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Total 18 results found since Jan 2013.

Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules. MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/ Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, prod...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Stomach flu
A couple of weeks ago I came down with a nasty case of viral gastroenteritis, more commonly known as the stomach flu. No idea how I got it…but…I got it. Well, at least Covid wasn’t involved in my case; my family doctor told me that a (small) percentage of his patients with my symptoms had turned up positive for Covid. That would have been a most unwelcome double whammy! Petunia, October 2022 Anyway, I was quite sick for about a week, sleeping most of the time, eating nothing but bananas and toast, and watching heaps of TV series and documentaries…The cats were very helpful nurses, always by my side,...
Source: Margaret's Corner - October 31, 2022 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll stomach flu Source Type: blogs

Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins." Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Test results
Yesterday I received the results from my Covid antibody test AND my routine myeloma tests. Yesterday was definitely an important day!!! So, even though I’m super busy today, I just had to stop and write an update. First, I tested negative for Covid, which means that I have never been exposed to it. I opted for the more complete antibody test, the one where they draw blood from your arm. There is another test, a mere finger prick, which tells you only if you are positive or negative. But I wanted to know if what I’d had back in January was coronavirus or not. Well, I have my answer now: it wasn’t Covid-19,...
Source: Margaret's Corner - July 24, 2020 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll myeloma test results Potter Source Type: blogs

Wow, what a holiday!
Stefano and I returned from England almost a week ago, last Saturday evening, but since then I’ve had a million things to do, not just heaps of laundry, food shopping, and the usual household-related stuff (cat litter, cat this, cat that, cat everything!), but also getting together with my girlfriends, a very important part of my life!, AND planning my English lessons for next week. I still  need to fit my sessions at the rehab center into my weekly schedule. These are the workouts I still need to do both for my shoulder AND for my tendinitis, which actually behaved incredibly well after the first week or so on holi...
Source: Margaret's Corner - September 6, 2019 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Lake District Peak District Sandsend Shambles Straithes Whitby York Source Type: blogs

Tough germs
Well, well…well. I mean, you try to be oh soooo careful whenever you set foot outside your house, especially during the flu season…For example: you never go food shopping during peak times you avoid seeing friends if they have the slightest sniffle you never shake hands or kiss anyone, or, well, you try not to… My “try to avoid getting sick” list goes on and on…I repeat, I try to be sooo careful. I always carry a little bottle of hand sanitizer in my purse, for emergencies, such as, well, let’s say that, due to social circumstances, I’ve been forced to shake hands with some...
Source: Margaret's Corner - March 21, 2019 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll germs and myeloma Source Type: blogs

A new anti-myeloma substance: andrographolide
Discussion: andrographolide also inhibits angiogenesis, which is so important for the survival and wellbeing of myeloma cells, so that’s good to know, too. Now we get to the above-mentioned importance of the TLR4 protein. TLR4 is apparently involved, not in a good way!!!, with a tumor’s microenvironment and has a lot of power over immune cells. So, if its activity can be blocked, that’s very good news. With andrographolide, this can be accomplished… I mentioned TLR4 in one of my earliest posts, written in 2007: TLRs, or toll-like receptors, play a key role in the immune system. Back then, I was interested i...
Source: Margaret's Corner - February 13, 2018 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll andrographolide anti-myeloma extract Source Type: blogs

No Bence Jones!!!
Wow. I haven’t been this sick in…ages. On Saturday morning, I woke up with a nasty sore throat, symptom no. 1. But Stefano and I had already made plans to go outside of Florence, not a pleasure trip by any means ( = long story that wouldn’t add anything useful to this post), and I didn’t want to back out. So, after coffee and Manuka honey, off we went. By the late afternoon, the sore throat had vanished, but symptom no. 2 was about to rear its ugly head: THE DREADED COUGH. Whenever I’m about to get a cough, I get a strange, almost metallic taste in my mouth. I know it sounds odd, but that tas...
Source: Margaret's Corner - April 6, 2017 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Source Type: blogs

The Study Is Over
For me. Sad to say, because this treatment was the easiest I ' ve ever been on, and it has worked well for other people (with other blood cancers). Yesterday ' s blood tests and PET/CT show progression of the myeloma, however, and after 13 weeks (a quarter of a year!) it certainly should be heading the other way. According to Dr WG the PET/CT does not show any new lesions in my bones, which probably means that the study treatment was doing some good. However, it does show increased activity in the existing lesions. For a while we wondered if that increasing activity was " flare, " caused by my own immun...
Source: Myeloma Hope - March 10, 2016 Category: Cancer & Oncology Source Type: blogs

DM / DNB Cardiology Entrance Mock Test 4
Please wait while the activity loads. If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled. If loading fails, click here to try again Click on the 'Start' button to begin the mock test. After answering all questions, click on the 'Get Results' button to display your score and the explanations. There is no time limit for this mock test. Start Congratulations - you have completed DM / DNB Cardiology Entrance Mock Test 4. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rate...
Source: Cardiophile MD - January 18, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Featured Source Type: blogs

A Year in Review: FDA 2015 New Drug Approvals
The approval of first-of-a-kind drugs rose last year to forty-one, resulting in the highest level of newly approved U.S. drugs in nineteen years. The total number of new drugs approved last year was even higher at sixty-nine. The rising figures reflect an industry-wide desire to research and develop drugs for rare and hard-to-treat diseases. The newly approved drugs serve to advance medical care and the health of patients suffering from many ailments, including various forms of cancer, heart failure, and cystic fibrosis. Additionally, more than 40% of the new therapies were approved for treatment of rare or "orphan" dise...
Source: Policy and Medicine - January 13, 2016 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs

Cardiac Reserve
Thursday, March 6, 2014    Pomalyst Study Cycle 78: My Doctor L and the crew of three CNP's were all unavailable for this visit to Mayo, so I saw Dr MG instead. In terms of the Mayo Clinic hierarchy, that's an upgrade. We had met before, but he had not seen me as a patient. We quickly agreed that the myeloms was still stable, and he in fact commented that the Pomalyst trial has been a home run for me. Indeed! Six years now, and still counting - I am so fortunate. IgG was up just slightly, but Lambda light chains are down a little, and maybe both changes are within measurement error anyway. No change. I am starti...
Source: Myeloma Hope - March 11, 2014 Category: Cancer Source Type: blogs

Oops - Intensive Care
Saturday, February 8, 2014,    Breaking News My sweeties and I ran a lovely marathon in New Orleans last Sunday. On Monday we flew home, and by Tuesday morning I felt a scratchy throat. That came on fast, knocked me flat (weak, fever, aches, severe cough, nausea), and by Thursday it was diagnosed at Mayo as Influenza Type A. Yes, I did get the flu shot, last November. By Friday morning I was having trouble breathing and my local doc found pneumonia. He checked me into the ICU in Lakeview Hospital in Stillwater, MN. The hospital staff treat me with respect, lots of smiles, but they put on gowns, masks, and glove...
Source: Myeloma Hope - February 9, 2014 Category: Cancer Source Type: blogs