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Infectious Disease: Malaria

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Stakeholder views of the practical and cultural barriers to epilepsy care in Uganda.
CONCLUSIONS: Based on these findings, there are four critical interventions that should be considered for improving epilepsy care in Uganda: the creation of dedicated epilepsy clinics, infrastructure strengthening to address medication stock-outs, community outreach programs for sensitization, and collaboration between biomedical providers and traditional healers. This article is part of the Special Issue "The Intersection of Culture, Resources, and Disease: Epilepsy Care in Uganda". PMID: 32758404 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - August 2, 2020 Category: Neurology Authors: Sanchez N, Kajumba M, Kalyegira J, Sinha DD, Bobholz S, Gualtieri A, Chakraborty P, Onuoha E, Fuller AT, Teuwen DE, Haglund MM, Koltai DC Tags: Epilepsy Behav Source Type: research

“They Merely Prescribe and I Merely Swallow”: Perceptions of Antenatal Pharmaceuticals and Nutritional Supplements Among Pregnant Women in Bamako, Mali
Conclusions for PracticeNational health programs looking to improve maternal and child health with ANC pharmaceuticals need to place greater attention on patient counseling and consistent implementation of administration guidelines. Communication that positions pharmaceuticals as beneficial to mother and child, while presenting understandable information about purpose, dosing and potential side effects can promote uptake of multi-drug regimens and ANC services in general.
Source: Maternal and Child Health Journal - September 11, 2019 Category: Health Management Source Type: research

Determinants of the use of insecticide-treated bed nets on islands of pre- and post-malaria elimination: an application of the health belief model in Vanuatu
The investigators applied Health Belief Model to examine perception or perceived perceptions and beliefs about malaria and the use of insecticide-treated nets on two islands of Vanuatu. The findings may have local and wider implications in settings similar to the study areas.
Source: Epidemiologic Perspectives and Innovations - November 20, 2014 Category: Epidemiology Authors: Noriko WatanabeAkira KanekoSam YamarHope LeodoroGeorge TaleoTakeo TanihataJ Koji LumPeter S Larson Source Type: research

Knowledge and social beliefs of malaria and prevention strategies among itinerant Nomadic Arabs, Fulanis and Dagazada groups in Chad: a mixed method study
Nomadic populations in Chad are at increased risk of contracting malaria because of their lifestyle. Being highly mobile they are often excluded from disease control programmes, and access to preventive measur...
Source: Malaria Journal - February 19, 2022 Category: Infectious Diseases Authors: Azoukaln é Moukénet, Beackgoubé Honoré, Helen Smith, Kebféné Moundiné, Wang-Mbe Djonkamla, Sol Richardson, Makido Dormbaye, Ngarkodje Ngarasta and Ibrahima Seck Tags: Research Source Type: research

Anemia among Schoolchildren with Malaria and Soil-Transmitted Helminth Coinfection after Repeated Rounds of Mass Drug Administration in Muheza District, Tanzania.
Abstract Coinfection with malaria and soil-transmitted helminths (STHs) has been common among school-aged children in Tanzania. However, after a countrywide scaling up of interventions for malaria and STHs, there are limited data on the prevalence of malaria-STH coinfection and its effect on anemia in schoolchildren in Tanzania. We assessed the distribution and risk factors for malaria, STHs, and malaria-STH coinfection, and its relation to anemia among 445 primary schoolchildren in Muheza district. A semi-structured questionnaire was used to collect demographic characteristics of the children. Malaria rapid diagn...
Source: The American Journal of Tropical Medicine and Hygiene - September 14, 2019 Category: Tropical Medicine Authors: Ngasala B, Matata F, Mwaiswelo R, Mmbando BP Tags: Am J Trop Med Hyg Source Type: research

Chronic Plasmodium chabaudi Infection Generates CD4 Memory T Cells with Increased T Cell Receptor Sensitivity but Poor Secondary Expansion and Increased Apoptosis Fungal and Parasitic Infections
Exposure to blood-stage malaria infection is often persistent, leading to generation of CD4 effector and effector memory T cells that contribute to protection. We showed previously that chronic exposure to blood-stage Plasmodium chabaudi offers the best protection from parasitemia and pathology in reinfection cases, correlating with an increase in Th1 cells. Although much is known about the features of resting or exhausted memory T cells (Tmem), little is known about the functional capacities of chronically stimulated but protective T cells. To determine the functional capacity of CD4 T cells generated by chronic infection...
Source: Infection and Immunity - February 22, 2017 Category: Infectious Diseases Authors: Opata, M. M., Stephens, R. Tags: Fungal and Parasitic Infections Source Type: research

Global Advocacy and Communications Effort Launched to Drive Action Against COVID-19 and Stop Future Pandemics
April 22, 2020, Seattle, WA – A network of leading international organizations announced today the creation of an advocacy initiative to ignite a global movement to help accelerate an end to the COVID-19 pandemic and enhance our preparedness to stop future pandemics. The Pandemic Action Network will advocate for policy changes and increased support and resources to ensure countries are better prepared to prevent, detect and respond to pandemic threats. This initiative will also host “For Humankind”, a new effort to promote accurate information to ensure people around the world understand what they need to do to prote...
Source: Johnson and Johnson - April 23, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Brokering the boundary between science and advocacy: the case of intermittent preventive treatment among infants
This article analyses a particular intervention in malaria control and the Consortium set up to accelerate its potential implementation. Using a framework that emphasizes the interplay of interests, institutions and ideas, it provides an example of how a network of committed researchers and funders attempted to follow a rational policy process, but faced conflicts and fundamental questions about their roles in generating scientific evidence and influencing global health policy. In an era of ever more and larger researcher groups and consortia, the findings offer insights and lessons to those engaged in the process of knowledge translation.
Source: Health Policy and Planning - August 27, 2013 Category: Health Management Authors: Cruz, V. O., Walt, G. Tags: Original articles Source Type: research

Rwanda ’s Nurses Communicate to Protect Themselves and Their Clients
By Casey Bishopp, Communications officer, IntraHealth International ; Philippe Kayibana, Community health facilitator, IngobyiApril 07, 2020Philippe Kayibanda is a registered nurse with 13 years of experience working to improve Rwanda’s health system. For him, it’s the power of communication that helps nurses meet their own needs while responding to COVID-19 and caring for patients.“I want nurses around the world to improve communication on their teams,” he says.“In order to be successful, we have to communicate our challenges, our experiences, and our lessons.”When Kayibanda became ...
Source: IntraHealth International - April 7, 2020 Category: International Medicine & Public Health Authors: cbishopp Tags: Infectious Diseases COVID-19 Education & Performance Leadership and Governance Health Workers Nurses Source Type: news

Factors associated with the use of deworming drugs during pregnancy in Tanzania; an analysis from the 2015 –16 Tanzanian HIV and malaria indicators survey
The use of deworming drugs is one of the important antenatal strategies in preventing anaemia in pregnancy. Little is known about the factors associated with the use of deworming drugs, which accounts for the ...
Source: BMC Pregnancy and Childbirth - January 22, 2022 Category: OBGYN Authors: Vicent Bankanie and Fabiola Vincent Moshi Tags: Research article Source Type: research

Reversible Conformational Change in the Plasmodium falciparum Circumsporozoite Protein Masks Its Adhesion Domains Fungal and Parasitic Infections
The extended rod-like Plasmodium falciparum circumsporozoite protein (CSP) is comprised of three primary domains: a charged N terminus that binds heparan sulfate proteoglycans, a central NANP repeat domain, and a C terminus containing a thrombospondin-like type I repeat (TSR) domain. Only the last two domains are incorporated in RTS,S, the leading malaria vaccine in phase 3 trials that, to date, protects about 50% of vaccinated children against clinical disease. A seroepidemiological study indicated that the N-terminal domain might improve the efficacy of a new CSP vaccine. Using a panel of CSP-specific monoclonal antibodi...
Source: Infection and Immunity - September 10, 2015 Category: Infectious Diseases Authors: Herrera, R., Anderson, C., Kumar, K., Molina-Cruz, A., Nguyen, V., Burkhardt, M., Reiter, K., Shimp, R., Howard, R. F., Srinivasan, P., Nold, M. J., Ragheb, D., Shi, L., DeCotiis, M., Aebig, J., Lambert, L., Rausch, K. M., Muratova, O., Jin, A., Reed, S. Tags: Fungal and Parasitic Infections Source Type: research

To end poverty, put science at the heart of development | Sue Desmond-Hellmann and Nick Hurd
Research and development must be harnessed to improve the lives of those with the greatest needs, whererever they areWe want to end extreme poverty. If you’re reading this, we’re pretty sure that you do as well. You will probably already know about the enormous progress being made – that between 1990 and 2015, the global under-five death rate, the malaria death rate, and the number of people living in extreme poverty all halved. Continue reading...
Source: Guardian Unlimited Science - March 16, 2016 Category: Science Authors: Sue Desmond-Hellmann and Nick Hurd Tags: Global development Department for International Development (DfID) Bill and Melinda Gates Foundation Medical research Science Research funding Africa Poverty Politics UK news World news Source Type: news

Knowledge, attitudes and practice of communities of Wolaita, Southern Ethiopia about long-lasting insecticidal nets and evaluation of net fabric integrity and insecticidal activity
This study was aimed at assessing knowledge, ...
Source: Parasites and Vectors - April 22, 2016 Category: Microbiology Authors: Zewdneh Tomass, Bereket Alemayehu, Meshesha Balkew and Dawit Leja Source Type: research

Native entomopathogenic Metarhizium spp. from Burkina Faso and their virulence against the malaria vector Anopheles coluzzii and non-target insects
Genetically enhanced Metarhizium pingshaense are being developed for malaria vector control in Burkina Faso. However, not much is known about the local prevalence and pathogenicity of this fungus, so we prospecte...
Source: Parasites and Vectors - March 27, 2018 Category: Microbiology Authors: Etienne Bilgo, Brian Lovett, Raymond J. St. Leger, Antoine Sanon, Roch K. Dabir é and Abdoulaye Diabaté Tags: Short report Source Type: research

Cost-effectiveness of a combined intervention of long lasting insecticidal nets and indoor residual spraying compared with each intervention alone for malaria prevention in Ethiopia
The effectiveness of long lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), for malaria prevention, have been established in several studies. However, the available evidence about the addit...
Source: Cost Effectiveness and Resource Allocation - November 22, 2018 Category: Health Management Authors: Alemayehu Hailu, Bernt Lindtj ørn, Wakgari Deressa, Taye Gari, Eskindir Loha and Bjarne Robberstad Tags: Research Source Type: research