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Total 106 results found since Jan 2013.

Characteristics of Cardiac Allograft Vasculopathy Induced by Immunomodulation in the Miniature Swine.
Conclusion: CAV mimicking human heart transplantation can be developed by appropriate immunomodulation in the swine. In swine CAV, proliferated SMCs seen in the intimal thickening were demonstrated to be from the donor origin. PMID: 24747545 [PubMed - as supplied by publisher]
Source: Annals of Thoracic and Cardiovascular Surgery - April 18, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Amano J, Akashima T, Terasaki T, Wada Y, Ito-Amano M, Suzuki JI, Isobe M Tags: Ann Thorac Cardiovasc Surg Source Type: research

Stable Mixed Hematopoietic Chimerism Permits Tolerance of Vascularized Composite Allografts Across a Full MHC Mismatch in Swine
This study tested the hypothesis that vascularized composite allografts (VCA) could be accepted in a robust model of hematopoietic chimerism by injecting allogeneic bone marrow cells (BMC) into swine fetuses. Outbred Yorkshire sows and boars were screened to ensure the absence of the MHC allele SLAcc of inbred MGH miniature swine and then mated. Bone marrow harvested from an SLAcc swine donor was T‐cell depleted and injected intravenously into the fetuses between days 50‐55 of gestation. After birth, the piglets were studied with flow cytometry to detect donor cells, and mixed lymphocyte reactions (MLR) and cell‐medi...
Source: Transplant International - June 25, 2014 Category: Transplant Surgery Authors: David W. Mathes, Mario G. Solari, G. Scott Gazelle, Peter E. M Butler, Anette Wu, Adam Nazzal, G. Petur Nielsen, Christene A. Huang, David H. Sachs, W.P. Andrew Lee, Mark A. Randolph Tags: Original Article Source Type: research

The Induction of Tolerance of Renal Allografts by Adoptive Transfer in Miniature Swine
In this study, we attempted to induce tolerance of class I‐mismatched kidneys by adoptive transfer of cells and/or kidneys from long‐term tolerant animals. Fifteen SLAdd miniature swine received 1.5 Gy whole body irradiation and class I‐mismatched (SLAgg) kidneys from naïve pigs with or without cotransplanted kidneys and/or adoptively transferred cells from long‐term tolerant (LTT) SLAdd recipients of SLAgg grafts. In addition, three SLAdd miniature swine received class I mismatched kidney with adoptively transferred cells from LTT SLAdd recipients. Naïve kidneys transplanted without a LTT kidney were rejected wi...
Source: American Journal of Transplantation - March 6, 2013 Category: Transplant Surgery Authors: M. Okumi, J. R. Scalea, B. C. Gillon, M. Tasaki, V. Villani, T. Cormack, A. Hirakata, A. Shimizu, D. H. Sachs, K. Yamada Tags: Original Article Source Type: research

An eligible biological allograft patch in tension-free herniorrhaphy of swine.
Authors: Deng MH, Zhong YS, Yan J, Hu KP, Yao ZC, Chen C, Xu GF Abstract Current patches made from macromolecular compounds or composix for tension-free herniorrhaphy are still unsatisfactory in biocompatibility. The ideal patch should be a biological patch with good biocompatibility. Herein allograft patches modified by tissue engineering were used in tension-free herniorrhaphy of swines. Tough membrane tissues from swine were modified with patented tissue engineering techniques to develop allograft patches for tension-free herniorrhaphy. Histological, and physical tests of the allograft patch were performed subse...
Source: BioScience Trends - December 1, 2014 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Ex Situ Limb Perfusion System to Extend Vascularized Composite Tissue Allograft Survival in Swine
Conclusions: We demonstrated the potential to preserve limb allograft using ex vivo circulation. This approach promises to extend the narrow time frame for revascularization of procured extremities in limb transplantation.
Source: Transplantation - October 1, 2015 Category: Transplant Surgery Tags: Original Basic Science-General Source Type: research

Molecules, Vol. 27, Pages 1694: Comparison of Hydroxyapatite/Poly(lactide-co-glycolide) and Hydroxyapatite/Polyethyleneimine Composite Scaffolds in Bone Regeneration of Swine Mandibular Critical Size Defects: In Vivo Study
manja Jovicic Gvozden Rosic Reconstruction of jaw bone defects present a significant problem because of specific aesthetic and functional requirements. Although widely used, the transplantation of standard autograft and allograft materials is still associated with significant constraints. Composite scaffolds, combining advantages of biodegradable polymers with bioceramics, have potential to overcome limitations of standard grafts. Polyethyleneimine could be an interesting novel biocompatible polymer for scaffold construction due to its biocompatibility and chemical structure. To date, there have been no in vivo studi...
Source: Molecules - March 4, 2022 Category: Chemistry Authors: Momir Stevanovic Dragica Selakovic Miroslav Vasovic Biljana Ljujic Suzana Zivanovic Milos Papic Marko Zivanovic Nevena Milivojevic Milica Mijovic Sasa Z. Tabakovic Vukoman Jokanovic Aleksandra Arnaut Pavle Milanovic Nemanja Jovicic Gvozden Rosic Tags: Article Source Type: research

The MHC-characterized Miniature Swine: Lessons Learned From a 40-Year Experience in Transplantation
Over the last 40 y, a specialized herd of miniature swine has been intentionally bred to develop lines of animals homozygous for the swine major histocompatibility complex (MHC), which have facilitated transplantation studies across reproducible MHC and minor antigen mismatch barriers. These MHC-characterized miniature swine (Mc-MS) have been used for the study of novel surgical techniques, various approaches to tolerance induction of solid organ and vascularized composite allografts, as well as studies of the immunobiology of allografts and xenografts. Mc-MS possess characteristics that are highly advantageous to these st...
Source: Transplantation - May 1, 2022 Category: Transplant Surgery Tags: Reviews Source Type: research

Recipient-matching of Passenger Leukocytes Prolongs Survival of Donor Lung Allografts in Miniature Swine
Background: Allograft rejection continues to be a vexing problem in clinical lung transplantation, and the role played by passenger leukocytes in the rejection or acceptance of an organ is unclear. We tested whether recipient-matching of donor graft passenger leukocytes would impact graft survival in a preclinical model of orthotopic left lung transplantation. Methods: In the experimental group (group 1), donor lungs were obtained from chimeric swine, in which the passenger leukocytes (but not the parenchyma) were major histocompatibility complex–matched to the recipients (n = 3). In the control group (group 2), both the...
Source: Transplantation - July 1, 2015 Category: Transplant Surgery Tags: Original Basic Science Source Type: research

Irradiation before and donor splenocyte infusion immediately after transplantation induce tolerance to lung, but not heart allografts in miniature swine
In conclusion, lungs and hearts vary in their potential to induce a state of tolerance after transplantation in a protocol with pre‐operative recipient irradiation and donor splenocyte co‐transplantation. This could be due to differential early levels of passenger leukocyte chimerism. This article is protected by copyright. All rights reserved.
Source: Transplant International - December 31, 2016 Category: Transplant Surgery Authors: Wiebke Sommer, Gwen Buechler, Katharina Jansson, Murat Avsar, Ann ‐Kathrin Knöfel, Jawad Salman, Klaus Hoeffler, Thierry Siemeni, Jens Gottlieb, Johann H Karstens, Danny Jonigk, Ansgar Reising, Axel Haverich, Martin Strüber, Gregor Warnecke Tags: Original Article Source Type: research

Recipient Adipose-Derived Stem Cells Enhance Recipient Cell Engraftment and Prolong Allotransplant Survival in a Miniature Swine Hind-Limb Model.
Abstract Donor mesenchymal stem cells (MSCs) could prolong vascularized composite allotransplantation (VCA) survival in our previous studies. However, recipient adipose tissue is easier to harvest than donor tissue for preconditioning modulation. Hence, this study investigated the efficacy of recipient autologous adipose-derived stem cells (rADSCs) for VCA survival. The heterotopic hind-limb transplantation from female donor to male recipient was performed in outbred miniature swine. Group I ( n = 6) was untreated controls. Group II ( n = 4) obtained rADSCs infusions (given on weeks 0, +1, +2, and +3). Group III (...
Source: Cell Transplantation - August 1, 2017 Category: Cytology Authors: Kuo YR, Chen CC, Chen YC, Chien CM Tags: Cell Transplant Source Type: research

Collagen/nano-sized β-tricalcium phosphate conduits combined with collagen filaments and nerve growth factor promote facial nerve regeneration in miniature swine: an in vivo study
ConclusionThe functional nerve biomedical system containing the COL/nβ-TCP conduit combined with COL filaments and NGF could promote facial nerve regeneration, thus showing promising potential for clinical applications.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 14, 2018 Category: ENT & OMF Source Type: research

Tacrolimus before CTLA4Ig and rapamycin promotes vascularized composite allograft survival in MGH miniature swine
CONCLUSION: A short course of CNI, followed by combined Co-SB and mTORi significantly delays acute rejection of VRAM allografts in SLA-mismatched miniature swine.PMID:35987329 | DOI:10.1016/j.trim.2022.101696
Source: Transplant Immunology - August 20, 2022 Category: Transplant Surgery Authors: Tarek Y Elgendy Matthias Waldner Wensheng Zhang Deokyeol Y Kim Marta I Minervini Chiaki Komatsu Yalcin Kulahci Kia M Washington Vijay S Gorantla Mohamed B Ezzelarab Mario G Solari Angus W Thomson Source Type: research

Letter Regarding: Continuous Versus Pulsatile Flow in 24-Hour Vascularized Composite Allograft Machine Perfusion in Swine: A Pilot Study
We read, with interest, the article “Continuous versus Pulsatile Flow in 24-Hour Vascularized Composite Allograft Machine Perfusion in Swine: A Pilot Study”.1 The authors present a pilot study in a swine partial hind limb model, investigating the outcomes of ex vivo subnormothermic perfusion with a modified Steen solution for 24  h with pulsatile flow (n = 3) compared to continuous flow (n = 3) at subnormothermic temperatures. They conclude that pulsatile perfusion may be more physiologic and beneficial in the preservation of VCAs based on improved endothelial function and decreased ischemic injury.
Source: Journal of Surgical Research - June 30, 2023 Category: Surgery Authors: Jacob Lammers, Mazen Al-Malak, Varun Kopparthy, Brian A. Figueroa, Antonio Rampazzo, Bahar Bassiri Gharb Tags: Letter to the editor Source Type: research

Induction of Cardiac Allograft Tolerance Across a Full MHC Barrier in Miniature Swine by Donor Kidney Cotransplantation
Abstract We have previously shown that tolerance of kidney allografts across a full major histocompatibility complex (MHC) barrier can be induced in miniature swine by a 12‐day course of high‐dose tacrolimus. However, that treatment did not prolong survival of heart allografts across the same barrier. We have now tested the effect of cotransplanting an allogeneic heart and kidney from the same MHC‐mismatched donor using the same treatment regimen. Heart allografts (n = 3) or heart plus kidney allografts (n = 5) were transplanted into MHC‐mismatched recipients treated with high‐dose tacrolimus for 12 days....
Source: American Journal of Transplantation - August 1, 2013 Category: Transplant Surgery Authors: M. L. Madariaga, S. G. Michel, M. Tasaki, V. Villani, G. M. La Muraglia, S. Sihag, J. Gottschall, E. A. Farkash, A. Shimizu, J. S. Allan, D. H. Sachs, K. Yamada, J. C. Madsen Tags: Original Article Source Type: research

An in vivo swine study for xeno-grafts of calcium sulfate-based bone grafts with human dental pulp stem cells (hDPSCs).
Abstract The purpose of this in vivo study was to evaluate the effect of human dental pulp stem cells (hDPSCs) on various resorbable calcium sulfate/calcium phosphate bone grafts in bone regeneration. Granular particles of calcium sulfate dehydrate (CSD), α-calcium sulfate hemihydrate/amorphous calcium phosphate (α-CSH/ACP), and CSD/β-tricalcium phosphates (β-TCP) were prepared for in vitro dissolution and implantation test. The chemical compositions of specimen residues after dissolution test were characterized by XRD. The ratios of new bone formation for implanted grafts/hDPSCs were evaluated using mandible ...
Source: Appl Human Sci - March 12, 2015 Category: Physiology Authors: Kuo TF, Lee SY, Wu HD, Poma M, Wu YW, Yang JC Tags: Mater Sci Eng C Mater Biol Appl Source Type: research