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Condition: Parkinson's Disease
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Total 4236 results found since Jan 2013.
Effect of the mGlu4 positive allosteric modulator ADX-88178 on parkinsonism, psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset
ConclusionsWhereas these results provide additional evidence of the anti-parkinsonian and anti-dyskinetic effects of mGlu4 positive allosteric modulation as an adjunct to L-DOPA, they also suggest that ADX-88178 may exacerbate dopaminergic psychosis. Further studies are needed to evaluate this possible adverse effect of mGlu4 PAMs on PD psychosis.
Source: Psychopharmacology - September 21, 2023 Category: Psychiatry Source Type: research
White Matter Microstructural Differences between Essential Tremor and Parkinson Disease, Evaluated Using Advanced Diffusion MRI Biomarkers
CONCLUSIONS: Advanced diffusion-based metrics may provide a better understanding of the white matter microstructural characteristics in disparate motor-associated diseases with different underlying phenotypes, such as ET and PD.PMID:37735131 | DOI:10.31083/j.jin2205114
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Maurizio Bergamino Sana Aslam Jacob J Knittel Lea Alhilali Ashley M Stokes Source Type: research
Brain Hemisphere Dissimilarity, a Self-Supervised Learning Approach for alpha-synucleinopathies prediction with FDG PET
Proc IEEE Int Symp Biomed Imaging. 2023 Apr;2023:10.1109/isbi53787.2023.10230560. doi: 10.1109/isbi53787.2023.10230560. Epub 2023 Sep 1.ABSTRACTIdiopathic Rem sleep Behavior Disorder (iRBD) is a significant biomarker for the development of alpha-synucleinopathies, such as Parkinson's disease (PD) or Dementia with Lewy bodies (DLB). Methods to identify patterns in iRBD patients can help in the prediction of the future conversion to these diseases during the long prodromal phase when symptoms are non-specific. These methods are essential for disease management and clinical trial recruitment. Brain PET scans with 18F-FDG PET ...
Source: Proceedings - International Symposium on Biomedical Imaging - September 14, 2023 Category: Radiology Authors: S Tripathi P Mattioli C Liguori A Chiaravalloti D Arnaldi L Giancardo Source Type: research
Gut microbiota-induced CXCL1 elevation triggers early neuroinflammation in the substantia nigra of Parkinsonian mice
This study may pave the way for understanding the "brain-gut-microbiota" molecular regulatory networks in PD pathogenesis. The aged C57BL/6 male mice with rotenone intragastric administration showed altered gut microbiota, which caused systemic inflammation, PPARγ signalling inhibition and neuroinflammation, brain iron deposition and ferroptosis, and eventually dopaminergic neurodegeneration in PD.PMID:37674043 | DOI:10.1038/s41401-023-01147-x
Source: Acta Pharmacologica Sinica - September 6, 2023 Category: Drugs & Pharmacology Authors: Xi-Zhen Ma Lei-Lei Chen Le Qu Hui Li Jun Wang Ning Song Jun-Xia Xie Source Type: research
A Complex Interplay of DJ-1, LRRK2, and Nrf2 in the Regulation of Mitochondrial Function in Cypermethrin-Induced Parkinsonism
Mol Neurobiol. 2023 Sep 6. doi: 10.1007/s12035-023-03591-6. Online ahead of print.ABSTRACTCypermethrin impairs mitochondrial function, induces redox imbalance, and leads to Parkinsonism in experimental animals. Knockdown of deglycase-1 (DJ-1) gene, which encodes a redox-sensitive antioxidant protein, aggravates cypermethrin-mediated α-synuclein overexpression and oxidative alteration of proteins. DJ-1 is also reported to be essential for maintaining stability of nuclear factor erythroid 2-related factor 2 (Nrf2), shielding cells against oxidative insult. Leucine-rich repeat kinase 2 (LRRK2), another protein associated wit...
Source: Molecular Medicine - September 6, 2023 Category: Molecular Biology Authors: Alika Sarkar Mahendra Pratap Singh Source Type: research
A review on neurodegeneration in the fast-ageing killifish, the first animal model to study the natural occurrence of neuronal cell loss
Ageing Res Rev. 2023 Sep 2:102065. doi: 10.1016/j.arr.2023.102065. Online ahead of print.ABSTRACTThanks to medical and technological improvements, our world population has become ever-greying. In consequence, the incidence and prevalence of age-related central nervous system neuropathies, such as Alzheimer's (AD) and Parkinson's disease (PD), are increasing tremendously. Despite many research efforts, the precise aetiology of these age-related neurodegenerative disorders remains elusive, highlighting the urgent need for more effective treatments. Current preclinical research mainly uses animal models that do not fully reca...
Source: Cell Research - September 4, 2023 Category: Cytology Authors: Steven Bergmans Laura Raes Lieve Moons Lies De Groef Source Type: research
Translating digital healthcare to enhance clinical management: a protocol for an observational study using a digital health technology system to monitor medication adherence and its effect on mobility in people with Parkinsons
This study aims to use a novel DHT system (DHTS) (comprising of a smartphone, smartwatch and inertial measurement unit (IMU)) to assess self-reported medication adherence, and its impact on digital mobility outcomes (DMOs) in PwP.
Methods and analysis
This single-centre, UK-based study, will recruit 55 participants with Parkinson’s. Participants will complete a range of clinical, and physical assessments. Participants will interact with a DHTS over 7 days, to assess self-reported medication adherence, and monitor mobility and contextual factors in the real world. Participants will complete a motor complications diar...
Source: BMJ Open - September 4, 2023 Category: General Medicine Authors: Packer, E., Debelle, H., Bailey, H. G. B., Ciravegna, F., Ireson, N., Evers, J., Niessen, M., Shi, J. Q., Yarnall, A. J., Rochester, L., Alcock, L., Del Din, S. Tags: Open access, Research methods Source Type: research
Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.
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Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/
Neurogenesis is the process by which new neurons are created by neural stem ce...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Deep Learning, the Retina, and Parkinson Disease —Reply
In Reply We appreciate the thoughtful comments provided by Dr Hamedani on our recent article. Dr Hamedani indicated that Parkinson disease (PD) is a clinical diagnosis for which no imaging or laboratory testing is required. In general, we agree it is possible to diagnose PD without any brain imaging or laboratory tests. However, it is also sometimes necessary to rule out other possible diseases. For example, brain magnetic resonance imaging is essential to rule out vascular parkinsonism, which tends to arise in geographic regions with a high prevalence of cerebral small-vessel disease and white matter hyperintensities (eg,...
Source: JAMA Ophthalmology - September 1, 2023 Category: Opthalmology Source Type: research
Mitophagy-promoting agents and their ability to promote healthy-aging
In conclusion, this article provides an up-to-date source of information about natural and synthetic substances that activate mitophagy and, hopefully, stimulates new hypotheses and studies that promote healthy human aging worldwide.PMID:37650304 | DOI:10.1042/BST20221363
Source: Biochemical Society Transactions - August 31, 2023 Category: Biochemistry Authors: Vijigisha Srivastava Einav Gross Source Type: research
Targeted protein degradation for the treatment of Parkinson's disease: Advances and future perspective
Biomed Pharmacother. 2023 Aug 29;166:115408. doi: 10.1016/j.biopha.2023.115408. Online ahead of print.ABSTRACTParkinson's disease (PD) is a progressive disorder that belongs to a class of neurodegenerative disorders (NDs) called Synucleinopathies. It has characterized by the misfolding and aggregation of a-synuclein. Our understanding of PD continues to evolve, and so does our approach to treatment. including therapies aimed at delaying pathology, quitting neuronal loss, and shortening the course of the disease by selectively targeting essential proteins suspected to play a role in PD pathogenesis. One emerging approach th...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 31, 2023 Category: Drugs & Pharmacology Authors: Roshanak Amirian Mehdi Azadi Badrbani Hossein Derakhshankhah Zhila Izadi Mohammad-Ali Shahbazi Source Type: research
