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Source: Experimental and Therapeutic Medicine

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Total 17866 results found since Jan 2013.

Gaps or links between hormonal therapy and schizophrenia? (Review).
Authors: Trifu SC, Istrate D, Miruna DA Abstract Schizophrenia is considered the most severe and debilitating psychiatric disorder. During the 80's, first reports on abnormalities of the schizophrenic brain which could be objectively observed on MRI, CT scans and other imagistic techniques were published. This showed that schizophrenia is a disorder that goes beyond the functional aspect of the symptomatology. The ties between psychiatry and endocrinology are easily observed, even empirically, by any mental health practitioner, and mirrored by endocrinology specialists. Disorders related to menstruation phase of th...
Source: Experimental and Therapeutic Medicine - September 10, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Risk of infection in patients with spondyloarthritis and ankylosing spondylitis receiving antitumor necrosis factor therapy: A meta-analysis of randomized controlled trials.
Authors: Xu Z, Xu P, Fan W, Yang G, Wang J, Cheng Q, Yu M Abstract Antitumor necrosis factor (TNF) agents have been widely used for the treatment of spondyloarthritis (SpA) and ankylosing spondylitis (AS). However, these agents may increase the risk of infection due to suppressing the immune response. The present meta-analysis was performed to systematically investigate the risk of overall infection, serious infection and tuberculosis in patients with SpA and AS treated with anti-TNF agents. Medline, Embase and the Cochrane library were searched for randomized controlled trials (RCTs) published between January 1998...
Source: Experimental and Therapeutic Medicine - October 19, 2017 Category: General Medicine Tags: Exp Ther Med Source Type: research

Effect of vegetable juice consumption prior to eating rice on postprandial blood glucose and insulin levels.
Authors: Kasuya N, Inoue N, Inoue Y, Murata I, Kanamoto I Abstract Vegetable juice has been demonstrated to attenuate the elevation of postprandial blood glucose when consumed prior to meals. The present study aimed to investigate the effect of pre-meal consumption of vegetable juice on blood glucose and insulin levels. A total of 10 healthy volunteers aged 20-29 years ingested 200 ml of either water, a sugar solution with the same sugar composition as the vegetable juice or vegetable juice 30 min prior to consuming the cooked rice, and their blood glucose and insulin levels were measured. At the time of rice consu...
Source: Experimental and Therapeutic Medicine - October 12, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

A model of health education and management for osteoporosis prevention.
Authors: Wang L, Xu X, Zhang Y, Hao H, Chen L, Su T, Zhang Y, Ma W, Xie Y, Wang T, Yang F, He L, Wang W, Fu X, Ma Y Abstract Osteoporosis, a chronic disease with no therapeutic cure, affects a growing number of people as the aging population in China rapidly increases. Therefore, developing an evidence-based model of health education and management for osteoporosis prevention is required. In the present study, an osteoporosis club was established, which is a novel model of health education and management for osteoporosis prevention. A unified management of membership was used based on a digitized database. A total ...
Source: Experimental and Therapeutic Medicine - January 22, 2017 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Risk factors for adiposity in the urban population and influence on the prevalence of overweight and obesity.
This study determined the prevalence of certain risk factors for adiposity and assesses their impact on overweight/obesity prevalence. Nine hundred individuals were evaluated, aged between 18-65 years, including clinical examination, evaluation of medical history, BMI determination and completion on questionnaires assessing nutritional intake and presence of depression symptoms. Overweight prevalence was 29.56% and obesity prevalence was 21.33%. Fast-food consumption was the most frequent risk factor for adiposity found in 61.67% of individuals, eating <3 meals/day was found in 58.89%, sedentary lifestyle in 53.33%, sle...
Source: Experimental and Therapeutic Medicine - June 9, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Pediatric obesity: Causes, symptoms, prevention and treatment.
Authors: Xu S, Xue Y Abstract Pediatric or childhood obesity is the most prevalent nutritional disorder among children and adolescents worldwide. Approximately 43 million individuals are obese, 21-24% children and adolescents are overweight, and 16-18% of individuals have abdominal obesity. The prevalence of obesity is highest among specific ethnic groups. Obesity increases the risk of heart diseases in children and adults. Childhood obesity predisposes the individual to insulin resistance and type 2 diabetes, hypertension, hyperlipidemia, liver and kidney diseases and causes reproductive dysfunction in adults. Obe...
Source: Experimental and Therapeutic Medicine - February 4, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

George N. Papanicolaou (1883-1962), an exceptional human, scientist and academic teacher: An interview with Dr Neda Voutsa-Perdiki.
Authors: Mammas IN, Spandidos DA Abstract Dr Neda Voutsa-Perdiki, former Director of Exfoliative Cytology at the University of Florida (Florida, USA), talks about her academic teacher Dr George N. Papanicοlaou, referred to as the 'Father of Exfoliative Cytology', and his wife Mache, known as Mary Papanicolaou. According to Dr Voutsa-Perdiki, Dr Papanicolaou was an exceptional teacher and a unique humanitarian in modern medical history. The secret of his scientific success was hard work, dedication, love of research, faith and the courage he gained from his wife and colleagues. According to Dr Voutsa-Perdiki, altho...
Source: Experimental and Therapeutic Medicine - October 19, 2017 Category: General Medicine Tags: Exp Ther Med Source Type: research

Hematopoietically expressed homeobox gene is associated with type 2 diabetes in KK Cg-Ay/J mice and a Taiwanese Han Chinese population.
Authors: Lu CC, Chen YT, Chen SY, Hsu YM, Lin CC, Tsao JW, Juan YN, Yang JS, Tsai FJ Abstract Diabetes mellitus (DM) is a chronic disease. The KK Cg-Ay/J (KK-Ay) mouse is an animal model to study type 2 diabetes mellitus (T2D) disease. The present study assessed the expression of hematopoietically expressed homeobox (HHEX) protein in liver tissues of different age groups of mice (6, 16 and 42 weeks) by immunohistochemistry (IHC). The results demonstrated a significant decrease in the percentage of HHEX-positive cells in KK-Ay mice as compared with that in KK-α/α control mice. Furthermore, in Taiwan's Han Chinese ...
Source: Experimental and Therapeutic Medicine - June 15, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Fluoro-edenite and carbon nanotubes: The health impact of 'asbestos-like' fibres.
Authors: Miozzi E, Rapisarda V, Marconi A, Costa C, Polito I, Spandidos DA, Libra M, Fenga C Abstract Several decades have passed since Wagner et al demonstrated a causal link between asbestos fibre inhalation and the development of pleural mesothelioma in 1960. It was later suggested that pleural plaques are a benign consequence of exposure to these fibres. Most recently, a significant association between exposure to asbestos and cancer diagnosed at various sites, such as the peritoneum, stomach, pharynx, colon and ovaries has been demonstrated. The great concerns about public health that arose from the scientific...
Source: Experimental and Therapeutic Medicine - February 20, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Accurate and continuous ultrasonography evaluation of small diameter vascular prostheses in vivo.
Authors: Shi J, Zhang J, Yin M, Wang Q, Du J Abstract There is a large clinical requirement for novel vascular grafts; however, the development of novel vascular grafts has not been extremely successful to date. The most successful method for the continuous evaluation of vascular grafts in vivo remains unclear. Therefore, an optimal successive, non-invasive imaging modality is necessary for the study of vascular transplantation. In the present study, a common rabbit model of carotid artery defect was utilized. The patency and hemodynamic characteristics of implanted grafts was examined following surgery by color Do...
Source: Experimental and Therapeutic Medicine - March 25, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Analysis of the miRNA and mRNA involved in osteogenesis of adipose-derived mesenchymal stem cells.
Authors: Jia B, Zhang Z, Qiu X, Chu H, Sun X, Zheng X, Zhao J, Li Q Abstract Mesenchymal stem cells (MSCs) are bone marrow stromal cells capable of differentiating into different tissue types. Osteoblastic differentiation is a complex process that is critical for bone formation. An increasing number of studies have suggested that microRNAs (miRNAs) may serve important roles in various biological processes, including osteogenesis of MSCs. However, less is known about the participation of particular miRNAs in the osteogenic differentiation of adipose-derived stem cells (ADSCs). In order to identify functional miRNAs ...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

lncRNA Malat1 modulates the maturation process, cytokine secretion and apoptosis in airway epithelial cell-conditioned dendritic cells.
Authors: Li Z, Zhang Q, Wu Y, Hu F, Gu L, Chen T, Wang W Abstract Airway epithelial cells (AECs) are the first point of contact with airborne antigens and are able to instruct resident immune cells to appropriate immune responses. Previous studies have shown that the abnormal expression of metastasis-associated lung adenocarcinoma transcript 1 (Malat1) was associated with tumorigenesis, progression, metastasis, and apoptosis in many cancer types. However, little is known about its functional involvement in the cross-talk of AECs with dendritic cells (DCs). The aim of the present study was to identify Malat1 as a no...
Source: Experimental and Therapeutic Medicine - October 24, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Cutaneous leukocytoclastic vasculitis associated with erlotinib treatment: A case report and review of the literature.
We report a case, a 58-year-old, 60 kg weight, non-smoking woman suffering of lung adenocarcinoma and brain metastases treated with erlotinib monotherapy with 150 mg/day dose, who presents cutaneous leukocytoclastic vasculitis after 8 months of initiating the treatment. The administration of the drug was discontinued and oral prednisolone treatment was introduced at 1 mg/kg body weight dose for two weeks, decreasing the dose with 5 mg, at every 3 days. The treatment was combined with topical potent steroid and antibiotic therapy used once, daily. The lesions cleared within 7 weeks without recurrence. The treatment with erl...
Source: Experimental and Therapeutic Medicine - January 28, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

lncRNA MIAT promotes cell invasion and migration in esophageal cancer.
Authors: Zhang W, Chen Q, Lei C Abstract Long non-coding RNAs (lncRNAs) serve crucial roles in carcinogenesis. Myocardial infarction-associated transcript (MIAT), originally isolated as a candidate gene for myocardial infarction, has been revealed to serve as an oncogene in chronic lymphocytic leukaemias and neuroendocrine prostate cancer. However, little is known about its expression pattern, biological function and underlying mechanism in esophageal cancer. Cell lines of esophageal cancer were used in the current study. The results of the present study revealed that MIAT knockdown decreased cell viability, migrat...
Source: Experimental and Therapeutic Medicine - April 10, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Non-sexual HPV transmission and role of vaccination for a better future (Review).
Authors: Petca A, Borislavschi A, Zvanca ME, Petca RC, Sandru F, Dumitrascu MC Abstract Human papilloma viruses (HPVs) belong to the Papillomaviridae family and are epitheliotropic infecting squamous epithelia (skin and mucosae). HPV is estimated to be the cause of 99% of cervical cancers (there is no evidence of significant genetic predisposition for cervical cancer), 90% of anal cancer, 65% vaginal cancers, 50% vulvar cancers, and 45-90% oropharyngeal cancers. The route of HPV transmission is primarily through skin-to-skin or skin-to-mucosa contact. Sexual transmission is the most documented, but there have been ...
Source: Experimental and Therapeutic Medicine - October 27, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research