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Procedure: Gastroschisis Repair

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Total 341 results found since Jan 2013.

Stage of Gestation at Porcine Epidemic Diarrhea Virus Infection of Pregnant Swine Impacts Maternal Immunity and Lactogenic Immune Protection of Neonatal Suckling Piglets
In this study, we infected pregnant first parity gilts in their first, second and third trimesters of gestation with PEDV to determine the impact of stage of gestation on generation of maternal B-cell immunity, the gut-MG-sIgA axis and lactogenic immune protection in PEDV challenged piglets. Our goal was to identify innate and adaptive immune factors during pregnancy that influence lymphocyte trafficking, in addition to immune correlates of lactogenic immune protection in neonatal suckling piglets. Understanding the impact of stage of gestation at PEDV infection or exposure on maternal immunity will allow more precise mate...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research

Development of a Reproducible Swine Model of Chronic Ischemic Mitral Regurgitation: Lessons Learned.
CONCLUSION: A reproducible percutaneous model of severe IMR in swine is feasible with a guided anesthetic and peri-operative approach. This model can serve as a platform to better understand the mechanism of IMR and subsequently to test novel repair techniques. PMID: 32553769 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - June 14, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Pasrija C, Quinn RW, Alkhatib H, Tran D, Bernstein D, Rice M, Kotloff E, Morales D, D'Ambra MN, Vesely M, Gammie JS Tags: Ann Thorac Surg Source Type: research

How to TEVAR swine for scientific research: Technical, anatomic, and device considerations to translate human TEVAR techniques into the large animal laboratory
CONCLUSIONS: This article describes a collection of related techniques and tips to translate human TEVAR imaging, sizing/selection, deployment, and anatomy to swine research. Using this framework alone, an experienced human vascular or endovascular surgeon may develop a complete aortic stenting animal model with strategies for scientific data acquisition.PMID:36880298 | DOI:10.1177/17085381231162121
Source: Vascular - March 7, 2023 Category: Surgery Authors: David P Stonko Rebecca N Treffalls Joseph Edwards Hossam Abdou Eric Lang Daniel C Stonko Pierce Cullen Caitlin W Hicks Jonathan J Morrison Source Type: research

Contraceptive pills not proven to protect against the flu
Conclusion These are interesting scientific findings but they have limited implications. Animal studies are useful for giving an indication of how biological processes may work in humans but we're not identical. Then the scenarios tested here – the progesterone, or the flu injection – can be taken as representative of real-life in humans. For one thing all the mice had surgery to remove their ovaries before being infected. It makes sense that the mice that had been given some additional recovery boost in the form of hormone replacement may have been in a better health state than those left hormone depleted. They wer...
Source: NHS News Feed - September 19, 2016 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news

Induced Hypothyroidism Alters Articular Cartilage in Skeletally Immature Miniature Swine.
CONCLUSIONS: The significant changes in articular cartilage structure in hypothyroid compared to control immature miniature swine suggest that thyroid hormone is critical in the growth and development of articular cartilage. CLINICAL SIGNIFICANCE: Understanding articular cartilage development in immature animal models may provide insight into healing or repair of degenerative human articular cartilage. PMID: 33073630 [PubMed - as supplied by publisher]
Source: Connective Tissue Research - October 21, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

A technique for creating an experimental type Ia endoleak model in the thoracic aorta of swine
ConclusionA novel technique to create a type Ia endoleak model can be successfully developed in swine.
Source: Japanese Journal of Radiology - May 31, 2021 Category: Radiology Source Type: research

Growth Hormone-Releasing Hormone Agonists Reduce Myocardial Infarct Scar in Swine With Subacute Ischemic Cardiomyopathy Heart Failure
Conclusions Daily subcutaneous administration of GHRH-A is feasible and safe in a large animal model of subacute ischemic cardiomyopathy. Furthermore, GHRH-A therapy significantly reduced infarct size and improved diastolic strain, suggesting a local activation of the GHRH pathway leading to the reparative process.
Source: JAHA:Journal of the American Heart Association - March 31, 2015 Category: Cardiology Authors: Bagno, L. L., Kanashiro-Takeuchi, R. M., Suncion, V. Y., Golpanian, S., Karantalis, V., Wolf, A., Wang, B., Premer, C., Balkan, W., Rodriguez, J., Valdes, D., Rosado, M., Block, N. L., Goldstein, P., Morales, A., Cai, R.-Z., Sha, W., Schally, A. V., Hare, Tags: Heart Failure Source Type: research

In vivo effects of radiofrequency ablation on long bones and the repair process in swine models
ConclusionRFA can quickly and effectively destroy the cancellous bone tissue without affecting the cortical bone and activate bone remodeling.
Source: Japanese Journal of Radiology - November 6, 2016 Category: Radiology Source Type: research

Safety and Efficacy of an Aortic Arch Stent Graft with Window-Shaped Fenestration for Supra-Aortic Arch Vessels: an Experimental Study in Swine.
CONCLUSION: The procedure with the FASG-W was able to be performed safely in a relatively short procedure time and involved an easy technique. The FASG-W was found to be safe and convenient for use in this preclinical study of swine. PMID: 28382077 [PubMed - in process]
Source: Korean Circulation Journal - April 8, 2017 Category: Cardiology Tags: Korean Circ J Source Type: research

Grafted Miniature-Swine Neural Stem Cells of Early Embryonic Mesencephalic Neuroepithelial Origin can Repair the Damaged Neural Circuitry of Parkinson’s Disease Model Rats
Publication date: 21 August 2018Source: Neuroscience, Volume 386Author(s): Yutaka Mine, Toshihiko Momiyama, Takuro Hayashi, Takeshi KawaseAbstractAlthough recent progress in the use of human iPS cell-derived midbrain dopaminergic progenitors is remarkable, alternatives are essential in the strategies of treatment of basal-ganglia-related diseases.Attention has been focused on neural stem cells (NSCs) as one of the possible candidates of donor material for neural transplantation, because of their multipotency and self-renewal characteristics. In the present study, miniature-swine (mini-swine) mesencephalic neuroepithelial s...
Source: Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research

GSE228096 Epicardial Placement of Human Placental Membrane Protects from Heart Injury in a Swine Model of Myocardial Infarction
We present comprehensive transcriptome and proteome profiles of infarct (IZ), border (BZ), and remote (RZ) zone punch biopsies from swine myocardium during the proliferative ca rdiac repair phase 14 days post-MI. Both HPAC-treated and untreated tissues showed regional dynamic responses, whereas only HPAC-treated IZ revealed active immune and extracellular matrix remodeling. Decreased endoplasmic reticulum (ER)-dependent protein secretion and increased anti-apoptotic and an ti-inflammatory responses were measured in HPAC-treated biopsies. Discussion: We provide quantitative evidence HPAC reduced cardiac injury from MI in a ...
Source: GEO: Gene Expression Omnibus - May 30, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Sus scrofa domesticus Source Type: research

Safety and efficacy of a novel, fenestrated aortic arch stent graft with a preloaded catheter for supraaortic arch vessels: an experimental study in Swine.
Abstract Thoracic endovascular aortic repair (TEVAR) shows limitations in cases in which the aortic pathology involves the aortic arch. The study aims were to test a fenestrated aortic arch stent graft (FASG) with a preloaded catheter for the supraaortic arch vessels and to perform a preclinical study in swine to evaluate the safety and efficacy of this device. Six FASGs with 1 preloaded catheter and 5 FASGs with 2 preloaded catheters were advanced through the iliac artery in 11 swines. The presence of endoleaks and the patency and deformity of the grafts were examined with computed tomography (CT) at 4 weeks post...
Source: J Korean Med Sci - April 1, 2015 Category: Journals (General) Authors: Kim SP, Lee HC, Park TS, Ahn JH, Lee HW, Park JH, Oh J, Choi JH, Cha KS Tags: J Korean Med Sci Source Type: research