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Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men. « Back to Top Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/ Neurogenesis is the process by which new neurons are created by neural stem ce...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

More Evidence for Vaccination to Reduce Alzheimer ' s Disease Risk
There is good evidence for the various forms of later life vaccination, such as for herpes zoster or influenza, to reduce the risk of later suffering Alzheimer's disease. One possibility is that people who take the time to obtain a vaccine tend to take better care of their health across the board. Another possibility is that vaccination produces a trained immunity effect that dampens age-related inflammation for a sustained period of time. It may also be the case that suffering from influenza, pneumonia, or similar infectious diseases causes sufficient additional inflammation to move the odds on suffering later neurodegene...
Source: Fight Aging! - August 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Myocarditis update from Sweden
BY ANISH KOKA The COVID19/vaccine myocarditis debate continues in large part because our public health institutions are grossly mischaracterizing the risks and benefits of vaccines to young people. A snapshot of what the establishment says as it relates to the particular area of concern: college vaccine mandates: Dr. Arthur Reingold, an epidemiology professor at UC-Berkeley, notes that UC also requires immunizations for measles and chickenpox, and people still are dying from COVID at rates that exceed those for influenza. As of Feb. 1, there were more than 400 COVID deaths a day across the U.S. “The arg...
Source: The Health Care Blog - February 27, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Anish Koka covid19 myocarditis Sweden Source Type: blogs

Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Viral Infection in Middle Age Correlates with Later Dementia Risk
A range of evidence suggests that persistent viral infection contributes to the risk of suffering neurodegenerative conditions such as Alzheimer's disease. This may be due to mechanisms relating to amyloid-β accumulation, in its role as an anti-microbial peptide, a part of the innate immune system. It may have more to do with lasting chronic inflammation subsequent to infection. Researchers here note another addition to the epidemiological data on this topic, in this case linking severe infections requiring hospitalization with later dementia risk. The effect sizes here are large and last for a long time following infecti...
Source: Fight Aging! - February 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The Year When Everything Changed: Covid, Self Care and High Tech Innovation In Medicine
By HANS DUVEFELT Life as we knew it and medicine as we had viewed it shapeshifted so dramatically in the past year that it is still hard to believe. Medicine has started to move from an in-person only profession to one that finally recognizes that clinical assessment and treatment have fewer boundaries than people assumed. A patient of mine with newly diagnosed mastocytosis had a productive first consultation with an immunologist hundreds of miles away right from her own living room. Efficiency increased when we could handle straightforward clinical issues electronically, even over the telephone, and still get...
Source: The Health Care Blog - December 14, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Medical Practice Hans Duvefelt Source Type: blogs

Discrimination, high blood pressure, and health disparities in African Americans
Over the past few months, we have all seen the results of significant disruption to daily life due to the COVID-19 pandemic, high levels of unemployment, and civil unrest driven by chronic racial injustice. These overlapping waves of societal insult have begun to bring necessary attention to the importance of health care disparities in the United States. Direct links between stress, discrimination, racial injustice, and health outcomes occurring over one’s lifespan have not been well studied. But a recently published article in the journal Hypertension has looked at the connection between discrimination and increased ris...
Source: Harvard Health Blog - September 21, 2020 Category: Consumer Health News Authors: Chester Hedgepeth, III, MD, PhD Tags: Health care disparities Hypertension and Stroke Source Type: blogs

Fight Aging! Newsletter, August 24th 2020
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit. Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - August 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Towards Better Vaccines and a Lower Burden of Infectious Disease in Old People
Over a lifetime, the burden of infectious disease - and particularly persistent infections such as cytomegalovirus - influences the pace of aging via its detrimental impact on immune function in later life. The slow upward trend in life expectancy over the past two centuries is due in no small part to reductions in infectious disease that accompanied improvements in sanitation and then medicine. In addition, in old age, once the immune system declines into ineffectieness, infectious disease becomes a much more serious concern. Infections that a young person defeats with ease become life-threatening. The primary strategy to...
Source: Fight Aging! - August 17, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, May 25th 2020
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitochondri...
Source: Fight Aging! - May 24, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Better Vaccines for Older People are a Poor Alternative to Better Immune Systems for Older People
The paper here offers a good overview of recent research and development aimed at improving the effectiveness of vaccines in old people. Vaccines are only poorly effective in the old because of the age-related decline of the immune system. A great deal of effort, with only some success, has gone into trying to improve vaccine effectiveness in older populations. Even if tinkering with vaccines boosts the percentage of patients who exhibit an immune response, however, that response is always going to be more anemic than that of a younger person, given the effects of aging on the immune system. This time and funding would per...
Source: Fight Aging! - May 20, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

COVID-19: Physicians in Shackles
By ANISH KOKA, MD A number of politically tinged narratives have divided physicians during the pandemic. It would be unfortunate if politics obscured the major problem brought into stark relief by the pandemic: a system that marginalizes physicians and strips them of agency. In practices big and small, hospital-employed or private practice, nursing homes or hospitals, there are serious issues raising their heads for doctors and their patients. No masks for you When I walked into my office Thursday, March 12th, I assembled the office staff for the first time to talk about COVID.  The prior weekend had been awa...
Source: The Health Care Blog - May 2, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Medical Practice Physicians Anish Koka medical autonomy Pandemic Source Type: blogs

No Relationship Between Notifiable Diseases and Immigrant Populations
Alex Nowrasteh andAndrew C. ForresterThe international spread of the SARS ‐​CoV‐​2 virus that causes the disease COVID-19 has prompted many governments to close their borders. Immigration policy plays an important role in limiting the international spread of contagious diseases.Prior to the COVID-19 crisis,several commentators were concerned that immigrants – especially illegal immigrants – were spreading serious diseases in the United States. This blog post is the first in a series to answer the question of whether immigrants spread serious notifiable diseases other than COVID-19 in the United States. This ...
Source: Cato-at-liberty - April 13, 2020 Category: American Health Authors: Alex Nowrasteh, Andrew C. Forrester Source Type: blogs

Some unconventional thoughts on coronavirus (COVID-19)
Public health authorities are advising frequent hand washing and social distancing, especially in the absence of confirmatory testing for COVID-19. I don’t have any wisdom to add to these practices. Vaccines are in the works, as are anti-viral drugs—nothing to add here, either. But let me reiterate what we do in the Wheat Belly and Undoctored lifestyles. In general, we do not treat diseases; we correct the factors that allow disease to emerge in the first place—a big difference. Take rheumatoid arthritis, for example. In conventional healthcare, the joint pain and swelling of rheumatoid arthritis are sup...
Source: Wheat Belly Blog - March 18, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open probiotic undoctored wheat belly Source Type: blogs

Vaccines for women: Before conception, during pregnancy, and after a birth
The rise of vaccine-preventable illnesses, such as measles and hepatitis, in the United States and around the globe has been alarming in recent years. For women — especially those hoping to become pregnant, as well as women who are pregnant or have recently had a baby — vaccines can be a worrisome topic. There are many misconceptions about vaccine safety in and around pregnancy that can lead to confusion and unnecessary fear of a lifesaving medical tool. As a practicing ob/gyn, I often discuss vaccines with my patients and help them sort out fears versus facts. Which vaccines should you consider before conception? The ...
Source: Harvard Health Blog - January 10, 2020 Category: Consumer Health News Authors: Ilona T. Goldfarb, MD, MPH Tags: Health Parenting Pregnancy Vaccines Women's Health Source Type: blogs