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Cancer: Squamous Cell Carcinoma
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Loneliness and quality of life after head and neck cancer
Loneliness is associated with a poor quality of life, mental illness, poor physical health, and premature mortality. Patients with head and neck cancer (HNC) are at risk of loneliness because of the effects of the disease and its treatment on important social interactive functions such as appearance, speech, facial expression, and eating. Patients treated for primary squamous cell HNC between January 2015 and December 2016 were surveyed in early 2019 using the University of Washington quality of life questionnaire version 4, the Cancer-related Loneliness Assessment Tool (C-LAT), and four nationally recommended indicator questions.
Source: The British Journal of Oral and Maxillofacial Surgery - July 10, 2020 Category: ENT & OMF Authors: A. Dahill, H. Al-Nakisbandi, K.B. Cunningham, G.M. Humphris, D. Lowe, S.N. Rogers Source Type: research
Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
Abstract B72: HPV knowledge and screening among gay men of color in South Florida
Conclusion: Similar to past research, HIV-infected gay and bisexual men reported willingness to screen for anal cancer, and they requested more widely communicated information about the risk for anal cancer and the need to screen. Future intervention work should use a community-based approach to raise awareness about SCCA among HIV-infected gay and bisexual men. Further, it is critical to ensure that both HIV primary care providers as well as general primary care providers promote HSIL screening, particularly among HIV-infected gay and bisexual men to prevent the development of anal cancer.Citation Format: Alexis Koskan, N...
Source: Cancer Epidemiology Biomarkers and Prevention - April 14, 2016 Category: Cancer & Oncology Authors: Koskan, A., Leblanc, N. Tags: Screening and Early Detection: Poster Presentations - Proffered Abstracts Source Type: research
Our Experience in Oral Commissure Reconstruction After Surgical Excision of Stage 3 and Stage 4 Oral Cavity Malignancy
ConclusionThe RFFF with Palmaris longus has excellent viability. It is a secure and reliable reconstructive option which produced satisfactory aesthetic and functional results.
Source: Journal of Maxillofacial and Oral Surgery - July 15, 2020 Category: ENT & OMF Source Type: research
Conditional Survival in Anal Carcinoma Using the National Population-Based Survey of Epidemiology and End Results Database (1988–2012)
CONCLUSIONS: Conditional survival showed improvement over time. Patients with advanced stage had the greatest improvement in conditional survival. This is the first study to provide specific conditional survival probabilities for patients with anal cancer.
Source: Diseases of the Colon and Rectum - March 12, 2016 Category: Gastroenterology Tags: Original Contributions: Colorectal/Anal Neoplasia Source Type: research
A case-case study on sinonasal cancer prevention: effect from dust reduction in woodworking and risk of mastic/solvents in shoemaking
Sinonasal cancers (SNCs) are rare neoplasms, accounting for about 3 % of head and neck cancers, with squamous cell carcinoma (SCC) and adenocarcinoma (ADC) as the most common subtypes. ADCs present strong asso...
Source: Journal of Occupational Medicine and Toxicology - July 21, 2016 Category: Occupational Health Authors: Enzo Emanuelli, Enrico Alexandre, Diego Cazzador, Vera Comiati, Tiziana Volo, Alessia Zanon, Maria Luisa Scapellato, Mariella Carrieri, Alessandro Martini and Giuseppe Mastrangelo Source Type: research
Comorbidity Assessment in Patients With Oral Squamous Cell Carcinoma: Can Imaging Techniques (Fludeoxyglucose Positron-Emission Tomographic Computed Tomography and Contrast-Enhanced Computed tomography) Provide Additional Information?
This study evaluated the role of imaging staging examinations (positron-emission tomographic computed tomography [PET/CT] and contrast-enhanced computed tomography [ceCT]) for the assessment of the comorbidity status of patients with oral squamous cell carcinoma (OSCC). A binary null hypothesis was drafted: 1) imaging staging examinations do not augment knowledge about the comorbidity status of patients with OSCC and 2) there is no difference between PET/CT and ceCT in this regard.
Source: Journal of Oral and Maxillofacial Surgery - May 31, 2017 Category: ENT & OMF Authors: Matthias Troeltzsch, Florian Andreas Probst, Axel Rominger, Ulrich M üller-Lisse, Monika Probst, Katharina Obermeier, Michael Ehrenfeld, Sven Otto Tags: Surgical oncology and reconstruction Source Type: research
Oral verrucous carcinoma in a 10-year old female: a case report and review of the literature
Oral verrucous carcinoma (VC) is an uncommon variant of squamous cell carcinoma and represents 3-4% of all carcinoma. VC was described by Ackerman in 1948 and it occurs in older males in the fifth-seventh decades of life. VC is exceedingly rare in young adults and children. Oral squamous cell carcinoma (OSCC), however, has been reported in patients younger than 40 and accounts for about 4-6% of such cases. Here, we present a rare case of VC in a 10-year-old female, making this is the first report of VC in a child.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 17, 2017 Category: ENT & OMF Authors: M. BINDAKHIL, M. ALJABRI, D. COHEN, M. ISLAM, I. BHATTACHARYYA Source Type: research
Effect of postoperative radiotherapy in pT1pN1cM0 and pT2p/cN0cM0 oropharyngeal squamous cell carcinoma
ConclusionsIn terms of disease‐free survival, patients with p16‐negative tumors may benefit from postoperative radiotherapy, whereas survival of p16‐positive patients is good regardless of additional treatment.
Level of Evidence4 Laryngoscope, 2017
Source: The Laryngoscope - August 22, 2017 Category: ENT & OMF Authors: Lorenz Kadletz, Gregor Heiduschka, Axel Wolf, Anna Haug ‐Lettenbichler, Lukas Poyntner, Thomas Primosch, Hermann Rogatsch, Michael Formanek, Matthias Stadler, Lukas Kenner, Hans E. Eckel, Markus Brunner Tags: Head and Neck Source Type: research
A Poorly Differentiated Squamous Cell Carcinoma of the Maxilla Extending to the Palate and Orbit: A Case Report
A 67-year-old man presented to a reference medical-surgical service with an extensive tumor in the left maxilla, extending to the hard palate and infiltrating the floor of the orbit at about 5 cm. Maxillectomy was performed, whereby the lesion was completely removed. The histopathologic examination revealed a malignant neoplasm of ectodermal origin, with hyperplastic cells and nuclear and cellular pleomorphism, hyperchromatism, and atypical mitoses. A small amount of keratin was observ ed. The margins were compromised, and there were vascular invasion, areas of necrosis, and infiltration to the bone tissue.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - September 1, 2018 Category: ENT & OMF Authors: J éssica Barroso Barbosa, Renata Gualberto Cunha, Moyara Mendonça Lima De Farias, Jefferson Moreira De Medeiros, Jeconias Câmara, Tatiana Nayara Libório-Kimura, Ricardo Alexandre G. Guimarães Tags: Oral and Maxillofacial Pathology Source Type: research
LncRNA NEAT1 Polymorphisms and Lung Cancer Susceptibility In a Chinese Northeast Han Population: a Case-control Study
ConclusionsThe polymorphisms rs2239895 were associated with the risk of lung squamous cell carcinoma. The interaction between the two SNPs and the cigarette smoking was no notable difference.
Source: Pathology Research and Practice - November 1, 2019 Category: Pathology Source Type: research
LncRNA NEAT1 polymorphisms and lung cancer susceptibility in a Chinese Northeast Han Population: A case-control study.
CONCLUSIONS: The polymorphisms rs2239895 were associated with the risk of lung squamous cell carcinoma. The interaction between the two SNPs and the cigarette smoking was no notable difference.
PMID: 31704150 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - October 30, 2019 Category: Pathology Authors: Wang S, Cui Z, Li H, Li J, Lv X, Yang Z, Gao M, Bi Y, Zhang Z, Zhou B, Yin Z Tags: Pathol Res Pract Source Type: research
Oral microbiome and oral cancer & #8211; The probable nexus
This article is an attempt to review the role of oral microbiome in oral cancer with a focus on the bacteriome, its related studies and in brief about the omics technologies in understanding the microbiome.
Source: Journal of Oral and Maxillofacial Pathology - September 8, 2020 Category: ENT & OMF Authors: Priya Nimish Deo Revati Deshmukh Source Type: research
The combinational application of photodynamic therapy and nanotechnology in skin cancer treatment: A review
Tissue Cell. 2022 Jun 15;77:101856. doi: 10.1016/j.tice.2022.101856. Online ahead of print.ABSTRACTSkin cancer is considered a risky worldwide disease. Traditional treatments have several weaknesses, necessitating the creation of more effective treatments. In this case, photodynamic therapy and nanotechnology were used to demonstrate their therapeutic efficacy as combinational approaches in treating different types of skin cancer. In this review, we will discuss the photoexcitation mechanism of PDT, its cell destruction capability, and give a comprehensive outlook of the different photosensitizer types. Also, light sources...
Source: Tissue and Cell - June 27, 2022 Category: Cytology Authors: Fadya Adnane Emad El-Zayat Heba Mohamed Fahmy Source Type: research
