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Janssen Presents New Data Demonstrating the Combination of Niraparib and Abiraterone Acetate Plus Prednisone Significantly Improved Radiographic Progression-Free Survival as a First-Line Therapy in Patients with HRR Gene-Mutated Metastatic Castration-Resistant Prostate Cancer
SAN FRANCISCO, Feb. 14, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced initial results from the Phase 3 MAGNITUDE study evaluating the investigational use of niraparib, a selective poly-ADP ribose polymerase (PARP) inhibitor, in combination with abiraterone acetate plus prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC) with or without specific homologous recombination repair (HRR) gene alterations. At the final analysis for radiographic progression-free survival (rPFS), the treatment combination of niraparib and abiraterone acetate plus prednisone de...
Source: Johnson and Johnson - February 14, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
Janssen Submits New Drug Application to the U.S. Food and Drug Administration Seeking Approval of Niraparib and Abiraterone Acetate Dual-Action Tablet, Plus Prednisone, as a First-Line Targeted Treatment for Patients with Metastatic Castration-Resistant Prostate Cancer with BRCA Gene Mutations
RARITAN, N.J., February 28, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the submission of a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) seeking approval of niraparib in combination with abiraterone acetate, in the form of a dual-action tablet (DAT), plus prednisone, for the treatment of patients with BRCA-positive metastatic castration-resistant prostate cancer (mCRPC). If approved, this will be the first DAT formulation available in the U.S. to patients with mCRPC with BRCA mutations, which are a type of homologous recombination repair (HRR) gene alt...
Source: Johnson and Johnson - March 1, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news
Effect of progesterone and first evidence about allopregnanolone action on the progression of epithelial human ovarian cancer cell lines
Publication date: Available online 12 October 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Laura Tatiana Pelegrina, Myriam LaconiAbstractOvarian carcinoma is one of the most common cause of death by gynecologic cancer. Several epidemiological and in vitro studies have shown controversial data about progesterone effects in ovarian cancer. Progesterone can be converted in its active metabolite, allopregnanolone, its effects in ovarian cancer are still unknown. Previously, we demonstrated that allopregnanolone modifies ovarian morphophysiology, being able to alter critical process of tumor d...
Source: The Journal of Steroid Biochemistry and Molecular Biology - October 14, 2019 Category: Biochemistry Source Type: research
The metastasizing mechanisms of lung cancer: Recent advances and therapeutic challenges
Biomed Pharmacother. 2021 Mar 6;138:111450. doi: 10.1016/j.biopha.2021.111450. Online ahead of print.ABSTRACTLung cancer is one of the common malignant tumors that threaten human life with serious incidence and high mortality. According to the histopathological characteristics, lung cancer is mainly divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). NSCLC accounts for about 80-85% of lung cancers. In fact, lung cancer metastasis is a major cause of treatment failure in clinical patients. The underlying reason is that the mechanisms of lung cancer metastasis are still not fully understood. Th...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 10, 2021 Category: Drugs & Pharmacology Authors: Shimin Xie Zhengguo Wu Yi Qi Binhua Wu Xiao Zhu Source Type: research
MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cells
In ovarian cancer (OC) cells, Snail was reported to induce the epithelial-to-mesenchymal transition (EMT), which is a critical step in OC metastasis. At present little is known about controlling Snail expressi...
Source: Journal of Experimental and Clinical Cancer Research - September 5, 2016 Category: Cancer & Oncology Authors: Peixin Dong, Ying Xiong, Hidemichi Watari, Sharon J. B. Hanley, Yosuke Konno, Kei Ihira, Takahiro Yamada, Masataka Kudo, Junming Yue and Noriaki Sakuragi Source Type: research
Penn study shows how some intestinal cells resist chemotherapy and radiation
(University of Pennsylvania) When treating cancer with chemotherapy and radiation, decisions about dose must walk a fine line between attacking cancerous cells and preserving healthy ones. Overly aggressive radiation therapy to the torso, for example, can damage the epithelial cells that line the intestines, leading to chronic gastrointestinal problems. A new study from the University of Pennsylvania now shows how some intestinal cells can withstand chemotherapy and radiation.
Source: EurekAlert! - Medicine and Health - October 31, 2016 Category: Global & Universal Source Type: news
PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma
Plant homeodomain finger protein 8 (PHF8) serves an activator of epithelial-mesenchymal transition (EMT) and is implicated in various tumors. However, little is known about PHF8 roles in hepatocellular carcino...
Source: Journal of Experimental and Clinical Cancer Research - September 4, 2018 Category: Cancer & Oncology Authors: Wuhua Zhou, Li Gong, Qinchuan Wu, Chunyang Xing, Bajin Wei, Tianchi Chen, Yuan Zhou, Shengyong Yin, Bin Jiang, Haiyang Xie, Lin Zhou and Shusen Zheng Tags: Research Source Type: research
Ovarian adult granulosa cell tumor in one of identical adolescence twin with uterus didelphys and kidney agenesis. A case report
Introduction: Ovarian masses represent the most frequent tumors of the female genital tract in children and adolescents, about a half of them are neoplastic. A quarter of all tumors is malignant, additionally 2 –5% of those accounts for granulosa cell tumor (GCT). Despite the fact that childhood ovarian cancer is a very rare pathology and has a better prognosis due to its non-epithelial origin, the early diagnosis and specific management is necessary.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 19, 2019 Category: OBGYN Authors: Diana Maldziute, Zana Bumbuliene Tags: Movies Case Reports 1 – General Gynaecology and Ectopic Source Type: research
Primary Intraosseous Adenoid Cystic Carcinoma of the Jaw: Clinical and Histopathologic Analysis
Conclusions: The differential diagnosis of intraosseous ACC from other common tumors of jaws should be determined by the clinical, radiographic, and histopathologic subtypes. For treatment, surgery is the first choice for patients, and radiotherapy or chemotherapy might improve the prognosis in the postoperative period. In addition, the histopathologic subtypes and biologic processes of ACC are related to patient prognosis.
Source: Journal of Oral and Maxillofacial Surgery - December 16, 2013 Category: ENT & OMF Authors: Rong-xin Deng, Xin Xu, Chen-ping Zhang, Zhi-yuan Zhang, Yue He Tags: Surgical Oncology and Reconstruction Source Type: research
Anion exchange chromatography for the determination of 5-methyl-2'-deoxycytidine: application to cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines.
Abstract
Epigenetic alterations are increasingly implicated in the initiation and progression of cancer. Genome-wide (global) hypomethylation seems to occur in early neoplasia and is a feature of genomic DNA derived from solid tumour tissues like ovarian cancer. Thus, analytical methods that provide sensitive and quantitative information about cytosine methylation in DNA are currently required. In this work, we compare two different anion-exchange columns for the separation of methylated cytosine from the other DNA nucleotides: a silica-based (Tracer Extrasil SAX) column and a polystyrene/divinyl benzene-based (Mo...
Source: Analytical and Bioanalytical Chemistry - August 21, 2014 Category: Chemistry Authors: Iglesias T, Espina M, Montes-Bayón M, Sierra LM, Blanco-González E Tags: Anal Bioanal Chem Source Type: research
Abstract B03: PVT1 exon 9 is a potential non-invasive biomarker that regulates apoptosis and the cell cycle in aggressive prostate cancer in black males
Prostate cancer (PCA) is the most common non-skin cancer and the second leading cause of cancer-related death for men in the U.S. Black males have a higher incidence of PCA, compared to White males. In fact, Black race is a confirmed, non-modifiable risk factor for PCA with a 2.5 fold greater risk of lethal PCA compared to Caucasian males. Discovery of effective early detection strategies are necessary to address the profound health disparity. The chromosomal region 8q24 is associated with aggressive PCA in Black men and variants of this region have been identified to interact with the PVT1 non-protein coding gene in PCA. ...
Source: Cancer Epidemiology Biomarkers and Prevention - April 14, 2016 Category: Cancer & Oncology Authors: Ilboudo, A., Das, D., Ogunwobi, O. O. Tags: Biomarkers in Cancer Surveillance and Screening: Poster Presentations - Proffered Abstracts Source Type: research
Abstract IA11: Life course epidemiology and breast cancer: translating risk into prevention
Molecular histology may be conceptualized as the microscopic and molecular characteristics of normal tissues that are required for physiologic function. Over the life course, the molecular histology of the breast changes in response to physiological alterations, imparting spatial and temporal heterogeneity within the breasts of individuals and among women. These transitions contribute to the enormous range and imprecisely defined limits of what pathologists consider normal. Appreciation that molecular histology may reflect the cumulative influence of prior exposures linked to breast cancer risk, and may provide information...
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Sherman, M. E. Tags: Improving Cancer Risk Prediction for Prevention and Early Detection: Oral Presentations - Invited Abstracts Source Type: research
Apoptotic induction and anti-metastatic activity of eugenol encapsulated chitosan nanopolymer on rat glioma C6 cells via alleviating the MMP signaling pathway
Publication date: Available online 2 January 2020Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Zhenjiang Li, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Srinivasa Rao Bolla, Hariprasath Lakshmanan, Subramanian Kumaran, Wilson Aruni, Aref Ali Mohammed Aladresi, Omar H.M. Shair, Sulaiman Ali Alharbi, Arunachalam ChinnathambiAbstractGlioma is the prime cause of cancer allied mortality in adolescent people and it accounts about 80% of all malignant tumours. Eugenol is a major bioactive constituent present in the essential oils with numerous pharmacological benefits including nueroprotective ...
Source: Journal of Photochemistry and Photobiology B: Biology - January 3, 2020 Category: Speech-Language Pathology Source Type: research
c-Jun, pc-Jun, and p27 are differently expressed in oral leukoplakias in smokers and never-smokers
Oral cancer may be preceded by potentially malignant lesions, and smoking is a risk factor. Oral leukoplakia (OL), which is the most common among these lesions, is defined by the World Health Organization as “a white plaque of questionable risk having excluded known diseases or disorders that carry no increased risk for cancer.” Thus, OL is a clinical diagnosis used to designate oral white lesions, which are histologically represented by hyperkeratosis associated or not associated with epithelial dysplasia.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - September 15, 2015 Category: ENT & OMF Authors: Joelma Sousa Lima, Luciana Correa, Maria Fátima Guarizo Klingbeil, Suzana C. Orsini Machado de Sousa Tags: Oral and maxillofacial pathology Source Type: research
