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High-Fiber Diet Linked To Lower Risk Of Death And Chronic Illness
(CNN) — People who eat diets that are high in fiber have lower risk of death and chronic diseases such as stroke or cancer compared with people with low fiber intake, a new analysis found. Dietary fiber includes plant-based carbohydrates such as whole-grain cereal, seeds and some legumes. Fiber’s health benefits have been recorded “by over 100 years of research,” Andrew Reynolds, a researcher at the University of Otago in New Zealand, wrote in an email. He is co-author of the new meta-analysis of existing research, which was published Thursday in the journal The Lancet. The research shows that high...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 11, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN fiber Local TV Source Type: news

IJERPH, Vol. 18, Pages 1208: Household Cooking and Eating out: Food Practices and Perceptions of Salt/Sodium Consumption in Costa Rica
odríguez This research aims to study the food practices and perceptions related to excessive consumption of salt/sodium when cooking and eating outside the home in a study population representing the wide intergenerational and sociocultural diversity of Costa Rica. Key communities from around the country, cultural experts, and key informants were selected. Four qualitative research techniques were applied. Data was systematized based on the Social Ecological Model. Women are generally in charge of cooking and family food purchases. Salt is perceived as a basic ingredient, used in small amounts that can be reduced&...
Source: International Journal of Environmental Research and Public Health - January 29, 2021 Category: Environmental Health Authors: Adriana Blanco-Metzler Hilda N úñez-Rivas Jaritza Vega-Solano Maria A. Montero-Campos Karla Benavides-Aguilar Nazareth Cubillo-Rodr íguez Tags: Article Source Type: research

Sodium Intake among US School-Aged Children: National Health and Nutrition Examination Survey, 2011-2012
Conclusions With the exception of plain milk, which naturally contains sodium, the top 10 food categories contributing to US schoolchildren’s sodium intake during 2011-2012 comprised foods in which sodium is added during processing or preparation. Sodium is consumed throughout the day from multiple foods and locations, highlighting the importance of sodium reduction across the US food supply.
Source: Journal of the Academy of Nutrition and Dietetics - November 2, 2016 Category: Nutrition Source Type: research

P7 Relationship Between Sodium Consumption and Systolic and Diastolic Blood Pressure In Adults
Unhealthy eating habits is a top contributor to chronic disease burden in United States. Per American Heart Association, excessive sodium intake can raise blood pressure.
Source: Journal of Nutrition Education and Behavior - June 30, 2020 Category: Nutrition Authors: Arpita Hazra, Jamila Conliffe Tags: Basic Food and Nutrition Knowledge Source Type: research

Janssen Submits New Drug Application to U.S. FDA for XARELTO ® (rivaroxaban) to Help Prevent and Treat Blood Clots in Pediatric Patients
RARITAN, NJ, June 23, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for the use of XARELTO® (rivaroxaban) in pediatric patients. The NDA seeks two pediatric indications: treatment of venous thromboembolism (VTE, or blood clots) and reduction in the risk of recurrent VTE in patients aged birth to less than 18 years of age after at least five days of initial parenteral anticoagulant treatment; and thromboprophylaxis (prevention of blood clots) in patients aged 2 years and older with congenita...
Source: Johnson and Johnson - June 23, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

FDA Approves Two New Indications for XARELTO ® (rivaroxaban) to Help Prevent and Treat Blood Clots in Pediatric Patients
RARITAN, NJ, Dec. 20, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved two pediatric indications for XARELTO® (rivaroxaban): the treatment of venous thromboembolism (VTE, or blood clots) and reduction in the risk of recurrent VTE in patients from birth to less than 18 years after at least five days of initial parenteral (injected or intravenous) anticoagulant treatment; and thromboprophylaxis (prevention of blood clots and blood-clot related events) in children aged two years and older with congenital heart disease who have...
Source: Johnson and Johnson - December 21, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Data from New VOYAGER PAD Analyses at ACC.22 Reinforce Benefit of XARELTO ® (rivaroxaban) Plus Aspirin in Patients with Peripheral Artery Disease (PAD) and Various Co-Morbid Conditions
RARITAN, N.J., April 1, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from new analyses from the Phase 3 VOYAGER PAD clinical trial reinforcing the benefit of the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily plus aspirin 100 mg once daily) in reducing severe vascular events in patients with PAD after lower-extremity revascularization (LER), a procedure that restores blood flow to the legs. Data from the two analyses demonstrate the role that the XARELTO® vascular dose plays in PAD patients with and without chronic kidney disease (CKD) and in PAD patients with and ...
Source: Johnson and Johnson - April 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

IJERPH, Vol. 16, Pages 2732: Progress Evaluation for Transnational Restaurant Chains to Reformulate Products and Standardize Portions to Meet Healthy Dietary Guidelines and Reduce Obesity and Non-Communicable Disease Risks, 2000 –2018: A Scoping and Systematic Review to Inform Policy
This study examined whether transnational restaurant chains reformulated products and standardized portions aligned with healthy dietary guidelines and criteria. Firstly, we describe the transnational restaurant industry structure and eating trends. Secondly, we summarize results from a scoping review of healthy dietary guidelines for restaurants. Thirdly, we describe a systematic review of five electronic databases (2000–2018) to identify studies on nutrient profile and portion size changes made by transnational restaurants over 18 years. We used Preferred Reporting Items for Systematic Reviews and Meta-Anal...
Source: International Journal of Environmental Research and Public Health - July 30, 2019 Category: Environmental Health Authors: Vivica Kraak Sofia Rinc ón-Gallardo Patiño Deepthi Renukuntla Eojina Kim Tags: Review Source Type: research

Platelet dysfunction during trauma involves diverse signaling pathways and an inhibitory activity in patient-derived plasma
CONCLUSION Platelet dysfunction in trauma patients included poor response to multiple agonists relevant to hemostatic function. Furthermore, the inhibitor effect of patient plasma on healthy platelets suggests that soluble plasma species may downregulate endogenous or transfused platelets during trauma.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - February 1, 2019 Category: Orthopaedics Tags: ORIGINAL ARTICLES Source Type: research

Feasibility of collecting 24-h urine to monitor sodium intake in the National Health and Nutrition Examination Survey Nutritional epidemiology and public health
Conclusion: Given the 53% final component response rate and 75% completion rate, 24-h urine collections were deemed feasible and implemented in the NHANES 2014 on a subsample of adults aged 20–69 y to assess population sodium intake. This study was registered at clinicaltrials.gov as NCT02723682.
Source: American Journal of Clinical Nutrition - July 31, 2016 Category: Nutrition Authors: Terry, A. L., Cogswell, M. E., Wang, C.-Y., Chen, T.-C., Loria, C. M., Wright, J. D., Zhang, X., Lacher, D. A., Merritt, R. K., Bowman, B. A. Tags: Nutritional epidemiology and public health Source Type: research

Lessons learned about epithelial sodium channels from transgenic mouse models
Purpose of review This review provides an up-to-date understanding about the regulation of epithelial sodium channel (ENaC) expression and function. In particular, we will focus on its implication in renal Na+ and K+ handling and control of blood pressure using transgenic animal models. Recent findings In kidney, the highly amiloride-sensitive ENaC maintains whole body Na+ homeostasis by modulating Na+ transport via epithelia. This classical role is mostly confirmed using genetically engineered animal models. Recently identified key signaling pathways that regulate ENaC expression and function unveiled some nonc...
Source: Current Opinion in Nephrology and Hypertension - August 1, 2022 Category: Urology & Nephrology Tags: MOLECULAR CELL BIOLOGY AND PHYSIOLOGY OF SOLUTE TRANSPORT: Edited by Gerardo Gamba and María Castañeda-Bueno Source Type: research

Effects of SGLT-2 inhibitors on adipose tissue distribution in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
Sodium-glucose cotransporter-2 (SGLT-2) inhibitors therapies were reported to affect adipose tissue distribution. However, the available evidence about the effect of SGLT-2 inhibitor on adipose tissue is contr...
Source: Diabetology and Metabolic Syndrome - May 31, 2023 Category: Endocrinology Authors: Xianghong Wang, Niujian Wu, Chuanchuan Sun, Donghua Jin and Hongyun Lu Tags: Research Source Type: research

5-HT neurons of the area postrema become c-Fos-activated after increases in plasma sodium levels and transmit interoceptive information to the nucleus accumbens
Serotonergic (5-hydroxytryptamine, 5-HT) neurons of the area postrema (AP) represent one neuronal phenotype implicated in the regulation of salt appetite. Tryptophan hydroxylase (Tryp-OH, synthetic enzyme-producing 5-HT) immunoreactive neurons in the AP of rats become c-Fos-activated following conditions in which plasma sodium levels are elevated; these include intraperitoneal injections of hypertonic saline and sodium repletion. Non-Tryp-OH neurons also became c-Fos-activated. Sodium depletion, which induced an increase in plasma osmolality but caused no significant change in the plasma sodium concentration, had no effect...
Source: AJP: Regulatory, Integrative and Comparative Physiology - May 1, 2014 Category: Physiology Authors: Miller, R. L., Loewy, A. D. Tags: Fluid and Electrolyte Homeostasis Source Type: research

Fibroblast growth factor 23 and α-Klotho co-dependent and independent functions
Purpose of review The current review examines what is known about the FGF-23/α-Klotho co-dependent and independent pathophysiological effects, and whether FGF-23 and/or α-Klotho are potential therapeutic targets. Recent findings FGF-23 is a hormone derived mainly from bone, and α-Klotho is a transmembrane protein. Together they form a trimeric signaling complex with FGFRs in target tissues to mediate the physiological functions of FGF-23. Local and systemic factors control FGF-23 release from osteoblast/osteocytes in bone, and circulating FGF-23 activates FGFR/α-Klotho complexes in kidney proximal and distal renal...
Source: Current Opinion in Nephrology and Hypertension - November 28, 2018 Category: Urology & Nephrology Tags: HORMONES, AUTACOIDS, NEUROTRANSMITTERS AND GROWTH FACTORS: Edited by Mark Cooper and Merlin Thomas Source Type: research

Factors affecting the removal of bromate and bromide in water by nanofiltration.
In this study, the removal of bromate and bromide by nanofiltration membranes were systematically investigated, considering the system pressure (0.2-0.3-0.4 MPa), pH (5-7-9), ionic strength (0.005-0.05-0.1 mM), membrane type (NF270 and NF90), and the influences of organic matters (humic acid and sodium alginate). The membrane flux and the removal efficiency of anions were taken into consideration. According to the results, the membrane flux increased along with the system pressure, but slight influence on the removal of bromate and bromide was observed. Rising pH and ionic strength could not obviously deteriorate the flu...
Source: Environmental Science and Pollution Research International - July 26, 2019 Category: Environmental Health Authors: Lin D, Liang H, Li G Tags: Environ Sci Pollut Res Int Source Type: research