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Total 107 results found since Jan 2013.

Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Aging as a Disease: a Zoo Contains Animals, But is Not Itself an Animal
The author of today's open access commentary is quite prolifically opinionated on the topic of mTOR and its status as a central pillar of programmed aging, particularly the hyperfunction version of programmed aging theories. Nonetheless, he sometimes has interesting things to say, as is the case here on the topic of whether aging is a disease. A great deal of ink has been spilled of late on the question of whether or not aging is a disease. This is the case not because everyone suddenly developed an interest in semantics, but rather because it directly affects the regulation of medical development, and thus the flow of fun...
Source: Fight Aging! - February 6, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Pharma – 2023 Health IT Predictions
As we head into 2023, we wanted to kick off the new year with a series of 2023 Health IT predictions.  We asked the Healthcare IT Today community to submit their predictions and we received a wide ranging set of responses that we grouped into a number of themes.  Check out our communities predictions below and be sure to add your own thoughts and/or places you disagree with these predictions in the comments and on social media. Check out our community’s pharma predictions. Jesse Cugliotta, Global Industry GTM Lead, Healthcare & Life Sciences at Snowflake Industry investments in data platforms to enable decentra...
Source: EMR and HIPAA - January 9, 2023 Category: Information Technology Authors: John Lynn Tags: Health IT Company Healthcare IT 2023 Health IT Predictions Abrpo BrainCheck Doceree Harshit Jain Ian Chen Jesse Cugliotta Kimberly Powell Lance Hill Lauren Ohlsson Mike Montalto NVIDIA Ofer Sharon OncoHost PathAI Pharma Source Type: blogs

A Look Back at 2022: Progress Towards the Treatment of Aging as a Medical Condition
At the end of 2022, we can reflect on the fact that we are steadily entering a new era of medicine, one in which mechanisms of aging are targeted rather than ignored. It is a profound change, one that will change the shape of a human life and ultimately the human condition by eliminating the greatest sources of suffering and death in the world. Year after year, we see increased funding, ongoing progress towards therapies capable of slowing aging or reversing aspects of aging, and a growing taxonomy of such potential therapies and their target mechanisms. The view of aging in the medical community and public at large...
Source: Fight Aging! - December 30, 2022 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs

A Change Of Heart: " For The Children "
Last night, I archived everything on the blog except " Why Pediatrics " .  More and more, it ' s become a question rather than a statement of purpose.  In the wake of the COVID 19 pandemic, where the entire US system shifted on its axis to shut down community Pediatrics services and " feed " children ' s hospitals (to free up resources for sick adults), the situation for those of us practicing inpatient Pediatrics (as " Pediatric Hospitalists " ) really went to hell.  You could not find/beg a job in the community setting during the pandemic.  Actually, jumping through the ABP ' s hoops to do a...
Source: Dr.J's HouseCalls - December 24, 2022 Category: American Health Source Type: blogs

Clinical Research 101: Lecture 3
Now that we ' ve cleared away a bit of the underbrush, let ' s say you think that Eye of Newt Toe of Frog (Eontof) is potentially therapeutically useful against Creeping Crud (CC), and you want to test it. You face a whole lot of considerations. One is that you ' re going to need funding, which means you need to persuade somebody -- either the National Institutes of Health or a pharmaceutical company, most likely -- to invest in your idea. They ' re going to want to know that there ' s a reasonable chance of success with Eontof, and in the case of the pharmaceutical company that they can make money off of it, which brings ...
Source: Stayin' Alive - October 17, 2022 Category: American Health Source Type: blogs

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
 September 08, 2022 Edition-----In the US we are seeing the outcomes of Climate Change really of and running with droughts and fires etc. Biden amped up the partisan divide with a fiery anti-Republican speech!In Russia the last leader of Soviet Russia died.In the UK we have a new PM while in Europe the energy crisis is just getting worse.In OZ we have survived the Jobs and Skills Summit with 36 prearranged outcomes. Stage management +++ in action. The GP crisis is not being addressed fully and worries regarding the Global Economy - esp. China - worsen.-----Major Issues.-----https://www.afr.com/work-and-careers/educati...
Source: Australian Health Information Technology - September 8, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Weekly Australian Health IT Links – 15 August, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----Interesting to see ongoing funding for the #myHR announced to help Accenture keep is all going. Not sure why?Lots of NBN news with the Annual Report released.-----https://itwire.com/business-it-news/security/ransomware-attacks-on-the-rise-report.htmlThursday, 11 August 2022 15:33Ransomware attacks on the rise: reportBy Staff Write...
Source: Australian Health Information Technology - August 15, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Weekly Australian Health IT Links – 1 August, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----Quite a lot this week – especially regarding the NBN and Labor trying to regain control of what it is actually for – service provision – and not making a huge profit – in their view. Love the new Minister has ambitions to be maximally photogenic and not a ‘techie’!Otherwise all sorts of fun things!-----https://www.ausd...
Source: Australian Health Information Technology - August 1, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Fight Aging! Newsletter, August 1st 2022
In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice. We observed marked differences in age-associated DNA methylation in these commonly used inbred mouse strains, indicating that epigenetic clocks for one strain cannot be simply applied to other strains without further verification. Interestingly, the CpGs with highest age-correlation were still overlapping in B6 and DBA mice and included the genes Hsf4, Prima1, Aspa, and Wnt3a. Furthermore, Hsf4, Aspa, and Wnt3a revealed highly significant age-associated DNA methyla...
Source: Fight Aging! - July 31, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, July 4th 2022
This study showed that centenarians had very specific changes in CD4+ T cell populations, which were manifested by an elevated Th17/Treg ratio in vivo, as well as a changed secretory phenotype. Although the T cells of centenarians cannot resist the aging-related expression of proinflammatory genes, their secretory phenotype was altered, explaining the relatively low level of inflammation in centenarians. These results suggested the presence of a mechanism to ameliorate inflammaging in centenarians. This may be achieved by reversing the imbalance of Th17/Treg cells and reducing pro-inflammatory cytokines. Longevit...
Source: Fight Aging! - July 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

No, it isn ' t over
The country as a whole, including apparently the CDC, has decided that the Covid-19 thing is over and done with. The Republicans in congress even insisted on stripping funding for Covid-19 testing and relief from the recent appropriation bill, and the Democrats went along with little protest.  While it is true that most of the country right now is experiencing a lull, there has been a bump up in hospitalizations in Europe. Look at the far right of the chart:  As you can see the uptick so far is small, but it ' s just beginning. It ' s because of the new Omicron BA.2 variant, which is more transmissible ...
Source: Stayin' Alive - March 28, 2022 Category: American Health Source Type: blogs

The (sort of, partial) Father mRNA Vaccines Who Now Spreads Vaccine Misinformation (Part 2)
By DAVID WARMFLASH, MD This is part 2 of David Warmlash’s takedown of Robert W. Malone’s appearance (transcript) on the Rogan podcast. Part 1 is here Menstruation and Fertility Much more than the line about reproductive damage in the Wisconsin News clip that we used to open the story, Malone used the Rogan interview to dive more deeply into the topic, starting with:  …there’s a huge number of dysmenorrhea and menometrorrhagia… By that, he meant excessive menstrual cramping and very heavy, often irregular, bleeding, which he followed up with: …they DENY it… Judging by other parts ...
Source: The Health Care Blog - March 18, 2022 Category: Consumer Health News Authors: matthew holt Tags: COVID-19 Health Policy antivaxxer COVID-19 vaccine David Warmflash Joe Rogan Robert Malone Source Type: blogs

Innovation, mRNA, and Public Policy
Chris EdwardsThe main weapons against COVID-19 are the vaccines developed by Moderna and BioNTech after a decade of their research into mRNA technologies. That research was supported by more than $3 billion of private angel investment and venture capital.Democrats and Republicans both support medical research funding, and Republicans tout the Trump administration ’s Operation Warp Speed. But governments were not the key to mRNA development. Instead, we can thank the leaders and scientists at Moderna and BioNTech and the suppliers of private capital to them, as I discusshere andhere.TheWall Street Journal ’s A...
Source: Cato-at-liberty - December 6, 2021 Category: American Health Authors: Chris Edwards Source Type: blogs