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Condition: Alzheimer's
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Total 4220 results found since Jan 2013.
The Role of Pyroptosis in Alzheimer's Disease
J Integr Neurosci. 2023 Aug 22;22(5):129. doi: 10.31083/j.jin2205129.ABSTRACTPyroptosis is a type of regulated cell death that relies on caspases, vesicles, and the cleavage of gasdermin proteins (which create pores in the cell membrane). The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome, which is involved in this process, is the most widely studied inflammasome. Caspase-1 activates pro-inflammatory cytokines, such as IL-1β and IL-18. Gasdermin D (GSDMD) is the most important executive protein. GSDMD, a substrate rather than an upstream protease, determines the occurrence of pyropt...
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Yanxiu Ju Ling Zhao Songtao Li Qing Zhao Source Type: research
Mechanistic multiscale modelling of energy metabolism in human astrocytes reveals the impact of morphology changes in Alzheimer ’s Disease
by Sofia Farina, Val érie Voorsluijs, Sonja Fixemer, David Bouvier, Susanne Claus, Mark Ellisman, Stéphane P. A. Bordas, Alexander Skupin
Astrocytes with their specialised morphology are essential for brain homeostasis as metabolic mediators between blood vessels and neurons. In neurodegenerative diseases such as Alzheimer ’s disease (AD), astrocytes adopt reactive profiles with molecular and morphological changes that could lead to the impairment of their metabolic support and impact disease progression. However, the underlying mechanisms of how the metabolic function of human astrocytes is impaired by their morpho l...
Source: PLoS Computational Biology - September 20, 2023 Category: Biology Authors: Sofia Farina Source Type: research
Low dose of levetiracetam counteracts amyloid β-induced alterations of hippocampal gamma oscillations by restoring fast-spiking interneuron activity
Exp Neurol. 2023 Sep 17:114545. doi: 10.1016/j.expneurol.2023.114545. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized at an early stage by memory alterations that worsen during the development of the disease. Several clinical trials in phase 3 have failed despite being able to counteract classical AD-related alterations, possibly because of the lack of recovery of the regular neuronal network activity essential for memory including low gamma oscillations (γ-Osc). Nowadays, Levetiracetam (LEV), an SV2A modulator approved for epilepsy, is being used in trials with AD patients without further support ...
Source: Experimental Neurology - September 19, 2023 Category: Neurology Authors: Arturo G Isla Hugo Balleza-Tapia Fengna Chu Gefei Chen Janne Johansson Per Nilsson Andr é Fisahn Source Type: research
Leaking Gut, Leaking Blood Vessels, Leaking Blood Brain Barrier
In today's open access paper, researchers attempt to throw a big tent over three distinct issues in the aging of the body and brain. Firstly, the intestinal barrier fails, allowing bacteria and bacterial metabolites into tissue and the circulation, where they can provoke dysfunction and inflammation. Secondly, blood vessels become leaky, harming surrounding tissues by allowing excessive fluid, inappropriate molecules and cells to escape. Lastly, the blood-brain barrier leaks; this is a more specialized barrier layer surrounding blood vessels in the brain, and when it leaks, the passage of unwanted cells and molecules into ...
Source: Fight Aging! - September 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Noradrenaline transporter PET reflects neurotoxin-induced noradrenaline level decrease in the rat hippocampus
Conclusions[11C]MRB PET may be used as an in vivo biomarker of noradrenaline concentrations in the hippocampus of the neurodegenerating brain. Further studies appear warranted to extend its applicability to AD studies.
Source: EJNMMI Research - September 15, 2023 Category: Radiology Source Type: research
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease
Annu Rev Pharmacol Toxicol. 2023 Sep 14. doi: 10.1146/annurev-pharmtox-040323-031929. Online ahead of print.ABSTRACTSleep is essential for human well-being, yet the quality and quantity of sleep reduce as age advances. Older persons (>65 years old) are more at risk of disorders accompanied and/or exacerbated by poor sleep. Furthermore, evidence supports a bidirectional relationship between disrupted sleep and Alzheimer's disease (AD) or related dementias. Orexin/hypocretin neuropeptides stabilize wakefulness, and several orexin receptor antagonists (ORAs) are approved for the treatment of insomnia in adults. Dysregulati...
Source: Pharmacological Reviews - September 14, 2023 Category: Drugs & Pharmacology Authors: Jarrah O-Z J Kron Ryan J Keenan Daniel Hoyer Laura H Jacobson Source Type: research
