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Drug: Dexamethasone
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Janssen to Highlight Latest Scientific Advances in Hematologic Diseases at ASH 2022 with Clinical and Real-World Data Across Innovative Pipeline and Distinguished Portfolio
RARITAN, N.J., November 3, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson are committed to redefining treatment outcomes in the hematology setting and today announced that abstracts from more than 50 company-sponsored studies, plus more than 20 investigator-initiated studies, will be presented at the American Society of Hematology (ASH) Annual Meeting in New Orleans from December 10-13, 2022. Janssen’s commitment to advancing an innovative portfolio of therapies for healthcare professionals and patients is evidenced through more than 70 presentations that span clinical studies and r...
Source: Johnson and Johnson - November 3, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
A Multicenter Randomized Comparison Between Intravenous and Perineural Dexamethasone for Ultrasound-Guided Infraclavicular Block
Conclusions: Compared with its IV counterpart, PN dexamethasone (5 mg) provides a longer duration of motor block, sensory block, and postoperative analgesia for US-guided infraclavicular block. Future dose-finding studies are required to elucidate the optimal dose of dexamethasone.
Source: Regional Anesthesia and Pain Medicine - April 21, 2016 Category: Anesthesiology Tags: Regional Anesthesia and Acute Pain: Original Articles Source Type: research
Whipworm Infection Promotes Bacterial Invasion, Intestinal Microbiota Imbalance, and Cellular Immunomodulation Host Response and Inflammation
Infections with Trichuris trichiura are among the most common causes of intestinal parasitism in children worldwide, and the diagnosis is based on microscopic egg identification in the chronic phase of the infection. During parasitism, the adult worm of the trichurid nematode maintains its anterior region inserted in the intestinal mucosa, which causes serious damage and which may open access for gut microorganisms through the intestinal tissue. The immune-regulatory processes taking place during the evolution of the chronic infection are still not completely understood. By use of the Swiss Webster outbred mouse model, mic...
Source: Infection and Immunity - February 19, 2020 Category: Infectious Diseases Authors: Schachter, J., Alvarinho de Oliveira, D., da Silva, C. M., de Barros Alencar, A. C. M., Duarte, M., da Silva, M. M. P., Ignacio, A. C. d. P. R., Lopes-Torres, E. J. Tags: Host Response and Inflammation Source Type: research
A Timeline of Trump ’s Symptoms and Treatments
What is known so far about what happened leading up to and during the president ’s hospitalization.
Source: NYT Health - October 6, 2020 Category: Consumer Health News Authors: Christina Morales, Allyson Waller and Marie Fazio Tags: Trump Coronavirus Positive Result United States Politics and Government Reed, Walter, National Military Medical Center Trump, Donald J Social Media Timeline Remdesivir (Drug) Dexamethasone (Drug) Coronavirus (2019-nCoV) Source Type: news
Autophagy mechanisms in sputum and peripheral blood cells of patients with severe asthma: a new therapeutic target
Conclusions and clinical relevanceAutophagy could play a role in the pathogenesis of severe asthma. Autophagy modulation may be a novel therapeutic target for conventional therapy‐resistant severe asthma.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - June 25, 2015 Category: Allergy & Immunology Authors: Ga‐Young Ban, Duy Le Pham, H K Tu Trinh, Seung‐Ihm Lee, Dong‐Hyeon Suh, Eun‐Mi Yang, Young‐Min Ye, Yoo Seob Shin, Young‐Joon Chwae, Hae‐Sim Park Tags: Original Article‐Asthma and Rhinitis Source Type: research
Effect of dexamethasone on gene expression of cannabinoid receptor type 1 and adenosine monophosphate-activated protein kinase in the hypothalamus of broilers (Gallus domesticus)
In conclusion, CB1 is mainly expressed in the hypothalamus of broilers; 72-h DEX exposure can regulate the CB1 system and AMPK signaling pathway of the broiler hypothalamus.PMID:34144188 | DOI:10.1016/j.cbpa.2021.111018
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - June 18, 2021 Category: Physiology Authors: Linglian Kong Chuanpi Xiao Hai Lin Johan Buyse Xianlei Li Zhigang Song Source Type: research
A Prospective Phase II Trial of Lenalidomide and Dexamethasone (Len-Dex) in POEMS Syndrome
We report 34 patients (pts) included in a prospective phase II trial using Len-Dex.
Source: Clinical Lymphoma, Myeloma and Leukemia - September 1, 2015 Category: Hematology Authors: A. Jaccard, A. Danielou-Lazareth, L. Karlin, S. Choquet, L. Frenzel, L. Garderet, M. Dib, L. Galicier, O. Tournilhac, K. Belhadj, P. Moreau, O. Decaux, L. Benboubker, B. Slama, B. Bonnotte, B. Hebraud, M. Cogné, L. Musset, J.-P. Fermand Tags: 3. Epidemiology, QoL, Toxicities, and Other Plasma Cell Dyscrasias Source Type: research
Carfilzomib (CFZ, Kyprolis®), Lenalidomide (LEN, Revlimid®), and Dexamethasone (DEX) (KRd) Combined with Autologous Stem Cell Transplant (ASCT) Shows Improved Efficacy Compared with Krd without ASCT in Newly Diagnosed Multiple Myeloma (NDMM)
We report results from a second ph 2 MMRC trial assessing KRd+ASCT in the context of updated results of KRd w/o ASCT.
Source: Biology of Blood and Marrow Transplantation - February 19, 2016 Category: Hematology Authors: Todd M. Zimmerman, Kent Griffith, Jagoda K. Jasielec, Cara A. Rosenbaum, Jesus G. Berdeja, Ravi Vij, Noopur Raje, Donna E. Reece, David H. Vesole, Sundar Jagannath, Mark Kaminski, Craig Cole, Jennifer Nam, Leonor A. Stephens, Shaun Rosebeck, Sandeep Gurbu Tags: Session C: Autologous Transplants, Lymphoma and Myeloma Source Type: research
The influence of dexamethasone on postoperative swelling and neurosensory disturbances after orthognathic surgery: a randomized controlled clinical trial
Orthognathic surgery is associated with considerable swelling and neurosensory disturbances. Serious swelling can lead to great physical and psychological strain. A randomized, prospective, controlled clinical...
Source: Head and Face Medicine - November 7, 2017 Category: ENT & OMF Authors: W. Semper-Hogg, M. A. Fuessinger, T. W. Dirlewanger, C. P. Cornelius and M. C. Metzger Tags: Research Source Type: research
Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin –angiotensin systems
Hypertension may result from high-fat (HF) diet induced-obesity and overexposure to glucocorticoids in utero. Recent studies demonstrated the potent contribution of adipose tissue ’s renin-angiotensin system (R...
Source: Lipids in Health and Disease - March 14, 2018 Category: Lipidology Authors: Hong-Ren Yu, You-Lin Tain, Mao-Meng Tiao, Chih-Cheng Chen, Jiunn-Ming Sheen, I-Chun Lin, Shih-Wen Li, Ching-Chou Tsai, Yu-Ju Lin, Kai-Sheng Hsieh and Li-Tung Huang Tags: Research Source Type: research
1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade
Despite recent improvements in the treatment of rheumatoid arthritis (RA), an insufficient treatment response and the development of treatment resistance in many patients illustrates the need for new therapeut...
Source: Arthritis Research and Therapy - September 20, 2018 Category: Rheumatology Authors: Wendy Dankers, Claudia Gonz ález-Leal, Nadine Davelaar, Patrick S. Asmawidjaja, Adriana M. C. Mus, Johanna M. W. Hazes, Edgar M. Colin and Erik Lubberts Tags: Research article Source Type: research
Prenatal genetic testing and treatment for congenital adrenal hyperplasia
Couples at risk for autosomal recessive congenital adrenal hyperplasia often request anticipatory guidance and genetic counseling. Initially, hormones in amniotic fluid were measured to distinguish affected female fetuses from unaffected fetuses. With the molecular era, more-targeted approaches became possible. Prenatal genetic diagnosis via amniocentesis or chorionic villus sampling was used to determine the need for continuing fetal therapy (dexamethasone), allowing cessation if the fetus was unaffected.
Source: Fertility and Sterility - January 1, 2019 Category: Reproduction Medicine Authors: Joe Leigh Simpson, Svetlana Rechitsky Tags: Views and reviews Source Type: research
Dexamethasone in the era of COVID-19: friend or foe? An essay on the effects of dexamethasone and the potential risks of its inadvertent use in patients with diabetes
The disclosure in the media of a benefit with the use of dexamethasone in patients with COVID-19 infection sets precedents for self-medication and inappropriate use of corticosteroids.
Source: Diabetology and Metabolic Syndrome - September 7, 2020 Category: Endocrinology Authors: Janine Alessi, Giovana B. de Oliveira, Beatriz D. Schaan and Gabriela H. Telo Tags: Review Source Type: research
Differential expression profiles of long noncoding RNAs and mRNAs in human bone marrow mesenchymal stem cells after exposure to a high dosage of dexamethasone
Abnormalities in apoptosis, cell cycle, proliferation, and differentiation of human bone marrow mesenchymal stem cells (hBMSCs) significantly impact bone metabolism and remodeling, resulting in various skeleta...
Source: Stem Cell Research and Therapy - January 6, 2021 Category: Stem Cells Authors: Tao Li, Yingxing Xu, Yingzhen Wang and Yaping Jiang Tags: Research Source Type: research
Antenatal dexamethasone use and respiratory distress in late preterm infants: results from first Vietnamese matched cohort study
Respiratory distress syndrome (RDS) is one of the leading causes of early neonatal morbidity and mortality in late preterm infants (LPIs) worldwide. This matched cohort study aimed to assess how the antenatal ...
Source: BMC Pregnancy and Childbirth - August 7, 2021 Category: OBGYN Authors: Tran Tuan Hung Ho, Quang Vinh Truong, Thi Kim Anh Nguyen, Minh Tam Le and Vu Quoc Huy Nguyen Tags: Research article Source Type: research
