 may reduce TLR4-mediated tissue damage. PMID: 27685793 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2016 Category: Drugs & Pharmacology Authors: Shao Z, Jiao B, Liu T, Cheng Y, Liu H, Liu Y Tags: Biomed Pharmacother Source Type: research

Effects of condensed organic matter on PCBs bioavailability in juvenile swine, an animal model for young children.
This study involved fourteen juvenile male swine as a digestive physiology model of young children. Animals were randomly distributed into 4 contaminated groups (3 replicates) and a control one (2 replicates). During 10d, the piglets were fed AS or a corn oil spiked with 19200ng of Aroclor 1254 per g of dry matter (6000ngg(-1) of NDL-PCBs) to achieve an exposure dose of 1200ngNDL-PCBskg(-1) of body weight per day. After 10d of oral exposure, NDL-PCBs in adipose tissue, liver and muscles were analyzed by GC-MS, after extraction and purification. Two distinct groups of treatments were found: on the one hand oil, SS and FA, o...
Source: Chemosphere - November 26, 2013 Category: Chemistry Authors: Delannoy M, Rychen G, Fournier A, Jondreville C, Feidt C Tags: Chemosphere Source Type: research

Modification of Portal Venous Pressure by Olprinone in a Swine Partial Hepatectomy Model: Translational Research from Rats to Humans
In conclusion, Pretreatment with OLP showed hepatoprotective effects in a swine partial hepatectomy model. OLP may have a potential to ameliorate patients' outcomes after hepatectomy or liver transplantation. Liver Transpl , 2014. © 2014 AASLD.
Source: Liver Transplantation - April 1, 2014 Category: Transplant Surgery Authors: Kohta Iguchi, Etsuro Hatano, Kenya Yamanaka, Motohiko Sato, Gen Yamamoto, Yosuke Kasai, Tatsuya Okamoto, Masayuki Okuno, Kojiro Taura, Kyoko Fukumoto, Kazuyuki Ueno, Shinji Uemoto Tags: Original Article Source Type: research

Hepatoprotective effect by pretreatment with olprinone in a swine partial hepatectomy model
In conclusion, pretreatment with OLP shows hepatoprotective effects in a swine partial hepatectomy model. OLP may have the potential to ameliorate patients' outcomes after hepatectomy or liver transplantation. Liver Transpl, 2014. © 2014 AASLD.
Source: Liver Transplantation - May 26, 2014 Category: Transplant Surgery Authors: Kohta Iguchi, Etsuro Hatano, Kenya Yamanaka, Motohiko Sato, Gen Yamamoto, Yosuke Kasai, Tatsuya Okamoto, Masayuki Okuno, Kojiro Taura, Kyoko Fukumoto, Kazuyuki Ueno, Shinji Uemoto Tags: Original Article Source Type: research

Swine cells could power artificial liver
(American Society of Animal Science) Scientists are examining a line of "immortal" swine cells that can differentiate into liver cells. These cells could be part of an artificial liver device, which could reduce the need for liver transplants.
Source: EurekAlert! - Medicine and Health - February 27, 2013 Category: Global & Universal Source Type: news

Repair of Extrahepatic Bile Duct Defect Using a Collagen Patch in a Swine Model
Abstract Extrahepatic bile duct (EBD) injury can happen during surgery. To repair a defect of the EBD and prevent postoperative biliary complications, a collagen membrane was designed. The collagen material was porous, biocompatible, and degradable and could maintain its shape in bile soaking for about 4 weeks. The goal was to induce rapid bile duct tissue regeneration. Twenty Chinese experimental hybrid pigs were used in this study and divided into a patch group and a control group. A spindle‐shaped defect (20 mm × 6 mm) was made in the anterior wall of the lower EBD in the swine model, and then the defect was ...
Source: Artificial Organs - October 27, 2014 Category: Transplant Surgery Authors: Liang Tao, Qiang Li, Haozhen Ren, Bing Chen, Xianglin Hou, Lingjun Mou, Siqiao Zhou, Jianxin Zhou, Xitai Sun, Jianwu Dai, Yitao Ding Tags: Main Text Article Source Type: research

Liver Regeneration Induced By Extracorporeal Portal Vein Arterialization in a Swine Model of Carbon Tetrachloride Intoxication
This study aimed to determine whether a controlled portal blood arterialization by a liver extracorporeal device (L.E.O2 NARDO) is effective in treating acute hepatic failure (AHF) induced in swine by carbon tetrachloride (CCl4) administration.
Source: Transplantation Proceedings - September 1, 2015 Category: Transplant Surgery Authors: A. Zullo, M. Cannistrà, G. Cavallari, L. Puviani, F. Atzeni, A. Pisano, E. Bonaiuto, M. Pariali, S. Vaccarisi, B. Nardo Tags: 38th National Congress of the Italian Transplantation Society Source Type: research

A hemodynamic, metabolic and histopathological study of a heterotopic auxiliary swine liver graft with portal vein arterialization.
CONCLUSIONS: The described arterialized liver graft model minimizes the number of vascular anastomoses vs. previously described models. It is hemodynamically and metabolically well tolerated and the double arterial vascularization of the graft does not cause significant changes in liver histology. PMID: 26615737 [PubMed - as supplied by publisher]
Source: Cirugia eEspanola - November 23, 2015 Category: Surgery Authors: Fernández-Rodríguez OM, Ríos A, Palenciano C, Ramírez P, Navarro JL, Martínez-Alarcón L, Martínez C, Fuente T, Pons JA, Navarro JA, Majado M, Martínez P, Parrilla P Tags: Cir Esp Source Type: research

Preclinical Swine Models for Monitoring of Hepatocyte Transplantation by MRI.
Abstract Hepatocyte transplantation is a promising approach for treatment of certain liver disorders, especially for metabolic liver disease in the juvenile. The lack of a clinically approved noninvasive imaging technique is a major limitation to the further development of hepatocyte transplantation. Cell tracking by Magnetic Resonance Imaging (MRI) is a promising approach for noninvasive monitoring of the fate of transplanted cells. Studies in large animal models are necessary to transfer this promising technique into the clinic. PMID: 27830555 [PubMed - in process]
Source: Mol Biol Cell - November 11, 2016 Category: Molecular Biology Authors: Raschzok N, Teichgräber U, Pratschke J, Sauer IM Tags: Methods Mol Biol Source Type: research