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Localization and distribution of goose astrovirus 2 antigens in different tissues at different times
Goose astrovirus 2 (GAstV-2) causes visceral gout in goslings and has resulted in significant economic losses in the goose industry of China since its outbreak in 2017. To further investigate the distribution ...
Source: BMC Veterinary Research - September 23, 2023 Category: Veterinary Research Authors: Feng Wei, Xiaoning Jiang, Dalin He, Youxiang Diao and Yi Tang Tags: Research Source Type: research
Hemolysis, icterus and lipemia interfere with the determination of two oxidative stress biomarkers in canine serum
Oxidative stress has been proven to play a role in numerous human and canine diseases. Among the biomarkers of oxidative stress, Thiobarbituric Acid Reactive Substances (TBARS) and Total Antioxidant Status (TA...
Source: BMC Veterinary Research - September 23, 2023 Category: Veterinary Research Authors: B. Perez-Montero, M. L. Fermin-Rodriguez, G. Miro, L. de Juan and F. Cruz-Lopez Tags: Research Source Type: research
Intranasal administration with recombinant vaccine PRVXJ-delgE/gI/TK-S induces strong intestinal mucosal immune responses against PDCoV
Porcine deltacoronavirus (PDCoV) is a novel coronavirus that causes enteric diseases in pigs leading to substantial financial losses within the industry. The absence of commercial vaccines and limited research...
Source: BMC Veterinary Research - September 23, 2023 Category: Veterinary Research Authors: Bingzhou Huang, Yao Huang, Lishuang Deng, Tong Xu, Zhijie Jian, Siyuan Lai, Yanru Ai, Ling Zhu and Zhiwen Xu Tags: Research Source Type: research
No evidence of hepatitis E virus (HEV) infection among pet cats and dogs, and low seroprevalence of hepatitis E virus among pet rabbits in Poland
AbstractThe seroprevalence ofPaslahepevirus balayani genotype 3 (hepatitis E virus genotype 3 – HEV-3;Hepeviridae family, genusPaslahepevirus) in pet cats, dogs and rabbits was evaluated. Samples from cats and dogs were collected from three veterinary practices from various parts of Poland: Poznan (wielkopolskie voivodeship), Przemysl (podkarpackie voivodeship) and Lublin (lubelskie voivodeship). Samples from rabbits were collected in Poznan. In total, serum samples from 90 cats, 82 dogs and 71 rabbits were selected and tested for specific anti-HEV-3 immunoglobulin (IgG) antibodies using a commercial ELISA test. Pathogen...
Source: Veterinary Research Communications - September 23, 2023 Category: Veterinary Research Source Type: research
Viruses, Vol. 15, Pages 1985: Recent Advances in Structural Studies of Single-Stranded RNA Bacteriophages
e Zhang
Positive-sense single-stranded RNA (ssRNA) bacteriophages (phages) were first isolated six decades ago. Since then, extensive research has been conducted on these ssRNA phages, particularly those infecting E. coli. With small genomes of typically 3–4 kb that usually encode four essential proteins, ssRNA phages employ a straightforward infectious cycle involving host adsorption, genome entry, genome replication, phage assembly, and host lysis. Recent advancements in metagenomics and transcriptomics have led to the identification of ~65,000 sequences from ssRNA phages, expanding our understanding of...
Source: Viruses - September 23, 2023 Category: Virology Authors: Jirapat Thongchol Zachary Lill Zachary Hoover Junjie Zhang Tags: Review Source Type: research
Viruses, Vol. 15, Pages 1984: PluriBAC: A Versatile Baculovirus-Based Modular System to Express Heterologous Genes in Different Biotechnological Platforms
tías L. Pidre
Baculoviruses are insect-specific pathogens widely used in biotechnology. In particular, the Autographa californica nucleopolyhedrovirus (AcMNPV) has been exploited as a platform for bio-inputs production. This is why the improvement of the technologies used for the production of recombinant baculoviruses takes on particular relevance. To achieve this goal, we developed a highly versatile baculoviral transfer vector generation system called PluriBAC. The PluriBAC system consists of three insert entry levels using Golden Gate assembly technology. The wide availability of vectors and sticky ends allows eno...
Source: Viruses - September 23, 2023 Category: Virology Authors: Leslie C. Amor ós Morales Abril Marchesini Santiago M. G ómez Bergna Mat ías García Fallit Silvana E. Tongiani Larisa V ásquez Mar ía Leticia Ferrelli Guillermo A. Videla-Richardson Marianela Candolfi V íctor Romanowski Mat ías L. Pidre Tags: Article Source Type: research
Viruses, Vol. 15, Pages 1982: Molecular Imaging of ACE2 Expression in Infectious Disease and Cancer
J. Thorek
Angiotensin-converting enzyme 2 (ACE2) is a cell-surface receptor that plays a critical role in the pathogenesis of SARS-CoV-2 infection. Through the use of ligands engineered for the receptor, ACE2 imaging has emerged as a valuable tool for preclinical and clinical research. These can be used to visualize the expression and distribution of ACE2 in tissues and cells. A variety of techniques including optical, magnetic resonance, and nuclear medicine contrast agents have been developed and employed in the preclinical setting. Positron-emitting radiotracers for highly sensitive and quantitative tomography have ...
Source: Viruses - September 23, 2023 Category: Virology Authors: Zhiyao Li Abbie Hasson Lasya Daggumati Hanwen Zhang Daniel L. J. Thorek Tags: Review Source Type: research
Viruses, Vol. 15, Pages 1983: Exploring the Comprehensive Kozak Sequence Landscape for AAV Production in Sf9 System
hin
The widespread successful use of recombinant Adeno-associated virus (rAAV) in gene therapy has driven the demand for scale-up manufacturing methods of vectors with optimized yield and transduction efficiency. The Baculovirus/Sf9 system is a promising platform for high yield production; however, a major drawback to using an invertebrate cell line compared to a mammalian system is a generally altered AAV capsid stoichiometry resulting in lower biological potency. Here, we introduce a term of the structural and biological “fitness” of an AAV capsid as a function of two interdependent parame...
Source: Viruses - September 23, 2023 Category: Virology Authors: Oleksandr Kondratov Sergei Zolotukhin Tags: Article Source Type: research
Viruses, Vol. 15, Pages 1981: A Baculovirus Expression Vector Derived Entirely from Non-Templated, Chemically Synthesized DNA Parts
Slack
Baculovirus expression system1s are a widely used tool in recombinant protein and biologics production. To enable the possibility of genome modifications unconstrained through low-throughput and bespoke classical genome manipulation techniques, we set out to construct a baculovirus vector (>130 kb dsDNA) built from modular, chemically synthesized DNA parts. We constructed a synthetic version of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) through two steps of hierarchical Golden Gate assembly. Over 140 restriction endonuclease sites were removed to enable the discrimination of the synt...
Source: Viruses - September 23, 2023 Category: Virology Authors: Christopher Nguyen Amanda Ibe-Enwo Jeffrey Slack Tags: Communication Source Type: research
Sensors, Vol. 23, Pages 8039: A Deep Learning Model for Correlation Analysis between Electroencephalography Signal and Speech Stimuli
o Turchetti
In recent years, the use of electroencephalography (EEG) has grown as a tool for diagnostic and brain function monitoring, being a simple and non-invasive method compared with other procedures like histological sampling. Typically, in order to extract functional brain responses from EEG signals, prolonged and repeated stimuli are needed because of the artifacts generated in recordings which adversely impact the stimulus-response analysis. To mitigate the artifact effect, correlation analysis (CA) methods are applied in the literature, where the predominant approaches focus on enhancing stimulus-response cor...
Source: Sensors - September 23, 2023 Category: Biotechnology Authors: Michele Alessandrini Laura Falaschetti Giorgio Biagetti Paolo Crippa Simona Luzzi Claudio Turchetti Tags: Article Source Type: research
Sensors, Vol. 23, Pages 8038: An Access Control Scheme Based on Blockchain and Ciphertext Policy-Attribute Based Encryption
i
Sihui Liu
Ciphertext policy–attribute-based encryption (CP-ABE), which provides fine-grained access control and ensures data confidentiality, is widely used in data sharing. However, traditional CP-ABE schemes often choose to outsource data to untrusted third-party cloud service providers for storage or to verify users’ access rights through third parties, which increases the risk of privacy leakage and also suffers from the problem of opaque permission verification. This paper proposes an access control scheme based on blockchain and CP-ABE, which is based on multiple authorization cent...
Source: Sensors - September 23, 2023 Category: Biotechnology Authors: Ronglei Hu Ziwei Ma Li Li Peiliang Zuo Xiuying Li Jiaxin Wei Sihui Liu Tags: Article Source Type: research
Characterization of the extracellular vesicles, ultrastructural morphology, and intercellular interactions of multiple clinical isolates of the brain-eating amoeba, Naegleria fowleri
DiscussionHerein we propose that N. fowleri secretes EVs in clusters from the plasma membrane, from multivesicular bodies, and via beading of thin filaments extruding from the membrane. Uptake assays demonstrate that EVs are taken up by other amoebae and mammalian cells, and we observed a real-time increase in metabolic activity for mammalian cells exposed to EVs from amoebae. Proteomic analysis revealed >2,000 proteins within the N. fowleri-secreted EVs, providing targets for the development of diagnostics or therapeutics. Our work expands the knowledge of intercellular interactions among these amoebae and subsequently...
Source: Frontiers in Microbiology - September 23, 2023 Category: Microbiology Source Type: research
Months after hospitalization for COVID-19, MRIs reveal multiorgan damage
This study found abnormal MRI results in 20% to 25% of both controls and hospitalized patients, suggesting
“a lot of these cardiac abnormalities that were seen in the COVID group must have been there beforehand.” Post–COVID-19 patients with lingering cardiac symptoms might have disorders like heartbeat irregularities that aren’t always visible with MRI, or dysfunction in other organs, he adds.
Although it can offer clues to an organ’s health, MRI is an imperfect measure of how a patient is faring after infection. Researchers found no connection between abnormal liver MRIs and symptoms such as gastroin...
Source: ScienceNOW - September 22, 2023 Category: Science Source Type: news
Hospital based injury and violence prevention programs : ATS Position Statement 2023 - American Trauma Society.
Injury and violence have a significant impact on the health and well-being of the U.S. population and are the leading cause of death for Americans ages 1 to 44.1 In 2021, 224,935 people were killed by unintentional injuries; an additional 48,183 persons di...
Source: SafetyLit - September 22, 2023 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
RSV Vaccine Given in Pregnancy to Help Shield Newborns Receives Full U.S. Approval
FRIDAY, Sept. 22, 2023 -- Women may soon have a vaccine they can take during a pregnancy to help protect their newborn from respiratory syncytial virus (RSV).
Following approval one month ago by the U.S. Food and Drug Administration, the Centers...
Source: Drugs.com - Daily MedNews - September 22, 2023 Category: General Medicine Source Type: news
