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Synthetic cannabinoids in hair —Prevalence of use in abstinence control programs for driver's license regranting in Germany
Synthetic cannabinoids (SCs) have steadily increased on the drug market but are rarely analyzed in abstinence control programs for driver's license regranting. Between March 2020 and March 2021, hair samples from this collective were retrospectively screened for SCs by liquid chromatography –tandem mass spectrometry (LC–MS/MS) analysis, and those testing positive were additionally screened by liquid chromatography-high resolution time of flight mass spectrometry (LC-qTOF/MS). AbstractAlthough the use, structural variety, and prevalence of synthetic cannabinoids (SCs) have steadily increased on the drug market, they are...
Source: Drug Testing and Analysis - September 21, 2023 Category: Drugs & Pharmacology Authors: Johannes Kutzler, Aldo Eliano Polettini, Sergej Bleicher, Christoph Sauer, Wolfgang Schultis, Merja A. Neukamm, Volker Auw ärter Tags: RESEARCH ARTICLE Source Type: research

Repeated chemogenetic activation of dopaminergic neurons induces reversible changes in baseline and amphetamine-induced behaviors
ConclusionsWe found that repeated DREADD activation of DA neurons evokes homeostatic changes that should be factored into the interpretation of chronic DREADD applications and their impact on circuit function and behavior. These effects are likely to also be seen in other neuronal systems and underscore the importance of studying neuroadaptive changes with chronic or repeated DREADD activation.
Source: Psychopharmacology - August 18, 2023 Category: Psychiatry Source Type: research

d-Amphetamine Transdermal System in Treatment of Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: Secondary Endpoint Results and Post Hoc Effect Size Analyses from a Pivotal Trial
Journal of Child and Adolescent Psychopharmacology,Volume 33, Issue 5, Page 176-182, June 2023.
Source: Journal of Child and Adolescent Psychopharmacology - June 16, 2023 Category: Pediatrics Authors: Andrew J. Cutler Katsumi Suzuki Brittney Starling Kanan Balakrishnan Marina Komaroff Suzanne Meeves Mariacristina Castelli Ann Childress Source Type: research

Behavioural effects of APH199, a selective dopamine D4 receptor agonist, in animal models
ConclusionsOur data challenged the hypothesis of the therapeutic benefits of DRD4 agonists, pointing out a possible aggravation of psychosis. We suggest a need for further preclinical studies to ensure the safety of antipsychotics with DRD4 stimulating properties.
Source: Psychopharmacology - March 21, 2023 Category: Psychiatry Source Type: research

Captagone & amp; Morbid Jealousy
This study aimed to explore the relationship between Captagon usage and the development of delusions of infidelity. The study sample; 101 male patients, was recruited from patients admitted to Eradah Complex for Mental Health and addiction, Jeddah, Saudi Arabia, with the diagnosis of amphetamine (Captagon) induced psychosis during the period from September 2021 to March 2022. All patients underwent an extensive psychiatric interview; including interview with patients' families; a demographic sheet, a drug use questionnaire, the structured clinical interview for DSM-IV (SCID 1), routine medical investigation, and urine scre...
Source: Psychopharmacology Bulletin - March 6, 2023 Category: Psychiatry & Psychology Authors: Amr Said Shalaby Osama Mohamed Badr Nassar Abdullah Osama Bahanan Mishal Hasan Alshehri Nasr Farid Nasr Abou Elzahab Source Type: research

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