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Childhood asthma clusters and response to therapy in clinical trials
Conclusions: In this study, we replicated SARP pediatric asthma clusters by using a separate, large clinical trials network. Early-onset/severe-lung function and early-onset/comorbidity clusters were associated with differential and limited response to therapy, respectively. Further prospective study of therapeutic response by cluster could provide new insights into childhood asthma treatment.
Source: Journal of Allergy and Clinical Immunology - October 17, 2013 Category: Allergy & Immunology Authors: Timothy S. Chang, Robert F. Lemanske, David T. Mauger, Anne M. Fitzpatrick, Christine A. Sorkness, Stanley J. Szefler, Ronald E. Gangnon, C. David Page, Daniel J. Jackson, Childhood Asthma Research and Education (CARE) Network Investigators Tags: Asthma and lower airway disease Source Type: research

Changing adherence-related beliefs about ICS maintenance treatment for asthma: feasibility study of an intervention delivered by asthma nurse specialists
Conclusions The intervention changed nurse consultations, but not sufficiently enough to fully address non-adherence or adherence-related ICS beliefs (necessity and concerns). More effective techniques are needed to support nurse specialists and other practitioners to apply the intervention in hospital asthma review consultations.
Source: BMJ Open - June 5, 2015 Category: Journals (General) Authors: Chapman, S. C. E., Barnes, N., Barnes, M., Wilkinson, A., Hartley, J., Piddock, C., Weinman, J., Horne, R. Tags: Open access, Patient-centred medicine, Pharmacology and therapeutics, Respiratory medicine Research Source Type: research

Changes in clinical conversations when providers are informed of asthma patients' beliefs about medication use and integrative medical therapies
Conclusion When providers had knowledge of their patient's IM endorsement or negative ICS beliefs, they initiated conversations about these modifiable beliefs. Without training in IM and in effective communication techniques, it is unlikely that providers will be able to effectively engage in shared decision-making aimed at improving asthma self-management.
Source: Heart and Lung: The Journal of Acute and Critical Care - December 18, 2015 Category: Respiratory Medicine Source Type: research

Late Breaking Abstract - Identifying and addressing patient beliefs driving SABA use and over-reliance
Conclusion: Patient beliefs driving SABA ROU are amenable to change using brief behaviourally-intelligent messages.References:1. Pavord et al. Lancet 2018;391:350-400.2. Horne et al. Psychology & Health 1999;14:1-24.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Horne, R., Chan, A., Haughney, J., Correia De Sousa, J., Williams, S., Kaplan, A. Tags: Airway pharmacology and treatment Source Type: research

Reframing asthma and inhaled corticosteroids (ICS) to modify treatment beliefs: an online randomised controlled trial
We examined its effect on ICS-beliefs and adherence in people without asthma (asthma-naïve, a proxy for newly-diagnosed patients) and with asthma.We randomised 503 adults reporting asthma and 388 asthma-naïve to: Control (NHS-information) vs BM-text vs BM-video. N-C medication beliefs, adherence and intentions were assessed post-intervention and follow-up (2wk).Asthma-naïve: BM-video participants reported higher N (F(2,252)=7.1, p=.001) and lower C (F(2,252)=9.6, p<.0001) than controls. Both BM-text and video groups reported higher intentions to adhere than controls post-intervention (F(2,252)=23...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Katzer, C. B., Wileman, V., Chan, A. H. Y., Taylor, S. J. C., Horne, R. Tags: Medical education, web and internet Source Type: research

Changes in clinical conversations when providers are informed of asthma patients' beliefs about medication use and integrative medical therapies
To explore whether patient's personal beliefs about inhaled corticosteroid (ICS) and integrative medicine (IM) are discussed at routine primary care visits for asthma.
Source: Heart and Lung - December 17, 2015 Category: Intensive Care Authors: Maureen George, Sarah Abboud, Michael V. Pantalon, Marilyn (Lynn) S. Sommers, Jun Mao, Cynthia Rand Tags: Care of Patients with Pulmonary Disorders Source Type: research

Asthma medication adherence: the role of God and other health locus of control factors.
CONCLUSION: Patients' belief in God's control of health appears to be a factor in asthma controller use, and therefore should be considered in physician-patient discussions concerning course of treatment. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00459368. PMID: 23352524 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - January 30, 2013 Category: Allergy & Immunology Authors: Ahmedani BK, Peterson EL, Wells KE, Rand CS, Williams LK Tags: Ann Allergy Asthma Immunol Source Type: research

Consumers attitudes and beliefs towards the receipt of antenatal corticosteroids and use of clinical practice guidelines
Active participation of consumers in health care decision making, policy and clinical research is increasingly encouraged by governments, influential bodies and funders. Identifying the best way to achieve thi...
Source: BMC Pregnancy and Childbirth - September 5, 2016 Category: OBGYN Authors: E. L. McGoldrick, T. Crawford, J. A. Brown, K. M. Groom and C. A. Crowther Source Type: research

Non‐adherence in children with asthma reviewed: the need for improvement of asthma care and medical education
This article is protected by copyright. All rights reserved.
Source: Pediatric Allergy and Immunology - February 23, 2015 Category: Allergy & Immunology Authors: Ted Klok, Adrian A. Kaptein, Paul L. Brand Tags: Review Source Type: research

Janssen Presents Study Results Showing Clinical Efficacy for TREMFYA ® (guselkumab) and Long-Term Safety Profile for STELARA® (ustekinumab) for Patients Living with Inflammatory Bowel Disease at Digestive Disease Week® 2022
SPRING HOUSE, PENNSYLVANIA, May 24, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new data from the Phase 2 GALAXI 1 clinical trial of TREMFYA® (guselkumab) in adult patients with moderately to severely active Crohn’s disease (CD), and from three separate long-term pooled analyses of adult patients with ulcerative colitis (UC) and CD treated with STELARA® (ustekinumab).1,2,3,4 These data are being presented as oral and poster presentations and are among 29 Janssen abstracts presented during the Digestive Disease Week® (DDW) meeting taking place in person and virtually in San Di...
Source: Johnson and Johnson - May 24, 2022 Category: Pharmaceuticals Source Type: news

A survey of prescriber perceptions about the prevention of stress‐related mucosal bleeding in the intensive care unit
Summary What is known and objectivePractices vary between institutions and amongst prescribers regarding when to initiate stress ulcer prophylaxis (SUP), which agent to choose (including doses and frequencies) and rationale, and decisions about escalation or discontinuation of therapy. The purpose of this survey is to evaluate the perceptions of prescribers about risk assessment of stress‐related mucosal bleeding (SRMB) and practice patterns of SUP. MethodsA cross‐sectional survey of 800 US critical care prescribers using the membership of the Society of Critical Care Medicine. The levels of agreement with specific sta...
Source: Journal of Clinical Pharmacy and Therapeutics - September 20, 2014 Category: Drugs & Pharmacology Authors: C. R. Preslaski, S.W. Mueller, T. H. Kiser, D. N. Fish, R. MacLaren Tags: Original Article Source Type: research

Late Breaking Abstract - What do children, parents and paediatricians feel about the risk of growth suppression of inhaled corticosteroids?
Conclusions: A risk of growth suppression of inhaled corticosteroids in the range of 0.5 to 2 cm does not worry most children and adolescents, young adults, parents or paediatricians. Paediatricians seem to be less worried about intermediate term growth suppression, however, more concerned about final height suppression of inhaled corticosteroids than children and adolescents, parents and young adults.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Wolthers, O. D. Tags: Paediatric asthma and allergy Source Type: research

Janssen to Highlight Latest Scientific Advances in Hematologic Diseases at ASH 2022 with Clinical and Real-World Data Across Innovative Pipeline and Distinguished Portfolio
RARITAN, N.J., November 3, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson are committed to redefining treatment outcomes in the hematology setting and today announced that abstracts from more than 50 company-sponsored studies, plus more than 20 investigator-initiated studies, will be presented at the American Society of Hematology (ASH) Annual Meeting in New Orleans from December 10-13, 2022. Janssen’s commitment to advancing an innovative portfolio of therapies for healthcare professionals and patients is evidenced through more than 70 presentations that span clinical studies and r...
Source: Johnson and Johnson - November 3, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

Antirheumatic medications in pregnancy and breastfeeding
Purpose of review As active rheumatic and musculoskeletal disease during pregnancy increases the risk for pregnancy loss, preterm birth, and maternal illness, ongoing management with pregnancy-compatible medications can improve these outcomes. Selecting and taking these medications can be challenging for rheumatologists and patients due to limited knowledge about potential risks and benefits. Recent findings Fortunately, the American College of Rheumatology, American College of Obstetrics and Gynecology, British Rheumatology Society, and the European League Against Rheumatism have each published recommendations to gui...
Source: Current Opinion in Rheumatology - March 28, 2020 Category: Rheumatology Tags: CLINICAL THERAPEUTICS AND HEMATOLOGIC COMPLICATIONS: Edited by W. Joseph McCune Source Type: research

Pregnancy, parturition and postpartum considerations among patients with vulvar lichen sclerosus: A retrospective cross-sectional online survey
CONCLUSION: In this online survey, we found reported symptom severity remained unchanged or decreased during pregnancy, but increased postpartum. Use of topical corticosteroids decreased during pregnancy compared with before and after pregnancy. Half of the respondents reported anxiety regarding VLS and delivery.PMID:37424180 | DOI:10.1111/1471-0528.17601
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 10, 2023 Category: OBGYN Authors: Alyssa B Shaffer Sarah T Cigna Rachel Pope Jill M Krapf Source Type: research