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Total 528 results found since Jan 2013.

New bird flu strain requires vigilance researchers warn
Conclusion This is important research tracking the origins of the new H7N9 bird flu virus, which gives some clues about how it might behave in the future. Scientists are particularly concerned that a future mutation could mean it is transmitted between humans, which increases the risk of a pandemic (an epidemic of infection across countries or continents). For travellers to China and other countries affected by bird flu, it's important to observe the following precautions: avoid visiting live animal markets and poultry farms avoid contact with surfaces that are contaminated with animal faeces don't eat or handle u...
Source: NHS News Feed - May 2, 2013 Category: Consumer Health News Tags: Genetics/stem cells Medical practice Source Type: news

An Overview of Hypocretin based Therapy in Narcolepsy.
Authors: Takenoshita S, Sakai N, Chiba Y, Matsumura M, Yamaguchi M, Nishino S Abstract INTRODUCTION: Narcolepsy with cataplexy is most commonly caused by a loss of hypocretin/orexin peptide-producing neurons in the hypothalamus (i.e., Narcolepsy Type 1). Since hypocretin deficiency is assumed to be the main cause of narcoleptic symptoms, hypocretin replacement will be the most essential treatment for narcolepsy. Unfortunately, this option is still not available clinically. There are many potential approaches to replace hypocretin in the brain for narcolepsy such as intranasal administration of hypocretin peptides, ...
Source: Expert Opinion on Investigational Drugs - April 7, 2018 Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research

Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy
Publication date: March 2015 Source:The Lancet Neurology, Volume 14, Issue 3 Author(s): Roland S Liblau , Anne Vassalli , Ali Seifinejad , Mehdi Tafti The discovery of hypocretins (orexins) and their causal implication in narcolepsy is the most important advance in sleep research and sleep medicine since the discovery of rapid eye movement sleep. Narcolepsy with cataplexy is caused by hypocretin deficiency owing to destruction of most of the hypocretin-producing neurons in the hypothalamus. Ablation of hypocretin or hypocretin receptors also leads to narcolepsy phenotypes in animal models. Although the exact mechanism of...
Source: The Lancet Neurology - February 16, 2015 Category: Neurology Source Type: research

Sphere ‐Induced Rejuvenation of Swine and Human Müller Glia Is Primarily Caused by Telomere Elongation
This article is protected by copyright. All rights reserved. Primary swine and human Müller glial cells isolated from the adult retinal tissue and conditioned in vitro suffer a great deal of physical and physiological stresses causing telomere attrition and leading to either cell senescence or death. Sphere suspension culture activates telomere elongation and induces expression of stemness factors not only for rejuvenation of both swine and human Müller cells, but probably also for immortalization of swine Müller cells. At the end, the rejuvenated cells would die of cellular senescence when the entire survival populati...
Source: Stem Cells - January 31, 2017 Category: Stem Cells Authors: Ni Xu, Yao Chen, Kevin C. Dean, Xiaoqin Lu, Xiao Liu, Wei Wang, Douglas C. Dean, Henry J. Kaplan, Ling Gao, Fangtian Dong, Yongqing Liu Tags: Tissue ‐Specific Stem Cells Source Type: research

Hepatitis C detector promises hope and nothing more | Síle Lane
Wherever people are confronted with serious threats and a lack of solutions there is a potential market in false hopeA new device that supposedly detects diseases remotely is being promoted. According to an excited report earlier this week in the Guardian, about a demonstration of the device in an Egyptian hospital, its developers hope it will first be used to detect swine flu and hepatitis C, and later other diseases.What is being plugged here is hope and nothing more. The device looks like a car radio aerial attached to a handle. It is said to work by detecting a specific frequency emitted by infected liver cells. It is ...
Source: Guardian Unlimited Science - February 28, 2013 Category: Science Tags: Blogposts Controversies Infectious diseases Health guardian.co.uk Medical research Society Science and scepticism Source Type: news

Adenovirus-mediated transfer of hepatocyte growth factor gene to human dental pulp stem cells under good manufacturing practice improves their potential for periodontal regeneration in swine
Conclusion: This study indicated that HGF-hDPSCs produced under GMP conditions significantly improved periodontal bone regeneration in swine; thus, this method represents a potential clinical application for periodontal regeneration.
Source: Stem Cell Research and Therapy - December 15, 2015 Category: Stem Cells Authors: Yu CaoZhenhai LiuYilin XieJingchao HuHua WangZhipeng FanChunmei ZhangJingsong WangChu-Tse WuSonglin Wang Source Type: research

Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.
Abstract Development of autologous tissue-engineered vascular constructs using vascular smooth muscle cells (VSMCs) derived from human induced pluripotent stem cells (iPSCs) holds great potential in treating patients with vascular disease. However, preclinical, large animal iPSC-based cellular and tissue models are required to evaluate safety and efficacy prior to clinical application. Herein, swine iPSC (siPSC) lines were established by introducing doxycycline-inducible reprogramming factors into fetal fibroblasts from a line of inbred Massachusetts General Hospital miniature swine that accept tissue and organ tr...
Source: Biomaterials - September 19, 2017 Category: Materials Science Authors: Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y Tags: Biomaterials Source Type: research

Grafted Miniature-Swine Neural Stem Cells of Early Embryonic Mesencephalic Neuroepithelial Origin can Repair the Damaged Neural Circuitry of Parkinson’s Disease Model Rats
Publication date: 21 August 2018Source: Neuroscience, Volume 386Author(s): Yutaka Mine, Toshihiko Momiyama, Takuro Hayashi, Takeshi KawaseAbstractAlthough recent progress in the use of human iPS cell-derived midbrain dopaminergic progenitors is remarkable, alternatives are essential in the strategies of treatment of basal-ganglia-related diseases.Attention has been focused on neural stem cells (NSCs) as one of the possible candidates of donor material for neural transplantation, because of their multipotency and self-renewal characteristics. In the present study, miniature-swine (mini-swine) mesencephalic neuroepithelial s...
Source: Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research

Addition of Melphalan to Fludarabine/Busulfan (FLU/BU4/MEL) Provides Survival Benefit for Patients with Myeloid Malignancy Following Allogeneic Bone Marrow Transplantation/Peripheral Blood Stem Cell Transplantation
In conclusion, FLU/BU4/MEL had curative potential even for patients with advanced myeloid malignancies, accompanied by the rapid complete chimerism achievement after allo-BMT/PBSCT. The NRM should be minimized to further improve the outcomes.DisclosuresYokota: Bristol-Myers Squibb: Research Funding; Pfizer Inc.: Research Funding; MSD K.K.: Research Funding; CHUGAI PHARMACEUTICAL CO., LTD.: Research Funding; Celgene: Research Funding. Shibayama: Bristol-Meyer Squibb K.K: Honoraria, Research Funding; Novartis Pharma K.K.: Honoraria, Research Funding; Fujimoto Pharmaceutical: Honoraria, Research Funding; Ono Pharmaceutical Co...
Source: Blood - November 21, 2018 Category: Hematology Authors: Ueda, T., Maeda, T., Fukushima, K., Fujita, J., Kusakabe, S., Yokota, T., Shibayama, H., Tomiyama, Y., Kanakura, Y. Tags: 721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities: Poster I Source Type: research

Effect of Rapamycin on mesenchymal stem cells treatment for swine myocardial infarction
Conclusions: Four weeks after MSCs transplantation for curing AMI, the myocardial perfusion and glucose metabolism improved significantly in the Rapamycin group; however, the cardiac function was decreased. It is speculated that Rapamycin might have impacted the effect of MSCs transplantation in infarcted hearts. The mechanism needs further research. Index on SPECT, PET and MRI in Three GroupsControl group MSCs groupRapamycin groupP valueSRS24.43±5.4728.63±3.3420.50±7.70<0.05Defect area (cm2)41.57±12.4844.25±12.8022.50±10.74<0.05SCR12.80±4.9715.33±8.636.20&...
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Cai, M., Feng, G., Li, L., Zhang, G., Yang, X. Tags: Cardiovascular Basic Science: Metabolism and Molecular Imaging Source Type: research

The evaluation of the safety and efficacy of intravenously administered allogeneic multilineage-differentiating stress-enduring cells in a swine hepatectomy model
ConclusionsAllogeneic Muse cell administration may provide a reparative effect and functional recovery in a 70% hepatectomy swine model and thus may contribute to the treatment of PHLF.
Source: Surgery Today - September 10, 2020 Category: Surgery Source Type: research

Mesenchymal Stem Cells Alleviate Post-resuscitation Cardiac and Cerebral Injuries by Inhibiting Cell Pyroptosis and Ferroptosis in a Swine Model of Cardiac Arrest
Following cardiopulmonary resuscitation (CPR), the ensuing cardiac and cerebral injuries contribute to the poor outcome of cardiac arrest (CA) victims, in which the pathogenetic process is possibly driven by cell pyroptosis and ferroptosis. Mesenchymal stem cells (MSCs) have been shown to be a promising strategy for post-resuscitation cardiac and cerebral protection in rat, but its effectiveness in the clinically relevant swine model and the potential protective mechanism remain unknown. The present study was designed to investigate whether MSCs administration could alleviate post-resuscitation cardiac and cerebral injurie...
Source: Frontiers in Pharmacology - December 9, 2021 Category: Drugs & Pharmacology Source Type: research

Characterization of different in vitro culture conditions to induce a fibro-chondrogenic differentiation of swine adipose-derived stem cells.
Authors: Tessaro I, Di Giancamillo A, Benasciutti E, Nguyen VT, Polito U, Mangiavini L, Peretti GM Abstract Meniscus repair is still a challenge for orthopaedic surgeons as this tissue has a scarce healing potential due to the limited vascularization and to the lack of progenitor cells. Lately, several tissue engineering strategies combining cells and scaffolds have been developed. Adipose-derived stem cells (ASCs) represent a novel cell source for meniscus repair as they are easy to harvest, and they possess an intrinsic chondrogenic potential. The aim of our study was to analyze and compare the chondrogenic diffe...
Source: Journal of Biological Regulators and Homeostatic Agents - January 17, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Customized 3D-printed occluders enabling the reproduction of consistent and stable heart failure in swine models
AbstractReproducibility of clinical output is important when investigating therapeutic efficacy in pre-clinical animal studies. Due to its physiological relevance, a swine myocardial infarction (MI) model has been widely used to evaluate the effectiveness of stem cells or tissue-engineered constructs for ischemic heart diseases. Several methods are used to induce MI in the swine model. However, it is difficult, using these approaches, to obtain a similar level of functional outcomes from a group of animals due to interpersonal variation, leading to increased experimental cost. Hence, in order to minimize human intervention...
Source: European Journal of Applied Physiology - September 21, 2021 Category: Physiology Source Type: research