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Total 102 results found since Jan 2013.

Is The Shocking News of the Sugar Industry's Influence Over Harvard Researchers Really Shocking?
Hey, Sugar, pay no attention to the man behind the curtain. Today, the Journal of the American Medical Association dropped an alleged bombshell when it disclosed that the sugar industry lobby influenced research on coronary heart disease by effectively bribing Harvard researchers to promote the theory that dietary fat, and not sugar, causes heart disease. The story is trending on Facebook at this very moment, and the JAMA Facebook post states that "Policymaking committees should consider giving less weight to food industry-funded studies, and include mechanistic and animal studies as well as studies appraising the effec...
Source: Healthy Living - The Huffington Post - September 14, 2016 Category: Consumer Health News Source Type: news

Characteristics of Cardiac Allograft Vasculopathy Induced by Immunomodulation in the Miniature Swine.
Conclusion: CAV mimicking human heart transplantation can be developed by appropriate immunomodulation in the swine. In swine CAV, proliferated SMCs seen in the intimal thickening were demonstrated to be from the donor origin. PMID: 24747545 [PubMed - as supplied by publisher]
Source: Annals of Thoracic and Cardiovascular Surgery - April 18, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Amano J, Akashima T, Terasaki T, Wada Y, Ito-Amano M, Suzuki JI, Isobe M Tags: Ann Thorac Cardiovasc Surg Source Type: research

Video-assisted thoracoscopic surgery in swine: an animal model for thoracoscopic lobectomy training
The objective of this study is to demonstrate the technique of lobectomy using videothoracoscopy in swine, highlighting the steps to be taken during its use in surgical experimentation. METHODS During the advanced course on video-assisted and thoracoscopic procedures carried out at IRCAD Latin America, Barretos, Brazil, 40 swine were used for the hands-on course on video-assisted upper left lobectomy. Monopulmonary ventilation was performed by blocking the left main bronchus. Surgical procedures were performed using three ports and the anterior dissection technique (fissureless approach). The pulmonary hilar structures we...
Source: Interactive CardioVascular and Thoracic Surgery - July 22, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Tedde, M. L., Brito Filho, F., Belmonte, E. d. A., Pinto Filho, D. R., Pereira, S. T. F. L., Okumura, E. M., Melani, A. G. F., Gossot, D. Tags: Cardiac - pharmacology, Education, Transplantation - heart Thoracic Source Type: research

Contraceptive pills not proven to protect against the flu
Conclusion These are interesting scientific findings but they have limited implications. Animal studies are useful for giving an indication of how biological processes may work in humans but we're not identical. Then the scenarios tested here – the progesterone, or the flu injection – can be taken as representative of real-life in humans. For one thing all the mice had surgery to remove their ovaries before being infected. It makes sense that the mice that had been given some additional recovery boost in the form of hormone replacement may have been in a better health state than those left hormone depleted. They wer...
Source: NHS News Feed - September 19, 2016 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news

Intracellular Ca2+ Dysregulation in Coronary Smooth Muscle Is Similar in Coronary Disease of Humans and Ossabaw Miniature Swine
AbstractIntracellular free Ca2+ ([Ca2+]i) dysregulation occurs in coronary smooth muscle (CSM) in atherosclerotic coronary artery disease (CAD) of metabolic syndrome (MetS) swine. Our goal was to determine how CAD severity, arterial structure, and MetS risk factors associate with [Ca2+]i dysregulation in human CAD compared to changes in Ossabaw miniature swine. CSM cells were dispersed from coronary arteries of explanted hearts from transplant recipients and from lean and MetS swine with CAD. CSM [Ca2+]i elicited by Ca2+ influx and sarcoplasmic reticulum (SR) Ca2+ release and sequestration was measured with fura-2. Increas...
Source: Journal of Cardiovascular Translational Research - July 20, 2021 Category: Cardiology Source Type: research

Intracellular Ca < sup > 2+ < /sup > Dysregulation in Coronary Smooth Muscle Is Similar in Coronary Disease of Humans and Ossabaw Miniature Swine
J Cardiovasc Transl Res. 2021 Jul 20. doi: 10.1007/s12265-021-10153-5. Online ahead of print.ABSTRACTIntracellular free Ca2+ ([Ca2+]i) dysregulation occurs in coronary smooth muscle (CSM) in atherosclerotic coronary artery disease (CAD) of metabolic syndrome (MetS) swine. Our goal was to determine how CAD severity, arterial structure, and MetS risk factors associate with [Ca2+]i dysregulation in human CAD compared to changes in Ossabaw miniature swine. CSM cells were dispersed from coronary arteries of explanted hearts from transplant recipients and from lean and MetS swine with CAD. CSM [Ca2+]i elicited by Ca2+ influx and...
Source: Cell Research - July 21, 2021 Category: Cytology Authors: Jill K Badin Caleb Eggenberger Stacey Dineen Rodenbeck Zubair A Hashmi I-Wen Wang Jose P Garcia Mouhamad Alloosh Michael Sturek Source Type: research

Effect of Rapamycin on mesenchymal stem cells treatment for swine myocardial infarction
Conclusions: Four weeks after MSCs transplantation for curing AMI, the myocardial perfusion and glucose metabolism improved significantly in the Rapamycin group; however, the cardiac function was decreased. It is speculated that Rapamycin might have impacted the effect of MSCs transplantation in infarcted hearts. The mechanism needs further research. Index on SPECT, PET and MRI in Three GroupsControl group MSCs groupRapamycin groupP valueSRS24.43±5.4728.63±3.3420.50±7.70<0.05Defect area (cm2)41.57±12.4844.25±12.8022.50±10.74<0.05SCR12.80±4.9715.33±8.636.20&...
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Cai, M., Feng, G., Li, L., Zhang, G., Yang, X. Tags: Cardiovascular Basic Science: Metabolism and Molecular Imaging Source Type: research

Characterization of the withdrawal phase in a swine controlled intestinal donation after circulatory death model.
CONCLUSION: A new swine CDCD model, simulating three stages of "withdrawal of ventilation, systemic anticoagulation and determination of death", which closely mimics the human DCD scenario and can thus be used in studies related to organ transplantation, was successfully established. PMID: 25282139 [PubMed - in process]
Source: Clinical and Investigative Medicine - October 7, 2014 Category: Biomedical Science Authors: Guo M, Li L, Lu C Tags: Clin Invest Med Source Type: research

Direct epicardial assist device using artificial rubber muscle in a swine model of pediatric dilated cardiomyopathy.
CONCLUSIONS: Use of a circumferential direct epicardial assistant device resulted in improvement in hemodynamic data in a dilated cardiomyopathy model. Although there is still a need for improvements in device components, the direct cardiac assist device may be a good alternative to recent heart failure device therapies. PMID: 26659480 [PubMed - as supplied by publisher]
Source: The International Journal of Artificial Organs - December 7, 2015 Category: Transplant Surgery Authors: Saito Y, Suzuki Y, Kondo N, Kowatari R, Daitoku K, Minakawa M, Fukuda I Tags: Int J Artif Organs Source Type: research

Irradiation before and donor splenocyte infusion immediately after transplantation induce tolerance to lung, but not heart allografts in miniature swine
In conclusion, lungs and hearts vary in their potential to induce a state of tolerance after transplantation in a protocol with pre‐operative recipient irradiation and donor splenocyte co‐transplantation. This could be due to differential early levels of passenger leukocyte chimerism. This article is protected by copyright. All rights reserved.
Source: Transplant International - December 31, 2016 Category: Transplant Surgery Authors: Wiebke Sommer, Gwen Buechler, Katharina Jansson, Murat Avsar, Ann ‐Kathrin Knöfel, Jawad Salman, Klaus Hoeffler, Thierry Siemeni, Jens Gottlieb, Johann H Karstens, Danny Jonigk, Ansgar Reising, Axel Haverich, Martin Strüber, Gregor Warnecke Tags: Original Article Source Type: research

A percutaneous approach to create tricuspid regurgitation in swine: a model for transcatheter tricuspid valve therapy assessment
ConclusionsSevere tricuspid regurgitation can be created by a simple and effective percutaneous approach with a grasping forceps in swine model and right heart dilation can be observed consistently at one-month follow-up. This model will be valuable in pre-clinical studies for developing new tricuspid valve repair or replacement technique to treat severe tricuspid regurgitation.
Source: Journal of Artificial Organs - January 22, 2021 Category: Transplant Surgery Source Type: research

Functional Consequences of Human Induced Pluripotent Stem Cells Therapy: Myocardial ATP Turnover Rate in the in vivo Swine Hearts with Post-Infarction Remodeling.
CONCLUSIONS: hiPSC-VC transplantation mobilized endogenous progenitor cells into the BZ, attenuated regional wall stress, stimulated neovascularization, and improved BZ perfusion, which in turn resulted in marked increases of BZ contractile function and ATP turnover rate. PMID: 23371930 [PubMed - as supplied by publisher]
Source: Circulation - January 31, 2013 Category: Cardiology Authors: Xiong Q, Ye L, Zhang P, Lepley M, Tian J, Li J, Zhang L, Swingen C, Vaughan JT, Kaufman DS, Zhang J Tags: Circulation Source Type: research

Hypoxia-preconditioned mesenchymal stromal cells improve cardiac function in a swine model of chronic myocardial ischaemia BASIC SCIENCE
CONCLUSION MSC engraftment with hypoxic preconditioning significantly improves capillary density and cell survival, resulting in improvement in global, regional and diastolic left ventricular functions. This highlights the therapeutic potential of transplanting hypoxic-preconditioned MSC in the setting of chronic ischaemic heart failure.
Source: European Journal of Cardio-Thoracic Surgery - April 8, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Jaussaud, J., Biais, M., Calderon, J., Chevaleyre, J., Duchez, P., Ivanovic, Z., Couffinhal, T., Barandon, L. Tags: BASIC SCIENCE Source Type: research

Induction of Cardiac Allograft Tolerance Across a Full MHC Barrier in Miniature Swine by Donor Kidney Cotransplantation
Abstract We have previously shown that tolerance of kidney allografts across a full major histocompatibility complex (MHC) barrier can be induced in miniature swine by a 12‐day course of high‐dose tacrolimus. However, that treatment did not prolong survival of heart allografts across the same barrier. We have now tested the effect of cotransplanting an allogeneic heart and kidney from the same MHC‐mismatched donor using the same treatment regimen. Heart allografts (n = 3) or heart plus kidney allografts (n = 5) were transplanted into MHC‐mismatched recipients treated with high‐dose tacrolimus for 12 days....
Source: American Journal of Transplantation - August 1, 2013 Category: Transplant Surgery Authors: M. L. Madariaga, S. G. Michel, M. Tasaki, V. Villani, G. M. La Muraglia, S. Sihag, J. Gottschall, E. A. Farkash, A. Shimizu, J. S. Allan, D. H. Sachs, K. Yamada, J. C. Madsen Tags: Original Article Source Type: research

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