Filtered By:
Vaccination: Pneomococcal Vaccine
This page shows you your search results in order of relevance.
Order by Relevance | Date
Total 10155 results found since Jan 2013.
Janssen to Highlight Latest Scientific Advances in Hematologic Diseases at ASH 2022 with Clinical and Real-World Data Across Innovative Pipeline and Distinguished Portfolio
RARITAN, N.J., November 3, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson are committed to redefining treatment outcomes in the hematology setting and today announced that abstracts from more than 50 company-sponsored studies, plus more than 20 investigator-initiated studies, will be presented at the American Society of Hematology (ASH) Annual Meeting in New Orleans from December 10-13, 2022. Janssen’s commitment to advancing an innovative portfolio of therapies for healthcare professionals and patients is evidenced through more than 70 presentations that span clinical studies and r...
Source: Johnson and Johnson - November 3, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
Risk Factors and Final Diagnoses of Patients first diagnosed as Infectious Acute Disseminated Encephalomyelitis (ADEM): A single-center study (I4-3B)
CONCLUSIONS: A large minority [17[percnt]] of patients was ultimately diagnosed with other conditions than ADEM, which may change longterm prognoses for patients. Vaccination prior to ADEM diagnosis is rare.Disclosure: Dr. Koelman has nothing to disclose. Dr. Chitnis has received personal compensation for activities with Biogen Idec and Alexion. Dr. Chitnis has received research support from Merck Serono and Novartis. Dr. Mateen has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Koelman, D., Chitnis, T., Mateen, F. Tags: Infectious, Paraneoplastic, and Autoimmune Encephalopathies: Advances in Clinical Diagnosis and Emerging Insights about Pathogenesis Data Blitz Presentations Source Type: research
Influenza A Virus Infection Predisposes Hosts to Secondary Infection with Different Streptococcus pneumoniae Serotypes with Similar Outcome but Serotype-Specific Manifestation Host Response and Inflammation
Influenza A virus (IAV) and Streptococcus pneumoniae are major causes of respiratory tract infections, particularly during coinfection. The synergism between these two pathogens is characterized by a complex network of dysregulated immune responses, some of which last until recovery following IAV infection. Despite the high serotype diversity of S. pneumoniae and the serotype replacement observed since the introduction of conjugate vaccines, little is known about pneumococcal strain dependency in the enhanced susceptibility to severe secondary S. pneumoniae infection following IAV infection. Thus, we studied how preinfecti...
Source: Infection and Immunity - November 17, 2016 Category: Infectious Diseases Authors: Sharma-Chawla, N., Sender, V., Kershaw, O., Gruber, A. D., Volckmar, J., Henriques-Normark, B., Stegemann-Koniszewski, S., Bruder, D. Tags: Host Response and Inflammation Source Type: research
Molecular characterization of penicillin non-susceptible Streptococcus pneumoniae isolated before and after pneumococcal conjugate vaccine implementation in Casablanca, Morocco
Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide, especially among children and the elderly. The ability to effectively treat pneumococcal infection has b...
Source: Annals of Clinical Microbiology and Antimicrobials - April 4, 2017 Category: Microbiology Authors: Idrissa Diawara, Abouddihaj Barguigua, Khalid Katfy, Kaotar Nayme, Houria Belabbes, Mohammed Timinouni, Khalid Zerouali and Naima Elmdaghri Source Type: research
Protective Role for Macrophages in Respiratory Francisella tularensis Infection Microbial Immunity and Vaccines
Francisella tularensis causes lethal pneumonia following infection of the lungs by targeting macrophages for intracellular replication; however, macrophages stimulated with interferon gamma (IFN-) can resist infection in vitro. We therefore hypothesized that the protective effect of IFN- against F. tularensis in vivo requires macrophages receptive to stimulation. We found that the lethality of pulmonary F. tularensis LVS infection was exacerbated under conditions of alveolar macrophage depletion and in mice with a macrophage-specific defect in IFN- signaling (termed mice with macrophages insensitive to IFN- [MIIG mice]). W...
Source: Infection and Immunity - May 23, 2017 Category: Infectious Diseases Authors: Steiner, D. J., Furuya, Y., Jordan, M. B., Metzger, D. W. Tags: Microbial Immunity and Vaccines Source Type: research
Evaluation of pneumococcal and tetanus vaccine responses in patients with rheumatoid arthritis receiving baricitinib: results from a long-term extension trial substudy
Clinical guidelines recommend pneumococcal and tetanus vaccinations in patients with rheumatoid arthritis (RA). Baricitinib is an oral, selective Janus kinase (JAK) 1/JAK 2 inhibitor and is approved for the tr...
Source: Arthritis Research and Therapy - April 18, 2019 Category: Rheumatology Authors: Kevin L. Winthrop, Clifton O. Bingham III, Wendy J. Komocsar, John Bradley, Maher Issa, Rena Klar and Cynthia E. Kartman Tags: Research article Source Type: research
Protection Induced by Oral Vaccination with a Recombinant Yersinia pseudotuberculosis Delivering Yersinia pestis LcrV and F1 Antigens in Mice and Rats against Pneumonic Plague
Infection and Immunity, Ahead of Print.
Source: Infection and Immunity - July 28, 2022 Category: Infectious Diseases Authors: Saugata Majumder,
Rachel M. Olson,
Amit Singh,
Xiuran Wang,
Peng Li,
Hatem Kittana,
Paul E. Anderson,
Deborah M. Anderson,
Wei Sun
aDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
bDepartment of Veteri Source Type: research
South Africa: Measles and Whooping Cough Outbreaks in South Africa - a Sign of Low Vaccination Coverage, Experts Warn
[The Conversation Africa] The concentrated global effort to use vaccination as a public health intervention began in 1974. Since then, vaccination has changed our lives. Worldwide, in the decades 2000-2020, childhood vaccination led to the reduction of deaths in children under 5 by 50% to 5.4 million deaths per year. Vaccination currently averts more than 5 million deaths each year worldwide. These are deaths that would have been caused by measles, whooping cough, tetanus, polio, diphtheria, pneumonia, rotavirus diarrhoea, and othe
Source: AllAfrica News: Health and Medicine - June 15, 2023 Category: African Health Tags: Health and Medicine South Africa Southern Africa Source Type: news
Human Antibodies to PhtD, PcpA, and Ply Reduce Adherence to Human Lung Epithelial Cells and Murine Nasopharyngeal Colonization by Streptococcus pneumoniae Microbial Immunity and Vaccines
Streptococcus pneumoniae adherence to human epithelial cells (HECs) is the first step in pathogenesis leading to infections. We sought to determine the role of human antibodies against S. pneumoniae protein vaccine candidates PhtD, PcpA, and Ply in preventing adherence to lung HECs in vitro and mouse nasopharyngeal (NP) colonization in vivo. Human anti-PhtD, -PcpA, and -Ply antibodies were purified and Fab fragments generated. Fabs were used to test inhibition of adherence of TIGR4 and nonencapsulated strain RX1 to A549 lung HECs. The roles of individual proteins in adherence were tested using isogenic mutants of strain TI...
Source: Infection and Immunity - November 10, 2014 Category: Infectious Diseases Authors: Kaur, R., Surendran, N., Ochs, M., Pichichero, M. E. Tags: Microbial Immunity and Vaccines Source Type: research
Mucosal Immunization with the Live Attenuated Vaccine SPY1 Induces Humoral and Th2-Th17-Regulatory T Cell Cellular Immunity and Protects against Pneumococcal Infection Microbial Immunity and Vaccines
Mucosal immunization with attenuated vaccine can protect against pneumococcal invasion infection, but the mechanism was unknown. Our study found that mucosal delivery with the live attenuated SPY1 vaccine strain can confer T cell- and B cell-dependent protection against pneumococcal colonization and invasive infection; yet it is still unclear which cell subsets contribute to the protection, and their roles in pneumococcal colonization and invasion remain elusive. Adoptive transfer of anti-SPY1 antibody conferred protection to naive μMT mice, and immune T cells were indispensable to protection examined in nude mice. A cr...
Source: Infection and Immunity - December 16, 2014 Category: Infectious Diseases Authors: Xu, X., Wang, H., Liu, Y., Wang, Y., Zeng, L., Wu, K., Wang, J., Ma, F., Xu, W., Yin, Y., Zhang, X. Tags: Microbial Immunity and Vaccines Source Type: research
Impact of Detergent on Biophysical Properties and Immune Response of the IpaDB Fusion Protein, a Candidate Subunit Vaccine against Shigella Species Microbial Immunity and Vaccines
Shigella spp. are causative agents of bacillary dysentery, a human illness with high global morbidity levels, particularly among elderly and infant populations. Shigella infects via the fecal-oral route, and its virulence is dependent upon a type III secretion system (T3SS). Two components of the exposed needle tip complex of the Shigella T3SS, invasion plasmid antigen D (IpaD) and IpaB, have been identified as broadly protective antigens in the mouse lethal pneumonia model. A recombinant fusion protein (DB fusion) was created by joining the coding sequences of IpaD and IpaB. The DB fusion is coexpressed with IpaB's cognat...
Source: Infection and Immunity - December 16, 2014 Category: Infectious Diseases Authors: Chen, X., Choudhari, S. P., Martinez-Becerra, F. J., Kim, J. H., Dickenson, N. E., Toth, R. T., Joshi, S. B., Greenwood, J. C., Clements, J. D., Picking, W. D., Middaugh, C. R., Picking, W. L. Tags: Microbial Immunity and Vaccines Source Type: research
Hypoalbuminemia, influenza vaccination and other factors related to the development of pneumonia acquired outside hospitals in southern Japan: A case–control study
ConclusionsHypoalbuminemia might be a risk factor for pneumonia among the elderly living in the community. Geriatr Gerontol Int 2015; ●●: ●●–●●.
Source: Geriatrics and Gerontology International - February 5, 2015 Category: Geriatrics Authors: Masakazu Washio, Kyoko Kondo, Nobumitsu Fujisawa, Eiji Harada, Hideki Tashiro, Tetsuya Mizokami, Hiroko Nogami, Tomoaki Iwanaga, Yoichi Nakanishi, Kanzo Suzuki, Satoko Ohfuji, Wakaba Fukushima, Yoshio Hirota, Tags: Original Article: Epidemiology, Clinical Practice and Health Source Type: research
Anti-Pneumococcal Capsular Polysaccharide Antibody Response and CD5 B Lymphocyte Subsets Microbial Immunity and Vaccines
The role of CD19+ CD5+ and CD19+ CD5– B cell subpopulations in the antibody response to pneumococcal capsular polysaccharides (caps-PSs) is controversial. In the present study, we evaluated the role of human CD19+ CD5+ and CD19+ CD5– cell populations in the serotype-specific antibody response to caps-PS. After vaccination of 5 healthy human adults with Pneumovax (23-valent pneumococcal polysaccharide vaccine [PPV23]), IgG anti-caps-PS serotype 4 antibody-producing cells resided mainly in the CD19+ CD5– B cell subset, as assessed by enzyme-linked immunosorbent spot (ELISpot) analysis. Moreover, in a humani...
Source: Infection and Immunity - June 15, 2015 Category: Infectious Diseases Authors: Moens, L., Verbinnen, B., Covens, K., Wuyts, G., Johnson, M., Roalfe, L., Goldblatt, D., Meyts, I., Bossuyt, X. Tags: Microbial Immunity and Vaccines Source Type: research
Novel Strategy To Protect against Influenza Virus-Induced Pneumococcal Disease without Interfering with Commensal Colonization Microbial Immunity and Vaccines
Streptococcus pneumoniae commonly inhabits the nasopharynx as a member of the commensal biofilm. Infection with respiratory viruses, such as influenza A virus, induces commensal S. pneumoniae to disseminate beyond the nasopharynx and to elicit severe infections of the middle ears, lungs, and blood that are associated with high rates of morbidity and mortality. Current preventive strategies, including the polysaccharide conjugate vaccines, aim to eliminate asymptomatic carriage with vaccine-type pneumococci. However, this has resulted in serotype replacement with, so far, less fit pneumococcal strains, which has changed the...
Source: Infection and Immunity - May 23, 2016 Category: Infectious Diseases Authors: Greene, C. J., Marks, L. R., Hu, J. C., Reddinger, R., Mandell, L., Roche-Hakansson, H., King-Lyons, N. D., Connell, T. D., Hakansson, A. P. Tags: Microbial Immunity and Vaccines Source Type: research
Protection against Streptococcus pneumoniae Invasive Pathogenesis by a Protein-Based Vaccine Is Achieved by Suppression of Nasopharyngeal Bacterial Density during Influenza A Virus Coinfection Microbial Immunity and Vaccines
An increase in Streptococcus pneumoniae nasopharynx (NP) colonization density during a viral coinfection initiates pathogenesis. To mimic natural S. pneumoniae pathogenesis, we commensally colonized the NPs of adult C57BL/6 mice with S. pneumoniae serotype (ST) 6A or 8 and then coinfected them with mouse-adapted H1N1 influenza A virus (PR/8/34). S. pneumoniae established effective commensal colonization, and influenza virus coinfection caused S. pneumoniae NP density to increase, resulting in bacteremia and mortality. We then studied histidine triad protein D (PhtD), an S. pneumoniae adhesin vaccine candidate, for its abil...
Source: Infection and Immunity - January 25, 2017 Category: Infectious Diseases Authors: Khan, M. N., Xu, Q., Pichichero, M. E. Tags: Microbial Immunity and Vaccines Source Type: research
