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C –H hydrogen bond and halogen bond directed self-assembly of ethereal podands and C–X⋯F−/HF2− halogen bonding in solution
CrystEngComm, 2023, Advance Article DOI: 10.1039/D3CE00599B, PaperDipjyoti Dutta, Anamika Gogoi, Rupjyoti Dutta, Sarvesh S. Harmalkar, Prem Lama, Sandeep Kumar Dey Crystallization of halophenyl-functionalized ethereal podands is largely facilitated by C –H hydrogen bonds and halogen bonds of similar strength, and anion binding in the solution state is exclusively governed by halogen bonding. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - CrystEngComm latest articles - September 23, 2023 Category: Chemistry Authors: Dipjyoti Dutta Source Type: research

Chiral Probes for Biosensing
Chem. Commun., 2023, Accepted Manuscript DOI: 10.1039/D3CC03660J, Feature ArticleChuanlai Xu, Changlong Hao, Hua Kuang Chiral inorganic nanomaterials have emerged as a highly promising area of research in nanoscience due to their exceptional light-matter interaction and vast potential applications in chiral sensing, asymmetric catalysis, enantiomer... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 23, 2023 Category: Chemistry Authors: Chuanlai Xu Source Type: research

Background free in vivo29Si MR imaging with hyperpolarized PEGylated silicon nanoparticles
This study demonstrated the potential of 50 nm PEGylated Si NPs for high-resolutionin vivo29Si MR imaging, emphasizing their biocompatibility and water dispersibility. The acquisition of in vivo Si... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - September 23, 2023 Category: Chemistry Authors: Seung-Hyun Yang Source Type: research

Light-up split aptamers: binding thermodynamics and kinetics for sensing
Analyst, 2023, Accepted Manuscript DOI: 10.1039/D3AN01368E, PaperYichen Zhao, Nikesh Patel, Peihuan Sun, Karen Faulds, Duncan Graham, Juewen Liu Due to their programmable structures, many aptamers can be readily split into two halves while still retaining their target binding function. While split aptamers are prevalent in the biosensor field,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - September 23, 2023 Category: Chemistry Authors: Yichen Zhao Source Type: research

Genes, Vol. 14, Pages 1847: Comparative Studies on Duplicated foxl2 Paralogs in Spotted Knifejaw Oplegnathus punctatus Show Functional Diversification
In this study, two foxl2 paralogs, foxl2 and foxl2l, were identified in the transcriptome of spotted knifejaw (Oplegnathus punctatus), which had varying expressions in the gonads. The foxl2 was expressed higher in the ovary, while foxl2l was expressed higher in the testis. Phylogenetic reconstruction, synteny analysis, and the molecular evolution test confirmed that foxl2 and foxl2l likely originated from the first two WGD. The expression patterns test using qRT-PCR and ISH as well as motif scan analysis revealed evidence of potentially functional divergence between the foxl2 and foxl2l paralogs in spotted knifejaw. Our re...
Source: Genes - September 23, 2023 Category: Genetics & Stem Cells Authors: Xinxin Du Haiyang Yu Yujue Wang Jinxiang Liu Quanqi Zhang Tags: Article Source Type: research

Genes, Vol. 14, Pages 1846: LRP5, Bone Mass Polymorphisms and Skeletal Disorders
K. Aaron The formation and maintenance of the gross structure and microarchitecture of the human skeleton require the concerted functioning of a plethora of morphogenic signaling processes. Through recent discoveries in the field of genetics, numerous genotypic variants have been implicated in pathologic skeletal phenotypes and disorders arising from the disturbance of one or more of these processes. For example, total loss-of-function variants of LRP5 were found to be the cause of osteoporosis-pseudoglioma syndrome (OPPG). LRP5 encodes for the low-density lipoprotein receptor-related protein 5, a co-receptor in the c...
Source: Genes - September 23, 2023 Category: Genetics & Stem Cells Authors: Jake Littman Wentian Yang Jon Olansen Chanika Phornphutkul Roy K. Aaron Tags: Review Source Type: research

Genes, Vol. 14, Pages 1845: INPP5D/SHIP1: Expression, Regulation and Roles in Alzheimer & rsquo;s Disease Pathophysiology
Genes, Vol. 14, Pages 1845: INPP5D/SHIP1: Expression, Regulation and Roles in Alzheimer’s Disease Pathophysiology Genes doi: 10.3390/genes14101845 Authors: Edward O. Olufunmilayo R. M. Damian Holsinger Alzheimer’s disease (AD) is the most common form of dementia, accounting for approximately 38.5 million cases of all-cause dementia. Over 60% of these individuals live in low- and middle-income countries and are the worst affected, especially by its deleterious effects on the productivity of both patients and caregivers. Numerous risk factors for the disease have been identified and our unde...
Source: Genes - September 23, 2023 Category: Genetics & Stem Cells Authors: Edward O. Olufunmilayo R. M. Damian Holsinger Tags: Review Source Type: research

Semi-automating abstract screening with a natural language model pretrained on biomedical literature
AbstractWe demonstrate the performance and workload impact of incorporating a natural language model, pretrained on citations of biomedical literature, on a workflow of abstract screening for studies on prognostic factors in end-stage lung disease. The model was optimized on one-third of the abstracts, and model performance on the remaining abstracts was reported. Performance of the model, in terms of sensitivity, precision, F1 and inter-rater agreement, was moderate in comparison with other published models. However, incorporating it into the screening workflow, with the second reviewer screening only abstracts with confl...
Source: Systematic Reviews - September 23, 2023 Category: International Medicine & Public Health Source Type: research

Professional identity formation among undergraduate pre-medical students: a scoping review protocol
The objective of this scoping review is to systematically map the literature on professional identity formation among undergraduate pre-medical students.MethodsThis review protocol has been designed following the Arksey and O ’Malley framework. We will search MEDLINE, CINAHL, Embase, and Scopus, as well as relevant grey literature, conference proceedings, and citations of selected articles. Inclusion criteria are articles (1) written in the English language, (2) involving undergraduate pre-medical students in the USA a nd Canada, and (3) containing original data about professional identity formation. Two independent revi...
Source: Systematic Reviews - September 23, 2023 Category: International Medicine & Public Health Source Type: research

What can the citations of systematic reviews of ethical literature tell us about their use? —an explorative empirical analysis of 31 reviews
Source: Systematic Reviews - September 23, 2023 Category: International Medicine & Public Health Source Type: research

Artificial intelligence to identify fractures on pediatric and young adult upper extremity radiographs
ConclusionAn object detection AI model identified pediatric upper extremity fractures with high accuracy.Graphical abstract
Source: Pediatric Radiology - September 23, 2023 Category: Radiology Source Type: research

Predictive value of chemokines (CCL 2) in bronchoalveolar lavage fluid for refractory mycoplasma pneumonia in children
ConclusionThe level of CCL2 in BALF was high in children with MPP and had a high predictive value for RMPP. CCL2 can be used as one of the biomarkers for predicting RMPP.
Source: Italian Journal of Pediatrics - September 23, 2023 Category: Pediatrics Source Type: research

Cancers, Vol. 15, Pages 4689: Estrogen Receptor Signaling in Breast Cancer
rzej Stepulak Estrogen receptor (ER) signaling is a critical regulator of cell proliferation, differentiation, and survival in breast cancer (BC) and other hormone-sensitive cancers. In this review, we explore the mechanism of ER-dependent downstream signaling in BC and the role of estrogens as growth factors necessary for cancer invasion and dissemination. The significance of the clinical implications of ER signaling in BC, including the potential of endocrine therapies that target estrogens’ synthesis and ER-dependent signal transmission, such as aromatase inhibitors or selective estrogen receptor modul...
Source: Cancers - September 23, 2023 Category: Cancer & Oncology Authors: Paulina Miziak Marzena Baran Ewa B łaszczak Alicja Przybyszewska-Podstawka Joanna Ka łafut Jolanta Smok-Kalwat Magdalena Dmoszy ńska-Graniczka Micha ł Kiełbus Andrzej Stepulak Tags: Review Source Type: research

Differential behavioral aging trajectories according to body size, expected lifespan, and head shape in dogs
We examined the effect of expected lifespan and three related factors (body size, head shape, and purebred status) on the age trajectory of various behavioral characteristics and the prevalence of canine cognitive dysfunction (CCD). Our findings reveal that, although age-related decline in most behavioral characteristics began around 10.5  years of age, the proportion of dogs considered “old” by their owners began to increase uniformly around 6 years of age. From the investigated factors, only body size had a systematic, although not gradual, impact on the aging trajectories of all behavioral characteristics. Dogs we...
Source: AGE - September 23, 2023 Category: Geriatrics Source Type: research

Clinical evaluation of sodium hypochlorite/amino acids and cross-linked hyaluronic acid adjunctive to non-surgical periodontal treatment: a randomized controlled clinical trial
ConclusionWithin their limits the present data indicate that: a) both treatments resulted in statistically significant improvements in all evaluated clinical parameters, and b) the adjunctive subgingival application of sodium hypochlorite/amino acid and xHyA to SRP yielded statistically significantly higher improvements compared to SRP alone.Clinical relevanceThe combination of sodium hypochlorite/amino acid and xHyA gels to subgingival mechanical debridement appears to represent a valuable approach to additionally improve the outcomes of non-surgical periodontal treatment.Clinical Trial Registration Number NCT04662216 (ClinicalTrials.gov).
Source: Clinical Oral Investigations - September 23, 2023 Category: Dentistry Source Type: research