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Frog slime could protect us against future flu epidemic
Conclusion This study has identified a substance in the mucus secreted by a south Indian frog which can kill certain types of flu virus. Researchers often turn to natural substances with known health-giving properties to find potential new drugs for humans. For example, aspirin was developed based on a compound found in willow bark – which had been used in traditional medicine for hundreds of years. Some other drugs – such as some chemotherapy and anticlotting drugs – have also been developed from chemicals found in plants. By isolating the substances that have an effect the researchers can make sure they are pure a...
Source: NHS News Feed - April 19, 2017 Category: Consumer Health News Tags: Heart/lungs Medication Medical practice Source Type: news

Kids and flu shots: Two common myths
As a pediatrician, I am really passionate about the flu shot. Influenza can be a nasty illness; every year, thousands of people are hospitalized with influenza and its complications, and some of those people die. The flu shot can protect my patients and their families, and I enthusiastically recommend it to all of them. And yet many of them refuse, despite my best efforts. What is particularly frustrating is that many of them refuse because of misunderstandings about the flu shot. There is all sorts of misinformation out there, but here are the two most common myths: 1. The flu shot can make you sick. This is the one I hea...
Source: New Harvard Health Information - October 9, 2015 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Cold and Flu Vaccines flu vaccine Source Type: news

HealthWatch: Flu Virus Used To Treat Pancreatic Cancer In Mice
BOSTON (CBS) – Pancreatic cancer is a particularly aggressive and deadly cancer, but now researchers in London have developed a modified flu virus to target and kill tumor cells. The virus has an extra protein that binds pancreatic cancer cells and scientists found the modified virus was able to stop cancer growth in mice. Pancreatic cancer is often caught late and is incredibly hard to treat because it can quickly become resistant to treatment. For a variety of cancers, researchers have been turning to mutated viruses to search out and kill cancer cells while trying to avoid drug resistance. The virus appears to hav...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 25, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Local News Seen On WBZ-TV Syndicated Local Dr. Mallika Marshall flu virus pancreatic cancer HealthWatch Source Type: news

Art Of Dying Conference Explores Spiritual, Scientific Approaches To Dying
Melanie Chaite has had many brushes with death. In 21 years of living with lymphangiomatosis, a rare cancer-like progressive lymphatic disorder that she’s had since birth, bouts of severe pneumonia have left her in intensive care. She’s had swine flu and emergency surgery for a collapsed lung. Fluid that has built up around her right lung currently threatens to stop her heart. She undergoes regular chemotherapy, and has tubes up her nostrils to provide the extra oxygen she needs to live. A full-body pain that she describes as “beyond tremendous” has become normal. “I have accepted the fact that I’m going to d...
Source: Healthy Living - The Huffington Post - April 24, 2015 Category: Consumer Health News Source Type: news

Report of mecC-carrying MRSA in domestic swine
Conclusions To the best of our knowledge, this is the first report of mecC-MRSA isolated from domestic swine. The investigation strongly indicates that transmission of mecC-MRSA has taken place on the swine farm between the farmers and swine. The close clustering of farm isolates and isolates from the same municipality suggests a local transmission of mecC-MRSA.
Source: Journal of Antimicrobial Chemotherapy - December 15, 2016 Category: Microbiology Authors: Angen, O., Stegger, M., Larsen, J., Lilje, B., Kaya, H., Pedersen, K. S., Jakobsen, A., Petersen, A., Larsen, A. R. Tags: Original research Source Type: research

Flu jab is not a 'waste of time'
“Flu jab given to millions is 'useless',” and "Flu jab is a waste of time," are the irresponsible headlines in The Daily Telegraph and the Daily Mail. While recent research shows that the current seasonal flu vaccine only has 3% protection against the main circulating strain – A(H3N2) – in adults, it can still protect against other strains. Both papers also ignore the fact that another version of the flu vaccine, in the form of a nasal spray designed for vulnerable children, is also available. Discouraging parents of vulnerable children from getting vaccinated could increase the risk of serious childhoo...
Source: NHS News Feed - February 6, 2015 Category: Consumer Health News Tags: Medical practice Heart/lungs QA articles Source Type: news

Is One Sample Enough? β-lactam Target Attainment and Penetration into Epithelial Lining Fluid based on Multiple Bronchoalveolar Lavage Sampling Time Points in a Swine Pneumonia Model.
This study compares the pharmacokinetics of two β-lactams, ceftolozane and piperacillin, among different ELF sampling approaches using simulated human regimens in a swine pneumonia model. Plasma and ELF concentration-time profiles were characterized in two-compartment models by robustly sampled ELF concentrations and by random selection of one or two ELF concentrations from each swine. A 5,000 subject Monte Carlo simulation was performed for each model to define the ELF penetration, as described by the ratio area under the concentration curve (AUC) in ELF to free AUC in plasma (AUCELF/fAUCplasma) and probability of target...
Source: Antimicrobial Agents and Chemotherapy - December 3, 2018 Category: Microbiology Authors: Motos A, Kuti JL, Li Bassi G, Torres A, Nicolau DP Tags: Antimicrob Agents Chemother Source Type: research

Circulation of plasmids harboring resistance genes to quinolones and/or extended spectrum cephalosporins in multiple Salmonella enterica serotypes from swine in the United States.
Abstract Nontyphoidal Salmonella enterica (NTS) poses a major public-health risk worldwide that is amplified by the existence of antimicrobial resistant strains, especially to quinolones and extended-spectrum cephalosporins (ESC). Little is known on the dissemination of plasmids harboring the acquired genetic determinants that confer resistance to these antimicrobials across NTS serotypes from livestock in the United States.NTS isolates (n=183) from U.S. swine clinical cases retrieved during 2014-2016 were selected for sequencing based on their phenotypic resistance to enrofloxacin (quinolone) or ceftiofur (3rd-ge...
Source: Antimicrobial Agents and Chemotherapy - February 11, 2019 Category: Microbiology Authors: Elnekave E, Hong SL, Lim S, Hayer SS, Boxrud D, Taylor AJ, Lappi V, Noyes N, Johnson TJ, Rovira A, Davies P, Perez A, Alvarez J Tags: Antimicrob Agents Chemother Source Type: research

P3-22-7 * efficacy and strategies to improve immunogenicity of flu vaccine in patients with solid organ malignancy on chemotherapy
Conclusion: The current literature supports annual flu vaccination in adult solid tumour patients on chemotherapy. Ongoing researches are sought to identify vaccine strategies which improve its immunogenicity.
Source: Annals of Oncology - October 19, 2014 Category: Cancer & Oncology Authors: Tomita, Y., Lim, K. J., Cain, M., Jasas, K. Tags: Poster Session (Poster presentations categorized by each organ) Source Type: research

P3-22-7 * efficacy and strategies to improve immunogenicity of flu vaccine in patients with solid organ malignancy on chemotherapy
Conclusion: The current literature supports annual flu vaccination in adult solid tumour patients on chemotherapy. Ongoing researches are sought to identify vaccine strategies which improve its immunogenicity.
Source: Annals of Oncology - October 19, 2014 Category: Cancer & Oncology Authors: Tomita, Y., Lim, K. J., Cain, M., Jasas, K. Tags: Poster Session (Poster presentations categorized by each organ) Source Type: research

Polymorphism of genes encoding PmrAB in colistin-resistant strains of Escherichia coli and Salmonella enterica isolated from poultry and swine
Conclusions E. coli strains carrying mutations in PmrAB that confer resistance to polymyxins, which might have evolved in vivo and have been rarely detected, are described for the first time in enterobacteria isolated from animals.
Source: Journal of Antimicrobial Chemotherapy - December 16, 2014 Category: Microbiology Authors: Quesada, A., Porrero, M. C., Tellez, S., Palomo, G., Garcia, M., Dominguez, L. Tags: Original research Source Type: research

PIPAC versus HIPEC: cisplatin spatial distribution and diffusion in a swine model.
Conclusions: With doses used in clinical practice, HIPEC guaranteed a higher cisplatin peritoneal uptake than PIPAC in this swine model. Spatial drug distribution was heterogeneous with both technics, with hotspots closed to the drug delivery sites. Nevertheless, considering the dose ratio, IP drug uptake yield was better with PIPAC. PMID: 32003300 [PubMed - in process]
Source: International Journal of Hyperthermia - February 1, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Species shift and multidrug resistance of Campylobacter from chicken and swine, China, 2008-14
Conclusions The high prevalence of fluoroquinolone and macrolide resistance in Campylobacter suggests that these two clinically important antibiotic classes may no longer be suitable for the treatment of human campylobacteriosis in China. Thus, enhanced surveillance and control efforts are needed to reduce antimicrobial resistance in this group of major foodborne pathogens.
Source: Journal of Antimicrobial Chemotherapy - February 5, 2016 Category: Microbiology Authors: Wang, Y., Dong, Y., Deng, F., Liu, D., Yao, H., Zhang, Q., Shen, J., Liu, Z., Gao, Y., Wu, C., Shen, Z. Tags: Original research Source Type: research

Carbapenemase-producing Enterobacteriaceae recovered from the environment of a swine farrow-to-finish operation in the United States.
Abstract Carbapenem-resistant Enterobacteriaceae (CRE) present an urgent threat to public health. While carbapenem antimicrobials are restricted in food-producing animals, other β-lactams, such as ceftiofur, are used in livestock. This use may provide selection pressure favoring the amplification of carbapenem resistance but this relationship has not been established. Previously unreported from US livestock, plasmid-mediated CREs have been reported from livestock in Europe and Asia.Environmental and fecal samples were collected from a 1,500 sow, US farrow-to-finish operation during 4 visits over a 5 month period,...
Source: Antimicrobial Agents and Chemotherapy - December 4, 2016 Category: Microbiology Authors: Mollenkopf DF, Stull JW, Mathys DA, Bowman AS, Feicht SM, Grooters SV, Daniels JB, Wittum TE Tags: Antimicrob Agents Chemother Source Type: research

Carbapenemase-producing Enterobacteriaceae in swine production in the United States: impact and opportunities.
Abstract The discovery of carbapenemase-producing Enterobacteriaceae in U.S. swine production is troubling, and underscores a tumultuous period where the outlook on the battle against superbugs is bleak. However, all is not lost. This commentary highlights both the good and the bad that can come from such findings. PMID: 27919893 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - December 4, 2016 Category: Microbiology Authors: Johnson TJ Tags: Antimicrob Agents Chemother Source Type: research