• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country
• Remove Filter

A novel oncolytic virus-based biomarker participates in prognosis and tumor immune infiltration of glioma
ConclusionOur research uncovered a critical role of PTBP1 in outcomes and immune cell infiltration of glioma patients, particularly in those with LGG.
Source: Frontiers in Microbiology - September 22, 2023 Category: Microbiology Source Type: research

Cancers, Vol. 15, Pages 4619: Repurposing Clemastine to Target Glioblastoma Cell Stemness
hristopher J. Pirozzi Yiping He Brain tumor-initiating cells (BTICs) and tumor cell plasticity promote glioblastoma (GBM) progression. Here, we demonstrate that clemastine, an over-the-counter drug for treating hay fever and allergy symptoms, effectively attenuated the stemness and suppressed the propagation of primary BTIC cultures bearing PDGFRA amplification. These effects on BTICs were accompanied by altered gene expression profiling indicative of their more differentiated states, resonating with the activity of clemastine in promoting the differentiation of normal oligodendrocyte progenitor cells (OPCs) into mat...
Source: Cancers - September 18, 2023 Category: Cancer & Oncology Authors: Michael A. Sun Rui Yang Heng Liu Wenzhe Wang Xiao Song Bo Hu Nathan Reynolds Kristen Roso Lee H. Chen Paula K. Greer Stephen T. Keir Roger E. McLendon Shi-Yuan Cheng Darell D. Bigner David M. Ashley Christopher J. Pirozzi Yiping He Tags: Article Source Type: research

Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Dendritic cell vaccine of gliomas: challenges from bench to bed
Gliomas account for the majority of brain malignant tumors. As the most malignant subtype of glioma, glioblastoma (GBM) is barely effectively treated by traditional therapies (surgery combined with radiochemotherapy), resulting in poor prognosis. Meanwhile, due to its “cold tumor” phenotype, GBM fails to respond to multiple immunotherapies. As its capacity to prime T cell response, dendritic cells (DCs) are essential to anti-tumor immunity. In recent years, as a therapeutic method, dendritic cell vaccine (DCV) has been immensely developed. However, there have long been obstacles that limit the use of DCV yet to be tack...
Source: Frontiers in Immunology - September 14, 2023 Category: Allergy & Immunology Source Type: research

Intrathecal Catheter for Chemotherapy in Leptomeningeal Carcinomatosis From HER2-Negative Metastatic Breast Cancer
CONCLUSION: Infusing chemotherapy using an implanted catheter is an efficient option for managing IT chemotherapy with a good tolerance profile. Patient-reported outcomes for the evaluation of IT chemotherapy toxicity are currently being developed.PMID:37704384 | DOI:10.4048/jbc.2023.26.e40
Source: Journal of Breast Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Denis Dupoiron Lila Autier Nathalie Lebrec Val érie Seegers Caroline Folliard Anne Patsouris Mario Campone Paule Augereau Source Type: research

Brain tumor-related epilepsy management: A Society for Neuro-oncology (SNO) consensus review on current management
Neuro Oncol. 2023 Sep 12:noad154. doi: 10.1093/neuonc/noad154. Online ahead of print.ABSTRACTTumor-related epilepsy (TRE) is a frequent and major consequence of brain tumors. Management of TRE is required throughout the course of disease and a deep understanding of diagnosis and treatment is key to improving quality of life. Gross total resection is favored from both an oncologic and epilepsy perspective. Shared mechanisms of tumor growth and epilepsy exist, and emerging data will provide better targeted therapy options. Initial treatment with antiseizure medications (ASM) in conjunction with surgery and/or chemoradiothera...
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Edward K Avila Steven Tobochnik Sara K Inati Johan A F Koekkoek Guy M McKhann James J Riviello Roberta Rud à David Schiff William O Tatum Jessica W Templer Michael Weller Patrick Y Wen Source Type: research

SIRT2 Inhibition Rescues Neurodegenerative Pathology but Increases Systemic Inflammation in a Transgenic Mouse Model of Alzheimer ’s Disease
In this study, we demonstrate that the specific SIRT2 inhibitor, the compound 33i, does not exhibit genotoxic or mutagenic properties. Moreover, pharmacological treatment with 33i, improved cognitive dysfunction and long-term potentiation, reducing amyloid pathology and neuroinflammation in the APP/PS1 AD mouse model. However, this treatment increased peripheral levels of the inflammatory cytokines IL-1β, TNF, IL-6 and MCP-1. Accordingly, peripheral SIRT2 inhibition with the blood brain barrier impermeable compound AGK-2, worsened the cognitive capacities and increased systemic inflammation. The analysis of human samples ...
Source: Journal of NeuroImmune Pharmacology - September 12, 2023 Category: Drugs & Pharmacology Source Type: research

Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

EGFR-mutated non-small lung cancer brain metastases and radiosurgery outcomes with a focus on leptomeningeal disease
ConclusionThe study shows that current-generation targeted therapy for EGFR-mutated NSCLC patients may prevent the development and progression of LMD, leading to improved survival outcomes. Nevertheless, LMD is associated with poor outcomes and neurologic death, making innovative strategies to treat LMD essential.
Source: Journal of Neuro-Oncology - September 10, 2023 Category: Cancer & Oncology Source Type: research

Coronavirus disease-19 is associated with decreased treatment access and worsened outcomes in malignant brain tumor patients
CONCLUSION: COVID-19 infection was associated with worse patient outcome in malignant brain tumor patients, including decreased likelihood of receiving surgery, increased likelihood of mortality, and increased likelihood of non-routine discharge. Our study highlights the need to balance the risks and benefits of delaying surgery for malignant brain tumor patients with COVID-19. Although the COVID-19 pandemic is no longer a public health emergency, understanding the pandemic's impact on outcome provides important insight in effective triage for these patients in the situations where resources are limited.PMID:37680935 | PMC...
Source: Surgical Neurology International - September 8, 2023 Category: Neurosurgery Authors: Kristie Qwan-Ting Liu Jonathan Dallas Talia A Wenger Hunter Richards Li Ding Frances Elaine Chow Gabriel Zada William J Mack Frank J Attenello Source Type: research

Pages: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20