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Total 1846 results found since Jan 2013.

Narcolepsy in Adolescence — A Missed Diagnosis: A Case Report
In this report, we present a case of an adolescent male with all four cardinal symptoms of narcolepsy who was misdiagnosed with epilepsy, psychosis, and depression. We also discuss various issues regarding narcolepsy in children and adolescents. Case Report Mr. A, an 18-year-old man, presented to psychiatry outpatient services with excessive daytime sleepiness of approximately 1.5 years’ duration. When the chronology of symptoms was evaluated, it was evident that about 1.5 years before presentation, the patient had an episode of high-grade fever (101–103?F) and was empirically treated for typhoid and malaria. Within a ...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue adolescence misdiagnosis narcolepsy Source Type: research

Narcolepsy Associated with Pandemrix Vaccine
AbstractPurpose of ReviewAfter the connection between AS03-adjuvanted pandemic H1N1 vaccine Pandemrix and narcolepsy was recognized in 2010, research on narcolepsy has been more intensive than ever before. The purpose of this review is to provide the reader with current concepts and recent findings on the Pandemrix-associated narcolepsy.Recent FindingsAfter the Pandemrix vaccination campaign in 2009 –2010, the risk of narcolepsy was increased 5- to 14-fold in children and adolescents and 2- to 7-fold in adults. According to observational studies, the risk of narcolepsy was elevated for 2 years after the Pandemrix vaccin...
Source: Current Neurology and Neuroscience Reports - June 1, 2018 Category: Neuroscience Source Type: research

Narcolepsy Diagnosis With Sleep Stage Features Using PSG Recordings
Narcolepsy is a sleep disorder affecting millions of people worldwide and causes serious public health problems. It is hard for doctors to correctly and objectively diagnose narcolepsy. Polysomnography (PSG) recordings, a gold standard for sleep monitoring and quality measurement, can provide abundant and objective cues for the narcolepsy diagnosis. There have been some studies on automatic narcolepsy diagnosis using PSG recordings. However, the sleep stage information, an important cue for narcolepsy diagnosis, has not been fully utilized. For example, some studies have not considered the sleep stage information to diagno...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - September 14, 2023 Category: Neuroscience Source Type: research

Challenges in the development of therapeutics for narcolepsy
Publication date: Available online 23 December 2015 Source:Progress in Neurobiology Author(s): Sarah Wurts Black, Akihiro Yamanaka, Thomas S. Kilduff Narcolepsy is a neurological disorder that afflicts 1 in 2000 individuals and is characterized by excessive daytime sleepiness and cataplexy-a sudden loss of muscle tone triggered by positive emotions. Features of narcolepsy include dysregulation of arousal state boundaries as well as autonomic and metabolic disturbances. Disruption of neurotransmission through the hypocretin/orexin (Hcrt) system, usually by degeneration of the HCRT-producing neurons in the posterior hyp...
Source: Progress in Neurobiology - December 25, 2015 Category: Neuroscience Source Type: research

Independent Component Analysis and Graph Theoretical Analysis in Patients with Narcolepsy
AbstractThe present study was aimed to evaluate resting-state functional connectivity and topological properties of brain networks in narcolepsy patients compared with healthy controls. Resting-state fMRI was performed in 26 adult narcolepsy patients and 30 matched healthy controls. MRI data were first analyzed by group independent component analysis, then a graph theoretical method was applied to evaluate the topological properties in the whole brain. Small-world network parameters and nodal topological properties were measured. Altered topological properties in brain areas between groups were selected as region-of-intere...
Source: Neuroscience Bulletin - November 13, 2018 Category: Neuroscience Source Type: research

Impaired histaminergic neurotransmission in children with narcolepsy type 1.
CONCLUSIONS: Narcolepsy type 1 children had a higher CSF HA level together with a lower t-MeHA level leading to a significant decrease in the t-MeHA/HA ratios. These results suggest a decreased HA turnover and an impairment of histaminergic neurotransmission in narcoleptic children and support the use of a histaminergic therapy in the treatment against narcolepsy. PMID: 30225986 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - September 17, 2018 Category: Neuroscience Authors: Franco P, Dauvilliers Y, Inocente CO, Guyon A, Villanueva C, Raverot V, Plancoulaine S, Lin JS Tags: CNS Neurosci Ther Source Type: research

The evolution of the narcolepsy concept in Russia: A historical view.
Authors: Kuts A, Poluektov M, Bassetti CLA Abstract Following the first descriptions of narcolepsy with cataplexy by Westphal, Gelineau, and Fischer (1878-1880), Russian authors started to report on "narcolepsy cases" in 1894. It was, however, only in 1925 that Mankovsky reported a (postencephalitic) case, satisfying current diagnostic criteria for the disease. In the following 66 years (the last publication appeared in 1991), Russian authors including Davidenkov, Vein, and Yakhno made interesting contributions on the clinical features, neurophysiological correlates (e.g., sleep states and boundary dyscontrol), pa...
Source: Journal of the History of the Neurosciences - July 2, 2020 Category: Neuroscience Tags: J Hist Neurosci Source Type: research

Quality of Life in Children with Narcolepsy.
CONCLUSIONS: Narcoleptic children and adolescents were at high risk for poor HRQL. Depressive symptoms had a major impact on HRQL. We recommend a more thorough assessment and management of psychological health in this population. PMID: 24922610 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - June 12, 2014 Category: Neuroscience Authors: Inocente CO, Gustin MP, Lavault S, Guignard-Perret A, Raoux A, Christol N, Gerard D, Dauvilliers Y, Reimão R, Bat-Pitault F, Lin JS, Arnulf I, Lecendreux M, Franco P Tags: CNS Neurosci Ther Source Type: research

Grey matter atrophy in narcolepsy: An Activation Likelihood Estimation meta-analysis
Publication date: Available online 28 March 2015 Source:Neuroscience & Biobehavioral Reviews Author(s): Hsu-Huei Weng , Chih-Feng Chen , Yuan-Hsiung Tsai , Chih-Ying Wu , Meng Lee , Yu-Ching Lin , Cheng-Ta Yang , Ying-Huang Tsai , Chun-Yuh Yang The authors reviewed the literature on the use of voxel-based morphometry (VBM) in narcolepsy magnetic resonance imaging (MRI) studies via the use of a meta-analysis of neuroimaging to identify concordant and specific structural deficits in patients with narcolepsy as compared with healthy subjects. We used PubMed to retrieve articles published between January 2000 and Mar...
Source: Neuroscience and Biobehavioral Reviews - March 28, 2015 Category: Neuroscience Source Type: research

Gray matter atrophy in narcolepsy: An activation likelihood estimation meta-analysis
Publication date: Available online 28 March 2015 Source:Neuroscience & Biobehavioral Reviews Author(s): Hsu-Huei Weng , Chih-Feng Chen , Yuan-Hsiung Tsai , Chih-Ying Wu , Meng Lee , Yu-Ching Lin , Cheng-Ta Yang , Ying-Huang Tsai , Chun-Yuh Yang The authors reviewed the literature on the use of voxel-based morphometry (VBM) in narcolepsy magnetic resonance imaging (MRI) studies via the use of a meta-analysis of neuroimaging to identify concordant and specific structural deficits in patients with narcolepsy as compared with healthy subjects. We used PubMed to retrieve articles published between January 2000 and Mar...
Source: Neuroscience and Biobehavioral Reviews - April 6, 2015 Category: Neuroscience Source Type: research

Prevalence of Depression or Depressive Symptoms in Patients with Narcolepsy: a Systematic Review and Meta-Analysis
AbstractA meta-analysis was conducted to review the prevalence and associated moderators of depression or depressive symptoms in patients with narcolepsy. An extensive search of the literature yielded 1104 articles and abstracts, of which 31 studies were included in the meta-analysis. Meta-analysis revealed that the overall pooled prevalence of depression or depressive symptoms in patients with narcolepsy was 32% (95% Confidence Interval, 28 –36%) with high between-study heterogeneity (Q = 249.77, df = 30,p <  0.001, τ2 = 0.0087,I2 = 88%). An analysis of 13 studies with healthy control groups indic...
Source: Neuropsychology Review - July 14, 2020 Category: Neuroscience Source Type: research

Diagnostic value of sleep stage dissociation as visualized on a 2-Dimensional sleep state space in human narcolepsy
Conclusion Sleep stage dissociation can be used for the diagnosis of narcolepsy. However the use of some medications and presence of undiagnosed hypersomnolence patients impacts the result.
Source: Journal of Neuroscience Methods - February 20, 2017 Category: Neuroscience Source Type: research

Neuroimaging correlates of narcolepsy with cataplexy: A systematic review
In conclusion, all the replicated findings are still controversial due to the limitations such as heterogeneity or size of the samples and lack of multimodal imaging or follow-up. Thus, future neuroimaging studies should employ multimodal imaging methods in a large sample size of patients with narcolepsy and consider age, duration of disease, age at onset, severity, human leukocyte antigen type, cerebrospinal fluid hypocretin levels, and medication intake in order to elucidate possible neuroimaging characteristic of narcolepsy and identify therapeutic targets.
Source: Neuroscience Research - March 24, 2018 Category: Neuroscience Source Type: research