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Total 116 results found since Jan 2013.

Flu vaccine uptake is down on last year, official figures show
20% fewer over-65s have received the vaccine this year as practices wait for vaccines to be delivered Related items fromOnMedica Rapid rise in flu consultations putting strain on GPs Adjuvanted trivalent flu vaccine best option for over-65s Good evidence for sublingual immunotherapy Sublingual immunotherapy effective in children with allergies BMJ report questions swine flu jab transparency
Source: OnMedica Latest News - October 29, 2018 Category: UK Health Source Type: news

An Overview of Hypocretin based Therapy in Narcolepsy.
Authors: Takenoshita S, Sakai N, Chiba Y, Matsumura M, Yamaguchi M, Nishino S Abstract INTRODUCTION: Narcolepsy with cataplexy is most commonly caused by a loss of hypocretin/orexin peptide-producing neurons in the hypothalamus (i.e., Narcolepsy Type 1). Since hypocretin deficiency is assumed to be the main cause of narcoleptic symptoms, hypocretin replacement will be the most essential treatment for narcolepsy. Unfortunately, this option is still not available clinically. There are many potential approaches to replace hypocretin in the brain for narcolepsy such as intranasal administration of hypocretin peptides, ...
Source: Expert Opinion on Investigational Drugs - April 7, 2018 Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research

Treatment Options for Narcolepsy
Abstract Narcolepsy type 1 and narcolepsy type 2 are central disorders of hypersomnolence. Narcolepsy type 1 is characterized by excessive daytime sleepiness and cataplexy and is associated with hypocretin-1 deficiency. On the other hand, in narcolepsy type 2, cerebrospinal fluid hypocretin-1 levels are normal and cataplexy absent. Despite major advances in our understanding of narcolepsy mechanisms, its current management is only symptomatic. Treatment options may vary from a single drug that targets several symptoms, or multiple medications that each treats a specific symptom. In recent years, narcolepsy treatme...
Source: CNS Drugs - May 6, 2016 Category: Neurology Source Type: research

Transient Impact of Rituximab in H1N1 Vaccination–associated Narcolepsy With Severe Psychiatric Symptoms
Conclusions: Effect of RXB on narcolepsy has not been reported before. Remarkable but short-lasting effect of RXB in narcolepsy is intriguing as it could imply that there is still ongoing B cell–mediated autoimmune response possible contributing to symptoms in narcolepsy.
Source: The Neurologist - August 29, 2016 Category: Neurology Tags: Case Report/Case Series Source Type: research

Untangling Narcolepsy and Diabetes: Pathomechanisms with Eyes on Therapeutic Options.
Abstract Narcolepsy (NA) is a primary sleep disorder characterized by loss of hypocretinergic/orexinergic neurons. NA is associated with an increased risk for metabolic disorders such as diabetes mellitus (DM). Proposed mechanisms for this association are alterations in food intake, disruption of energy balance, glucose tolerance, and insulin sensitivity, as well as inflammation and genetic factors. Orexin deficiency, is associated with increased food intake and reduced basal metabolic rate (BMR) both leading to obesity. The anti-apoptotic effect of orexin on pancreatic beta-cells, increase in peripheral insulin s...
Source: Brain Research - April 14, 2019 Category: Neurology Authors: Mohammadi S, Dolatshahi M, Zare-Shahabadi A, Rahmani F Tags: Brain Res Source Type: research

Immunotherapy in Narcolepsy
AbstractPurpose of reviewNarcolepsy type 1 (NT1) is a chronic and disabling sleep disorder due to the loss of hypocretinergic neurons in the lateral hypothalamus pathophysiologically linked to an autoimmune process. Current treatment is symptomatic, and no cure is available to date. Immunotherapy is considered a promising future therapeutic option, and this review discusses the rationale for immunotherapy in narcolepsy, current evidences of its effects, outcome measures, and future directions.Recent findingsA limited number of case reports and uncontrolled small case series have reported the effect of different immunothera...
Source: Current Treatment Options in Neurology - January 29, 2020 Category: Neurology Source Type: research

Bone vascularized composite allotransplantation model in swine tibial defect: Evaluation of surgical angiogenesis and transplant viability
ConclusionImplantation of autogenous AV bundles into vascularized bone allotransplants resulted in the rapid formation of a neoangiogenic autogenous blood supply in a swine tibia model that maintained bone viability, improved bone healing, and minimized rejection.
Source: Microsurgery - March 5, 2018 Category: Surgery Authors: Dimitra Kotsougiani, Caroline A. Hundepool, Liselotte F. Bulstra, Patricia F. Friedrich, Alexander Y. Shin, Allen T. Bishop Tags: RESEARCH ARTICLE Source Type: research

Monoclonal Antibody Against HA Protein of the European Avian-Like H1N1 Swine Influenza Virus.
Authors: Wang Q, Wang SY, Zhang P, Liu XM, Yu LX, Shan TL, Tong W, Zhou YJ, Li GX, Zheng H, Gao F, Jiang YF, Kong N, Li LW, Tong GZ, Yu H Abstract The purified whole-virus proteins derived from A/swine/Shanghai/1/2014 (H1N1) (SH1) were chosen to immunize BALB/c mice to prepare the monoclonal antibody (MAb) against hemagglutinin (HA) protein of an European avian-like (EA) H1N1 swine influenza virus (SIV). After cloning three times by limiting dilution, one strain of hybridoma cells named 3C7 secreting anti-HA protein MAb was obtained by hybridoma technique. The results of indirect immunofluorescence assay and wester...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - April 11, 2018 Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research

Genes, Vol. 10, Pages 915: Melanoma-Bearing Libechov Minipig (MeLiM): The Unique Swine Model of Hereditary Metastatic Melanoma
Skalnikova National cancer databases document that melanoma is the most aggressive and deadly cutaneous malignancy with worldwide increasing incidence in the Caucasian population. Around 10% of melanomas occur in families. Several germline mutations were identified that might help to indicate individuals at risk for preventive interventions and early disease detection. More than 50% of sporadic melanomas carry mutations in Ras/Raf/mitogen-activated protein kinase (MAPK/MEK) pathway, which may represent aims of novel targeted therapies. Despite advances in targeted therapies and immunotherapies, the outcomes in metasta...
Source: Genes - November 8, 2019 Category: Genetics & Stem Cells Authors: Vratislav Horak Anna Palanova Jana Cizkova Veronika Miltrova Petr Vodicka Helena Kupcova Skalnikova Tags: Review Source Type: research

OK for Flu Shot With Nivolumab, Other Checkpoint Inhibitors?OK for Flu Shot With Nivolumab, Other Checkpoint Inhibitors?
Is it safe and effective to give a flu shot to cancer patients on new immunotherapies? Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - October 8, 2015 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Monoclonal Antibody to Bone Marrow Stromal Cell Antigen 2 Protein of Swine.
In this study, we generated monoclonal antibodies (MAbs) against porcine BST-2 encoding 34-112 aa of porcine BST-2, which was cloned and inserted into the prokaryotic expression vector pCold-I to construct a recombinant plasmid pCold-pBST-2. The recombinant porcine BST-2 protein (rpBST-2 protein) was induced by isopropyl-β-D-thiogalactoside in Escherichia coli BL21 (DE3). Then, BALB/c mice were immunized with the purified rpBST-2 protein to prepare MAbs of BST-2. After subcloning, one strain of hybridoma cells named 1B2 secreting porcine BST-2 protein monoclonal antibody (MAb) was obtained. Indirect immunofluorescence ass...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - May 7, 2016 Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research

Monoclonal Antibody Against Bone Marrow Stromal Cell Antigen 2 Protein of Swine.
Authors: PMID: 27328062 [PubMed - as supplied by publisher]
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - June 22, 2016 Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research

CDC officials worry that new flu vaccine recommendations could reduce use
Flu season is about to start, and public health officials are worried that their recommendation earlier this year to avoid using the nasal spray version of the annual vaccine will result in fewer people getting protection. The CDC has recommended annual flu shots for everyone ages 6 months and older for the past six years. During the […]Related:CDC issues Zika travel notice for 11 Southeast Asian countriesMystery Zika case in Utah was likely spread through sweat or tearsCancer immunotherapy is moving fast. Here’s what you need to know.
Source: Washington Post: To Your Health - September 29, 2016 Category: Consumer Health News Source Type: news

Flu Vaccine in Lung Cancer Patients Could Increase Immunotherapy Toxicities
Seasonal influenza vaccination resulted in increased risk of immune-related adverse events in lung cancer patients treated with PD-1/PD-L1 checkpoint inhibitors, though risk of the flu itself may still outweigh the risks associated with vaccination.
Source: CancerNetwork - May 11, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Lung Cancer News Source Type: news

Can the flu shot help fight cancer?
(Rush University Medical Center) Physicians and scientists at Rush University Medical Center have found that injecting tumors with influenza vaccines, including some FDA-approved seasonal flu shots, turns cold tumors to hot, a discovery that could lead to an immunotherapy to treat cancer. The study results were published December 30th in the Proceedings of the National Academy of Sciences.
Source: EurekAlert! - Cancer - January 7, 2020 Category: Cancer & Oncology Source Type: news