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Development and Validation of a Model to Predict Absolute Vascular Risk Reduction by Moderate-Intensity Statin Therapy in Individual Patients With Type 2 Diabetes Mellitus: The Anglo Scandinavian Cardiac Outcomes Trial, Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, and Collaborative Atorvastatin Diabetes Study Original Articles
Conclusions— ARRs of major cardiovascular events by statin therapy can be accurately estimated for individual patients with type 2 diabetes mellitus using a model based on routinely available patient characteristics. There is a wide distribution in ARR that may complement informed decision making. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00327418 (CARDS) and NCT00000542 (ALLHAT).
Source: Circulation: Cardiovascular Quality and Outcomes - May 16, 2016 Category: Cardiology Authors: Kaasenbrood, L., Poulter, N. R., Sever, P. S., Colhoun, H. M., Livingstone, S. J., Boekholdt, S. M., Pressel, S. L., Davis, B. R., van der Graaf, Y., Visseren, F. L. J., on behalf of the CARDS, ALLHAT, and ASCOT Investigators Tags: Lipids and Cholesterol, Diabetes, Type 2, Primary Prevention, Secondary Prevention Original Articles Source Type: research

A twist on the genetic link between Alzheimer’s and heart disease
Alzheimer’s disease often strikes fear in people’s hearts because it gradually erodes a person’s ability to remember, think, and learn. There is no cure, and available treatments alleviate symptoms only temporarily. An estimated 5.3 million Americans currently have Alzheimer’s disease, yet this brain disorder is far less common than heart disease. More than 85 million people in the United States are living with some form of cardiovascular disease or the after-effects of stroke, which also affects brain function. Many people don’t realize that Alzheimer’s and heart disease share a genetic link: the apolipoprotei...
Source: New Harvard Health Information - March 25, 2016 Category: Consumer Health News Authors: Julie Corliss Tags: Alzheimer's Disease Behavioral Health Brain and cognitive health Genes Healthy Aging Heart Health Memory Mental Health Source Type: news

A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions
Conclusion In closing, our patient’s episode of TGA combined with her emotional and perceptual response lends credence to the proposal of a “fear/paranoia” circuit in the genesis of paranoid delusions—a circuit incorporating amygdala, frontal, and parietal cortices. Here, neutral or irrelevant stimuli, thoughts, and percepts come to engender fear and anxiety, while dysfunction in frontoparietal circuitry engenders inappropriate social predictions and maladaptive inferences about the intentions of others.[54] Hippocampus relays information about contextual information based on past experiences and the current situat...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Behavioral and Cognitive Neurology Case Report Cognition Current Issue Dementia Medical Issues Neurologic Systems and Symptoms Psychiatry Schizophrenia delusions hippocampus neurobiology Transient global amnesia Source Type: research

Data from New VOYAGER PAD Analyses at ACC.22 Reinforce Benefit of XARELTO ® (rivaroxaban) Plus Aspirin in Patients with Peripheral Artery Disease (PAD) and Various Co-Morbid Conditions
RARITAN, N.J., April 1, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from new analyses from the Phase 3 VOYAGER PAD clinical trial reinforcing the benefit of the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily plus aspirin 100 mg once daily) in reducing severe vascular events in patients with PAD after lower-extremity revascularization (LER), a procedure that restores blood flow to the legs. Data from the two analyses demonstrate the role that the XARELTO® vascular dose plays in PAD patients with and without chronic kidney disease (CKD) and in PAD patients with and ...
Source: Johnson and Johnson - April 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

Development and Validation of Electronic Quality Measures to Assess Care for Patients With Transient Ischemic Attack and Minor Ischemic Stroke Original Articles
Conclusions— It is feasible to construct valid eQMs for processes of transient ischemic attack and minor ischemic stroke care. Healthcare systems with EHRs should consider using electronic data to evaluate care for their patients with transient ischemic attack and to complement and expand quality measurement programs currently focused on patients with stroke.
Source: Circulation: Cardiovascular Quality and Outcomes - September 14, 2017 Category: Cardiology Authors: Bravata, D. M., Myers, L. J., Cheng, E., Reeves, M., Baye, F., Yu, Z., Damush, T., Miech, E. J., Sico, J., Phipps, M., Zillich, A., Johanning, J., Chaturvedi, S., Austin, C., Ferguson, J., Maryfield, B., Snow, K., Ofner, S., Graham, G., Rhude, R., William Tags: Quality and Outcomes, Transient Ischemic Attack (TIA) Original Articles Source Type: research

Diabetes Mellitus and Cardiovascular Events in Older Patients With Myocardial Infarction Prescribed Intensive-Dose and Moderate-Dose Statins Original Articles
Conclusions— In older patients with myocardial infarction, we found intensive-dose statin therapy to be effective in reducing repeat hospitalization for acute coronary syndrome. The rate of new-onset diabetes mellitus at long term was not significantly different between intensive-dose and moderate-dose statins.
Source: Circulation: Cardiovascular Quality and Outcomes - May 21, 2013 Category: Cardiology Authors: Ko, D. T., Wijeysundera, H. C., Jackevicius, C. A., Yousef, A., Wang, J., Tu, J. V. Tags: Health policy and outcome research, Type 2 diabetes, Acute myocardial infarction Original Articles Source Type: research

Quantitative assessment of the contribution of sodium‐dependent taurocholate co‐transporting polypeptide (NTCP) to the hepatic uptake of rosuvastatin, pitavastatin and fluvastatin
This article is protected by copyright. All rights reserved.
Source: Biopharmaceutics and Drug Disposition - July 1, 2013 Category: Drugs & Pharmacology Authors: Yi‐an Bi, Xi Qiu, Charles J. Rotter, Emi Kimoto, Mary Piotrowski, Manthena V. Varma, Ayman F. EI‐Kattan, Yurong Lai Tags: Original Papers Source Type: research

Relationship Between Care Gaps and Projected Life Expectancy After Acute Myocardial Infarction Original Articles
Conclusions— Life expectancy of a patient strongly influences evidence-based treatment in acute myocardial infarction. It was seen not only among patients with limited life expectancies but also among those with many years to live. Treatment care gaps may reflect clinicians’ synthesis about frailty and life-expectancy gains.
Source: Circulation: Cardiovascular Quality and Outcomes - July 15, 2014 Category: Cardiology Authors: Ko, D. T., Austin, P. C., Tu, J. V., Lee, D. S., Yun, L., Alter, D. A. Tags: Health policy and outcome research, Secondary prevention, Acute myocardial infarction Original Articles Source Type: research

Update on the pathogenesis and treatment of the antiphospholipid syndrome
Purpose of review: Many advancements in our understanding of the pathogenic mechanisms of the antiphospholipid syndrome (APS) have been accomplished over the recent months. Such progresses are paralleled by the development of innovative pharmacological tools that could provide novel therapeutic windows in APS management. The most recent and innovative findings about the biologic effects of antiphospholipid antibodies (aPLs) and the treatment APS will be hereby critically appraised. Recent findings: Antibodies against the domain I of β2 glycoprotein I (β2GPI) are increasingly recognized as the main pathogenic subset; pion...
Source: Current Opinion in Rheumatology - July 31, 2015 Category: Rheumatology Tags: SYSTEMIC LUPUS ERYTHEMATOSUS AND SJOGREN'S SYNDROME: Edited by Mariana J. Kaplan Source Type: research

Clinician time used for decision making: a best case workflow study using cardiovascular risk assessments and Ask Mayo Expert algorithmic care process models
Risk calculation is increasingly used in lipid management, congestive heart failure, and atrial fibrillation. The risk scores are then used for decisions about statin use, anticoagulation, and implantable defi...
Source: BMC Medical Informatics and Decision Making - July 20, 2016 Category: Information Technology Authors: Frederick North, Samuel Fox and Rajeev Chaudhry Source Type: research

Response of PXR signaling pathway to simvastatin exposure in mosquitofish (Gambusia affinis) and its histological changes.
Abstract As a widely used lipid lowering agent, simvastatin recently has been frequently detected in aquatic environment and the potential adverse effects from simvastatin exposure to non-target organisms such as fish is worthy of more attention. The aim of this study was to reveal the responses of detoxification system in fish to simvastatin exposure. In this investigation a ubiquitous small freshwater fish, mosquito fish (Gambusia affinis), was employed as test organism, and the transcriptional expression of nucleus transcriptional factor pregnane X receptor (PXR) and its downstream genes, including P-glycoprote...
Source: Ecotoxicology and Environmental Safety - February 21, 2018 Category: Environmental Health Authors: Bao S, Nie X, Liu Y, Wang C, Liu S Tags: Ecotoxicol Environ Saf Source Type: research

Is Statin Use Associated With New Joint‐Related Symptoms, Physical Function, and Quality of Life? Results From Two Population‐Based Cohorts of Women
ConclusionThis large study did not demonstrate an association between statin use and reduced onset of joint pain/stiffness. Associations between statin use and poor physical functioning and poor SRH may be explained by factors other than joint pain/stiffness, e.g., muscle pain.
Source: Arthritis Care and Research - December 27, 2014 Category: Rheumatology Authors: Geeske Peeters, Susan E. Tett, Philip G. Conaghan, Gita D. Mishra, Annette J. Dobson Tags: Special Theme Articles: Mobility and the Rheumatic Diseases Source Type: research

Long-Term Effect of Fee-For-Service-Based Reimbursement Cuts on Processes and Outcomes of Care for Stroke: Interrupted Time-Series Study From Taiwan Original Articles
Conclusions— There are improvement trends in processes and outcomes of care over time. However, the reimbursement cuts from the FFS-based global budget cap are associated with trend changes in processes and outcomes of care for stroke. The FFS-based reimbursement cuts may have long-term positive and negative associations with stroke care.
Source: Circulation: Cardiovascular Quality and Outcomes - January 20, 2015 Category: Cardiology Authors: Tung, Y.-C., Chang, G.-M., Cheng, S.-H. Tags: Health policy and outcome research Original Articles Source Type: research

Abstract 112: Adherence and Persistence with Statins in Patients with ASCVD Session Title: Abstract Poster Session I and Reception
Conclusions: While patients remained on their first statin (or ezetimibe) therapy for a substantial period of time, a large proportion of patients eventually discontinue therapy. Overall, adherence was high, indicating that ASCVD patients are compliant with their LLT. Interventions and new treatments to improve lipid lowering therapy seem necessary in patients with ASCVD.
Source: Circulation: Cardiovascular Quality and Outcomes - February 26, 2016 Category: Cardiology Authors: Burke, J. P., Paoli, C. J., McPheeters, J., Gandra, S. R., Simpson, R. J. Tags: Session Title: Abstract Poster Session I and Reception Source Type: research

Statins Are Associated With Reduced Risk of Esophageal Cancer, Particularly in Patients With Barrett's Esophagus: A Systematic Review and Meta-analysis
Conclusions: Based on meta-analysis of observational studies, statin use may be associated with lower risk of esophageal cancer, particularly risk of EAC in patients with BE.
Source: Clinical Gastroenterology and Hepatology - January 28, 2013 Category: Gastroenterology Authors: Siddharth Singh, Abha Goyal Singh, Preet Paul Singh, Mohammad Hassan Murad, Prasad G. Iyer Tags: Systematic Reviews and Meta-analyses Source Type: research