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Total 290035 results found since Jan 2013.

Volatile organic compounds in gastrointestinal stromal tumour tissue originating from patient-derived xenografts
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract and localize mainly in the stomach or small intestine. The metabolomic signatures of GISTs driven by different KIT gene mutations remain undiscovered and unexplored. The main aim of this pilot study was to determine and compare metabolomic profiles in GIST xenograft models with different genetic backgrounds. Metabolomic profiling using gas chromatography coupled with mass spectrometry followed by univariate and multivariate statistical analyses was applied to select metabolites that differentiated the GIST...
Source: Journal of Breath Research - June 28, 2017 Category: Respiratory Medicine Authors: Renata Wawrzyniak, Agnieszka Wo źniak, YeMarshet K Gebreyohannes, Bartosz Dykcik, Patrick Schöffski and Michał J Markuszewski Source Type: research

Gastrointestinal stromal tumour of the stomach with osseous differentiation: a case report.
Authors: Giorlandino A, Caltabiano R, Gurrera A, Lanzafame S Abstract Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal tract, while osseous metaplasia of this tumour is an unexpected event. To date, no cases have been reported in the literature. Herein, we report a case of a 60-year-old man affected by a GIST with benign osseous metaplasia and mature bone formation. We also discuss the pathogenesis of intratumoural ossification and review the relevant literature. The prognostic significance of ossification in GIST remains unclear because of the limited cases ...
Source: Pathologica - November 13, 2015 Category: Pathology Tags: Pathologica Source Type: research

Present and future role of surgery in metastatic gastrointestinal malignancies
Purpose of review: Metastases from gastrointestinal malignancies are systemic or abdominal disseminations of cancer cells. From a biological perspective surgical resections are questionable but case series show that for some tumour types, surgery influences survival outcome. This review focuses on management and indications for surgery in recent literature of these metastatic gastrointestinal malignancies. Recent findings: A few gastrointestinal malignancies have emerged to be candidates for surgery in case of metastatic disease. Surgery can be considered in selected cases with liver metastases or abdominal dissemination ...
Source: Current Opinion in Oncology - June 4, 2016 Category: Cancer & Oncology Tags: GASTROINTESTINAL TRACT: Edited by Alain Hendlisz Source Type: research

Resistance to treatment in gastrointestinal stromal tumours: What radiologists should know
Gastrointestinal stromal tumour resistance to treatment with imatinib occurs due to pre-existing or acquired mutations. Computed tomography and positron-emission tomography play an essential role in prompt recognition of resistance to treatment. Primary resistance to treatment, which is encountered in the first 6 months of treatment, is associated with specific mutations. Imaging of these tumours shows no anatomical or metabolic response to treatment. Secondary resistance to treatment, which develops after an initial response, is associated with a variety of mutations acquired after the start of treatment. Imaging findings...
Source: Clinical Radiology - April 29, 2013 Category: Radiology Authors: S.H. Tirumani, J.P. Jagannathan, J.L. Hornick, N.H. Ramaiya Tags: Reviews Source Type: research

Correspondence Management of small gastrointestinal stromal tumours
In his Seminar of gastrointestinal stromal tumour (GIST), Heikki Joensuu and colleagues (Sept 14, p 973) state that GISTs larger than 2 cm in diameter should be removed, whereas smaller tumours can be excised or monitored by endoscopy at intervals of 6–12 months. This statement is based on the 2011 National Comprehensive Cancer Network (NCCN) clinical practice guidelines for GIST. In the 2013 version, NCCN provides the guidelines for risk assessment of malignant potential of gastric and small intestinal GISTs, but does not recommend that all GISTs larger than 2 cm should be excised.
Source: LANCET - November 23, 2013 Category: Journals (General) Authors: Tetsuji Fujita Tags: Correspondence Source Type: research

Comparison of performance of various tumour response criteria in assessment of regorafenib activity in advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib
Conclusions: RECIST 1.1 and WHO performed somewhat better than Choi criteria as TRC for response evaluation in patients with advanced GIST after prior failure on imatinib and sunitinib.
Source: European Journal of Cancer - January 6, 2014 Category: Cancer & Oncology Authors: Atul B. Shinagare, Jyothi P. Jagannathan, Vikram Kurra, Trinity Urban, Judith Manola, Edwin Choy, George D. Demetri, Suzanne George, Nikhil H. Ramaiya Tags: Sarcoma Source Type: research

Gastrointestinal Stromal Tumour in a Patient with Multiple Cutaneous and Uterine Leiomyomatosis- Implications and Anaesthetic Management
Abstract Multiple cutaneous leiomyomatosis have been associated with uterine leiomyomatosis and known as Reed’s syndrome or Multiple Cutaneous and Uterine Leiomyomatosis (MCUL). Gastrointestinal Stromal Tumours (GIST) have been reported to be associated with this syndrome only once previously in literature to the best of our knowledge. Here we report a rare case of GIST and multiple uterine leiomyomatosis in a middle aged patient with longstanding cutaneous leiomyomatosis who underwent GIST excision and hysterectomy. A 35 year old female patient with multiple cutaneous leiomyomatosis for the past 20 years was ...
Source: Indian Journal of Surgical Oncology - December 19, 2014 Category: Cancer & Oncology Source Type: research

Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review
Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of the digestive tract, derived from Cajal interstitial cells. Bone metastases are very rare, and there is no consensus regarding their treatment. Here, we present the unusual case of a 66-year-old man with a gastric GIST with synchronous bone and liver metastases, fully documented at the pathological and molecular levels with aKIT exon 11 mutation. After 9 months of imatinib, the scanner showed a 33% partial response of target lesions. We also review the literature and describe the characteristics, treatment, and outcome of all cases previously reported.Case...
Source: Case Reports in Oncology - January 17, 2017 Category: Cancer & Oncology Source Type: research

Clinicopathological characteristics of KIT and protein kinase C ‐δ expression in adenoid cystic carcinoma: comparison with chromophobe renal cell carcinoma and gastrointestinal stromal tumour
ConclusionsPKC‐δ expression is associated with KIT expression and the prognosis of patients with AdCCs, suggesting that PKC‐δ may be a potential therapeutic target for AdCCs.
Source: Histopathology - August 2, 2017 Category: Pathology Authors: Cheol Keun Park, Won Kyu Kim, Hoguen Kim Tags: Original Article Source Type: research

Gastrointestinal stromal tumours of the oesophagus: a clinicopathological and molecular analysis of 27 cases
ConclusionsComplete surgical resection with clear margins is recommended, if technically feasible, and genotyping can help to improve diagnosis and further patient management in oesophageal GIST.
Source: Histopathology - September 6, 2017 Category: Pathology Authors: Guhyun Kang, Yuna Kang, Kyung ‐Hee Kim, Sang Yun Ha, Jung Yeon Kim, Young Mog Shim, Michael C Heinrich, Kyoung‐Mee Kim, Christopher L Corless Tags: Original Article Source Type: research

Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST)
Gastrointestinal Stromal Tumours (GISTs) are the most common mesenchymal tumours. Currently, different pharmacological and surgical options are used to treat localised and metastatic GISTs, although this resea...
Source: BMC Medical Research Methodology - September 7, 2017 Category: Research Authors: M ónica Ballesteros, Nadia Montero, Antonio López-Pousa, Gerard Urrútia, Ivan Solà, Gabriel Rada, Hector Pardo-Hernandez and Xavier Bonfill Tags: Research article Source Type: research

Clinical outcomes of imatinib dose escalation versus sunitinib in first-line imatinib-failure gastrointestinal stromal tumour.
CONCLUSIONS: Both imatinib dose escalation and sunitinib were optional in Asian patients after failure of first-line imatinib, and patients with KIT exon 11 mutation benefited more from a direct shift to sunitinib. PMID: 30346846 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - October 24, 2018 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Relationship between R1 resection, tumour rupture and recurrence in resected gastrointestinal stromal tumour.
CONCLUSION: Positive resection margins are strongly associated with tumour rupture. R1 resection does not independently influence prognosis. Adjuvant imatinib may not be justified after R1 resection in the absence of tumour rupture or other high-risk features. PMID: 30507040 [PubMed - as supplied by publisher]
Source: The British Journal of Surgery - December 3, 2018 Category: Surgery Authors: Hølmebakk T, Bjerkehagen B, Hompland I, Stoldt S, Boye K Tags: Br J Surg Source Type: research

1712PPrognostic significance of circulating PD-1, PD-L1, pan-BTN3As and BTN3A1 in patients with metastatic gastrointestinal stromal tumours (mGISTs)
ConclusionsOur study, for the first time, reveals that monitoring the concentration of soluble forms of inhibitory immune checkpoints in plasma can help predict survival in metastatic GIST patients and therefore improve their treatments. We showed that high plasma levels of these immune checkpoints correlate with poor outcome and could be used in future as prognostic factors.Legal entity responsible for the studyThe authors.FundingDepartment of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

Gastrointestinal stromal tumour of stomach: Feasibility of laparoscopic resection in large lesions and its long-term outcomes
Conclusion: Our study establishes laparoscopic resection is feasible and safe in treating gastric GISTs for tumours >5 cm size. The long-term disease-free survival in our study shows acceptable oncological results in comparison to historical open resections.
Source: Journal of Minimal Access Surgery - September 16, 2020 Category: Surgery Authors: Parthasarathi Sharma Dhawal Bhushan Chittawadagi Bharath Cumar Saravana Kumar Chinnusamy Palanivelu Source Type: research