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Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules. MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/ Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, prod...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 4th 2021
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - January 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Look Back at 2020: Progress Towards the Treatment of Aging as a Medical Condition
While I suspect that COVID-19 will feature prominently in most retrospectives on 2020, I'll say only a little on it. The data on mortality by year end, if taken at face value, continues to suggest that the outcome will fall at the higher end of the early estimates of a pandemic three to six times worse than a bad influenza year, ten times worse than a normal influenza year. The people who die are near entirely the old, the co-morbid, and the immunocompromised. They die because they are suffering the damage and dysfunction of aging. Yet the societal conversation and the actions of policy makers ignore this. There is ...
Source: Fight Aging! - December 31, 2020 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs

Federal Aid Creates Central ‐​Planning Power
This study argues that Congress should repeal all federal aid-to-state programs for many reasons, including that aid comes with costly strings attached that destroy local democracy.Richard Epstein and Mario Loyolanoted about aid programs: “When Americans vote in state and local elections, they think they are voting on state and local policies. But often they are just deciding which local officials get to implement the dictates of distant and insulated federal bureaucrats, whom even Congress can’t control.”I came across a table (p. 82) in New Jersey ’s budget that lists the $15 billion the state received in 2020 fro...
Source: Cato-at-liberty - September 4, 2020 Category: American Health Authors: Chris Edwards Source Type: blogs

Fight Aging! Newsletter, January 27th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Vaccines for women: Before conception, during pregnancy, and after a birth
The rise of vaccine-preventable illnesses, such as measles and hepatitis, in the United States and around the globe has been alarming in recent years. For women — especially those hoping to become pregnant, as well as women who are pregnant or have recently had a baby — vaccines can be a worrisome topic. There are many misconceptions about vaccine safety in and around pregnancy that can lead to confusion and unnecessary fear of a lifesaving medical tool. As a practicing ob/gyn, I often discuss vaccines with my patients and help them sort out fears versus facts. Which vaccines should you consider before conception? The ...
Source: Harvard Health Blog - January 10, 2020 Category: Consumer Health News Authors: Ilona T. Goldfarb, MD, MPH Tags: Health Parenting Pregnancy Vaccines Women's Health Source Type: blogs

Fight Aging! Newsletter, July 29th 2019
In this study we show, for the first time, significant alterations in cholesterol efflux capacity in adolescents throughout the range of BMI, a relationship between six circulating adipocyte-derived EVs microRNAs targeting ABCA1 and cholesterol efflux capacity, and in vitro alterations of cholesterol efflux in macrophages exposed to visceral adipose tissue adipocyte-derived EVs acquired from human subjects. These results suggest that adipocyte-derived EVs, and their microRNA content, may play a critical role in the early pathological development of ASCVD. Commentary on the Developing UK Government Position on Hea...
Source: Fight Aging! - July 28, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, June 3rd 2019
In conclusion, there is solid evidence that obesity deregulates cellular mechanisms related to nutrient sensing. Altered Intercellular Communication It is accepted that aging impacts the organism at the cellular level, but also decreases the capacity of cells of an organism to interact. During aging, there is a decreased communication at the neuronal, neuroendocrine, and endocrine levels. Two of the most compelling examples of impaired communication are inflammaging and immunosenescence. The inflammaging phenotype results in elevated cytokines. These cytokines can accelerate and propagate the aging process. T...
Source: Fight Aging! - June 2, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Everyone Has a Part to Play in Ending Vaccine Hesitancy
Felicia D. Goodrum Sterling Heidi L. Pottinger By FELICIA D. GOODRUM STERLING, PhD and HEIDI L. POTTINGER, DrPH, MPH, MA The measles outbreak in Washington state this week has brought new attention to the anti-vaccine movement.  In fact, the World Health Organization recently identified “vaccine hesitancy” as one of top threats to global health. In the US, the number of unvaccinated children has quadrupled since 2001, enabling the resurgence of infectious diseases long-since controlled.  In fact, the WHO claims a staggering 1.5 million deaths could be prevented worldwide by improved vaccination rates. Amidst the medi...
Source: The Health Care Blog - February 12, 2019 Category: Consumer Health News Authors: matthew holt Tags: Patients Felicia Goodrum Sterling Global Health Heidi L. Pottinger public health The OpEd Project vaccines Source Type: blogs

Fight Aging! Newsletter, July 30th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - July 29, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Luxury to Choose
By TRAVIS BIAS, MD The 80 year-old woman lay on her mat, her legs powerless, looking up at the small group that had come to visit her. There were no more treatment options left. The oral liquid morphine we had brought in the small plastic bottle had blunted her pain. But, she would be dead in the coming days. The cervical cancer that was slowly taking her life is a notoriously horrible disease if left undetected and untreated and that is exactly what had happened in this case. We had traveled hours by van along dirt roads to this village with a team of health workers from Hospice Africa Uganda, the country’s authority o...
Source: The Health Care Blog - February 25, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Gardasil Hospice Africa Uganda vaccines Source Type: blogs

Why President Trump Should Use Foreign Aid For Health To Make America Great
The Trump administration recently proposed to make major cuts to US foreign assistance, including the $10.3 billion a year that the federal government spends to advance global health through the National Institutes of Health (NIH), the Centers for Disease Control and Prevention, the US Agency for International Development (USAID), and the United Nations. As practitioners with more than 60 years of combined experience, we believe that the Trump administration is making a terrible mistake. Investing in global health is essential to the safety, security, and future prosperity of the United States, in addition to being a highl...
Source: Health Affairs Blog - April 17, 2017 Category: Health Management Authors: Robert Hecht and Sten Vermund Tags: Costs and Spending Featured Global Health Policy Population Health Public Health epidemics foreign aid humanitarian aid infectious diseases PEPFAR US foreign assistance Source Type: blogs

Everything You Wanted to Know About Vaccine Marketing, PR, Earned Media, Lobbying, and " Anti-Vaxxers "
Anti-HPV vaccines (e.g., Merck & #39;s Gardisil) are back in the news these days. Last night, NBC Nightly News reported & quot;Study Shows Alarming Rise in HPV-Related Cancers. & quot; The takeaways are (1) HPV infection causes cancers, (2) those cancers can be prevented with new vaccines, but (3) not enough kids are getting vaccinated. A woman with cervical cancer attributed to HPV says at the end of the piece & quot;I don & #39;t know how you can not prevent your child from getting cancer if there is a way to do it. & quot; This comes on the heels of a new Merck campaign that blames parents for not getting their child...
Source: Pharma Marketing Blog - July 8, 2016 Category: Pharmaceuticals Tags: anti-vaxxers Flu Gardasil GSK HPV Merck Vaccine Whooping cough Source Type: blogs

Everything You Wanted to Know About Vaccine Marketing, PR, Earned Media, Lobbying, and "Anti-Vaxxers"
Anti-HPV vaccines (e.g., Merck's Gardisil) are back in the news these days.Last night, NBC Nightly News reported "Study Shows Alarming Rise in HPV-Related Cancers." The takeaways are (1) HPV infection causes cancers, (2) those cancers can be prevented with new vaccines, but (3) not enough kids are getting vaccinated.A woman with cervical cancer attributed to HPV says at the end of the piece "I don't know how you can not prevent your child from getting cancer if there is a way to do it."This comes on the heels of a new Merck campaign that blames parents for not getting their children vaccinated (...
Source: Pharma Marketing Blog - July 8, 2016 Category: Pharmaceuticals Tags: anti-vaxxers Flu Gardasil GSK HPV Merck Vaccine Whooping cough Source Type: blogs

My Children are Vaccine-Damaged; are Yours?
Conclusion A growing number of today’s children suffer from vaccine damage. Most individuals do not make the connection between health problems and vaccines. When asked about the cause of autoimmune disorders, asthma, allergies, diabetes, learning disabilities, attention deficit disorder, autism, and other common childhood diseases and illness, the majority of health care providers advise patients that the causes are unknown. Doctors, including most integrative physicians, fail to make the connection to vaccines. It takes one moment to permanently damage the health of an adult or child, but takes a lifetime to t...
Source: vactruth.com - February 5, 2016 Category: Allergy & Immunology Authors: Michelle Goldstein Tags: Logical Michelle Goldstein Top Stories autoimmune disorders gardasil HPV Vaccine Medical Authority vaccine injury Source Type: blogs