Filtered By:
Therapy: Corticosteroid Therapy

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 126 results found since Jan 2013.

Fungal retinitis following influenza virus type A (H1N1) infection
Nitin K Menia, Surya P Sharma, Reema BansalIndian Journal of Ophthalmology 2019 67(9):1483-1484 A 43-year-old male presented with left eye foveal retinits causing an acute visual loss following influenza virus type A infection (H1N1 infection or Swine flu). Considering viral (influenza) etiology, a prompt treatment with oral corticosteroids was started. But an initial poor response prompted an immediate diagnostic vitrectomy, which revealed Candida albicans. The retinitis healed with scar formation following anti-fungal therapy. This case highlights that even in the setting of an acute retinitis in an immunocompetent pati...
Source: Indian Journal of Ophthalmology - August 21, 2019 Category: Opthalmology Authors: Nitin K Menia Surya P Sharma Reema Bansal Source Type: research

Bullous pemphigoid after second dose of mRNA- (Pfizer-BioNTech) Covid-19 vaccine: A case report
CONCLUSION: Although uncommon, several dermatological side reactions like bullous eruptions have been reported following the mRNA Pfizer Covid-19 vaccination. According to this case report, Bullous pemphigoid might be caused by the mRNA- (Pfizer) Covid-19 Vaccine.PMID:35251600 | PMC:PMC8885466 | DOI:10.1016/j.amsu.2022.103420
Source: Annals of Medicine - March 7, 2022 Category: Internal Medicine Authors: Fouad Alshammari Mohammed Alzomia Abdulrahman Korairi Mohammed Alajlan Yacoub Abuzied Mohammed AlSheef Source Type: research

Immunotherapy in Narcolepsy
AbstractPurpose of reviewNarcolepsy type 1 (NT1) is a chronic and disabling sleep disorder due to the loss of hypocretinergic neurons in the lateral hypothalamus pathophysiologically linked to an autoimmune process. Current treatment is symptomatic, and no cure is available to date. Immunotherapy is considered a promising future therapeutic option, and this review discusses the rationale for immunotherapy in narcolepsy, current evidences of its effects, outcome measures, and future directions.Recent findingsA limited number of case reports and uncontrolled small case series have reported the effect of different immunothera...
Source: Current Treatment Options in Neurology - January 29, 2020 Category: Neurology Source Type: research

The Effect of EDS-FLU on Objective and Patient-Reported Subjective Outcomes for Patients with Chronic Rhinosinusitis with Nasal Polyps
CONCLUSIONS: Meaningful improvements were seen across multiple response criteria with EDS-FLU, suggesting that the broad treatment effect of EDS-FLU includes objective reduction in polyp grade and improvements in several patient-reported outcomes.TRIAL REGISTRATION: ClinicalTrials.gov (NAVIGATE I: NCT01622569 and NAVIGATE II: NCT01624662).PMID:35437059 | DOI:10.1177/01455613221088698
Source: Ear, Nose and Throat Journal - April 19, 2022 Category: ENT & OMF Authors: Randall A Ow John P McGinnis Harry J Sacks Mark E Mehle Source Type: research

P458 exhalation delivery system with fluticasone (eds-flu) improves outcomes regardless of baseline eosinophil count
Chronic rhinosinusitis with nasal polyps (CRSwNP), although commonly associated with Th2/eosinophilic inflammation, can also be characterized by Th1, Th3, or a combination. Corticosteroids inhibit multiple inflammatory pathways, eliciting broad immunosuppressive effects and well-characterized treatment responses. EDS-FLU improves outcomes in CRSwNP. This post-hoc analysis compared EDS-FLU response by baseline blood eosinophils to determine if there was a differential response to EDS-FLU among cohorts.
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: S. Weinstein, D. Okhotin, H. Sacks, J. Messina Source Type: research

Exhalation Delivery System with Fluticasone (EDS-FLU) Improves Health-Related Quality of Life (HRQoL) in Patients with Chronic Rhinosinusitis with Nasal Polyps: Results from NAVIGATE II
We report the effect of EDS-FLU on QoL as measured by the Rhinosinusitis Disability Index (RSDI).
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Shaila U. Gogate, John C. Messina, Jennifer L. Carothers, Per G. Djupesland, Ramy A. Mahmoud Source Type: research

CXCR4 Antagonist Reduced the Incidence of Acute Rejection and Controlled Cardiac Allograft Vasculopathy in a Swine Heart Transplant Model Receiving a Mycophenolate-based Immunosuppressive Regimen
Conclusions The augmentation of conventional MMF plus corticosteroids with a CXCR4 antagonist is potentially effective in improving outcomes after heart transplantation in minipigs. Future studies are warranted into optimizing the therapeutic regimens for humans.
Source: Transplantation - November 22, 2018 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research

EDS-FLU performs differently than other nasal corticosteroids
We appreciate the commentary by Fokkens and Reitsma1 and respectfully wish to draw attention to several issues raised by the discussion. A  Cochrane analysis of previous inhaled nasal corticosteroid (INCS) studies was used as the basis for comparison with phase 3 data for the exhalation delivery system with fluticasone (EDS-FLU).2-4 However, this meta-analysis included a combination of data for “conventional” nasal sprays, nasal d rops, and a phase 2 study with an earlier version of the EDS-FLU.3,4 Given the expectation that effects of locally acting drugs can vary substantially based on the location of deposition and...
Source: Journal of Allergy and Clinical Immunology - May 6, 2019 Category: Allergy & Immunology Authors: Donald A. Leopold, David Elkayam, John C. Messina, Per G. Djupesland, Harry J. Sacks, Ramy A. Mahmoud Tags: Correspondence Source Type: research

Typical gene expression profile of pseudorabies virus reactivation from latency in swine trigeminal ganglion
In this study, PRV-free piglets were infected with PRV. Viral shedding in nasal and ocular swabs demonstrated that PRV infection entered the latent period. The anti-PRV antibody was detected by enzyme-linked immunosorbent assay and the serum neutralization test, which suggested that the PRV could establish latent infection in the presence of humoral immunity. Immunohistochemistry and viral genome detection of TG neurons suggested that PRV was reactivated from latency. Viral gene expressions of IE180, EP0, VP16, and LLT-intron were readily detected at 3-h post-DEX treatment, but gB, a γ1 gene, was not detectable. The diffe...
Source: Journal of NeuroVirology - July 14, 2020 Category: Neurology Source Type: research

Severe flu management: a point of view
AbstractAnnual flu seasons are typically characterized by changes in types and subtypes of influenza, with variations in terms of severity. Despite remarkable improvements in the prevention and management of patients with suspected or laboratory-confirmed diagnosis of influenza, annual seasonal influenza continues to be associated with a high morbidity and mortality. Admission to the intensive care unit is required for patients with severe forms of seasonal influenza infection, with primary pneumonia being present in most of the cases. This review summarizes the most recent knowledge on the diagnosis and treatment strategi...
Source: Intensive Care Medicine - January 6, 2020 Category: Intensive Care Source Type: research

Neuroendocrine, Autonomic, and Metabolic Responses to an Orexin Antagonist, Suvorexant, in Psychiatric Patients with Insomnia
Conclusion: Suvorexant treatment resulted in overall improvement in the quality of sleep and the severity of anxiety and depression. This dual orexin antagonist may be related to autonomic functions and neuroendocrine systems, especially in the hypothalamus-pituitary-adrenal axis in psychiatric subjects. Introduction The hypothalamus plays a critical role in the integrated control of sleep/wakefulness, thermogenesis, and energy homeostasis, and the lateral hypothalamus area (LHA) in this region has been regarded as an important center for arousal and feeding.[1] The neuropeptide orexin A and orexin B (also known as hypocre...
Source: Innovations in Clinical Neuroscience - April 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Current Issue Depression Original Research Psychiatry Psychopharmacology Sleep Disorders Autonomic nervous insomnia neuroendocrine orexin antagonist suvorexant Source Type: research

Efficacy and safety of the single-capsule combination of fluticasone/formoterol in patients with persistent asthma: a non-inferiority trial
CONCLUSIONS: The single-capsule combination of FLU/FOR showed non-inferiority to the BUD/FOR and FLU formulations regarding efficacy and safety, making it a new treatment option for persistent asthma. OBJETIVO: A fluticasona e o formoterol são efetivos no tratamento da asma. A terapia combinada é o tratamento de escolha quando o corticosteroide isolado não controla a asma. O objetivo deste estudo foi comparar a eficácia e segurança de formulações contendo budesonida/formoterol (BUD/FOR), fluticasona (FLU) e fluticasona/formoterol (FLU/FOR) em cápsula única sobre a função pulmonar em...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research