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Drug: Estradiol

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What Every Gynecologist Should Know About Perimenopause
Perimenopause often represents a physiologically challenging phase in women’s lives. The clinical presentation of the perimenopause includes infertility, irregular menstrual cycles, menorrhagia, and new onset of or worsening of mood disorders. Unlike menopause, which is characterized by low levels of estradiol and progesterone, the hallmark of perimenopause is highly variable levels of estradiol and progesterone with abrupt increases and decreases that are often described as a hormonal roller coaster. This chapter invites general gynecologists to understand the hormonal basis of the common complaints of perimenopause and...
Source: Clinical Obstetrics and Gynecology - October 27, 2020 Category: OBGYN Tags: What the Generalist Should Know About REI Source Type: research

Triiodothyronine (T3) and metabolic rate in adolescents with eating disorders: is there a correlation?
Conclusion: In patients with AN, T3 correlated significantly with markers of malnutrition and %EREE and may serve as a surrogate measure when IC is unavailable. Following T3 during treatment of AN may assist clinicians in assessing metabolic suppression and recovery and help guide caloric prescriptions and goal weights. PMID: 23221424 [PubMed - as supplied by publisher]
Source: Eating and weight disorders : EWD - November 26, 2012 Category: Eating Disorders and Weight Management Authors: Aschettino-Manevitz DL, Ornstein RM, Meyer Sterling W, Kohn N, Fisher M Tags: Eat Weight Disord Source Type: research

Renewal of conditioned responding to food cues in rats: Sex differences and relevance of estradiol
Publication date: 1 November 2015 Source:Physiology & Behavior, Volume 151 Author(s): Lauren C. Anderson, Gorica D. Petrovich Cues associated with food can stimulate food anticipation, procurement, and consumption, independently of hunger. These and other behaviors driven by learned cues are persistent and can reappear after extinction, because the original learned associations continue to exist. Renewal, or reinstatement, of extinguished conditioned behavior may explain the inability to change maladaptive eating habits driven by food cues, similar to the mechanisms of drug use relapse. Here, we investigated se...
Source: Physiology and Behavior - August 15, 2015 Category: Physiology Source Type: research

Estradiol levels in women predict skin conductance response but not valence and expectancy ratings in conditioned fear extinction.
Abstract Anxiety disorders are more prevalent in women than men. One contributing factor may be the sex hormone estradiol, which is known to impact the long term recall of conditioned fear extinction, a laboratory procedure that forms the basis of exposure therapy for anxiety disorders. To date, the literature examining estradiol and fear extinction in humans has focused primarily on physiological measures of fear, such as skin conductance response (SCR) and fear potentiated startle. This is surprising, given that models of anxiety identify at least three important components: physiological symptoms, cognitive bel...
Source: Neurobiology of Learning and Memory - August 16, 2016 Category: Neurology Authors: White EC, Graham BM Tags: Neurobiol Learn Mem Source Type: research

Structural equation modeling of food craving across the menstrual cycle using behavioral, neuroendocrine, and metabolic factors
ConclusionsOur theoretical model suggests that ECs and ECLs influence craving. Since these metabolites can be modulated via dietary fat intake, they could be potential targets to alter menstrual cycle cravings.Clinical Trial Registration Number: NCT01407692Graphical abstract
Source: Physiology and Behavior - July 19, 2018 Category: Physiology Source Type: research

Arsenic exposure during juvenile and puberty significantly affected reproductive system development of female SD rats
In conclusion, juvenile and pubertal arsenic exposures at environmental-relevant levels significantly reduced reproductive functions and capacity by adult. Since the lowest effective dose is very close to the government safety standards, the relevancy of arsenic over exposure to reproductive defects in human deserves further study.PMID:35809398 | DOI:10.1016/j.ecoenv.2022.113857
Source: Ecotoxicology and Environmental Safety - July 9, 2022 Category: Environmental Health Authors: Panpan Chen Qiong Luo Yifeng Lin Jiani Jin Kai-Lun Hu Feixia Wang Jiwei Sun Ruixue Chen Juan Wei Guangdi Chen Dan Zhang Source Type: research

Comparison on Metabolism of Estradiol and Its 17-Sulfate by Recombinant Human CYP Isoforms
Biol Pharm Bull. 2021;44(9):1344-1347. doi: 10.1248/bpb.b21-00275.ABSTRACTTo identify the CYP isoforms involved in the production of 2-hydroxyestradiol 17-sulfate (2-OH-ES), which we assume to be an antioxidant in vivo, the 2-hydroxylation reaction of estradiol 17-sulfate (ES) by human liver microsome was investigated. As a result, it was estimated that CYP2C8 and 2C9 were largely involved in the production of 2-OH-ES. Therefore, the 2-hydroxylation kinetic analysis of ES was performed for both CYPs, and the metabolic clearance Vmax/Km (µL/nmol CYP/min) was determined. On comparing the results of ES with those of estradio...
Source: Biological and Pharmaceutical Bulletin - September 2, 2021 Category: Drugs & Pharmacology Authors: Shinji Yuasa Kaori Takanashi Kenta Ukiana Yoshihiro Mihara Shinji Itoh Source Type: research