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Sorry Vegans: Here’s How Meat-Eating Made Us Human
Science doesn’t give a hoot about your politics. Think global warming is a hoax or that vaccines are dangerous? Doesn’t matter, you’re wrong. Something similar is true of veganism. Vegans are absolutely right when they say that a plant-based diet can be healthy, varied and exceedingly satisfying, and that—not for nothing—it spares animals from the serial torments of being part of the human food chain. All good so far. But there’s veganism and then there’s Veganism—the upper case, ideological veganism, the kind that goes beyond diet and lifestyle wisdom to a sort of counterfac...
Source: TIME: Top Science and Health Stories - March 9, 2016 Category: Science Authors: Jeffrey Kluger Tags: Uncategorized Australopithecus carnivorousness Evolution Food Nutrition Veganism Vegetarianism Source Type: news

Why we gave in and bought a dog
Genevieve Fox and her husband held out for years against their children's pleas for a dog. Stick insects and a hamster came and went before they finally caved in and Pepper, a miniature schnauzer, joined the familyDogs are good for families. People always say that, and I've always wondered what they meant. Good in what way? It's not as if they come with government benefits or John Lewis vouchers. I suspect they mean "good" in a rather po-faced, censorious way – a dog, to them, is a family chore, like setting the table or emptying the dishwasher. How you approach that chore sorts the muckers from the shirkers. Equally, "A...
Source: Guardian Unlimited Science - February 1, 2014 Category: Science Tags: The Guardian Family Features Life and style Animal behaviour Pets Dogs Source Type: news

Top 10 Mesothelioma News Stories of 2017
Every year, mesothelioma specialists and researchers make strides to advance the standard of care, improve treatment strategies and develop new diagnostic practices. Mesothelioma remains a rare cancer, with an estimated 3,000 people diagnosed each year in the U.S., but the fight to find a cure only grows stronger. And while researchers are busy finding breakthroughs in care, advocates are hard at work campaigning for a ban on asbestos, the main cause of mesothelioma. This was a memorable year on both fronts. Immunotherapy continues to be the hot topic among emerging treatments. Drugs such as pembrolizumab (Keytruda) and ni...
Source: Asbestos and Mesothelioma News - December 22, 2017 Category: Environmental Health Authors: Daniel King Tags: canada asbestos ban Food and Drug Administration Furthering Asbestos Claims Transparency Act keytruda Medical marijuana mesothelioma mesothelioma vaccine Opdivo Scott Pruitt talcum powder lawsuit yervoy Source Type: news

Janssen to Highlight Latest Scientific Advances in Hematologic Diseases at ASH 2022 with Clinical and Real-World Data Across Innovative Pipeline and Distinguished Portfolio
RARITAN, N.J., November 3, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson are committed to redefining treatment outcomes in the hematology setting and today announced that abstracts from more than 50 company-sponsored studies, plus more than 20 investigator-initiated studies, will be presented at the American Society of Hematology (ASH) Annual Meeting in New Orleans from December 10-13, 2022. Janssen’s commitment to advancing an innovative portfolio of therapies for healthcare professionals and patients is evidenced through more than 70 presentations that span clinical studies and r...
Source: Johnson and Johnson - November 3, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

Association Between PRRSV ORF5 Genetic Distance and Differences in Space, Time, Ownership and Animal Sources Among Commercial Pig Herds
The objective of this study was to investigate associations between genetic distance of porcine reproductive and respiratory syndrome virus (PRRSV) detected in Ontario swine herds, and the distance between the herds with respect to space, time, ownership and animal sources. PRRSV sequence data between September 2004 and August 2007 were obtained from the Animal Health Laboratory of the University of Guelph. Geographical coordinates were obtained from the Ontario Pork marketing board, and network information about ownership and animal suppliers was obtained using a telephone interview. The matrices of sequence, spatial, tem...
Source: Transboundary and Emerging Diseases - August 1, 2014 Category: Veterinary Research Authors: T. Rosendal, C. Dewey, R. Friendship, S. Wootton, B. Young, Z. Poljak Tags: Original Article Source Type: research

Stochastic Simulation Model Comparing Distributions of STEC O157 Faecal Shedding Prevalence Between Cattle Vaccinated With Type III Secreted Protein Vaccines and Non‐Vaccinated Cattle
Summary Pens of cattle with high Escherichia coli O157:H7 (STEC O157) prevalence at harvest may present a greater risk to food safety than pens of lower prevalence. Vaccination of live cattle against STEC O157 has been proposed as an approach to reduce STEC O157 prevalence in live cattle. Our objective was to create a stochastic simulation model to evaluate the effectiveness of pre‐harvest interventions. We used the model to compare STEC O157 prevalence distributions for summer‐ and winter‐fed cattle to summer‐fed cattle immunized with a type III secreted protein (TTSP) vaccine. Model inputs were an estimate of vac...
Source: Zoonoses and Public Health - June 1, 2013 Category: Infectious Diseases Authors: A. R. Vogstad, R. A. Moxley, G. E. Erickson, T. J. Klopfenstein, D. R. Smith Tags: Original Article Source Type: research

Animal models in HIV-1 protection and therapy
Purpose of review: The purpose of this review is to highlight major advances in the development and use of animal models for HIV-1 research during the last year. Recent findings: Animal model research during the last year has focused on the development and refinement of models; use of these models to explore key questions about HIV entry, immune control, and persistence; and key discoveries with these models testing therapeutic and vaccine concepts. Some of the greatest breakthroughs have been in understanding early events surrounding transmission, the effectiveness of broadly neutralizing human monoclonal antibodies as pa...
Source: Current Opinion in HIV and AIDS - April 13, 2015 Category: Infectious Diseases Tags: ANTIBODIES FOR PREVENTION AND THERAPY: Edited by John R. Mascola and Richard A. Koup Source Type: research

Self-amplifying mRNA-Based Vaccine Technology and Its Mode of Action
Curr Top Microbiol Immunol. 2021 Apr 17. doi: 10.1007/82_2021_233. Online ahead of print.ABSTRACTSelf-amplifying mRNAs derived from the genomes of positive-strand RNA viruses have recently come into focus as a promising technology platform for vaccine development. Non-virally delivered self-amplifying mRNA vaccines have the potential to be highly versatile, potent, streamlined, scalable, and inexpensive. By amplifying their genome and the antigen encoding mRNA in the host cell, the self-amplifying mRNA mimics a viral infection, resulting in sustained levels of the target protein combined with self-adjuvanting innate immune...
Source: Current Topics in Microbiology and Immunology - April 16, 2021 Category: Microbiology Authors: Giulietta Maruggi Jeffrey B Ulmer Rino Rappuoli Dong Yu Source Type: research

Lethal zoonotic coronavirus infections of humans – comparative phylogenetics, epidemiology, transmission, and clinical features of coronavirus disease 2019, The Middle East respiratory syndrome and severe acute respiratory syndrome
Purpose of review Severe acute respiratory syndrome-coronaviruses-2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged as a new zoonotic pathogen of humans at the end of 2019 and rapidly developed into a global pandemic. Over 106 million COVID-19 cases including 2.3 million deaths have been reported to the WHO as of February 9, 2021. This review examines the epidemiology, transmission, clinical features, and phylogenetics of three lethal zoonotic coronavirus infections of humans: SARS-CoV-1, SARS-CoV-2, and The Middle East respiratory syndrome coronavirus (MERS-COV). Recent findings Bats app...
Source: Current Opinion in Pulmonary Medicine - April 10, 2021 Category: Respiratory Medicine Tags: INFECTIOUS DISEASES: Edited by Michael S. Niederman and Alimuddin Zumla Source Type: research

Mucosal Antibodies to the C Terminus of Toxin A Prevent Colonization of Clostridium difficile Microbial Immunity and Vaccines
Mucosal immunity is considered important for protection against Clostridium difficile infection (CDI). We show that in hamsters immunized with Bacillus subtilis spores expressing a carboxy-terminal segment (TcdA26–39) of C. difficile toxin A, no colonization occurs in protected animals when challenged with C. difficile strain 630. In contrast, animals immunized with toxoids showed no protection and remained fully colonized. Along with neutralizing toxins, antibodies to TcdA26–39 (but not to toxoids), whether raised to the recombinant protein or to TcdA26–39 expressed on the B. subtilis spore surface, cros...
Source: Infection and Immunity - March 23, 2017 Category: Infectious Diseases Authors: Hong, H. A., Hitri, K., Hosseini, S., Kotowicz, N., Bryan, D., Mawas, F., Wilkinson, A. J., van Broekhoven, A., Kearsey, J., Cutting, S. M. Tags: Microbial Immunity and Vaccines Source Type: research

Molecular characterization of a 31 kDa protein from Trichinella spiralis and its induced immune protection in BALB/c mice
Trichinella spiralis is an important foodborne zoonotic parasite and it is necessary to develop a vaccine in order to interrupt transmission from animals to humans. A 31 kDa protein from T. spiralis (Ts31) is an ...
Source: Parasites and Vectors - December 5, 2018 Category: Microbiology Authors: Hua Nan Ren, Kai Xia Guo, Yao Zhang, Ge Ge Sun, Ruo Dan Liu, Peng Jiang, Xi Zhang, Li Wang, Jing Cui and Zhong Quan Wang Tags: Research Source Type: research