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Total 712 results found since Jan 2013.
New ESC 2023, ACS guidelines : “ STEMI merges with NSTEMI ” for some good reasons.
Is it a STEMI or Non -STEMI ? The apparently realistic dichotomous thinking about ACS among physicians has existed for quite a long time. However, since the underlying pathobiology being same , it is worth wondering whether the conventional bifurcation of ACS is fool -proof , when applied to management decsions. The rapidity and totality of plaque fissusre, rupture eruption,or erosion and the subsequent response of the local hemorheological system, determine the ferocity of the event.
How to recognise all these deep intracellular events in bed side ? Unfortunately, still with a lot of gratitude, we have to rely on the ...
Source: Dr.S.Venkatesan MD - September 3, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Novel Anti-Inflammatory Therapies in Coronary Artery Disease and Acute Coronary Syndromes
Life (Basel). 2023 Jul 31;13(8):1669. doi: 10.3390/life13081669.ABSTRACTEvidence suggests that inflammation plays an important role in atherosclerosis and the consequent clinical presentation, including stable coronary artery disease (CAD) and acute coronary syndromes (ACS). The most essential elements are cytokines, proteins with hormone-like properties that are produced by the immune cells, endothelial cells, platelets, fibroblasts, and some stromal cells. Interleukins (IL-1β and IL-6), chemokines, interferon-γ (IFN-γ), and tumor necrosis factor-alpha (TNF-α) are the cytokines commonly associated with endothelial dys...
Source: Atherosclerosis - August 26, 2023 Category: Cardiology Authors: Yannis Dimitroglou Constantina Aggeli Panagiotis Theofilis Panagiotis Tsioufis Evangelos Oikonomou Christos Chasikidis Konstantinos Tsioufis Dimitris Tousoulis Source Type: research
Berberine and aspirin prevent traumatic heterotopic ossification by inhibition of BMP signalling pathway and osteogenic differentiation
J Cell Mol Med. 2023 Aug 22. doi: 10.1111/jcmm.17919. Online ahead of print.ABSTRACTHeterotopic ossification (HO) is a pathological process that often occurs in soft tissues following severe trauma. There is no effective therapy for HO. The BMP signalling pathway plays an essential role in the pathogenesis of HO. Our previous study showed that AMPK negatively regulates the BMP signalling pathway and osteogenic differentiation. The present study aims to study the effect of two AMPK activators berberine and aspirin on osteogenic differentiation and HO induced by traumatic injury. The effects of two AMPK activators, berberine...
Source: Molecular Medicine - August 22, 2023 Category: Molecular Biology Authors: Jingjing Fan Jiayu Gao Jie Chen Jia Hou Mengchao Liu Yanmiao Dang Hui Lin Source Type: research
Multi-omics reveals aspirin eugenol ester alleviates neurological disease
CONCLUSIONS: In conclusion, AEE could play positive effects on neurological-related diseases.PMID:37572635 | DOI:10.1016/j.biopha.2023.115311
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 12, 2023 Category: Drugs & Pharmacology Authors: Qi Tao Zhen-Dong Zhang Xiao-Rong Lu Zhe Qin Xi-Wang Liu Shi-Hong Li Li-Xia Bai Bo-Wen Ge Jian-Yong Li Ya-Jun Yang Source Type: research
The effect of thrombocytapheresis on hemogram and biochemistry parameters in patients with essential thrombocytemia
CONCLUSION: The use of thrombocytapheresıs in patients with essential thrombocytosis causes a rapid decrease in platelet values as well as an effect on hemogram and biochemistry parameters. Other hemogram and biochemistry parameters such as platelet value should be monitored in patients.PMID:37558046 | DOI:10.1016/j.tracli.2023.08.001
Source: Transfusion Clinique et Biologique - August 9, 2023 Category: Hematology Authors: Ahmet Kaya İrfan Kuku Mehmet Ali Erkurt Emin Kaya İlhami Berber Soykan Bi çim Emine Hidayet Salih C ırık S üleyman Arslan Fatma Hilal Ya ğin Ahmet Sar ıcı Source Type: research
The effect of thrombocytapheresis on hemogram and biochemistry parameters in patients with essential thrombocytemia
CONCLUSION: The use of thrombocytapheresıs in patients with essential thrombocytosis causes a rapid decrease in platelet values as well as an effect on hemogram and biochemistry parameters. Other hemogram and biochemistry parameters such as platelet value should be monitored in patients.PMID:37558046 | DOI:10.1016/j.tracli.2023.08.001
Source: Transfusion Clinique et Biologique - August 9, 2023 Category: Hematology Authors: Ahmet Kaya İrfan Kuku Mehmet Ali Erkurt Emin Kaya İlhami Berber Soykan Bi çim Emine Hidayet Salih C ırık S üleyman Arslan Fatma Hilal Ya ğin Ahmet Sar ıcı Source Type: research
WHO Endorses Polypills; SAVR Valve Recall; Bronny James Recovering
(MedPage Today) -- The WHO Model List of Essential Medicines added three polypills for the prevention of atherosclerotic cardiovascular disease.
Low-dose aspirin failed to reduce ischemic stroke among older adults in a secondary analysis of ASPREE...
Source: MedPage Today Cardiovascular - August 2, 2023 Category: Cardiology Source Type: news
Blood Pressure Meds vs Blood Thinners: What ’ s The Difference?
Conclusion
In conclusion, while blood pressure medicines and blood thinners are both crucial to heart health, their roles and mechanisms of action are notably distinct. Blood pressure medication works primarily on the vascular system, aiding in reducing blood pressure by relaxing blood vessels or altering the heart’s function. On the other hand, blood thinners target the blood itself, working to prevent the formation of potentially dangerous blood clots.
Throughout this article, one thing becomes undeniably clear: the importance of regular consultations with your healthcare provider. When it comes to managing m...
Source: The EMT Spot - July 20, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Application of multiple machine learning approaches to determine key pyroptosis molecules in type 2 diabetes mellitus
ConclusionAltogether, this work proposes the key pyroptosis genes in T2DM, which might become possible molecules for the management and treatment of T2DM and its complications.
Source: Frontiers in Endocrinology - July 19, 2023 Category: Endocrinology Source Type: research
I was reading ECGs on the system when I came across this one, called " normal " by the conventional computer algorithm
I come in early for every shift to read the ECGs on the system that have not yet been " confirmed " . I came across this one:The computer calls is: " SINUS RHYTHM. NORMAL ECG "What do you think? Be VERY careful when the computer calls the ECG " Normal " . I saw the inferior ST depression (which is reciprocal to subtle STE in aVL) and the subtle ST depression in precordial leads and thought:" If this patient came in with chest pain, then it is an acute OMI. "So I looked on the computer. Turns out that it was a 50-something patient with no previous cardiac history who had called 911 for chest pain...
Source: Dr. Smith's ECG Blog - July 12, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
< em > In Silico < /em > Analysis: HLA-DRB1 Gene's Variants and Their Clinical Impact
In conclusion, these previously functional identified variants could lead to gene alteration, which may directly or indirectly contribute to the occurrence of many diseases. The study's results could be an important guide in the research of potential diagnostic and therapeutic interventions that require experimental mutational validation and large-scale clinical trials.PMID:37387418 | DOI:10.1177/09636897231184473
Source: Cell Transplantation - June 30, 2023 Category: Cytology Authors: Mohamed M Hassan Mohamed A Hussain Sababil S Ali Mohammed A Mahdi Source Type: research
