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Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues. Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/ With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Senolytic Treatment Fails to Improve Measures of the Immune Response to Influenza in Old Mice
At this point in the development of senolytic therapies to clear harmful, lingering senescent cells from aged tissues, it is more interesting to find an aspect of aging that isn't improved by removal of senescent cells than to continue adding to the long list of age-related conditions and dysfunctions that are meaningfully reversed by senescent cell clearance. Here, researchers show that measures of the immune response to influenza infection in mice are not improved followed treatment with the senolytic combination of dasatinib and quercetin. This is a perhaps surprising result, given the expectation based on evidence to d...
Source: Fight Aging! - July 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Can You Follow A Keto Diet With Hypertension?
Conclusion Navigating the maze of diet and health can indeed be a challenge. Especially when it comes to the trendy keto diet and its potential effects on hypertension. So, where do we land on the question, “Can you follow a keto diet with hypertension?” From the studies we’ve reviewed and the real-life experiences we’ve heard, the answer is a cautious yes. It seems a well-managed keto diet could potentially benefit individuals with hypertension, mainly through weight loss, improved metabolic health, and lower blood sugar levels. However, it’s not a one-size-fits-all approach. The key...
Source: The EMT Spot - June 21, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 11th 2021
This study demonstrates the potential of a natural (o-Vanillin) and a synthetic (RG-7112) senolytic compounds to remove senescent IVD cells, decrease SASP factors release, reduce the inflammatory environment and enhance the IVD matrix production. Removal of senescent cells, using senolytics drugs, could lead to improved therapeutic interventions and ultimately decrease pain and a provide a better quality of life of patients living with intervertebral disc degeneration and low back pain. From Ying Ann Chiao of Oklahoma Medical Research Foundation: Mitochondrial dysfunction plays a central role in aging and cardiovasc...
Source: Fight Aging! - January 10, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, August 10th 2020
This study aimed to characterize the role of BDNF in age-related microglial activation. Initially, we found that degrees of microglial activation were especially evident in the substantia nigra (SN) across different brain regions of aged mice. The levels of BDNF and TrkB in microglia decreased with age and negatively correlated with their activation statuses in mice during aging. Interestingly, aging-related microglial activation could be reversed by chronic, subcutaneous perfusion of BDNF. Peripheral lipopolysaccharide (LPS) injection-induced microglial activation could be reduced by local supplement of BDNF, while shTrkB...
Source: Fight Aging! - August 9, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Keeping Kids Healthy in the Age of Coronavirus: Dr. Greene on The People ’ s Pharmacy
Transcript [00:00:00] Joe Graedon: I’m Joe Graedon. [00:00:01] Terry Graedon: And I’m Terry Graedon. Welcome to this podcast of the People’s Pharmacy. [00:00:06] Joe Graedon: You can find previous podcasts and more information on a range of health topics at PeoplesPharmacy.com.  [00:00:14] How’s your family holding up during the coronavirus pandemic? Isolation can be especially challenging for children. [00:00:22] This is the People’s Pharmacy with Terry and Joe Graedon. [00:00:33] Terry Graedon:  Children appear less susceptible than older adults to serious complications of COVID-19...
Source: Conversations with Dr Greene - April 21, 2020 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog COVID COVID-19 Viral Infection Source Type: blogs

Keeping Kids Healthy in the Age of Coronavirus: Dr. Greene on The People ’ s Pharmacy
Transcript [00:00:00] Joe Graedon: I’m Joe Graedon. [00:00:01] Terry Graedon: And I’m Terry Graedon. Welcome to this podcast of the People’s Pharmacy. [00:00:06] Joe Graedon: You can find previous podcasts and more information on a range of health topics at PeoplesPharmacy.com.  [00:00:14] How’s your family holding up during the coronavirus pandemic? Isolation can be especially challenging for children. [00:00:22] This is the People’s Pharmacy with Terry and Joe Graedon. [00:00:33] Terry Graedon:  Children appear less susceptible than older adults to serious complications of COVID-19...
Source: Conversations with Dr Greene - April 21, 2020 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog COVID COVID-19 Viral Infection Source Type: blogs

Fight Aging! Newsletter, April 13th 2020
This study is par for the course, looking at Japanese Olympic participants. Interestingly, it hints at the upper end of the dose-response curve for physical activity, in that a longer career as a professional athlete may be detrimental in comparison to lesser degrees of exercise and training. From this large, retrospective cohort study targeting 3546 Japanese Olympic athletes, we observed significant lower mortality among Olympians compared with the Japanese general population. The overall standardised mortality ratio (SMR) was 0.29. The results were consistent with previous studies conducted in other non-Asian co...
Source: Fight Aging! - April 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Lonnie and Carrie ’ s Wheat Belly journey
“ Living the Wheat Belly and Undoctored lifestyle will not rid our lives of all adversity. But it can make you stronger, more optimistic, and resilient. Here is Lonnie and Carrie’s story: “One year ago today, my life changed in unthinkable ways. I discovered the Wheat Belly 10-Day Grain Detox book and read it during my kids’ spring break. I had dabbled in the ‘paleo’ diet world a bit over the last five years with inconsistent success and had some idea about how good I felt when eliminating grains… “But the protocols in this book seemed to go further then just diet, like addressin...
Source: Wheat Belly Blog - March 31, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open Depression grain-free Inflammation undoctored Weight Loss wheat belly Source Type: blogs

Some unconventional thoughts on coronavirus (COVID-19)
Public health authorities are advising frequent hand washing and social distancing, especially in the absence of confirmatory testing for COVID-19. I don’t have any wisdom to add to these practices. Vaccines are in the works, as are anti-viral drugs—nothing to add here, either. But let me reiterate what we do in the Wheat Belly and Undoctored lifestyles. In general, we do not treat diseases; we correct the factors that allow disease to emerge in the first place—a big difference. Take rheumatoid arthritis, for example. In conventional healthcare, the joint pain and swelling of rheumatoid arthritis are sup...
Source: Wheat Belly Blog - March 18, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open probiotic undoctored wheat belly Source Type: blogs

Vaping-related illness highlights the complexities of diagnosing rare conditions
When patients started showing up in doctors’ offices and emergency departments with coughs, shortness of breath, chest pain, nausea, vomiting, abdominal pain, diarrhea, fever, chills and weight loss, physicians’ first instincts were that the cause of these symptoms were common illnesses such as pneumonia or flu. But treatments that are usually highly effective for these […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - November 7, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/miles-j-varn" rel="tag" > Miles J. Varn, MD < /a > < /span > Tags: Conditions Pulmonology Source Type: blogs

Gary ’ s Wheat Belly journey
Gary, founder of Wheat-Free Market, shared his 8-year update living the Wheat Belly lifestyle. “The passing of Labor Day weekend marked 8 years since I began my grain-free journey to weight loss and better health. In these years I haven’t had a single bite of bread, pasta, pizza, or cake, unless they were made with the ingredients we have come to love as alternatives to cereal grains. The profound changes in me resulting from this simple dietary change are what drove me to create Wheat-Free Market Foods, so I could offer others not only food products but recipes to support this lifestyle. “I cringe when I...
Source: Wheat Belly Blog - September 8, 2019 Category: Cardiology Authors: Dr. Davis Tags: Open Inflammation Weight Loss wheat belly Source Type: blogs

Is it SAFE to be grain-free?
Listen to critics of the Wheat Belly lifestyle and you’d think that, by banishing all things wheat and grains from your life, you will be excommunicated from your church, tossed out of your club, ostracized by friends and family, and suffer dire health consequences like heart disease and colon cancer. After all, they say that you are eliminating an entire food group and will be crippled by lack of fiber and nutrients. Worse, our focus on increasing our intake of fats and oils will get you a heart attack, three stents, or bypass surgery and you’ll be obliged to take Lipitor and Repatha for a lifetime. First of a...
Source: Wheat Belly Blog - June 25, 2019 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle grain-free Weight Loss Source Type: blogs

Fight Aging! Newsletter, June 3rd 2019
In conclusion, there is solid evidence that obesity deregulates cellular mechanisms related to nutrient sensing. Altered Intercellular Communication It is accepted that aging impacts the organism at the cellular level, but also decreases the capacity of cells of an organism to interact. During aging, there is a decreased communication at the neuronal, neuroendocrine, and endocrine levels. Two of the most compelling examples of impaired communication are inflammaging and immunosenescence. The inflammaging phenotype results in elevated cytokines. These cytokines can accelerate and propagate the aging process. T...
Source: Fight Aging! - June 2, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs