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Therapy: Neoadjuvant Therapy
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Topographic expression of the Hippo transducers TAZ and YAP in triple-negative breast cancer treated with neoadjuvant chemotherapy
The Hippo signaling acts as a tumor-suppressor pathway that negatively regulates TAZ and YAP. Increasing evidence supports the activation of TAZ and YAP in breast cancer. Moreover, the Hippo pathway is involve...
Source: Journal of Experimental and Clinical Cancer Research - April 2, 2016 Category: Cancer & Oncology Authors: Patrizia Vici, Cristiana Ercolani, Anna Di Benedetto, Laura Pizzuti, Luigi Di Lauro, Francesca Sperati, Irene Terrenato, Teresa Gamucci, Clara Natoli, Franco Di Filippo, Claudio Botti, Maddalena Barba, Marcella Mottolese, Ruggero De Maria and Marcello Mau Source Type: research
Evaluation of intraarterial and intravenous cisplatin chemotherapy in the treatment of metastatic osteosarcoma using an orthotopic xenograft mouse model
Osteosarcoma is the most common primary malignancy of bone. Its treatment relies on the administration of neoadjuvant and adjuvant chemotherapy combined with surgery. Alternative to common intravenous (i.v.) a...
Source: Journal of Experimental and Clinical Cancer Research - July 16, 2016 Category: Cancer & Oncology Authors: Bernhard Robl, Sander Martijn Botter, Giovanni Pellegrini, Olga Neklyudova and Bruno Fuchs Source Type: research
The role of extracelluar matrix in osteosarcoma progression and metastasis
Osteosarcoma (OS) is the most common primary bone malignancy and responsible for considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although neoadjuvant chemotherapy has improv...
Source: Journal of Experimental and Clinical Cancer Research - September 4, 2020 Category: Cancer & Oncology Authors: Juncheng Cui, Dylan Dean, Francis J. Hornicek, Zhiwei Chen and Zhenfeng Duan Tags: Review Source Type: research
The global landscape of neoadjuvant and adjuvant anti-PD-1/PD-L1 clinical trials
The neoadjuvant and adjuvant anti-PD-1/PD-L1 treatment has been increasingly noticed. To summarize the global landscape of these clinical trials will provide essential data for all the stakeholders of drug dev...
Source: Journal of Hematology and Oncology - February 8, 2022 Category: Hematology Authors: Dawei Wu, Huiyao Huang, Minghui Zhang, Ziwei Li, Shuhang Wang, Yue Yu, Yuan Fang, Ning Jiang, Huilei Miao, Peiwen Ma, Yu Tang and Ning Li Tags: Letter to the Editor Source Type: research
Survival of patients with pathologic T0N+ oral and oropharyngeal cancer after neoadjuvant therapy and surgery: the minority report
Conclusions:
Survival analyses showed that patients with OOSCC with ypT0N+ disease have a similar prognosis to those with pathologic TNM stage I.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 31, 2012 Category: ENT & OMF Authors: Christos Perisanidis, Irene Sulzbacher, Martina Mittlböck, David Mitchell, Cornelia Czembirek, Rudolf Seemann, Rolf Ewers, Christian Schopper, Edgar Selzer Tags: Oral and Maxillofacial Surgery Source Type: research
Current treatment of rectal cancer: The watch-and-wait method. Are we there yet?
Abstract: Surgery remains the standard treatment of rectal carcinoma, with the use of neoadjuvant chemotherapy and radiation for locally advanced rectal carcinoma significantly decreasing local recurrence rates, as well as providing tumor downstaging. In those patients who exhibit complete pathological response, the question of the benefit of surgical resection and the utility of a ‘wait-and-see’ approach has been raised. However, the variability in determining a true pathological complete response, as well as the inability to accurately stage the nodes, argues against a non-operative approach. Many small series have a...
Source: Seminars in Colon and Rectal Surgery - August 30, 2013 Category: Gastroenterology Authors: Sarah Y. Boostrom, Heidi Nelson Tags: Current Treatment of Rectal Cancer: Optimizing Surgery and Individualizing Chemoradiation Source Type: research
Are Females Predisposed to Complications in Head and Neck Cancer Free Flap Reconstruction?
Conclusions: Multivariate analysis of the data revealed that the factor associated with an increased incidence of postoperative complications was preoperative radiotherapy. Moreover, the variable that remained statistically significant and correlated with an increased incidence and severity of free flap reconstruction complications was female gender. Identifying the etiology of these findings is an intriguing field for additional research.
Source: Journal of Oral and Maxillofacial Surgery - July 15, 2013 Category: ENT & OMF Authors: Anastasia Loupatatzi, Spyridon Dimitrios Stavrianos, Fotios Filippos Karantonis, Anastasios Machairas, Alexander D. Rapidis, George Kokkalis, Othon Papadopoulos Tags: Surgical Oncology and Reconstruction Source Type: research
Incidence and location of lymph node metastases in patients undergoing radical cystectomy for clinical non–muscle invasive bladder cancer: Results from a prospective lymph node mapping study
Conclusions: Routine LND is important in patients with cT1 and cTis-only bladder cancer, but may have limited value in patients with cTa. LNM beyond the boundaries of a standard LND occurred in up to one-third of node-positive patients. In the absence of skip metastases, however, performing a standard LND would correctly identify all node-positive patients. Whether removal of LNM proximal to the common iliac vessels provides a survival benefit remains to be evaluated in future prospective studies.
Source: Urologic Oncology: Seminars and Original Investigations - February 8, 2013 Category: Urology & Nephrology Authors: Harman M. Bruins, Eila C. Skinner, Ryan P. Dorin, Hamed Ahmadi, Hooman Djaladat, Gus Miranda, Jie Cai, Siamak Daneshmand Tags: Abstracts for Online Original Articles and Reviews Source Type: research
The presence of positive surgical margins in patients with organ-confined prostate cancer results in biochemical recurrence at a similar rate to that in patients with extracapsular extension and PSA≤10ng/ml
Abstract: Purposes: We investigated whether patients with organ-confined prostate cancer (PCa) and positive surgical margins (SMs) had a similar biochemical recurrence (BCR) risk compared with patients with pT3a and preoperative prostate-specific antigen (PSA) levels≤10ng/ml. Furthermore, we examined the effects of incorporating SM status, Gleason score (Gls), and preoperative PSA level into the discrimination accuracy of the current tumor node metastasis-staging system.Materials and methods: We analyzed 863 PCa patients treated with radical prostatectomy from 1999 to 2008. Only individuals with pT2N0 or pT3N0, without n...
Source: Urologic Oncology: Seminars and Original Investigations - February 21, 2013 Category: Urology & Nephrology Authors: Okyaz Eminaga, Reemt Hinkelammert, Ulf Titze, Mahmoud Abbas, Elke Eltze, Olaf Bettendorf, Axel Semjonow Tags: Abstracts for Online Original Articles and Reviews Source Type: research
High rates of advanced disease, complications, and decline of renal function after radical nephroureterectomy
Abstract: Objectives: Recurrences remain common following radical nephroureterectomy (RNU) for locally advanced upper-tract urothelial carcinoma (UTUC). We review a cohort of RNU patients to identify the incidence of locally advanced disease, decline in renal function, complications, and utilization of adjuvant chemotherapy (AC).Methods: Institutional databases from 7 academic medical centers identified 414 RNU patients treated between 2003 and 2012 who had not received neoadjuvant chemotherapy. Glomerular filtration rate was estimated using the Modification of Diet in Renal Disease equation. Complications were classified ...
Source: Urologic Oncology: Seminars and Original Investigations - October 21, 2013 Category: Urology & Nephrology Authors: Jay D. Raman, Yu-Kuan Lin, Matthew Kaag, Timothy Atkinson, Paul Crispen, Mark Wille, Norm Smith, Mark Hockenberry, Thomas Guzzo, Benoit Peyronnet, Karim Bensalah, Jay Simhan, Alexander Kutikov, Eugene Cha, Michael Herman, Douglas Scherr, Shahrokh F. Shari Tags: Abstracts for Online Original Articles and Reviews Source Type: research
Effect of diabetes mellitus and metformin use on oncologic outcomes of patients treated with radical cystectomy for urothelial carcinoma
Conclusions: Diabetic patients who do not use metformin appear to be at higher risk of cancer-specific and any-cause mortality than patients without DM. It remains unclear, whether the severity of DM in this group of patients or the use of metformin itself affects outcomes of UCB. The mechanisms behind the effect of DM on patients with UCB and the potential protective effect of metformin need further elucidation.
Source: Urologic Oncology: Seminars and Original Investigations - October 21, 2013 Category: Urology & Nephrology Authors: Malte Rieken, Evanguelos Xylinas, Luis Kluth, Joseph J. Crivelli, James Chrystal, Talia Faison, Yair Lotan, Pierre I. Karakiewicz, Maxine Sun, Harun Fajkovic, Marek Babjuk, Alexander Bachmann, Douglas S. Scherr, Shahrokh F. Shariat Tags: Abstracts for Online Original Articles and Reviews Source Type: research
Abstract PL01-01: Distinct immune and metabolic signatures in prostate and breast tumors of African American patients
Not all segments of the U.S. population have equally benefited from the advances in our knowledge and treatment of cancer. As a result, some population groups experience a disproportionally high cancer burden, leading to excessively high cancer mortality rates in the African American community when compared with other communities. For example, African American patients have the highest prostate and breast cancer mortalities among all U.S. racial and ethnic groups. This survival disparity has been attributed to a number of factors including differences in insurance status and medical care. However, other observations sugges...
Source: Cancer Epidemiology Biomarkers and Prevention - November 13, 2014 Category: Cancer & Oncology Authors: Ambs, S. Tags: Tumor Microenvironment Differences among African American and Caucasian Breast and Prostate Cancer Patients: Oral Presentations - Invited Abstracts Source Type: research
miR-17-92a-1 cluster host gene (MIR17HG) evaluation and response to neoadjuvant chemoradiotherapy in rectal cancer
Chiara Molinari,1 Samanta Salvi,1 Flavia Foca,2 Nazario Teodorani,3 Luca Saragoni,4 Maurizio Puccetti,5 Alessandro Passardi,6 Stefano Tamberi,7 Andrea Avanzolini,8 Enrico Lucci,8 Daniele Calistri1 1Biosciences Laboratory, 2Unit of Biostatistics and Clinical Trials, 3Radiotherapy Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, 4Pathology Unit, Morgagni-Pierantoni Hospital, Forlì, 5Pathology Unit, Santa Maria delle Croci Hospital, Ravenna, 6Department of Medical Oncology, IRST IRCCS, Meldola, 7Department of Medical Oncology, Infermi Hospital, Faenza, 8Department of Genera...
Source: OncoTargets and Therapy - May 5, 2016 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Dual HER2 blockade in the neoadjuvant and adjuvant treatment of HER2-positive breast cancer
Pooja Advani,1 Lauren Cornell,2 Saranya Chumsri,1 Alvaro Moreno-Aspitia1 1Division of Hematology and Oncology, 2Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA Abstract: Human epidermal growth factor receptor 2 (HER2) is a tyrosine kinase transmembrane receptor that is overexpressed on the surface of 15%–20% of breast tumors and has been associated with poor prognosis. Consistently improved pathologic response and survival rates have been demonstrated with use of trastuzumab in combination with standard chemotherapy in both early and advanced breast cancer. However, resistance to trastuzumab may p...
Source: Vascular Health and Risk Management - September 22, 2015 Category: Cardiology Tags: Breast Cancer: Targets and Therapy Source Type: research
