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Epigenetic reprogramming of a distal developmental enhancer cluster drives SOX2 overexpression in breast and lung adenocarcinoma
Nucleic Acids Res. 2023 Sep 22:gkad734. doi: 10.1093/nar/gkad734. Online ahead of print.ABSTRACTEnhancer reprogramming has been proposed as a key source of transcriptional dysregulation during tumorigenesis, but the molecular mechanisms underlying this process remain unclear. Here, we identify an enhancer cluster required for normal development that is aberrantly activated in breast and lung adenocarcinoma. Deletion of the SRR124-134 cluster disrupts expression of the SOX2 oncogene, dysregulates genome-wide transcription and chromatin accessibility and reduces the ability of cancer cells to form colonies in vitro. Analysis...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Luis E Abatti Patricia Lado-Fern ández Linh Huynh Manuel Collado Michael M Hoffman Jennifer A Mitchell Source Type: research

Tetrahydrobiopterin from cyanide-degrading bacterium Bacillus pumilus strain SVD06 induces apoptosis in human lung adenocarcinoma cell (A549)
Biotechnol Appl Biochem. 2023 Sep 20. doi: 10.1002/bab.2509. Online ahead of print.ABSTRACTTetrahydrobiopterin (BH4) is an essential biological cofactor and a derivative of pterin which is considered potent anticancer agents. In continuation of our previous study on the identification of BH4 from cyanide-degrading Bacillus pumilus, the present study focuses on evaluating the anticancer properties of BH4 on A549, a human lung adenocarcinoma. Anticancer activity analysis shows that BH4 inhibited A549 cell growth after 24 h of incubation with 0.02 mg/mL. In acridine orange/ethidium bromide staining, BH4-treated A549 cells sho...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Ramasamy Mahendran Sanjay Prasad Selvaraj Anand Raj Dhanapal Sabna Bhaskaran Sarasa Beutline Malgija Mathias Bency Thankappan Daniel Raja Femil Selta Palanivel Naveen Rhenghachar Poorani Navaneethan Sundhar Mamatha M Pillai Rajendran Selvakumar Chih-Yang Source Type: research

Tetrahydrobiopterin from cyanide ‐degrading bacterium Bacillus pumilus strain SVD06 induces apoptosis in human lung adenocarcinoma cell (A549)
AbstractTetrahydrobiopterin (BH4) is an essential biological cofactor and a derivative of pterin which is considered potent anticancer agents. In continuation of our previous study on the identification of BH4 from cyanide-degradingBacillus pumilus, the present study focuses on evaluating the anticancer properties of BH4 on A549, a human lung adenocarcinoma. Anticancer activity analysis shows that BH4 inhibited A549 cell growth after 24  h of incubation with 0.02 mg/mL. In acridine orange/ethidium bromide staining, BH4-treated A549 cells showed apoptotic morphology. BH4 treatment caused cell cycle arrest at G0/G1 phase c...
Source: Biotechnology and Applied Biochemistry - September 21, 2023 Category: Biochemistry Authors: Ramasamy Mahendran, Sanjay Prasad Selvaraj, Anand Raj Dhanapal, Sabna Bhaskaran sarasa, Beutline Malgija Mathias, Bency Thankappan, Daniel Raja Femil Selta, Palanivel Naveen, Rhenghachar Poorani, Navaneethan Sundhar, Mamatha M. Pillai, Rajendra Tags: ORIGINAL ARTICLE Source Type: research

Fibroblast subtypes in pancreatic cancer and pancreatitis: from mechanisms to therapeutic strategies
AbstractExcessive fibrosis is a predominant feature of pancreatic stroma and plays a crucial role in the development and progression of pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). Emerging evidence showed diversity and heterogeneity of fibroblasts play crucial and somewhat contradictory roles, the interactions between fibroblasts and pancreatic cells or infiltrating immune cells are of great importance during PDAC and CP progression, with some promising therapeutic strategies being tested. Therefore, in this review, we describe the classification of fibroblasts and their functions in PDAC and pan...
Source: Cellular Oncology - September 18, 2023 Category: Cancer & Oncology Source Type: research

Comprehensive analysis of Cuproplasia and immune microenvironment in lung adenocarcinoma
Conclusion: The Cuproplasia related gene can be used to predict the prognosis and immunotherapy outcome of LUAD patients, and may exert its effect by affecting chromosome-related pathways and macrophages.
Source: Frontiers in Pharmacology - September 15, 2023 Category: Drugs & Pharmacology Source Type: research

Gastric Metastasis from Invasive Lobular Breast Cancer, Resembling Primary Gastric Cancer
This report presents a case of breast ILC for which the initial presentation was gastric metastasis. A 62-y-old woman presented with gastric outlet obstruction secondary to a gastric mass that had been diagnosed on upper gastrointestinal endoscopy and biopsy. The patient had been referred for 18F-FDG PET/CT for staging. The baseline 18F-FDG PET/CT scan demonstrated extensive axillary nodal and gastric metastases with a breast mass, which raised suspicion of a primary breast carcinoma. Distinguishing primary gastric adenocarcinoma from metastatic breast ILC is essential, considering that the 2 diagnoses lead to divergent tr...
Source: Journal of Nuclear Medicine Technology - September 12, 2023 Category: Nuclear Medicine Authors: Hasnain Dilawar Akhtar Ahmed Salman Habib Javaid Iqbal Talal Abdul Rehman Imran Hadi Noor Nisa Shazia Fatima Source Type: research

Gastric adenocarcinoma complicated by an intra ‐abdominal abscess: A case report
AbstractPerforated gastric adenocarcinoma is a rare and challenging complication of gastric cancer, which can lead to intra-abdominal abscesses and other complications. Management of perforated gastric adenocarcinoma with an intra-abdominal abscess requires a multidisciplinary approach, including empiric antibiotic therapy and fluid resuscitation, partial gastrectomy with Roux-en-Y reconstruction, and image-guided drainage. This case report highlights the complex and challenging nature of managing perforated gastric adenocarcinoma with intra-abdominal abscesses. Prompt recognition and timely intervention are essential for ...
Source: Clinical Case Reports - September 12, 2023 Category: General Medicine Authors: Zubir S. Rentiya, Carlo Kristian Chu  Carredo, Oluwasayo Owolabi, Pugazhendi Inban, Faiza Arslan, Victor Ameh Odoma, Abiodun Adegbite, Maya Ann Francis, Isioma R. Okobia, Taha Sajjad, Aadil Mahmood Khan, Anasonye Emmanuel Kelechi Tags: CASE REPORT Source Type: research

Integrated transcriptome and proteome analysis indicates potential biomarkers of prostate cancer in offspring of pregnant rats exposed to a phthalate mixture during gestation and lactation
Chemosphere. 2023 Sep 8:140020. doi: 10.1016/j.chemosphere.2023.140020. Online ahead of print.ABSTRACTAs the second leading cause of death for cancer among men worldwide, prostate cancer (PCa) prevention and detection remain a critical challenge. One aspect of PCa research is the identification of common environmental agents that may increase the risk of initiation and progression of PCa. Endocrine disrupting chemicals (EDCs) are strong candidates for risk factors, partially because they alter essential pathways for prostate gland development and oncogenesis. Phthalates correspond to a set of commercially used plasticizers...
Source: Chemosphere - September 10, 2023 Category: Chemistry Authors: A M Aquino L G Alonso-Costa Santos Saa V A Rocha L F Barbisan A Bedrat L A Justulin J A Flaws B Lemos W R Scarano Source Type: research

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